阅读说明：本技术 淫羊藿炮制的一体化制备方法 (Integrated preparation method for processing epimedium ) 是由 胡芳弟 王燕萍 李成楠 贾旭森 于 2020-07-20 设计创作，主要内容包括：本发明公开了淫羊藿炮制的一体化制备方法,是将鲜心叶淫羊藿烘制一定含水量,切丝,加羊油炒干即可；烘干温度为70℃-120℃；烘干程度为烘至含水量为药材原始含水量的30%；羊油的加入量为鲜淫羊藿重量的20%。本发明的有益效果为：本发明提供的制备方法,能大大的缩短加工时间,与传统饮片加工方法相比,因避免了药材二次闷润的过程,极大程度地保留了淫羊藿中的活性成分,能有效的促进淫羊藿的开发利用；采用此制备方法炮制的淫羊藿药材,无掉渣现象,5种主要黄酮含量和、总黄酮含量较高,且DPPH自由基和超氧阴离子自由基清除能力较强。(The invention discloses an integrated preparation method for processing epimedium, which comprises the steps of baking fresh epimedium heartleaf with certain water content, shredding, adding mutton fat and frying to dry; the drying temperature is 70-120 ℃; the drying degree is that the water content is dried to be 30% of the original water content of the medicinal materials; the addition amount of the mutton fat is 20 percent of the weight of the fresh epimedium herb. The invention has the beneficial effects that: compared with the traditional decoction piece processing method, the preparation method provided by the invention can greatly shorten the processing time, greatly retains the active ingredients in the epimedium due to avoiding the secondary moistening process of the medicinal materials, and can effectively promote the development and utilization of the epimedium; the epimedium herb processed by the preparation method has no slag drop phenomenon, the content of 5 main flavones is high, the content of total flavones is high, and the scavenging capacity of DPPH free radicals and superoxide anion free radicals is strong.)

1. An integrated preparation method for processing epimedium is characterized in that fresh epimedium is baked to a certain water content or dried in the shade, cut into shreds, added with mutton fat and fried to be dry; the fresh epimedium is fresh epimedium brevicornum; the drying temperature is 30-120 ℃; the drying degree is that the raw materials are dried until the water content is 0-100% of the original water content of the raw materials; the addition amount of the mutton fat is 20 percent of the weight of the fresh epimedium; moistening and shredding after drying in the shade.

2. The integrated preparation method for processing epimedium herb according to claim 1, which is characterized by comprising the following steps: directly shredding fresh herba Epimedii, adding adeps Caprae Seu Ovis, and parching to dry, wherein the addition amount of adeps Caprae Seu Ovis is 20% of fresh herba Epimedii weight.

3. The integrated herba epimedii processing preparation method according to claim 1, wherein the drying temperature is 50 ℃, and the drying degree is to dry until the water content is 0-100% of the original water content of the medicinal materials.

4. The integrated preparation method for processing epimedium herb according to claim 1, wherein the drying temperature is 30-120 ℃; the drying degree is that the water content is 30 percent of the original water content of the medicinal materials.

5. The integrated preparation method for processing epimedium herb according to claim 1, wherein the drying temperature is 70-120 ℃; the drying degree is that the water content is 30 percent of the original water content of the medicinal materials.

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparation methods, in particular to an integrated preparation method for processing epimedium.

Background

The traditional Chinese medicine is processed from medicinal plants to traditional Chinese medicine decoction pieces in 2 links from production places to decoction pieces processing. The target product of the former is Chinese medicinal materials, and the target product of the latter is Chinese medicinal decoction pieces. In recent years, the state increases the supervision of traditional Chinese medicine decoction pieces, but problem decoction pieces appear, and are caused by disordered processing to a great extent, so that some scholars put forward the concept of integration (integration for short) of traditional Chinese medicine production place processing and decoction piece processing, and aim to grab from the source, stop problem hidden troubles, and ensure the quality, clinical safety and curative effect of the decoction pieces.

The epimedium alcohol extract, the total flavone, the epimedin A-C, the icariin and the baohuoside I have obvious pharmacological activity. Modern pharmacological studies show that the epimedium alcohol extract has the effects of oxidation resistance and neuroprotection; herba Epimedii total flavone has effects in resisting osteoporosis, resisting oxidation, enhancing immunity, protecting nerve, resisting aging and protecting kidney; the epimedin A has antibacterial and antioxidant activities; the epimedin B has anti-osteoporosis, antibacterial and antioxidant activities; the epimedin C has the activities of resisting osteoporosis, oxidation, bacteria and tumors; icariin has effects of resisting osteoporosis, protecting nerve, resisting tumor, resisting inflammation and resisting oxidation; baohuoside I has anti-tumor, anti-osteoporosis, blood sugar lowering and antioxidant activities. Researches show that the main active ingredient of herba Epimedii is flavone, wherein the contents of epimedin A-C, icariin and baohuoside I are high.

Disclosure of Invention

The invention aims to provide an integrated preparation method for processing epimedium aiming at the defects in the prior art.

In order to achieve the purpose, the technical scheme provided by the invention is as follows: an integrated preparation method of herba Epimedii comprises oven drying fresh herba Epimedii to certain water content or drying in the shade, shredding, adding adeps Caprae Seu Ovis, and parching to dry; the fresh epimedium is fresh epimedium brevicornum; the drying temperature is 30-120 ℃; the drying degree is that the raw materials are dried until the water content is 0-100% of the original water content of the raw materials; the addition amount of the mutton fat is 20 percent of the weight of the fresh epimedium; moistening and shredding after drying in the shade.

Further, the integrated preparation method for processing epimedium comprises the following steps: directly shredding fresh herba Epimedii, adding adeps Caprae Seu Ovis, and parching to dry, wherein the addition amount of adeps Caprae Seu Ovis is 20% of fresh herba Epimedii weight.

Furthermore, in the integrated preparation method for processing epimedium, the drying temperature is 50 ℃, and the drying degree is to dry until the water content is 0-100% of the original water content of the medicinal materials.

Further, in the integrated preparation method for processing epimedium, the drying temperature is 30-120 ℃; the drying degree is that the water content is 30 percent of the original water content of the medicinal materials.

Further, in the integrated preparation method for processing epimedium, the drying temperature is 70-120 ℃; the drying degree is that the water content is 30 percent of the original water content of the medicinal materials.

The invention has the beneficial effects that: compared with the traditional decoction piece processing method, the integrated preparation method for processing the epimedium can greatly shorten the processing time, greatly reserve the active ingredients in the epimedium due to the fact that the secondary stuffy and moist process of medicinal materials is avoided, and can effectively promote the development and utilization of the epimedium; the epimedium herb processed by the preparation method has no residue phenomenon, high content of total flavone, strong capability of removing DPPH free radical and superoxide anion free radical, and relatively high content of icariin and baohuoside I, content of 5 main flavone and content of alcohol extract.

Drawings

Figure 1 shows photographs of samples of different processes.

FIG. 2 shows 5 flavonoids in Epimedium (A-control, B-sample, 1-epimedin A, 2-epimedin B, 3-epimedin C, 4-icariin, 5-baohuoside 1)

FIG. 3 shows the sum of 5 flavone contents of S1-S12.

FIG. 4 shows the sum of 5 flavone contents of S12-S22.

FIG. 5 shows the total flavone content as S1-S12.

FIG. 6 shows the total flavone content as S12-S22.

Figure 7 shows the alcohol extract content.

FIG. 8 shows DPPH radical clearance rates from S12 to S22.

FIG. 9 shows hydroxyl radical scavenging rates for S12-S22.

FIG. 10 shows superoxide anion radical scavenging rates from S12 to S22.

Detailed Description

The experiment starts from fresh heart-leaf epimedium herb (hereinafter abbreviated as epimedium herb), takes the content of 5 main flavones (epimedin A-C, icariin, baohuoside I, hereinafter abbreviated as 5 flavones), the content of total flavones, the content of alcohol extract and the clearance rate of free radicals as indexes, adopts an oven drying method for drying, and uses mutton tallow oil for frying to optimize the processing and processing integrated process of the best producing place, and designs 21 new processes in total, wherein 1 traditional process respectively comprises the following steps: shredding while the fresh food is fresh, adding 20% mutton fat, and parching to dry to obtain sample S1; oven drying at 50 deg.C until the water content is different (0-90% of the original water content, i.e. one-time drying to complete drying), respectively taking out, shredding, adding 20% adeps Caprae Seu Ovis, and parching to dry to obtain 10 decoction piece samples (S2-S11); drying the fresh medicinal materials in the shade by using a traditional method, adding 20% mutton fat, and frying to be dry to obtain a decoction piece sample S12; oven drying at different temperatures (30-120 deg.C) until the water content is 30% (seven dry) of the original water content, shredding, adding 20% adeps Caprae Seu Ovis, and parching to dry to obtain 10 decoction piece samples (S13-S22).