基于检测肿瘤细胞中rad51焦点的方法
阅读说明:本技术 基于检测肿瘤细胞中rad51焦点的方法 (Methods based on detection of RAD51 focus in tumor cells ) 是由 比奥莱塔·塞拉埃利萨尔德 朱迪斯·博尔马纳赫尔皮 克里斯蒂娜·克鲁斯桑布拉诺 阿尔瓦·洛普格瓦 于 2018-12-21 设计创作,主要内容包括:本发明提供了允许确定被诊断为患有癌症的对象对抗癌治疗是具有敏感性还是抗性的方法,其基于从所述对象中分离的包含肿瘤细胞的样品中具有RAD51焦点之细胞的水平,其中所述对象在分离所述样品之前24小时未接受选自AC、FEC、ECF和诺维本/表柔比星的化学治疗,并且其中所述样品在确定具有RAD51焦点之细胞的水平之前未用诱导DNA损伤的方法进行处理。(The present invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer therapy based on the level of cells having a focus of RAD51 in a sample comprising tumor cells isolated from said subject, wherein said subject has not received a chemotherapy selected from the group consisting of AC, FEC, ECF and novabin/epirubicin 24 hours before isolating said sample, and wherein said sample has not been treated with a method of inducing DNA damage prior to determining the level of cells having a focus of RAD 51.)