脂质生产
阅读说明:本技术 脂质生产 (Lipid production ) 是由 M·韦塞尔 S·沙费尔 A·耶雷米亚斯 M·希林 H·H·温克 于 2019-02-08 设计创作,主要内容包括:本发明涉及至少一种从至少一种碳底物生产至少一种具有通式II的脂质的细胞,其中R<Sup>1</Sup>和R<Sup>2</Sup>彼此独立地包含相同或不同的各具有5-13个碳原子的有机残基,其中所述细胞是非致病性细胞,其经过遗传修饰以相对于野生型细胞增加酶(E<Sub>2</Sub>)的异源表达,所述酶(E<Sub>2</Sub>)能够将3-羟基烷酰基-3-羟基烷酰基辅酶A/ACP或3-(3-羟基烷酰氧基)链烷酸(HAA)和NDP-葡萄糖转化成β-D-吡喃葡萄糖基-3-羟基烷酰基-3-羟基链烷酸酯<Image he="135" wi="310" file="860206DEST_PATH_IMAGE001.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>。(The invention relates to at least one cell for producing at least one lipid having the general formula II, wherein R is a carbon substrate 1 And R 2 Containing identical or different organic residues each having 5 to 13 carbon atoms, independently of one another, wherein the cells are nonpathogenic cells which have been genetically modified to increase the enzyme (E) relative to wild-type cells 2 ) The heterologous expression of (A), the enzyme (E) 2 ) Capable of converting 3-hydroxyalkanoyl-CoA/ACP or 3- (3-Hydroxyalkanoyloxy) Alkanoic Acid (HAA) and NDP-glucose into β -D-glucopyranosyl-3-hydroxyalkanoyl-3-hydroxyalkanoate 。)