阅读说明：本技术 一种富硒壳寡糖片及其制备方法 (Selenium-rich chitosan oligosaccharide tablet and preparation method thereof ) 是由 郑委 于 2021-07-27 设计创作，主要内容包括：本发明涉及一种富硒壳寡糖片,所述的富硒壳寡糖片包括如下原料制成：富硒食用菌粉、壳寡糖、低聚木糖、麦苗粉和鹿鞭。本发明制备的富硒壳寡糖片具有如下作用：保护心脏、保护肝脏、控制糖尿病并发症、提高自身免疫力、清理血管、修复人体细胞、修复人体糖链、激活人体40多种酶、清理肠道；本发明人经过大量试验发现,采用本发明的原料及配方制备的富硒壳寡糖片在有机硒含量高,各原料符合传统中医学中君臣佐使的组方原则,无添加,是一种复合型的功能性食品。(The invention relates to a selenium-rich chitosan oligosaccharide tablet, which is prepared from the following raw materials: selenium-rich edible fungus powder, chitosan oligosaccharide, xylooligosaccharide, wheat seedling powder and penis cervi. The selenium-rich chitosan oligosaccharide tablet prepared by the invention has the following functions: protecting heart and liver, controlling diabetic complications, improving immunity, cleaning blood vessel, repairing human body cell, repairing human body sugar chain, activating human body more than 40 enzymes, and cleaning intestinal tract; through a large number of experiments, the inventor discovers that the selenium-rich chitosan oligosaccharide tablet prepared by adopting the raw materials and the formula disclosed by the invention has high organic selenium content, each raw material accords with the formula principle of monarch, minister, assistant and guide in the traditional Chinese medicine, and the selenium-rich chitosan oligosaccharide tablet is a compound functional food without addition.)

1. The selenium-rich chitosan oligosaccharide tablet is characterized by comprising the following raw materials: selenium-rich edible fungus powder, chitosan oligosaccharide, xylooligosaccharide, wheat seedling powder and penis cervi.

2. The selenium-rich chitosan oligosaccharide tablet as claimed in claim 1, wherein the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 8-35 parts of selenium-rich edible fungus powder, 5-10 parts of chitosan oligosaccharide, 5-10 parts of xylo-oligosaccharide, 5-10 parts of wheat seedling powder and 15-35 parts of penis cervi.

3. The selenium-rich chitosan oligosaccharide tablet as claimed in claim 2, wherein the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 20-23 parts of selenium-rich edible fungus powder, 7-8 parts of chitosan oligosaccharide, 7-8 parts of xylo-oligosaccharide, 7-8 parts of wheat seedling powder and 23-27 parts of penis cervi.

4. The selenium-rich chitosan oligosaccharide tablet as claimed in claim 3, wherein the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 21.5 parts of selenium-rich edible fungus powder, 7.5 parts of chitosan oligosaccharide, 7.5 parts of xylo-oligosaccharide, 7.5 parts of wheat seedling powder and 25 parts of penis cervi.

5. The method for preparing the selenium-enriched chitosan oligosaccharide tablet as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, and then adding 55-65% of ethanol by volume fraction for wet granulation;

(3) and drying the prepared granules at low temperature, adding an anticaking agent, granulating and tabletting to obtain the selenium-enriched chitosan tablet.

6. The method for preparing selenium-enriched chitosan oligosaccharide tablet as claimed in claim 5, wherein the mixing and stirring speed in step (2) is 22-26r/min, and the stirring time is 12-18 min.

7. The method for preparing selenium-enriched chitosan oligosaccharide tablet according to claim 6, wherein the mixing and stirring speed in the step (2) is 24r/min, and the stirring time is 15 min.

8. The method for preparing selenium-enriched chitosan oligosaccharide tablet as claimed in claim 5, wherein the temperature for low-temperature drying in step (3) is 50-60 deg.C, and the drying time is 10-15 min.

9. The method for preparing selenium-enriched chitosan oligosaccharide tablet as claimed in claim 8, wherein the temperature for low-temperature drying in step (3) is 55 ℃, and the drying time is 12.5 min.

Technical Field

The invention belongs to the technical field of food, and particularly relates to a selenium-rich chitosan oligosaccharide tablet and a preparation method thereof.

Background

With the improvement of the substance level of people, various health-care foods gradually come into the field of view of the people, the intake of dietary selenium becomes a focus of attention of people, and people mostly take selenium element through foods for a long time, but the selenium element has low content and low absorption and utilization rate, and the selenium supplement requirement of the human body cannot be met. Selenium is a trace element necessary for human bodies, participates in the synthesis of glutathione peroxidase in vivo, can scavenge free radicals in cells, protects organism tissues from oxidative damage, and has the effects of delaying senescence, enhancing immunity, preventing cancers and the like; selenium deficiency not only affects the redox status of the population, but also causes cellular DNA damage. In recent years, researches show that selenium is an important dietary component and has a wide biological effect, and once the balance of selenium in a body is broken, metabolic abnormality is caused, a series of physiological changes are caused, and serious influence is generated on the occurrence and development of diseases.

At present, the selenium-containing food in the market has low organic selenium concentration, can not meet the requirements of human bodies, and the existing selenium-containing food is not easy to absorb by human bodies.

The present invention has been made in view of the above circumstances.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides the selenium-rich chitosan oligosaccharide tablet and the preparation method thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials: selenium-rich edible fungus powder, chitosan oligosaccharide, xylooligosaccharide, wheat seedling powder and penis cervi.

Further, the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 8-35 parts of selenium-rich edible fungus powder, 5-10 parts of chitosan oligosaccharide, 5-10 parts of xylo-oligosaccharide, 5-10 parts of wheat seedling powder and 15-35 parts of penis cervi.

Further, the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 20-23 parts of selenium-rich edible fungus powder, 7-8 parts of chitosan oligosaccharide, 7-8 parts of xylo-oligosaccharide, 7-8 parts of wheat seedling powder and 23-27 parts of penis cervi.

Further, the selenium-rich chitosan oligosaccharide tablet is prepared from the following raw materials in parts by weight: 21.5 parts of selenium-rich edible fungus powder, 7.5 parts of chitosan oligosaccharide, 7.5 parts of xylo-oligosaccharide, 7.5 parts of wheat seedling powder and 25 parts of penis cervi.

The selenium-rich edible fungus powder manufacturer of the invention is Chengdyun selenium edible fungus planting Limited company,

the selenium-rich edible fungus powder has high purity of organic selenium, good absorption for human body, high content of amino acid,

chitosan oligosaccharide is called chitosan oligosaccharide and oligomeric chitosan, is an oligosaccharide product with the polymerization degree of 2-20, is obtained by degrading chitosan through a special biological enzyme technology (reports of using chemical degradation and microwave degradation technologies), has the molecular weight of less than or equal to 3200Da, and is a low-molecular-weight product with good water solubility, large functional effect and high biological activity. It has several unique functions of high solubility, complete water solubility, easy absorption and utilization by organism, etc. and its action is 14 times that of chitosan.

The xylo-oligosaccharide is also called xylo-oligosaccharide, and is a functional polysaccharide formed by combining 2-7 xylose molecules by beta-1, 4 glycosidic bonds. Compared with the commonly used soybean oligosaccharide, fructo-oligosaccharide, isomaltose hypgather and the like, the bifidobacterium propagation promoter has unique advantages and can selectively promote the proliferation activity of intestinal bifidobacteria. The bifidus factor function is 10-20 times of other polymeric saccharides. The xylo-oligosaccharide is used for improving intestinal environment.

Wheat seedling powder is emerald green powder prepared by carrying out microwave drying and low-temperature (0 +/-5 ℃) airflow crushing on wheat young leaves, and wheat seedlings contain various rich nutrient elements such as plant protein, chlorophyll, antioxidant enzyme, dietary fiber and the like. The wheat seedling powder is alkaline food, and can improve acid-base balance of human body.

The penis cervi is an extreme object, and has the effects of tonifying yang and kidney, improving testosterone of a human body and enabling the kidney to be more dynamic.

The invention also provides a preparation method of the selenium-rich chitosan oligosaccharide tablet, which comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, and then adding 55-65% of ethanol by volume fraction for wet granulation;

(3) and drying the prepared granules at low temperature, adding an anticaking agent, granulating and tabletting to obtain the selenium-enriched chitosan tablet.

Further, the mixing and stirring speed in the step (2) is 22-26r/min, and the stirring time is 12-18 min.

Further, in the step (2), the mixing and stirring speed is 24r/min, and the stirring time is 15 min.

Further, the temperature of the low-temperature drying in the step (3) is 50-60 ℃, and the drying time is 10-15 min.

Further, the temperature of the low-temperature drying in the step (3) is 55 ℃, and the drying time is 12.5 min.

The anticaking agent in the invention is magnesium stearate, and the addition amount is determined according to the actual situation, so long as the anticaking agent can be formed by tabletting.

The selenium-rich chitosan oligosaccharide tablet prepared by the invention is 0.5 g/tablet.

Compared with the prior art, the invention has the beneficial effects that:

(1) the selenium-rich chitosan oligosaccharide tablet prepared by the invention has the following functions: protecting heart and liver, controlling diabetic complications, improving immunity, cleaning blood vessel, repairing human body cell, repairing human body sugar chain, activating human body more than 40 enzymes, and cleaning intestinal tract;

(2) the inventor discovers through a large number of experiments that the selenium-rich chitosan oligosaccharide tablet prepared by adopting the raw materials and the formula has high organic selenium content, each raw material accords with the composing principle of monarch, minister, assistant and guide in the traditional Chinese medicine, the selenium-rich edible fungus powder is monarch, the chitosan oligosaccharide is minister, the penis cervi is assistant, and the wheat seedling powder and the xylooligosaccharide are guide.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Example 1

The selenium-enriched chitosan tablet of the embodiment is prepared from the following raw materials: 8kg of selenium-rich edible fungus powder, 10kg of chitosan oligosaccharide, 5kg of xylo-oligosaccharide, 10kg of wheat seedling powder and 15kg of penis cervi.

The preparation method of the selenium-rich chitosan oligosaccharide tablet comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, wherein the mixing and stirring speed is 22r/min, the stirring time is 18min, adding a proper amount of ethanol with the volume fraction of 55%, performing wet granulation, and after adding the ethanol, observing the change of the materials, wherein the materials can be agglomerated by a hand test, and the materials can be scattered by tapping;

(3) and drying the prepared granules at low temperature of 50 ℃ for 15min, adding a proper amount of magnesium stearate, granulating, and tabletting to obtain the selenium-enriched chitosan tablets.

Example 2

The selenium-enriched chitosan tablet of the embodiment is prepared from the following raw materials: 20kg of selenium-rich edible fungus powder, 8kg of chitosan oligosaccharide, 7kg of xylo-oligosaccharide, 8kg of wheat seedling powder and 23kg of penis cervi.

The preparation method of the selenium-rich chitosan oligosaccharide tablet comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, wherein the mixing and stirring speed is 23r/min, the stirring time is 16min, adding a proper amount of ethanol with the volume fraction of 58% for wet granulation, and after the ethanol is added, the materials can be agglomerated by a hand test and can be scattered by tapping;

(3) drying the prepared granules at low temperature of 53 ℃ for 14min, adding a proper amount of magnesium stearate, granulating, and tabletting to obtain the selenium-enriched chitosan tablets.

Example 3

The selenium-enriched chitosan tablet of the embodiment is prepared from the following raw materials: 21.5kg of selenium-rich edible fungus powder, 7.5kg of chitosan oligosaccharide, 7.5kg of xylo-oligosaccharide, 7.5kg of wheat seedling powder and 25kg of penis cervi.

The preparation method of the selenium-rich chitosan oligosaccharide tablet comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, wherein the mixing and stirring speed is 24r/min, the stirring time is 15min, adding a proper amount of ethanol with the volume fraction of 60% for wet granulation, and after the ethanol is added, the materials can be agglomerated by a hand test and can be scattered by tapping;

(3) drying the prepared granules at low temperature of 55 ℃ for 12.5min, adding a proper amount of magnesium stearate, granulating, and tabletting to obtain the selenium-enriched chitosan tablet.

Example 4

The selenium-enriched chitosan tablet of the embodiment is prepared from the following raw materials: 23kg of selenium-rich edible fungus powder, 7kg of chitosan oligosaccharide, 8kg of xylo-oligosaccharide, 7kg of wheat seedling powder and 27kg of penis cervi.

The preparation method of the selenium-rich chitosan oligosaccharide tablet comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, wherein the mixing and stirring speed is 25r/min, the stirring time is 14min, adding a proper amount of ethanol with the volume fraction of 62%, performing wet granulation, and after adding the ethanol, observing the change of the materials, wherein the materials can be agglomerated by a hand test, and the materials can be scattered by tapping;

(3) and drying the prepared granules at a low temperature of 58 ℃ for 13min, adding a proper amount of magnesium stearate, granulating, and tabletting to obtain the selenium-enriched chitosan tablets.

Example 5

The selenium-enriched chitosan tablet of the embodiment is prepared from the following raw materials: 35kg of selenium-rich edible fungus powder, 5kg of chitosan oligosaccharide, 10kg of xylooligosaccharide, 5kg of wheat seedling powder and 35kg of penis cervi.

The preparation method of the selenium-rich chitosan oligosaccharide tablet comprises the following steps:

(1) weighing the raw materials according to the weight of the raw materials for later use;

(2) stirring and mixing the raw materials uniformly, wherein the mixing and stirring speed is 26r/min, the stirring time is 12min, adding a proper amount of ethanol with the volume fraction of 65% for wet granulation, and after the ethanol is added, the materials can be agglomerated by a hand test and can be scattered by tapping;

(3) and drying the prepared granules at a low temperature of 60 ℃ for 10min, adding a proper amount of magnesium stearate, granulating, and tabletting to obtain the selenium-enriched chitosan tablets.

Test example 1

The selenium-rich chitosan oligosaccharide tablets prepared in example 3 were subjected to component detection, and the results are shown in table 1.

TABLE 1

Detecting items	Detection method	Test results (mg/kg)
			Selenium	First method of GB5009.93-2017	110
Calcium carbonate	First method of GB5009.92-2016	374
			Zinc	First method of GB5009.14-2017	20.3

The inventor also carries out the above detection on the selenium-rich chitosan oligosaccharide tablets prepared in other examples, and the results are basically consistent and are not listed any more due to limited space.

Detailed description of the preferred embodiment

Case 1

When a certain part of Liu, male, Jiangxi Ganzhou, and people in Jiangxi province take antihypertensive drugs for a long time, the blood pressure is unstable, when the selenium-rich chitosan oligosaccharide tablet prepared in the embodiment 3 of the invention is taken, 3 tablets are taken once, 2 times a day and 5 days continuously, the blood pressure is slowly and stably, and the selenium-rich chitosan oligosaccharide tablet is continuously taken until now, the blood pressure is stable, and the reaction is better during return visit.

Case 2

The Jiangxi people in the Yangtze river, male and female have diabetes and complications, and the effect of taking the diabetes medicine all the time is not obvious, and the selenium-enriched chitosan oligosaccharide tablet prepared in the embodiment 1 of the invention is taken 3 tablets at a time and 2 times a day for ten days continuously, so that the complications are reduced.

Case 3

Zhengqi, male, 50 years old, Jiangxi Ganzhou, suffered from cerebral infarction and dizziness, and after taking the selenium-enriched chitosan oligosaccharide tablet prepared in the embodiment 2 of the invention, 4 tablets are taken once, 2 times a day, and the dizziness is improved after continuous 5 days, and then the selenium-enriched chitosan oligosaccharide tablet is continuously taken.

Case 4

Convalesce A male, 28 years old, Jiangxi Ganzhou, suffering from depression and affecting normal work, the selenium-rich chitosan oligosaccharide prepared in the invention 3 is taken 4 tablets at a time, 2 times a day, and improved after 7 days of continuous taking, and the selenium-rich chitosan oligosaccharide can work normally about three months each day when taken continuously till now.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.