阅读说明：本技术 一种足部用皮肤抑菌液及其制备方法 (Foot skin antibacterial liquid and preparation method thereof ) 是由 刘海军 仝伯胜 李志增 胡宁宁 董婷婷 肖灿华 于 2020-07-14 设计创作，主要内容包括：本发明涉及一种足部用皮肤抑菌液,包括以下组分的原料：以100.0ml为单位,1单位足部用皮肤抑菌液成品包括渗漉提取液45.0-55.0ml、水杨酸0.4-0.6g、苯甲酸0.4-0.6g、硼酸0.4-0.6g、醋酸氯己定0.15-0.25g、余量为重量百分比浓度为60％-70％的乙醇水溶液,其中渗漉提取液由白鲜皮0.9-1.1g、土荆皮0.9-1.1g、苦参0.9-1.1g、黄柏0.9-1.1g、蛇床子0.9-1.1g、蒲公英0.9-1.1g、金银花0.9-1.1g和地肤子0.9-1.1g渗漉提取、浓缩制得；本发明的足部用皮肤抑菌液为澄清抑菌液,不仅对多种真菌造成的足癣有效且对多汗、细菌大量繁殖造成的脚臭有较好的作用,而且对蚊虫叮咬效果甚好；采用抑菌圈法测试本产品的抑菌性,实际产品测试效果为：金黄葡萄球菌18mm,大肠杆菌14.92mm,白色念珠菌13.48mm,抑菌效果极佳。(The invention relates to a foot skin antibacterial liquid, which comprises the following raw materials: taking 100.0ml as a unit, 1 unit of the finished product of the foot skin bacteriostasis liquid comprises 45.0-55.0ml of percolation extract, 0.4-0.6g of salicylic acid, 0.4-0.6g of benzoic acid, 0.4-0.6g of boric acid, 0.15-0.25g of chlorhexidine acetate and the balance of ethanol water solution with the weight percentage concentration of 60-70 percent, wherein the percolation extract is prepared by 0.9-1.1g of cortex dictamni, 0.9-1.1g of golden larch bark, 0.9-1.1g of radix sophorae flavescentis, 0.9-1.1g of golden cypress, 0.9-1.1g of fructus cnidii, 0.9-1.1g of dandelion, 0.9-1.1g of honeysuckle and 0.9-1.1g of belvedere fruit through percolation extraction and concentration; the foot skin antibacterial liquid is a clear antibacterial liquid, not only has good effect on tinea pedis caused by various fungi and foot odor caused by excessive sweating and mass bacterial reproduction, but also has good effect on mosquito bite; the bacteriostatic activity of the product is tested by adopting a bacteriostatic ring method, and the test effect of the actual product is as follows: 18mm of staphylococcus aureus, 14.92mm of escherichia coli and 13.48mm of candida albicans, and the bacteriostatic effect is excellent.)

1. The foot skin antibacterial liquid is characterized by comprising the following raw materials: taking 100.0ml as a unit, 1 unit of the finished product of the foot skin bacteriostasis liquid comprises 45.0-55.0ml of percolation extract, 0.4-0.6g of salicylic acid, 0.4-0.6g of benzoic acid, 0.4-0.6g of boric acid, 0.15-0.25g of chlorhexidine acetate and the balance of ethanol water solution with the weight percentage concentration of 60-70 percent, wherein the percolation extract is prepared by 0.9-1.1g of dittany bark, 0.9-1.1g of golden larch bark, 0.9-1.1g of lightyellow sophora root, 0.9-1.1g of amur corktree bark, 0.9-1.1g of common cnidium fruit, 0.9-1.1g of dandelion, 0.9-1.1g of honeysuckle flower and 0.9-1.1g of belvedere fruit through percolation extraction and concentration.

2. The foot skin bacteriostatic liquid according to claim 1, wherein: the skin bacteriostatic solution for feet of 1 unit comprises 50.0ml of diacolation extract, 0.5g of salicylic acid, 0.5g of benzoic acid, 0.5g of boric acid, 0.2g of chlorhexidine acetate and the balance of ethanol water solution with the weight percentage concentration of 60-70%, wherein the diacolation extract is prepared by diacolation extraction and concentration of 1.0g of cortex dictamni, 1.0g of cortex pseudolaricis, 1.0g of radix sophorae flavescentis, 1.0g of golden cypress, 1.0g of fructus cnidii, 1.0g of dandelion, 1.0g of honeysuckle and 1.0g of fructus kochiae.

3. The foot skin bacteriostatic liquid according to claim 1 or 2, wherein the bacteriostatic liquid comprises the following components in percentage by weight: 1 unit of foot skin antibacterial liquid finished product also comprises 1.0-2.0g of water-soluble azone.

4. The foot skin bacteriostatic liquid according to claim 1 or 2, wherein the bacteriostatic liquid comprises the following components in percentage by weight: the pH value of the foot skin bacteriostatic liquid is 2.5-4.5.

5. A preparation method of foot skin antibacterial liquid is characterized by comprising the following steps:

1) crushing: accurately weighing 0.9-1.1g of cortex dictamni, 0.9-1.1g of golden larch bark, 0.9-1.1g of golden cypress, 0.9-1.1g of radix sophorae flavescentis, 0.9-1.1g of dandelion, 0.9-1.1g of fructus cnidii, 0.9-1.1g of honeysuckle and 0.9-1.1g of fructus kochiae, mixing, starting a medicinal material grinder to grind into coarse powder of 60 meshes for later use;

2) dipping: putting the crushed coarse powder into a percolation tank of a percolation device, and soaking the coarse powder for 24-48 hours by using 60% ethanol in percentage by weight;

3) and (3) percolation: extracting coarse powder by percolation to obtain percolate coarse solution;

4) concentration: vacuum concentrating the percolate crude liquid at 70-80 deg.C to 45-50% of original volume of percolate crude liquid to obtain percolate extractive solution;

5) preparation: dissolving 0.4-0.6g of salicylic acid, 0.4-0.6g of benzoic acid, 0.4-0.6g of boric acid, 0.15-0.25g of chlorhexidine acetate and 1.0-2.0g of water-soluble azone in 50.0ml of diacolation extract in a container, adding 60-70% of ethanol by weight percentage concentration until the total volume of the solution is 100.0ml, and filtering 100um to obtain 1 unit of finished product of the foot skin antibacterial solution.

6. The method for preparing foot skin bacteriostatic liquid according to claim 5, characterized by comprising the following steps:

1) crushing: accurately weighing 1.0g of cortex dictamni, 1.0g of golden larch bark, 1.0g of golden cypress, 1.0g of radix sophorae flavescentis, 1.0g of dandelion, 1.0g of fructus cnidii, 1.0g of honeysuckle and 1.0g of fructus kochiae, mixing, and crushing into 60-mesh coarse powder by a medicinal material crusher for later use;

2) dipping: putting the crushed coarse powder into a percolation tank, adding 60% ethanol which is 0.8 time of the total amount of the medicinal materials, uniformly stirring, soaking and placing for 24-48 hours to ensure that the solvent is fully permeated and diffused;

3) and (3) percolation: adding 60% ethanol into an ethanol tank of a percolation device, slowly opening a valve of the ethanol tank, keeping the flow rate of 1/30 of the total amount of medicinal materials per minute, adjusting a percolate valve at the bottom of the percolation tank to keep the balance with the flow rate of the ethanol, and finishing the collection when the color of the percolate is lighter to obtain a percolate crude liquid;

4) concentration: pumping the percolation crude liquid into a vacuum concentration device with the vacuum degree of-0.05 to-0.08 Mpa, heating to 70-80 ℃, and then starting to concentrate until the concentration is 45-50% of the total volume of the percolation crude liquid to obtain percolation extract;

5) preparation: accurately weighing 0.5g of salicylic acid, 0.5g of benzoic acid, 0.5g of boric acid, 0.2g of chlorhexidine acetate and 1.0-2.0g of water-soluble azone into a preparation tank, adding 50ml of percolation extract, adding 60-70% ethanol with weight percentage concentration to constant volume to 100.0ml, stirring to fully dissolve the materials, and filtering by 100um to obtain 1 unit of finished product of the skin bacteriostatic solution for feet.

Technical Field

The invention belongs to the technical field of external drugs, and particularly relates to a foot skin antibacterial liquid and a preparation method thereof.

Background

Foot odor and beriberi are common diseases of feet of people, the foot odor is caused by that sweat glands are abundant in the hearts of feet, sweat is abundant, sweat contains a large amount of moisture and salt, and simultaneously bacteria are propagated and decomposed in a large amount of keratin, urea and lactic acid in the sweat, so that odor can be generated to cause the foot odor; dermatophytosis is foot dermatophyte infection caused by dermatophyte, the dermatophytosis is often generated on the skin between soles and toes, the foot side edges and other parts, mild dermatophytosis is manifested as blister and desquamation, and severe dermatophytosis can generate erosion, liquid seepage and bacterial infection. Although the beriberi and the foot odor are caused by different reasons, the beriberi and the foot odor are often caused at the same time, the beriberi is extremely itchy, and the foot odor makes family members and colleagues worried.

At present, various foot skin antibacterial liquids in the market are various, mainly inhibit candida albicans, staphylococcus aureus and escherichia coli, and treat foot odor mainly focusing on tinea pedis, but do not treat foot odor caused by bacterial infection of the foot odor.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a foot skin antibacterial liquid and a preparation method thereof.

The technical scheme of the invention is as follows:

a foot skin antibacterial liquid comprises the following raw materials: taking 100.0ml as a unit, 1 unit of the finished product of the foot skin bacteriostasis liquid comprises 45.0-55.0ml of percolation extract, 0.4-0.6g of salicylic acid, 0.4-0.6g of benzoic acid, 0.4-0.6g of boric acid, 0.15-0.25g of chlorhexidine acetate and the balance of ethanol water solution with the weight percentage concentration of 60-70 percent, wherein the percolation extract is prepared by 0.9-1.1g of cortex dictamni, 0.9-1.1g of golden larch bark, 0.9-1.1g of radix sophorae flavescentis, 0.9-1.1g of golden cypress, 0.9-1.1g of fructus cnidii, 0.9-1.1g of dandelion, 0.9-1.1g of honeysuckle and 0.9-1.1g of belvedere fruit through percolation extraction and concentration; in actual production, the content of each component of 1 unit is converted into an equal ratio.

Further, 1 unit of the foot skin bacteriostat comprises 50.0ml of diacolation extract, 0.5g of salicylic acid, 0.5g of benzoic acid, 0.5g of boric acid, 0.2g of chlorhexidine acetate and the balance of ethanol water solution with the weight percentage concentration of 60-70%, wherein the diacolation extract is prepared by diacolation extraction and concentration of 1.0g of cortex dictamni, 1.0g of golden larch bark, 1.0g of radix sophorae flavescentis, 1.0g of golden cypress, 1.0g of fructus cnidii, 1.0g of dandelion, 1.0g of honeysuckle and 1.0g of fructus kochiae.

Furthermore, 1 unit of the foot skin bacteriostat liquid finished product also comprises 1.0-2.0g of water-soluble azone.

Further, the pH value of the foot skin bacteriostatic liquid is 2.5-4.5.

Further, the finished product of the foot skin bacteriostatic liquid with 1 unit also comprises 0.1g of essence so as to increase the compliance of a user.

A preparation method of foot skin antibacterial liquid comprises the following steps:

1) crushing: accurately weighing 0.9-1.1g of cortex dictamni, 0.9-1.1g of golden larch bark, 0.9-1.1g of golden cypress, 0.9-1.1g of radix sophorae flavescentis, 0.9-1.1g of dandelion, 0.9-1.1g of fructus cnidii, 0.9-1.1g of honeysuckle and 0.9-1.1g of fructus kochiae, mixing, starting a medicinal material grinder to grind into coarse powder of 60 meshes for later use;

2) dipping: putting the crushed coarse powder into a percolation tank of a percolation device, and soaking the coarse powder for 24-48 hours by using 60% ethanol in percentage by weight;

3) and (3) percolation: extracting coarse powder by percolation to obtain percolate coarse solution;

4) concentration: vacuum concentrating the percolate crude liquid at 70-80 deg.C to 45-50% of original volume of percolate crude liquid to obtain percolate extractive solution;

5) preparation: dissolving 0.4-0.6g of salicylic acid, 0.4-0.6g of benzoic acid, 0.4-0.6g of boric acid, 0.15-0.25g of chlorhexidine acetate and 1.0-2.0g of water-soluble azone in 50.0ml of diacolation extract in a container, adding 60-70% of ethanol by weight percentage concentration until the total volume of the solution is 100.0ml, and filtering 100um to obtain 1 unit of finished product of the foot skin antibacterial solution.

Further, the preparation method of the foot skin bacteriostatic liquid comprises the following steps:

1) crushing: accurately weighing 1.0g of cortex dictamni, 1.0g of golden larch bark, 1.0g of golden cypress, 1.0g of radix sophorae flavescentis, 1.0g of dandelion, 1.0g of fructus cnidii, 1.0g of honeysuckle and 1.0g of fructus kochiae, mixing, and crushing into 60-mesh coarse powder by a medicinal material crusher for later use;

2) dipping: putting the crushed coarse powder into a percolation tank, adding 60% ethanol which is 0.8 time of the total amount of the medicinal materials, uniformly stirring, soaking and placing for 24-48 hours to ensure that the solvent is fully permeated and diffused;

3) and (3) percolation: adding 60% ethanol into an ethanol tank of a percolation device, slowly opening a valve of the ethanol tank, keeping the flow rate of 1/30 of the total amount of medicinal materials per minute, adjusting a percolate valve at the bottom of the percolation tank to keep the balance with the flow rate of the ethanol, and finishing the collection when the color of the percolate is lighter to obtain a percolate crude liquid;

4) concentration: pumping the percolation crude liquid into a vacuum concentration device with the vacuum degree of-0.05 to-0.08 Mpa, heating to 70-80 ℃, and then starting to concentrate until the concentration is 45-50% of the total volume of the percolation crude liquid to obtain percolation extract;

5) preparation: accurately weighing 0.5g of salicylic acid, 0.5g of benzoic acid, 0.5g of boric acid, 0.2g of chlorhexidine acetate and 1.0-2.0g of water-soluble azone into a preparation tank, adding 50ml of percolation extract, adding 60-70% ethanol with weight percentage concentration to constant volume to 100.0ml, stirring to fully dissolve the materials, and filtering by 100um to obtain 1 unit of finished product of the skin bacteriostatic solution for feet.

Further, in the step 5), a proper amount of essence is added into 50ml of diacolation extract.

Further, 6) filling is further included after 5) preparing: and (3) filling the prepared finished foot skin bacteriostasis liquid prepared in the step 5) into a bottle, screwing a cover, sticking a bottle label, boxing and warehousing.

Furthermore, the plastic bottle is used for the finished product bottle of the foot skin antibacterial liquid, and the spraying device is arranged at the bottle opening, so that the carrying and the use are convenient, a patient can conveniently carry and use, the itching can be instantly sprayed, and the deodorization can be instantly carried out.

The pharmacology of the components of the foot skin bacteriostatic liquid is explained as follows:

the Chinese medicinal materials are screened out by utilizing the research of the traditional Chinese medicine theory and the modern Chinese medicine theory, and are subjected to 60-70% ethanol percolation extraction, so that the alcohol-soluble and water-soluble active ingredients are completely extracted, and meanwhile, the active ingredients are not damaged, so that the foot skin antibacterial liquid has strong killing and inhibiting effects on foot odor caused by bacterial infection, tinea pedis caused by fungal infection, chapped skin and even onychomycosis; wherein the content of the first and second substances,

and (3) preparing cortex dictamni: bitter and cold in nature; has effects in clearing away heat, eliminating dampness, dispelling pathogenic wind, and removing toxic substances; it is often used for treating damp-heat sore, eczema, rubella, scabies, skin ulcer, and yellow dripping, and is combined with Chinese herbs such as Ku Shen to achieve good effect; modern research proves that: the Dictamnus dasycarpus aqueous extract has different inhibitory effects on various pathogenic fungi such as Trichophyton, Trichophyton fulvescens, Trichophyton epidermidis and Nocardia stellatophii;

golden larch bark: pungent and warm; has the effects of killing parasites, treating tinea and relieving itching, and is clinically used for treating tinea corporis, tinea manuum, tinea pedis and tinea capitis; also can be used for treating scabies, eczema, dermatitis, skin pruritus, etc.; modern researches on organic acid and alcohol extract of cortex pseudolaricis have certain bacteriostatic action on 10 common pathogenic dermatophytes and candida albicans in China, and are special medicines (only used for external application) for treating skin diseases;

flavescent sophora root: bitter and cold in nature; has the functions of clearing heat, drying dampness, killing parasites and relieving itching, and is a key medicine for treating skin diseases; has good treatment effect on eczema, skin itch, scabies, leprosy; modern researches prove that the sophora flavescens mainly contains matrine, oxymatrine, isomatrine and the like, the sophora flavescens decoction has obvious inhibition effects on dysentery bacillus, staphylococcus aureus, escherichia coli, beta streptococcus and the like, and has different inhibition effects on dermatophytes such as tricholoma matsutake, fresh yellow bacteria, fresh red epidermal bacteria and the like;

phellodendron bark: the external preparation is bitter and cold in nature, has the effects of clearing heat and drying dampness, purging fire and removing toxicity, and is clinically used for treating skin diseases, sore toxicity and swelling, eczema and eczema; modern researches prove that the product contains berberine, jateorhizine and tetrandrine, has certain inhibitory action on staphylococcus aureus, escherichia coli and the like, has stronger inhibitory action on skin disease-treating fungi such as candida albicans, epidermophyton floccosum, microsporum and the like, and has the advantages of simple preparation process, low cost, high safety and the like;

fructus cnidii: warm in nature and bitter in taste; for external use, it can cure external eczema of vulva, pudendal pruritus of women, trichomonas vaginitis, skin scabies, tinea and eczema, from ancient times to present, the Chinese medicine "cnidium fruit" is regarded as the essential medicine for curing dermatosis and pruritus by doctors of all generations; the traditional Chinese medicine composition has the advantages of being widely used for treating tinea of children, malignant boil, skin eczema, allergic dermatitis, head sore, female pruritus vulvae, trichomonas vaginitis and the like, and having obvious effects; modern pharmacological studies show that the cnidium fruit water solution has an inhibiting effect on drug-resistant staphylococcus aureus and pseudomonas aeruginosa, and the cnidium fruit flowing and soaking paste can kill trichomonas vaginalis.

Dandelion: bitter, sweet and cold; has effects in clearing away heat and toxic materials, promoting urination, and dispersing pathogen accumulation; treating acute mastitis, lymphadenitis, scrofula, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection; the literature reports that: the "the herbal atlas" (the book's Manual of medical science): it is indicated for treating skin ulcer, malignant spur and bromhidrosis; the Yunnan herbal medicine: applying sore and pyogenic infections, scabies, tinea and sore; dispelling pathogenic wind, eliminating sore toxin, and dispersing scrofula and tuberculosis; modern pharmacological research proves that the decoction or infusion of the product has strong inhibiting effect on staphylococcus aureus, hemolytic streptococcus and catacoccus, and also has certain inhibiting effect on pneumococcus, meningococcus, diphtheria bacillus and pseudomonas aeruginosa;

honeysuckle flower: sweet and cold; the efficacy is as follows: clearing away heat and toxic materials, and dispelling pathogenic wind and heat; modern pharmacological research proves that: the chlorogenic acid compounds contained in the product have certain inhibitory effect on Staphylococcus aureus, hemolytic streptococcus, Shigella dysenteriae, Vibrio cholerae and other pathogenic bacteria;

the preparation method comprises the following steps of (1) preparing broom cypress fruit: sweet, bitter and cold; induce diuresis, clear damp-heat. Treating dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, tinea, and pudendal pruritus; modern pharmacological research proves that: the belvedere fruit water-soaking agent has different degrees of inhibition effects on dermatophytes such as syphonium schrenbergii, syphonium ovatum, cyphonium ferrugineum, cyphonium lanuginosum, syphonium asteroideum and the like.

② the foot skin bacteriostat liquid takes water-soluble benzoic acid, boric acid and salicylic acid as the fungus inhibitor, the pH value is strictly controlled between 2.5-4.5, the effective inhibition effect on the fungus is ensured, and the foot skin bacteriostat liquid has good treatment effect on the tinea pedis caused by various fungus infections.

The chlorhexidine acetate is used as an effective skin bacteriostatic component, is efficient and safe, and can kill staphylococcus aureus, escherichia coli and candida albicans; the effective content of the antibacterial composition is strictly controlled, and the antibacterial composition can effectively control staphylococcus aureus, escherichia coli and candida albicans which are common to skin;

fourthly, according to the modern pharmaceutical TDDS skin transdermal technology, azone is used as a high-efficiency skin penetration enhancer, the skin permeability of the medicine is improved, and the transdermal absorption effect can be multiplied, so that the use effect of the foot skin antibacterial liquid is enhanced, the use of main medicines and nutrients is reduced, and the medicine cost is reduced.

Compared with the prior art, the invention has the beneficial effects that:

the foot skin antibacterial liquid is a clear antibacterial liquid, not only has good effect on tinea pedis caused by various fungi and foot odor caused by excessive sweating and mass bacterial reproduction, but also has good effect on mosquito bite; the bacteriostatic activity of the product is tested by adopting a bacteriostatic ring method, and the test effect of the actual product is as follows: 18mm of staphylococcus aureus, 14.92mm of escherichia coli and 13.48mm of candida albicans, and has excellent bacteriostatic effect which is larger than the common bacteriostatic requirement (the staphylococcus aureus is more than or equal to 8mm, the escherichia coli is more than or equal to 8mm, and the candida albicans is more than or equal to 8 mm);

the foot skin bacteriostatic liquid strictly controls the pH value, ensures the pH value to be between 2.5 and 4.5, ensures the inhibitory effect of salicylic acid, benzoic acid and boric acid on fungi, and simultaneously reduces the irritation to the skin; the high-efficiency bacteriostatic agent chlorhexidine acetate is used to ensure the inhibition effect on escherichia coli, staphylococcus aureus and candida albicans; the effect of the percolate of radix sophorae flavescentis, cortex dictamni, cortex phellodendri, cortex pseudolaricis, honeysuckle, dandelion, fructus cnidii and fructus kochiae is enhanced on bacterial infection and other fungal infections; by using a modern TDDS transdermal absorption technology, the water-soluble azone of the skin penetration enhancer is added, and the effect of the antibacterial liquid on dermal bacteria and fungi is enhanced; it can also increase the compliance of users by adding proper essence.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.