阅读说明：本技术 一种无糖型板蓝根颗粒生产工艺 (Production process of sugar-free isatis root granules ) 是由 李国军 于 2020-04-13 设计创作，主要内容包括：本发明公开了一种无糖型板蓝根颗粒生产工艺,包括如下步骤：对板蓝根原药材进行预处理得到预处理药材；对所述预处理药材进行煎煮得到板蓝根溶液；将所述板蓝根溶液通过浓缩罐进行浓缩得到浓缩液A；向所述浓缩液A中加入乙醇得到乙醇浓度为90％的浓缩液B；将所述浓缩液B静置24小时以上,提取上清液；将所述上清液降温冷却至00C以下,析出上清液中的蔗糖晶体,滤除所述蔗糖晶体得到浓缩液C；将所述浓缩液C加热至780C,蒸发出乙醇,直至得到乙醇含量为60％的浓缩液D；将所述浓缩液D再次浓缩得到板蓝根浸膏；将所述板蓝根浸膏通过颗粒机制备得到板蓝根颗粒。本申请从板蓝根自带的蔗糖方面和外加入蔗糖两方面设计,大大降低甚至完全实现了无糖。(The invention discloses a production process of sugar-free isatis root granules, which comprises the following steps: pretreating the raw isatis root medicinal material to obtain a pretreated medicinal material; decocting the pretreated medicinal materials to obtain an isatis root solution; concentrating the isatis root solution through a concentration tank to obtain a concentrated solution A; adding ethanol into the concentrated solution A to obtain a concentrated solution B with the ethanol concentration of 90%; standing the concentrated solution B for more than 24 hours, and extracting a supernatant; cooling the supernatant to be below 00 ℃, separating out sucrose crystals in the supernatant, and filtering the sucrose crystals to obtain a concentrated solution C; heating the concentrated solution C to 780C, and evaporating ethanol until a concentrated solution D with the ethanol content of 60% is obtained; concentrating the concentrated solution D again to obtain an isatis root extract; and preparing the isatis root extract into isatis root granules by a granulator. The application designs from the aspect of cane sugar carried by the radix isatidis and the aspect of adding cane sugar, thereby greatly reducing and even completely realizing sugar-free.)

1. A production process of sugar-free isatis root granules is characterized by comprising the following steps:

step S1: pretreating the raw isatis root medicinal material to obtain a pretreated medicinal material;

step S2: decocting the pretreated medicinal materials to obtain an isatis root solution;

step S3: concentrating the isatis root solution through a concentration tank to obtain a concentrated solution A;

step S4: adding ethanol into the concentrated solution A to obtain a concentrated solution B with the ethanol concentration of 90%;

step S5: standing the concentrated solution B for more than 24 hours, and extracting a supernatant;

step S6: cooling the supernatant to below 0 ℃, separating out sucrose crystals in the supernatant, and filtering the sucrose crystals to obtain a concentrated solution C;

step S7: heating the concentrated solution C to 78 ℃, and evaporating ethanol until a concentrated solution D with the ethanol content of 60% is obtained;

step S8: concentrating the concentrated solution D again to obtain an isatis root extract;

step S9: and preparing the isatis root extract into isatis root granules by a granulator.

2. The process for producing sugar-free isatis root granules according to claim 1, wherein the step S1 includes:

step S101: cleaning and sorting the raw medicinal materials so as to remove impurities;

step S102: continuously cleaning with high-pressure water until the washing water is not turbid;

step S103: softening the washed raw medicinal materials;

step S104: slicing the softened raw medicinal materials into thick pieces;

step S105: drying is carried out.

3. The process for producing sugar-free isatis root granules according to claim 2, wherein the impurities are less than or equal to 3%.

4. The process for producing sugar-free isatis root granules according to claim 2, wherein in step S103, the softening process comprises: vacuum for 2min, and softening for 10 min.

5. The process for producing sugar-free isatis root granules according to claim 2, wherein the drying temperature is 80 ℃ at the upper limit, 78 ℃ at the lower limit, the drying time is 3 hours, and the material is turned over at a frequency of 1/hour during the drying process.

6. The process for producing sugar-free isatis root granules according to claim 1, wherein the step S2 includes: the first time, adding 6 times of drinking water of the raw medicinal materials, decocting for 2 hours, and the second time, adding 4 times of drinking water of the raw medicinal materials, decocting for 1 hour.

7. The process for producing sugar-free isatis root granules according to claim 1, wherein dextrin and effervescent agent are further added to the granulation machine in the step S9.

Technical Field

The invention relates to the field of traditional Chinese medicine preparation, in particular to a production process of sugar-free isatis root granules.

Background

Radix Isatidis (commonly known as indigo root, and radix Clerodenri Cyrtophylli root) is a Chinese medicinal material. Is prepared from dried root of Isatis tinctoria L of Brassicaceae by digging in autumn, and processing. Produced in all parts of China. The radix Isatidis is divided into radix Isatidis and radix Isatidis, and the radix Isatidis is derived from root of Isatis tinctoria L of Brassicaceae; the radix Isatidis is rhizome and root of herba Kalimeridis (Baphicanthus cusia (Nees) Brem.) of Acanthaceae. It is cold in nature, slightly sweet in taste and bitter in flavor, and has effects of clearing away heat and toxic materials, preventing common cold, and relieving sore throat. Is mainly used for treating diseases such as warm toxicity and macula, crimson and dark tongue, throat ulcer and erysipelas.

Because the isatis root is bitter in taste and difficult to be eaten, sucrose is often added in the preparation process, although the taste is ideal, the sucrose has strong physiological action, so that the operation function of spleen and stomach is easily hindered, dampness is remained to produce pathogenic factors, and the preparation method is especially not suitable for people with diabetes, hyperlipidemia and obesity, so that the sugar-free isatis root is required to be prepared.

Disclosure of Invention

The invention aims to provide a production process of sugar-free isatis root granules, aiming at reducing sugar content in the isatis root granules.

The invention is realized by the following steps:

a production process of sugar-free isatis root granules is characterized by comprising the following steps:

step S1: pretreating the raw isatis root medicinal material to obtain a pretreated medicinal material;

step S2: decocting the pretreated medicinal materials to obtain an isatis root solution;

step S3: concentrating the isatis root solution through a concentration tank to obtain a concentrated solution A;

step S4: adding ethanol into the concentrated solution A to obtain a concentrated solution B with the ethanol concentration of 90%;

step S5: standing the concentrated solution B for more than 24 hours, and extracting a supernatant;

step S6: cooling the supernatant to below 0 ℃, separating out sucrose crystals in the supernatant, and filtering the sucrose crystals to obtain a concentrated solution C;

step S7: heating the concentrated solution C to 78 ℃, and evaporating ethanol until a concentrated solution D with the ethanol content of 60% is obtained;

step S8: concentrating the concentrated solution D again to obtain an isatis root extract;

step S9: and preparing the isatis root extract into isatis root granules by a granulator.

Further, the step S1 includes:

step S101: cleaning and sorting the raw medicinal materials so as to remove impurities;

step S102: continuously cleaning with high-pressure water until the washing water is not turbid;

step S103: softening the washed raw medicinal materials;

step S104: slicing the softened raw medicinal materials into thick pieces;

step S105: drying is carried out.

Further, the impurity is less than or equal to 3%.

Further, in the step S103, the softening process includes: vacuum for 2min, and softening for 10 min.

Further, the upper limit of the drying temperature is 80 ℃, the lower limit of the drying temperature is 78 ℃, the drying time is 3 hours, and the materials are turned over according to the frequency of 1 time/hour in the drying process.

Further, the step S2 includes: the first time, adding 6 times of drinking water of the raw medicinal materials, decocting for 2 hours, and the second time, adding 4 times of drinking water of the raw medicinal materials, decocting for 1 hour.

Further, in step S9, dextrin and a effervescent agent are added to the granulation machine.

Compared with the prior art, the invention has the beneficial effects that: 1. after the first concentration, adding ethanol into the concentrated solution A to obtain a concentrated solution B with the concentration of 90%, compared with the prior art, the amount of the added ethanol is increased, on one hand, the amount of the sucrose component separated out from the isatis root concentrated solution which is not dissolved in the alcoholic solution can be increased; however, since a small amount of sucrose is still dissolved in water and does not precipitate due to a part of water in the alcohol solution, sucrose is crystallized and precipitated due to the solubility of sucrose, and since the alcohol solution is not frozen when the temperature is reduced to below 0 ℃, and the solubility of the sucrose component is greatly reduced when the temperature is reduced to below 0 ℃, the addition amount of ethanol is increased, sucrose is crystallized and precipitated from the alcohol solution, and the sucrose component carried by isatis roots is greatly reduced.

2. The application also abandons the process of adding cane sugar as a flavoring agent in the prior art, takes an effervescent agent as the flavoring agent, can narcotize taste buds to correct the flavor, is usually used for bitter taste and astringent taste, and does not contain any sugar in the effervescent agent.

Therefore, the application designs from the aspect of cane sugar carried by the radix isatidis and the aspect of adding cane sugar, thereby greatly reducing and even completely realizing sugar-free.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the embodiments of the present invention will be described in detail and completely, and it is apparent that the described embodiments are some, but not all embodiments of the present invention. Thus, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.

A production process of sugar-free isatis root granules comprises the following steps:

step S1: pretreating the raw isatis root medicinal material to obtain a pretreated medicinal material;

specifically, the step S1 includes:

step S101: cleaning and sorting the raw medicinal materials so as to remove impurities;

step S102: continuously cleaning with high-pressure water until the washing water is not turbid;

step S103: softening the washed raw medicinal materials;

step S104: slicing the softened raw medicinal materials into thick pieces;

step S105: drying is carried out.

Further, the impurity is less than or equal to 3%.

Further, in the step S103, the softening process includes: vacuum for 2min, and softening for 10 min.

Further, the upper limit of the drying temperature is 80 ℃, the lower limit of the drying temperature is 78 ℃, the drying time is 3 hours, and the materials are turned over according to the frequency of 1 time/hour in the drying process.

Step S2: decocting the pretreated medicinal materials to obtain an isatis root solution;

specifically, the step S2 includes: the first time, 6 times of drinking water is added into the raw medicinal materials for decoction for 2 hours, and the second time, 4 times of drinking water is added into the raw medicinal materials for decoction for 1 hour.

Step S3: concentrating the isatis root solution through a concentration tank to obtain a concentrated solution A; specifically, the drug solution was concentrated until the relative density of the drug solution became 1.20(50 ℃ C.).

Step S4: adding ethanol into the concentrated solution A to obtain a concentrated solution B with the ethanol concentration of 90%;

step S5: standing the concentrated solution B for more than 24 hours, and extracting a supernatant;

step S6: cooling the supernatant to below 0 ℃, separating out sucrose crystals in the supernatant, and filtering the sucrose crystals to obtain a concentrated solution C;

step S7: heating the concentrated solution C to 78 ℃, and evaporating ethanol until a concentrated solution D with the ethanol content of 60% is obtained; in one example, concentrate D has a solution concentration of 1.26(50 ℃).

Since the concentration of ethanol is too high to affect the activity of the drug, a part of ethanol is evaporated by using the boiling point of ethanol.

Step S8: concentrating the concentrated solution D again to obtain an isatis root extract;

step S9: and preparing the isatis root extract into isatis root granules by a granulator.

Further, in step S9, dextrin and a effervescent agent are added to the granulation machine. Specifically, adding dextrin and an effervescent agent, stirring uniformly, then adding the isatis root extract, mixing for 15-20 minutes to prepare a soft material, preparing the soft material into wet granules, and drying to obtain the final isatis root granules.

In the embodiment of the application, the effervescent agent is used as a flavoring agent, for example, bicarbonate and organic acid (citric acid and tartaric acid) can be used as the effervescent agent, and CO2 is generated after the effervescent agent is mixed with water. CO2 is dissolved in water to be acidic, can anaesthetize taste bud to correct taste, and can be used in bitter, astringent and salty preparations in combination with sweetener and aromatic agent to obtain cool and refreshing taste.

After the first concentration, adding ethanol into the concentrated solution A to obtain a concentrated solution B with the concentration of 90%, compared with the prior art, the amount of the added ethanol is increased, and on one hand, the amount of sucrose contained in the radix isatidis concentrated solution which is not compatible with an alcoholic solution is increased; however, since the alcoholic solution contains a part of water, a small part of sucrose is still dissolved in water and is not precipitated, the sucrose is crystallized and precipitated by utilizing the solubility of the sucrose, the alcoholic solution is not frozen when being cooled to below 0 ℃, and the solubility of the sucrose component is greatly reduced when being cooled to below 0 ℃, so that the addition amount of the ethanol is increased, the sucrose is crystallized and precipitated from the alcoholic solution, and the sucrose component carried by the isatis root is greatly reduced. The application also abandons the working procedure of adding cane sugar as a flavoring agent in the prior art, and takes the effervescent agent as the flavoring agent, the effervescent agent can narcotize taste buds to correct the taste and is commonly used for bitter taste and astringent taste, and the effervescent agent does not contain any sugar. Therefore, the application designs from the aspect of cane sugar carried by the radix isatidis and the aspect of adding cane sugar, thereby greatly reducing and even completely realizing sugar-free.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and variations of the present invention may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.