阅读说明：本技术 抗病毒双壳微胶囊及其制备方法和具有该抗病毒双壳微胶囊的消毒涂料及其制备方法和应用 (Antiviral double-shell microcapsule, preparation method thereof, disinfection coating with antiviral double-shell microcapsule, preparation method and application thereof ) 是由 喻学锋 吴列 杨新耕 康翼鸿 于 2020-05-09 设计创作，主要内容包括：本发明公开了抗病毒双壳微胶囊及其制备方法和具有该抗病毒双壳微胶囊的消毒涂料及其制备方法和应用。该胶囊,首先以聚环氧乙烷或\和聚乙二醇为内层壁材,以消毒剂材料为芯材,通过相分离法制备多孔微胶囊；然后再以无机氧化物或\和金属颗粒为外层壁材,以所得的多孔微胶囊为芯材,通过原位聚合制备得到抗病毒双壳微胶囊；消毒剂材料为挥发性或半挥发性消毒剂。一种消毒涂料,包括含多嵌段含氟共聚物组成的溶胶和抗病毒双壳微胶囊。该胶囊达到消毒剂的缓控释以及与壳材的协同灭杀病毒的作用。该消毒涂料,包含抗病毒双壳微胶囊,同时含有多嵌段含氟共聚物,在制成涂层时,可以减少病毒的沾附,消毒涂层病毒灭杀效率高。(The invention discloses an antiviral double-shell microcapsule, a preparation method thereof, a disinfection coating with the antiviral double-shell microcapsule, a preparation method and application thereof. The capsule is prepared by taking polyethylene oxide or/and polyethylene glycol as inner-layer wall materials and disinfectant materials as core materials and preparing porous microcapsules by a phase separation method; then, taking inorganic oxide or/and metal particles as outer-layer wall materials, taking the obtained porous microcapsule as a core material, and preparing the antiviral double-shell microcapsule by in-situ polymerization; the disinfectant material is a volatile or semi-volatile disinfectant. A disinfecting paint contains sol containing multi-block fluoric copolymer and antiviral double-shell microcapsule. The capsule has effects of sustained release of disinfectant and synergistic virucidal effect with shell material. The disinfection coating comprises the antivirus double-shell microcapsule and the multiblock fluorine-containing copolymer, can reduce the adhesion of viruses when being prepared into a coating, and has high virus killing efficiency of the disinfection coating.)

1. An antiviral double-shell microcapsule, which is characterized in that: firstly, preparing porous microcapsules by a phase separation method by taking polyethylene oxide or/and polyethylene glycol as inner-layer wall materials and disinfectant materials as core materials; then, taking inorganic oxide or/and metal particles as outer-layer wall materials, taking the obtained porous microcapsule as a core material, and preparing the antiviral double-shell microcapsule by in-situ polymerization; the disinfectant material is a volatile or semi-volatile disinfectant.

2. An antiviral double-shell microcapsule according to claim 1, wherein: the disinfectant material includes one or more of chlorine dioxide, hypochlorite, peroxide.

3. An antiviral double-shell microcapsule according to claim 2, wherein: the pore diameter of the porous microcapsule is 10-20 nm.

4. An antiviral double-shell microcapsule according to claim 3, wherein: the particle size of the antiviral double-shell microcapsule is 500 nm-5 mu m.

5. An antiviral double shell microcapsule preparation process as claimed in any one of claims 1 to 4, characterized in that: the method comprises the following steps:

s1: preparing a disinfectant mixed solution: uniformly mixing a disinfectant material and an aqueous solution containing a metal ion compound;

s2: porous microcapsules: dropwise adding the disinfectant mixed solution prepared in the step S1 into a polyethylene oxide and/or polyethylene glycol solution for emulsification, and then adding a coagulant to form porous microcapsules;

s3: antiviral double-shell microcapsule: dissolving inorganic oxide or/and metal particles in an organic solvent, uniformly mixing with the porous microcapsule obtained in the step S2, and adding a proper amount of HNO₃Stirring for a period of time to obtain the antiviral double-shell microcapsule.

6. A disinfecting coating, characterized in that: comprising a sol comprising a multiblock fluorine-containing copolymer composition and an antiviral double-shell microcapsule according to any one of claims 1 to 5.

7. A disinfecting paint as claimed in claim 6, characterized in that: the disinfection coating comprises the following raw materials in parts by weight: 15-25 parts of curing agent, 30-50 parts of ethanol, 25-30 parts of multi-block fluorine-containing copolymer and 10-15 parts of antiviral double-shell microcapsule.

8. A disinfecting paint as claimed in claim 7, characterized in that: the curing agent comprises epoxy resin or/and silicon ether resin.

9. The method of claim 7, wherein the step of preparing a disinfecting coating comprises: dissolving a curing agent in ethanol, adding the antiviral double-shell capsule and the multi-block fluorine-containing copolymer ethanol dispersion, uniformly stirring, adding a low-surface-energy fluoride, and mixing to obtain the disinfection coating.

10. The use of a disinfecting coating as claimed in claim 6, characterized in that: smearing the disinfection paint on a substrate, and curing at high temperature to obtain a hydrophobic coating with an antiviral function; the target viruses that the hydrophobic coating can resist are single-stranded RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses and double-stranded DNA viruses.

Technical Field

The invention relates to the technical field of disinfection products, in particular to an antiviral double-shell microcapsule, a preparation method thereof, a disinfection coating with the antiviral double-shell microcapsule, a preparation method and an application thereof.

Background

Common disinfectant products can be divided into chlorine-containing disinfectants, alcohol disinfectants, phenol disinfectants, photocatalytic nano-material disinfectants, metal disinfectants and the like according to the components. At present, chlorine-containing disinfectants are most widely used, but the chlorine-containing disinfectants also have the defects of overhigh concentration, short action time, residue after use, short action time and the like caused by instant release. Photocatalytic nanomaterials and metal nanoparticles are the direction of current research, however these solutions suffer from various drawbacks. For example, photocatalytic disinfection requires an additional light source, requires a long time, is sensitive to humidity, and the catalyst surface is susceptible to contamination. The use of silver nanoparticles increases material and manufacturing costs. In addition, widespread use and abuse has led to an increase in drug resistance. For these reasons, the use of secondary technologies and inclusion of slow-release disinfectants remains a concern for manufacturability, safety, and long-term stability.

Disclosure of Invention

The invention aims to provide an antiviral double-shell microcapsule with good virus killing effect and a preparation method thereof, and a disinfection coating with the antiviral double-shell microcapsule, which has high virus killing efficiency, long action time, sustainable and stable release and less residue, and a preparation method and application thereof, aiming at the defects in the prior art.

The invention relates to an antiviral double-shell microcapsule, which is prepared by taking polyethylene oxide or/and polyethylene glycol as inner-layer wall materials and disinfectant materials as core materials through a phase separation method; then, taking inorganic oxide or/and metal particles as outer-layer wall materials, taking the obtained porous microcapsule as a core material, and preparing the antiviral double-shell microcapsule by in-situ polymerization; the disinfectant material is a volatile or semi-volatile disinfectant.

Further, the disinfectant material includes one or more of chlorine dioxide, hypochlorite, peroxide.

Further, the anti-virus double-shell microcapsule comprises 20-50 wt% of disinfectant material by mass.

Furthermore, the particle size of the antiviral double-shell microcapsule is 500 nm-5 μm.

A preparation method of an antiviral double-shell microcapsule is characterized by comprising the following steps: the method comprises the following steps:

s1: preparing a disinfectant mixed solution: uniformly mixing a disinfectant material and an aqueous solution containing a metal ion compound;

s2: porous microcapsules: dropwise adding the disinfectant mixed solution prepared in the step S1 into a polyethylene oxide and/or polyethylene glycol solution for emulsification, and then adding a coagulant to form porous microcapsules;

s3: antiviral double-shell microcapsule: dissolving inorganic oxide or/and metal particles in an organic solvent, uniformly mixing with the porous microcapsule obtained in the step S2, and adding a proper amount of HNO₃Stirring for a period of time to obtain the antiviral double-shell microcapsule.

A disinfecting paint contains sol containing multi-block fluoric copolymer and antiviral double-shell microcapsule.

Further, the disinfection coating comprises the following raw materials in parts by weight: 15-25 parts of curing agent, 30-50 parts of ethanol, 25-30 parts of multi-block fluorine-containing copolymer and 10-15 parts of antiviral double-shell microcapsule.

Further, the curing agent comprises epoxy resin or/and silicon ether resin.

A preparation method of the disinfection coating comprises the steps of dissolving a curing agent in ethanol, adding the antiviral double-shell capsule and the segmented fluorine-containing copolymer ethanol dispersion liquid, stirring uniformly, adding a fluoride with low surface energy, and mixing to obtain the disinfection coating.

The application of the disinfection paint comprises the steps of coating the disinfection paint on a substrate, and curing at high temperature to obtain a hydrophobic coating with an antiviral function; the target viruses that the hydrophobic coating can resist are single-stranded RNA viruses, double-stranded RNA viruses, single-stranded DNA viruses and double-stranded DNA viruses.

The invention provides an antiviral double-shell microcapsule, which comprises at least one volatile or semi-volatile disinfectant, wherein a microcapsule shell material comprises a mixture of one or more polymers and one or more metal compounds so as to achieve the slow and controlled release of the disinfectant and the synergistic virus killing effect with the shell material. Compared with the traditional solid polymer particles, the invention has the advantages of high specific surface area, higher porosity, strong adsorption force, increased brittleness and the like.

The invention provides a multi-effect hydrophobic disinfection coating, which comprises an antiviral double-shell microcapsule and a multi-block fluorine-containing copolymer, and can reduce the attachment of viruses when a coating is prepared.

Drawings

FIG. 1 is a schematic contact angle diagram of the hydrophobic coating obtained in examples 1-3;

fig. 2 is a graph showing the sustained release of chlorine dioxide by the antiviral double-shell microcapsule obtained in example 1.

Detailed Description

The following are specific embodiments of the present invention and are further described with reference to the drawings, but the present invention is not limited to these embodiments.