阅读说明：本技术 三环化合物、组合物及其医药应用 (Tricyclic compounds, compositions and medical uses thereof ) 是由 苏贾伊·巴苏 萨钦·托拉特 约格什·舒尔 阿尼尔·潘曼 米纳·帕特尔 高克莎·科赛 拉杰 于 2019-01-04 设计创作，主要内容包括：本公开内容涉及一系列三环化合物、其互变异构体、多晶型物、立体异构体、前药、溶剂合物、可药用盐,包含它们的药物组合物以及治疗由腺苷受体(AR)活性介导的病症和疾病的方法。本公开内容还涉及制备式I的这些三环化合物的方法。这些化合物可用于治疗、预防或抑制可对通过腺苷受体拮抗而实现的改善敏感的疾病和障碍。本公开内容还涉及制备三环化合物的方法,以及涉及包含它们的药物组合物。式(I),其中D表示选自式(II)或式(III)的三环环系。D——A——B——Z(I)<Image he="346" wi="700" file="DDA0002644162170000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(The present disclosure relates to a series of tricyclic compounds, tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and methods of treating conditions and diseases mediated by Adenosine Receptor (AR) activity. The present disclosure also relates to methods of making these tricyclic compounds of formula I. These compounds are useful for treating, preventing or inhibiting diseases and disorders susceptible to amelioration by antagonism of the adenosine receptor. The disclosure also relates to processes for preparing tricyclic compounds, and to pharmaceutical compositions comprising them. Formula (I), wherein D represents a tricyclic ring system selected from formula (II) or formula (III). D-A-B-Z (I))