阅读说明：本技术 瓶尔小草及车前子组合物在制备降血糖及降血压的药物组合物中的应用 (Application of coleus blumei and plantain seed composition in preparation of pharmaceutical composition for reducing blood sugar and blood pressure ) 是由 傅耀贤 翁庆丰 陈思霈 陈永轩 伊雪 于 2019-09-20 设计创作，主要内容包括：本发明公开了瓶尔小草及车前子组合物在制备降血糖及降血压的药物组合物中的应用,该药物组合物为口服给药,该瓶尔小草及车前子组合物由车前子原药粉末或车前子萃取物以及瓶尔小草原药粉末或瓶尔小草萃取物组成。本发明中的瓶尔小草及车前子组合物对降血糖和降血压均有明显的疗效,可用于制备有效的药物组合物,用以治疗患有糖尿病(及)或高血压的个体。(The invention discloses an application of a coleus blumei and plantain seed composition in preparing a medicine composition for reducing blood sugar and blood pressure, wherein the medicine composition is orally taken, and the coleus blumei and plantain seed composition consists of plantain seed raw medicine powder or plantain seed extract and coleus blumei raw medicine powder or coleus blumei extract. The coleus blumei and plantain seed composition has obvious curative effect on reducing blood sugar and blood pressure, and can be used for preparing effective pharmaceutical compositions for treating individuals suffering from diabetes (and) or hypertension.)

1. The application of the coleus blumei and plantain seed composition in preparing the medicinal composition for reducing blood sugar and blood pressure is characterized in that: the medicinal composition is orally administered, and comprises crude Plantago ovata or Plantago asiatica extract and crude Plantago ovata or crude Plantago ovata powder.

2. The use of claim 1, wherein: the preparation method of the plantain seed extract and the small coleus extract comprises the following steps: pulverizing semen plantaginis or herba Lysimachiae Capillipedis, and extracting with ethanol water or high temperature and high pressure water.

3. Use according to claim 2, characterized in that: in the ethanol-water extraction, the volume ratio of ethanol to water is 1: 10-10: 1.

4. Use according to claim 2, characterized in that: the temperature of the high-temperature high-pressure water extraction is 80-105 ℃, and the pressure is 14-20 Bar.

5. The use according to any one of claims 1 to 4, wherein: the formula of the coleus blumei and plantain seed composition for reducing blood sugar is as follows: 10-100mg/60kg of Boraginaceae original drug powder or Boraginaceae extract B.W./day human, and 1000mg/60kg of Plantain seed original drug powder or Plantain seed extract B.W./day human; the formula for reducing blood pressure is as follows: 5-100mg/60kg of B.W./day human medicine of veronicastrum paniculatum technical powder or veronicastrum paniculatum extract, and 50-1000mg/60kg of B.W./day human medicine of plantain seed technical powder or plantain seed extract.

6. An oral pharmaceutical composition for reducing blood sugar and blood pressure, which is characterized in that: the effective components of the composition comprise the coleus blumei and plantain seed composition, and the coleus blumei and plantain seed composition consists of plantain seed raw material powder or plantain seed extract and coleus blumei raw material powder or coleus blumei extract.

7. The oral pharmaceutical composition of claim 6, wherein: the preparation method of the plantain seed extract and the small coleus extract comprises the following steps: pulverizing semen plantaginis or herba Lysimachiae Capillipedis, and extracting with ethanol water or high temperature and high pressure water.

8. The oral pharmaceutical composition of claim 7, wherein: in the ethanol-water extraction, the volume ratio of ethanol to water is 1: 10-10: 1.

9. The oral pharmaceutical composition of claim 7, wherein: the temperature of the high-temperature high-pressure water extraction is 80-105 ℃, and the pressure is 14-20 Bar.

10. The oral pharmaceutical composition of any one of claims 6 to 8, wherein: the formula of the coleus blumei and plantain seed composition for reducing blood sugar is as follows: 10-100mg/60kg of B.W./day human of veronicastrum paniculatum original drug powder or veronicastrum paniculatum extract, and 1000mg/60kg of B.W./day human of plantain seed original drug powder or plantain seed extract; the formula for reducing blood pressure is as follows: 5-100mg/60kg of B.W./day human medicine of veronicastrum paniculatum technical powder or veronicastrum paniculatum extract, and 50-1000mg/60kg of B.W./day human medicine of plantain seed technical powder or plantain seed extract.

Technical Field

The invention belongs to the technical field of Chinese patent medicines, and particularly relates to an application of a coleus blumei and plantain seed composition in preparing a medicinal composition for reducing blood sugar and blood pressure.

Background

Current treatment of diabetes is divided into three components: regular exercise, diet control and medication. The medicinal treatment of diabetes is divided into oral hypoglycemic agent or insulin injection; when the blood sugar is still poorly controlled after oral hypoglycemic agent treatment, insulin injection therapy may be required instead. However, with the difference of the action mechanism of the medicine, the time of taking medicine is also different: firstly, the medicine is taken thirty minutes before a meal, is taken immediately before the meal or is taken along with the meal, and has the function of stimulating insulin secretion; secondly, the drugs taken after meals are used for improving insulin resistance and reducing glucose output of the liver, but the effect is mostly in the gastrointestinal tract, so that the side effect of gastrointestinal discomfort can be avoided when patients take the drugs after meals. Among the side effects of hypoglycemic drugs, hypoglycemia is the most common, especially when patients take drugs and are not matched with diet time or do not eat and engage in activities that consume blood sugar; secondly, gastrointestinal discomfort; in addition, hepatotoxicity may be caused.

Insulin for injection is the same as or almost the same as insulin produced in a human body, is widely used at present, can achieve the most effective treatment on diabetes, and reduces problems possibly caused by poor blood sugar control, such as pathological changes of eyes, kidneys and peripheral nerves. However, the injection position, injection depth, movement and dosage all affect the absorption of insulin. In order to obtain stable insulin absorption and action, attention must be paid to the fact that the injection frequency in the same injection region is not too frequent, so that the injection is not suitable to be injected into the same point every time, the injection point and the last injection point are kept at the distance of three fingers, so that the stable absorption of the insulin can be ensured, the delayed absorption is avoided, and the injury of subcutaneous tissues of the injection region caused by the too frequent injection frequency in the same region is avoided.

Hypertension is the most common chronic disease (systolic pressure is more than or equal to 140 mm Hg, diastolic pressure is more than or equal to 90 mm Hg), and is also the most main risk factor of cardiovascular and cerebrovascular diseases, and can be divided into two types in clinical hypertension: 1. essential hypertension accounts for more than 90% of all hypertensive patients, and the cause of the essential hypertension is an independent disease which is not clear. 2. Secondary hypertension, also known as symptomatic hypertension, has a clear cause and may be temporarily or permanently elevated. Hypertension is caused by 1. about 60% of hypertension patients with family history and polygenic inheritance, and 30% -50% of hypertension patients have genetic background. 2. Mental and environmental factors 3. age factors above 40 years of age the incidence is high. 4. Lifestyle factors smoking can accelerate the process of atherosclerosis, a risk factor for hypertension. 5. Effects of drugs 6. effects of other diseases obesity, diabetes, sleep apnea hypopnea syndrome, thyroid disease, renal artery stenosis, renal parenchymal lesions, adrenal space occupying lesions, pheochromocytoma, other neuroendocrine tumors, and the like. On the other hand, hypertension is often combined with other risk factors for cardiovascular and cerebrovascular diseases, such as hypercholesterolemia, obesity, diabetes, etc., to synergistically increase the risk of cardiovascular diseases. Symptomatic administration and long-term control are the most important.

The current treatment of hypertension is divided into three parts: regular exercise, diet control and medication. The medicine for treating hypertension is usually taken regularly for a long time so as to achieve effective treatment and reduce the occurrence of complications such as stroke, heart disease, kidney disease and the like. However, some kinds of hypertension drugs cause side effects and cause discomfort after being taken by patients, so the existing hypertension drugs are adopted after large-scale research and evaluation of curative effect and side effect.

The traditional Chinese medicine composition consisting of the small lysimachia christinae hance and the plantain seeds is not yet applied to the market for treating diabetes and hypertension.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides the application of the coleus blumei and plantain seed composition in preparing the medicinal composition for reducing blood sugar and blood pressure.

The invention also aims to provide an oral pharmaceutical composition for reducing blood sugar and blood pressure.

The technical scheme of the invention is as follows:

the application of the coleus blumei and plantain seed composition in preparing the medicine composition for reducing blood sugar and blood pressure is characterized in that the medicine composition is orally taken, and the coleus blumei and plantain seed composition consists of plantain seed raw medicine powder or plantain seed extract and coleus blumei raw medicine powder or coleus blumei extract.

In a preferred embodiment of the present invention, the psyllium seed extract and the colewort extract are prepared by a method comprising: pulverizing semen plantaginis or herba Lysimachiae Capillipedis, and extracting with ethanol water or high temperature and high pressure water. The high temperature and high pressure water is processed by an Italian coffee machine or other devices with the same temperature control and pressure extraction functions.

Further preferably, in the ethanol-water extraction, the volume ratio of ethanol to water is 1: 10-10: 1.

Further preferably, the temperature of the high-temperature high-pressure water extraction is 80-105 ℃, and the pressure is 14-20 Bar.

In a preferred embodiment of the present invention, the formula of the coleus and psyllium composition for lowering blood sugar is: 10-100mg/60kg of B.W./day human of veronicastrum paniculatum original drug powder or veronicastrum paniculatum extract, and 1000mg/60kg of B.W./day human of plantain seed original drug powder or plantain seed extract; the formula for reducing blood pressure is as follows: 5-100mg/60kg of B.W./day human medicine of veronicastrum paniculatum technical powder or veronicastrum paniculatum extract, and 50-1000mg/60kg of B.W./day human medicine of plantain seed technical powder or plantain seed extract.

The dosage form of the pharmaceutical composition comprises pills, pastilles, capsules, granules, syrups, vials, drops and emulsions, and the components further comprise at least one pharmaceutically acceptable adjuvant, carrier and/or excipient. Furthermore, coffee, chocolate or other natural sweeteners such as licorice or cinnamon may be added to flavor, improve mouthfeel and enhance user preference.

The other technical scheme of the invention is as follows:

an oral pharmaceutical composition for reducing blood sugar and blood pressure comprises herba Lysimachiae Christinae and semen plantaginis composition as effective components, wherein the herba Lysimachiae Christinae and semen plantaginis composition comprises semen plantaginis powder or semen plantaginis extract and herba Lysimachiae Christinae powder or herba Lysimachiae Christinae extract.

In a preferred embodiment of the present invention, the psyllium seed extract and the colewort extract are prepared by a method comprising: pulverizing semen plantaginis or herba Lysimachiae Capillipedis, and extracting with ethanol water or high temperature and high pressure water. The high temperature and high pressure water is processed by an Italian coffee machine or other devices with the same temperature control and pressure extraction functions.

Further preferably, in the ethanol-water extraction, the volume ratio of ethanol to water is 1: 10-10: 1.

Further preferably, the temperature of the high-temperature high-pressure water extraction is 80-105 ℃, and the pressure is 14-20 Bar.

In a preferred embodiment of the present invention, the formula of the coleus and psyllium composition for lowering blood sugar is: 10-100mg/60kg of B.W./day human of veronicastrum paniculatum original drug powder or veronicastrum paniculatum extract, and 1000mg/60kg of B.W./day human of plantain seed original drug powder or plantain seed extract; the formula for reducing blood pressure is as follows: 5-100mg/60kg of B.W./day human medicine of veronicastrum paniculatum technical powder or veronicastrum paniculatum extract, and 50-1000mg/60kg of B.W./day human medicine of plantain seed technical powder or plantain seed extract.

The oral pharmaceutical composition can be prepared into pills, lozenges, capsules, granules, syrups, vials, drops and emulsions, and also comprises at least one pharmaceutically acceptable adjuvant, carrier and/or excipient. Furthermore, coffee, chocolate or other natural sweeteners such as licorice or cinnamon may be added to flavor, improve mouthfeel and enhance user preference.

The invention has the beneficial effects that: the coleus blumei and plantain seed composition has obvious curative effect on reducing blood sugar and blood pressure, and can be used for preparing effective pharmaceutical compositions for treating individuals suffering from diabetes (and) or hypertension.

Drawings

FIG. 1 is a graph showing the response of the oral pharmaceutical composition to the detection of blood glucose changes in diabetic ICR mice administered with glucose in example 1 of the present invention;

FIG. 2 is a histogram comparing the change in blood glucose in diabetic ICR mice for each group in the experiment of example 1, in accordance with the present invention, calculated as the area under the curve of FIG. 1 (AUC for short in the present invention).

FIG. 3 is a bar graph of the hypotensive effect of the oral pharmaceutical composition of example 1 on normotensive SD rats after one administration;

FIG. 4 is a bar graph of the blood pressure lowering effect of the oral pharmaceutical composition of example 1 of the present invention on stage I hypertensive P1-HT rats after a single use;

FIG. 5 is a bar graph of the change in heart rhythm after a single administration of the oral pharmaceutical composition of example 1 of the present invention to hypertensive first-phase P1-HT rats.

Detailed Description

The technical solution of the present invention will be further illustrated and described below with reference to the accompanying drawings by means of specific embodiments.

The coleus alternifolius used in the present invention is also called a leaf grass, a striga asiatica, a single leaf of golden gunnery, a golden sword grass, an arrow, a spearmint, a single leaf of arrow, a single spearmint, a paradoxical grass and a Chinese snake beard. The two types of the L-type medical tea are 1. the Ophiopogon angustifolia (Ophiopogon thermale Komar.2. the L-type medical tea is slightly sweet, bitter and cool in character. Cool blood, clear heat and remove toxicity, resolve swelling and alleviate pain. Can be used for treating laryngalgia, pharyngitis, diphtheria, oral diseases, infantile pneumonia, abdominal pain, venomous snake bite, sore, and toxic swelling; it can be used for treating acute conjunctivitis, corneal nebula, and blepharitis.

Plantago asiatica Plantago seed (Plantago asiatica) Plantago of the invention has sweet and cold nature and flavor, enters kidney, bladder, liver and lung channels, has the functions of inducing diuresis for treating stranguria, excreting dampness and stopping diarrhea, clearing liver and improving vision, mainly induces diuresis, clears heat, improves vision and eliminates phlegm. It is indicated for dysuria, stranguria with turbid urine, leukorrhagia, hematuria, summer-heat dampness, dysentery, cough with excessive phlegm, damp arthralgia, conjunctival congestion and nebula.

The term "stem, root and whole plant extract" as used herein and the like refers to a mixture obtained by contacting the corresponding parts of the plant with a solvent after breaking the structure (optionally washed) and then using the method of the present invention. The extraction solvent is ethanol water, wherein the volume ratio of ethanol to water can be 1: 10-10: 1, such as 1: 1, 1: 2, 1: 3, 3: 1 or 2: 1. The extract comprises a crude extract (raw extract), more specifically a product obtained by simple extraction, and a treated, purified, refined extract (refined extract), wherein selected plant parts are contacted with at least one extraction solvent, and, optionally, the obtained crude extract may be subjected to one or more separation and/or purification treatments to obtain the refined extract. The stem, root and whole plant extracts may be in liquid form (e.g., solutions, concentrates or distillates) or may be solvent-free solids (e.g., pastes, granules or dried powders) and the solids may be further dissolved in an oil, such as, but not limited to, an edible oil, such as soybean oil.

An effective amount (effective mount) as used herein refers to an amount of a pharmaceutical composition sufficient to produce the desired therapeutic result, wherein the exact nature of the result will vary depending on the particular disease being treated. The specific effective amount will depend upon a variety of factors such as the particular condition being treated, the physiological condition of the patient (e.g., the patient's weight, age or sex), the type of animal being treated, the duration of treatment, the mode of administration, the nature of the current therapy (if any), and the specific formulation and structure of the compound or derivative thereof being used. An effective amount also refers to a compound or composition whose therapeutic benefit exceeds its toxic or deleterious effects. For example, an effective amount may be expressed as the total weight of the drug (e.g., in grams, milligrams, or micrograms) or as the ratio of the weight of the drug to the body weight in milligrams per kilogram (mg/kg).

The pharmaceutical composition used in the present invention means a mixture or compound consisting of two or more substances and containing the extract of the present invention as an active ingredient, whether it is a gas, liquid, powder or solid. The pharmaceutical compositions for oral administration may be in the form of capsules, cachets, pellets, lozenges, powders, granules, or as a solution or suspension in an aqueous or non-aqueous liquid, or as an oil-in-water or water-in-oil liquid emulsion, or as a syrup, or in the form of tablets and the like. In solid dosage forms (capsules, tablets, pills, dragees, powders, granules and other oral dosage forms) of the pharmaceutical composition for oral administration, the composition of the present invention can be used for applications such as the production of foods, pharmaceuticals, industrial materials and the like. Examples of the food of the present invention include nutritional supplement foods, health foods, functional foods, foods for the elderly, and the like.