阅读说明：本技术 一种治疗近视的中药组合物及其制备方法 (A Chinese medicinal composition for treating myopia, and its preparation method ) 是由 杜广宝 于 2020-08-05 设计创作，主要内容包括：本发明公开了一种治疗近视的中药组合物,包括野菊花、丹参、天花粉、黄连、红花、桑叶、车前子、决明子、冰片、薄荷脑和珍珠粉。将其制备成药膏外敷使用,再配合按摩经络和眼肌训练方法,可有效治疗近视症,有效率达99％。(The invention discloses a traditional Chinese medicine composition for treating myopia, which comprises wild chrysanthemum flower, red sage root, trichosanthes root, coptis root, safflower, mulberry leaf, plantain seed, cassia seed, borneol, menthol and pearl powder. The ointment is prepared into ointment for external application and is matched with a method for massaging channels and collaterals and training eye muscles, the myopia can be effectively treated, and the effective rate reaches 99%.)

1. A traditional Chinese medicine composition for treating myopia is characterized by comprising the following medicines in parts by weight:

5-15 parts of wild chrysanthemum flower, 5-15 parts of salvia miltiorrhiza, 15-15 parts of trichosanthes root, 5-15 parts of coptis chinensis, 5-15 parts of safflower, 5-15 parts of mulberry leaf, 5-15 parts of plantain seed, 5-15 parts of cassia seed, 1-3 parts of borneol, 1-3 parts of menthol and 5-15 parts of pearl powder.

2. The traditional Chinese medicine composition for treating myopia as claimed in claim 1, which comprises the following medicines in parts by weight: 10 parts of wild chrysanthemum flower, 10 parts of salvia miltiorrhiza, 10 parts of trichosanthes root, 10 parts of coptis chinensis, 10 parts of safflower, 10 parts of mulberry leaf, 10 parts of plantain seed, 10 parts of cassia seed, 2 parts of borneol, 2 parts of menthol and 10 parts of pearl powder.

3. Use of a solid composition according to claim 1 or 2 for the manufacture of a pharmaceutical preparation for the treatment of myopia.

4. A method for preparing an ointment by using the traditional Chinese medicine composition for treating myopia as claimed in claim 1 or 2, which is characterized by comprising the following steps:

step 1), crushing wild chrysanthemum flower, salvia miltiorrhiza, trichosanthes root, coptis chinensis and safflower, sieving, adding 5-6 times of water, decocting, and filtering to obtain a decoction thick juice;

step 2), putting the wild chrysanthemum flower, the salvia miltiorrhiza, the trichosanthes root, the coptis chinensis, the safflower, the mulberry leaf, the plantain seed, the cassia seed, the borneol, the menthol and the pearl powder into the decoction thick juice obtained in the step 1), soaking for 3-5h, and naturally drying to obtain a dried substance;

step 3), drying the substances in the step 2), crushing at 60 ℃, sieving, sterilizing at high temperature, and grinding into fine powder for later use;

and 4) uniformly mixing honey and the fine powder obtained in the step 3) into a paste to obtain the myopia-recovering paste.

5. The method for preparing an ointment of the Chinese medicinal composition for treating myopia according to claim 4, wherein in the step 1), the ointment is filtered through a 30-80 mesh sieve and decocted for 60-120 min.

6. The method for preparing an ointment of claim 4, wherein in step 3), the ointment is sieved through a 100-mesh and 300-mesh sieve.

7. The method for preparing an ointment of the Chinese medicinal composition for treating myopia according to claim 4, wherein in the step 3), the ointment is sterilized at 120 ℃ for 0.5-2 h.

8. The method for preparing an ointment of claim 4, wherein in step 3), the ointment is ground into 200 mesh or more fine powder for later use.

9. The method for preparing an ointment of the Chinese medicinal composition for treating myopia according to claim 4, wherein in the step 4), 1.2-1.5 parts of honey and 1 part of fine powder are used.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating myopia and a preparation method thereof.

Background

Myopia is one of the refractive errors. When the eye is in a relaxed state of accommodation, parallel rays of light enter the eye, which focus in front of the retina, resulting in the inability to form a sharp image on the retina, known as myopic eyes (mypia). In recent years, the incidence rate of myopia in China is on a remarkable rising trend, and myopia has become a great public health problem affecting the eye health of the national people, particularly teenagers. The most common ophthalmic diseases are listed as one of three diseases in the world, and the incidence rate of myopia in the population of China is about 33 percent and is 1.5 times of the average level of the world (accounting for 22 percent of the total population).

The causes of myopia are relatively complex. All the transmitters, hormones and growth factors involved in retinal-RPE-choroid-sclera are related to the occurrence of myopia.

At present, the western medicines such as atropine, racanisodamine, pirenzepine and the like are commonly used as M receptor blockers in myopia treatment.

Atropine is used for treating myopia:

atropine belongs to a non-selective M receptor blocker. The mechanism of treating myopia by using the medicine is not clear. Atropine is believed to control myopia by acting on the M receptors of the extraretinal tissues or by inhibiting the growth of the eyeball through a non-cholinergic system. However, long-term use or too high concentration can cause patients to have adverse reactions such as mydriasis, near vision blur, photophobia, allergic conjunctivitis and the like.

Racanisodamine for the treatment of myopia:

racanisodamine is also a non-selective M receptor blocker. The medicine has wide application in treating digestive system diseases. However, the effect of the drug on inhibiting and regulating vision and mydriasis is only 1/10-1/20 of atropine, so that adverse reactions of the atropine can not occur in normal use, the drug only plays a certain role in preventing and treating myopia of children, and the treatment effect on existing myopia is poor.

Pirenzepine for the treatment of myopia: with pirenzepine, elongation of the axis of the eye is inhibited by blocking M1 receptors of the sclera, choroid or retinal pigment epithelium, inhibiting degradation of scleral collagen and glycosaminoglycans; simultaneously, the compound acts on M receptors or non-M receptors on the retina, increases the secretion amount of dopamine, and ensures that retinal pigment epithelium secretes a plurality of neurotransmitters or growth factors, thereby regulating and controlling scleral tissue remodeling and preventing the growth of the axis of the eye.

And (3) treating myopia through refractive surgery:

excimer laser in situ keratomileusis (LASIK): a corneal lamellar knife is used for manufacturing a complete pedicle-carrying corneal flap with the thickness of 130-; the operation has the advantages of small injury, quick recovery of vision, light adverse reaction after operation, no pain, no corneal upper and lower skin turbidness and the like, but has certain requirements on the thickness of a corneal stroma layer. For a high-degree myopia patient with high myopia degree and relatively thin cornea thickness, the risk of performing the operation is high, and the dry eye syndrome is counted to be a necessary complication.

Laser keratomileusis (SBK) under the anterior elastic layer: the operation process is basically the same as that of LASIK operation, and the difference between the two is that SBK operation is to make a corneal flap between an anterior elastic layer and a stroma layer, the thickness of the corneal flap is about 95um, the operation is more suitable for patients with high myopia degree and thin cornea, but the risk of LASIK operation exists.

Intraocular lens implantation (PIOL) of a lens eye: the PIOL operation for treating myopia is an intraocular refractive operation which can be divided into an anterior chamber type operation and a posterior chamber type operation. At present, the operation is mainly used for clinically treating patients with high and ultrahigh myopia who cannot perform corneal refractive operation due to the limitation of corneal conditions. But the price is high, and the crystal is not suitable after the operation, so the risks of glaucoma, cataract and the like can be induced.

Surgery to reinforce the sclera: the operation is to limit the growth of the axis of the eye by strengthening the biomechanical strength of the sclera, and is generally divided into posterior sclera reinforcement and sclera crosslinking, and the weak sclera is thickened by implanting a reinforcing material into the posterior pole of the eyeball. For the patients with pathological myopia, the treatment by the operation can effectively control the rapidly growing axis of the eyes and prevent the occurrence of the related blindness-causing complications. Scleral crosslinking is the hardening of the sclera by a physical or chemical means that produces a crosslinking reaction between the collagen molecules of the sclera. But it can cause the patients to have complications such as chronic visual function injury and retinal cell apoptosis after operation.

In summary, the existing methods for treating myopia have certain disadvantages. The traditional Chinese medicine for external treatment is applied to the body surface, can be observed at any time to determine the adaptation and tolerance conditions of the traditional Chinese medicine for removing the drug, cannot be like oral medicines, and has more complex treatment if no symptom occurs and side effect, and the external treatment only needs to be applied and prepared properly, so that the safety is higher and the side effect is less. If the traditional Chinese medicine is effectively used for treating myopia, the traditional Chinese medicine is a new chapter for treating myopia.

Therefore, how to provide an economical, effective and small-side-effect traditional Chinese medicine composition for improving eyesight and a using method thereof is a problem to be solved in the field.

Disclosure of Invention

The invention discloses a traditional Chinese medicine composition for treating myopia and a preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating myopia comprises the following medicines in parts by weight:

5-15 parts of wild chrysanthemum flower, 5-15 parts of salvia miltiorrhiza, 15-15 parts of trichosanthes root, 5-15 parts of coptis chinensis, 5-15 parts of safflower, 5-15 parts of mulberry leaf, 5-15 parts of plantain seed, 5-15 parts of cassia seed, 1-3 parts of borneol, 1-3 parts of menthol and 5-15 parts of pearl powder.

Preferably, the weight parts of the medicine are as follows: 10 parts of wild chrysanthemum flower, 10 parts of salvia miltiorrhiza, 10 parts of trichosanthes root, 10 parts of coptis chinensis, 10 parts of safflower, 10 parts of mulberry leaf, 10 parts of plantain seed, 10 parts of cassia seed, 2 parts of borneol, 2 parts of menthol and 10 parts of pearl powder.

The application of the solid composition in preparing a medicinal preparation for treating myopia.

A method for preparing an ointment by using the traditional Chinese medicine composition for treating myopia comprises the following steps:

step 1), crushing wild chrysanthemum flower, salvia miltiorrhiza, trichosanthes root, coptis chinensis and safflower, sieving, adding 5-6 times of water, decocting, and filtering to obtain a decoction thick juice;

step 2), putting the wild chrysanthemum flower, the salvia miltiorrhiza, the trichosanthes root, the coptis chinensis, the safflower, the mulberry leaf, the plantain seed, the cassia seed, the borneol, the menthol and the pearl powder into the decoction thick juice obtained in the step 1), soaking for 3-5h, and naturally drying to obtain a dried substance;

step 3), drying the substances in the step 2), crushing at 60 ℃, sieving, sterilizing at high temperature, and grinding into fine powder for later use;

step 4), uniformly mixing honey and the fine powder obtained in the step 3) into a paste to obtain a myopia recovery paste;

in the step 1), sieving with a 30-80 mesh sieve, and decocting for 60-120 min;

preferably, sieving with 50 mesh sieve, and decocting for 90 min;

in the step 3), sieving the mixture by a sieve of 100-300 meshes;

preferably, 200 mesh sieve;

in the step 3), 100-150 ℃ high-temperature sterilization is carried out for 0.5-2 h;

preferably, sterilizing at 120 ℃ for 1 h;

in the step 3), grinding into fine powder of more than 200 meshes for later use;

in the step 4), 1.2-1.5 parts of honey and 1 part of fine powder are added.

Wild chrysanthemum is bitter and pungent in property and slightly cold in property, and enters lung and liver meridians; has the effects of soothing liver, improving eyesight, dispelling wind, clearing heat, clearing away heat and toxic materials, and the like; contains various volatile oils including camphene, camphor, carvone, limonene, etc., and also contains linarin, luteolin glycoside, cyanidin, chrysanthemums, polysaccharides, coumarins, and wild chrysanthemum lactone, etc.

Salvia miltiorrhiza, bitter in flavor and slightly cold in nature, enters heart and liver meridians; has effects of dredging channels and collaterals, promoting blood circulation, removing blood stasis, etc.; contains tanshinone I, II A, II B, iso-tanshinone I, II A, cryptotanshinone, iso-cryptotanshinone, methyl tanshinone, hydroxy tanshinone, etc.

The smallpox powder is sweet, slightly bitter and slightly cold in property, and enters lung and stomach meridians; has the effects of clearing heat, promoting fluid production, relieving swelling, and expelling pus; contains trichosanthin, alpha-hydroxymethyl serine, aspartic acid, citrulline, serine, glutamic acid, threonine, glycine, valine, tyrosine, phenylalanine, histidine, lysine, arginine, ornithine and peptides, ribose, xylose, arabinose, glucose and galactose; trichosanthes kirilowii root polysaccharides A, B, C, D and E; is prepared from glucose, galactose, fructose, mannose, xylose, 7-stigmasten-3 beta-ol, bryozoan acid, cucurbitacin B and D, 23, 24-dihydrocucurbitacin B, etc.

Coptis root is bitter in property and cold in property, and enters heart, spleen, stomach, liver, gallbladder and large intestine channels; has the effects of clearing heat, eliminating dampness, purging fire, removing toxin and the like; contains berberine, coptisine, epiberberine, berrubine, tetrandrine, jateorhizine, african tetrandrine, jateorhizine, methyl coptisine, magnoflorine, ferulic acid, phellodendron ketone, phellodendron lactone, etc.

Safflower is pungent in nature, warm in nature, and enters heart and liver meridians; has effects in promoting blood circulation, dispelling blood stasis, cooling blood, removing toxic substances, relieving depression, tranquilizing mind, dispelling blood stasis, and relieving pain; contains safflower yellow, carthamin, 15 alpha, 20 beta-dihydroxy-delta 4-pregnene-3-ketone, and luteolin-7-glucoside in leaf.

The mulberry leaves are sweet, bitter and cold in nature and enter lung and liver meridians; has the effects of dispelling wind and heat, clearing lung-heat, moistening dryness, removing liver fire, improving eyesight, etc.; contains rutin, quercetin, isoquercitrin, quercetin-3-triglucoside, trace beta-sitosterol, campesterol, beta-sitosterol, beta-D-glucoside, lupulin, meso-inositol, insect allergy hormone hyssopterone and ecdysterone, hemolysin, and chlorogenic acid. The volatile oil comprises acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, caproic acid, isocaproic acid, methyl salicylate, guaiacol, phenol, o-cresol, m-cresol, eugenol and the like, and also comprises oxalic acid, fumaric acid, tartaric acid, citric acid, succinic acid, palmitic acid, ethyl palmitate, hentriacid, hentriacontane, hydroxycoumarin, sucrose, fructose, glucose, aspartic acid and glutamic acid, vitamin C-200-300, glutathione, folic acid, 5-formyltetrahydrofolic acid, vitamin B1, vitamin B2, adenine, choline, trigonelline, copper, zinc, boron, manganese and the like.

The plantain seed is sweet in nature and slightly cold, and enters liver, kidney, lung and small intestine channels; has effects of clearing heat, promoting diuresis, eliminating dampness, treating stranguria, and improving eyesight; contains lunate leaf sarcodictyin, plantaginoside A, racemic-plantaginin, ficollic acid, plantaginic acid, succinic acid, adenine, choline, fatty oil, beta-sitosterol-3-O-beta-D-glucopyranoside, aucubin, isoquercitrin, succinic acid, vitamin B1, A, etc.

Semen Cassiae is sweet, bitter, salty, and slightly cold, and enters liver and large intestine meridians; has the effects of clearing heat, improving eyesight, relieving exterior syndrome, loosening bowel to relieve constipation, dispelling pathogenic wind, relieving spasm, eliminating dampness, etc.; comprises chrysophanol, physcion, cassia tora essence, yellow cassia essence, orange yellow cassia essence, glucose-based yellow cassia essence, glucose-based orange yellow cassia essence, red sickle rose essence, cassia seed glycoside, cassia anthranone, iso-cassia seed lactone, 2, 5-dimethoxy benzoquinone, cassia seed lactone, emodin, aloe-emodin, chrysophanol-9-anthrone, cassia seed glycoside B and C, red sickle rose essence-6-O-gentiobioside, Italian rhamnoquinone-1-O-glucoside, physcion-8-O-glucoside, 1-demethyl cassia essence, 1-demethyl orange cassia essence, 1-demethyl cassia essence, chrysophanol-10, 10' -bianthrone, emodin-8-methyl ether, and benzoic acid.

Borneol is pungent, bitter and slightly cold in property, and enters heart, spleen and lung meridians; has effects in inducing resuscitation, refreshing mind, clearing away heat, cooling blood, and relieving pain; contains sesquiterpenes such as d, humulene, beta-elemene, caryophyllene, oleanolic acid, hordenic acid, asiatic acid, camphol ketone, and coca glycol.

Menthol is pungent in property and cool in property, and enters lung and liver meridians; has effects in relieving itching, relieving pain, dispelling pathogenic wind heat, refreshing head, and promoting eruption; comprises menthol, menthone, menthyl acetate, camphene, limonene, isomenthone, pinene, menthenone, resin, and small amount of tannin and rosmarinic acid.

The pearl powder is sweet, salty and cold in property, and enters heart and liver meridians; has effects in removing toxic materials, promoting granulation, tranquilizing mind, arresting convulsion, improving eyesight, and eliminating nebula; containing calcium carbonate, magnesium carbonate, silica, calcium phosphate, alumina, iron oxide, organic matter, and inorganic salt, respectively: aluminum, copper, iron, magnesium, manganese, sodium, zinc, silicon, titanium, strontium, and the like.

The combination of the prescription does not simply stack the medicines and add the medicine effects with similar functions, but combines the medicines selected according to the theoretical combination principle on the basis of dialectical legislation according to the requirements of pathogenesis to form the prescription. The principle of the formula is called monarch, minister, assistant and guide. Su Wen-Zhi Zhen Yao Da Lun say that: the principal disease is called monarch, the assistant is called minister, and the assistant is called minister. This is the basic principle of formulation. Wang 21855;: the main patient is taken as the monarch, the assistant monarch is taken as the minister, and the assistant is taken as the assistant. The principal and subordinate formula principles of monarch, minister, assistant and guide show that the principal and subordinate relationship of the medicines used in the prescription is a main criterion when the prescription is combined, and the medicines in the prescription can be matched with each other to exert better treatment effect. From ancient times to present, any prescription with curative effect must have strong pertinence, strict prescription, concentrated drug effect and precise and appropriate drug selection. For example, the principal yang-warming herbs selected for cold syndrome are monarch drugs, the other warm-heat drugs are ministerial drugs of assistant drugs, and the drugs which are few in cold drugs for controlling the excess of heat-preventing drugs and can prevent the warm from generating side effects are adjuvant drugs. In addition, the guiding herbs should be added to the five zang-organs and six fu-organs and the meridians and collaterals and acupoints to direct the disease directly, which is the guiding herb. Also said by Lidonkeys ". The herbs are divided into the most part, the minister part and the assistant part. The same principle as the syndrome can be equally divided "or used as the main reference.

The principle of the formula must be observed, but the monarch, the minister, the adjuvant and the dispatcher do not need to be forced to have in each prescription, and some monarch drugs or ministerial drugs have the functions of adjuvant drugs or conductant drugs. But plays a more unique role in clinic

In conclusion, the invention relates to a traditional Chinese medicine composition for nourishing and improving eyesight and a preparation method, a use method and a training method thereof. The Chinese medicine is a natural therapy of thousands of years in traditional Chinese medicine, is delivered to the present by the safety and effectiveness thereof, is prepared by refining more than ten rare Chinese herbal medicines by modern high-tech biotechnology, has the effective rate of 99 percent and has no side effect.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The mechanism of action of the medicine is as follows:

firstly, dredging channels and collaterals:

1. the channels and collaterals are dredged by the traditional Chinese medicine massage technique, the channels and the collaterals and the acupuncture points are massaged by the technique, the physiological and biochemical processes of eye tissue cells are changed, the elasticity of the vessel wall is increased, the blood vessel is expanded, the blood and lymph circulation around the eyes is promoted, the blood flow is accelerated, the embolism is eliminated, the channel and the collateral congestion are dredged finally, and the blood activity is increased. Only the airway, the blood channel, the valley channel, the water channel and the channels are naturally communicated, and the sufficient supply of qi and blood of the eyes is the precondition of the rehabilitation of the true myopia.

2. Combing thoracic vertebrae and cervical vertebrae: thoracic vertebra and cervical vertebra are the channels of qi and blood in the head, and the blood supply of thoracic and cervical vertebra arteries is insufficient, so that the central flow of the visual projection of cerebral cortex is reduced, and central vision is reduced. The important key for the rehabilitation of amblyopia is to correct the small dislocation of cervical vertebra and thoracic vertebra caused by bad eye use habit, so that the smooth qi and blood of the thoracic vertebra and the cervical vertebra is solved.

Secondly, cleaning clogging:

according to the pathogenesis of myopia, a local therapy of promoting blood circulation to remove blood stasis and strengthening vital qi to eliminate pathogenic factors is applied, and various natural rare precious plants are adopted to extract essence. Adopts a biological micromolecule cutting technology to carry out micromolecule treatment on a pure biological formula, and the medicinal composition has a constant release effect for 24 hours on specific acupuncture points, thereby reinforcing deficiency and strengthening body resistance along the meridian inside and treating internal diseases by external application. The essence of rare plants can rapidly and continuously clear stasis, dissolve stasis and supplement nutrition through liver collaterals, bladder channels, spleen channels and the like. The cleaned healthy blood can nourish the eye muscle again, so that the ciliary muscle, the extraocular muscle and the like can complete self-repair, and the regulation effect on the eyes can be recovered fundamentally. The balance of internal and external circulation of internal organs of the eyeball is fundamentally solved, and the intraocular pressure of the crystalline lens is changed normally, so that the eyeball is reset naturally, the axis of the eye is recovered to be normal, and the myopia and amblyopia are recovered.

Thirdly, training eye muscles:

"Yin Ping Yang Bing and Shen Zhi Qiang" physiotherapy of myopia requires stimulation of yang qi of human body, mainly depending on training. Through five-second training, the essential spirit is gathered, qi and blood can be regulated, the liver and qi are soothed, and eye muscles such as ciliary muscles are exercised, so that the purpose of internal regulation and external repair is achieved, and the ciliary muscles are enabled to be recovered to be strong and powerful. The five-second training method is the key to the stable and rapid promotion of true myopia and the rehabilitation of myopia amblyopia.

Fourthly, regulating internal and nourishing external: although the worldwide problem of true myopia is overcome, patients cannot be treated with true myopia. The good eye use habit and the correct maintenance method are important guarantees of stable vision. The possibility of relapse is avoided.