阅读说明：本技术 一种便携式的一氧化氮发生装置及其使用方法 (Portable nitric oxide generating device and using method thereof ) 是由 陈涛 徐海宏 耿翔 秦玉 毛雯 曹贵平 于 2020-06-19 设计创作，主要内容包括：本发明提供了一种便携式的一氧化氮发生装置及其使用方法,所述的一氧化氮发生装置包括依次连接的一氧化氮发生模块和气体混合模块；所述的一氧化氮发生模块包括循环连接的电解池和气液分离装置；所述的气体混合模块包括与所述的气液分离装置连接的气体混合装置,所述的气体混合装置外接空气源,由气液分离装置排出的NO进入气体混合装置后与空气源通入的空气混合得到治疗气体。本发明通过电解池电解产生NO,可以根据使用需求实现NO气体的即时发生,与现有技术采用的NO钢瓶相比,设备占地面积更小,操作更灵活,集成度更高,携带更便捷,使用更安全。(The invention provides a portable nitric oxide generating device and a using method thereof, wherein the nitric oxide generating device comprises a nitric oxide generating module and a gas mixing module which are sequentially connected; the nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner; the gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas. The invention generates NO through electrolysis of the electrolytic cell, can realize the instant generation of NO gas according to the use requirement, and compared with the NO steel cylinder adopted in the prior art, the invention has the advantages of smaller occupied area of equipment, more flexible operation, higher integration level, more convenient carrying and safer use.)

1. A portable nitric oxide generating device is characterized by comprising a nitric oxide generating module and a gas mixing module which are sequentially connected;

the nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner;

the gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas.

2. The nitric oxide generating device according to claim 1, wherein the gas-liquid separating device comprises a housing and a membrane module axially arranged inside the housing, a gas accommodating cavity of an annular columnar structure is formed between an inner wall of the housing and an outer wall of the membrane module, NO gas generated by the electrolytic cell enters the membrane module along with the electrolyte, NO gas in the electrolyte passes through membrane holes to enter the gas accommodating cavity in the process of flowing through the membrane module, and the electrolyte with NO gas filtered flows back to the electrolytic cell;

preferably, a liquid pump is arranged on a connecting pipeline between a liquid outlet of the membrane module and a liquid return port of the electrolytic cell, and the electrolyte with NO gas filtered out is returned to the electrolytic cell through the liquid pump;

preferably, the outer wall of the shell is provided with an air inlet and an air outlet which are communicated with the gas containing cavity, the air inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas into the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the air outlet is divided into two paths, and one path is connected with an NO gas inlet of the gas mixing device;

preferably, the carrier gas source is a first air pump, and the first air pump delivers air into the gas accommodating chamber as carrier gas for driving discharge of NO gas.

3. The nitric oxide generating device according to claim 1 or 2, further comprising a gas concentration control module, wherein the gas concentration control module is used for detecting the concentration of NO in the mixed gas and controlling the output flow of NO gas in a feedback manner;

preferably, the gas concentration control module comprises a gas concentration sensing device and a flow control device connected with the gas concentration sensing device in a feedback manner, the flow control device is arranged on a connecting pipeline between the gas-liquid separation device and the gas mixing device, the gas concentration sensing device is connected to a sampling port of the gas mixing device, and the gas concentration sensing device is used for detecting the concentration of NO in the sampled gas;

preferably, a sampling pump is arranged on a connecting pipeline between the gas concentration sensing device and the sampling port of the gas mixing device;

preferably, a second air pump is arranged on a connecting pipeline between the gas-liquid separation device and the flow control device;

preferably, the therapeutic gas outlet of the gas mixing device is connected with a patient inhalation device;

preferably, the patient inhalation device is an oronasal mask.

4. The nitric oxide generating device according to any one of claims 1 to 3, wherein the electrolytic cell is a closed container with electrolyte, two electrodes are inserted into the electrolyte and are arranged at intervals, and the two electrodes are an anode electrode of an external power supply anode and a cathode electrode of an external power supply cathode respectively;

preferably, the electrolyte comprises a buffer solution, nitrite and a copper-based catalyst;

preferably, the concentration of the buffer solution is 0.01-3 mol/L;

preferably, the buffer solution comprises 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, 3-morpholine propanesulfonic acid buffer solution, phosphate buffer solution or organic buffer solution;

preferably, the concentration of the nitrite is 0.01-5 mol/L;

preferably, the concentration of the copper-based catalyst is 1-7 mmol/L;

preferably, the copper-based catalyst is selected from one or a combination of at least two of copper (II) tris (2-pyridylmethyl) amine, copper (II) 1, 4, 7-triazacyclononane, copper (II) 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane, copper (II) tris (2-aminoethyl) amine, copper (II) tris (2-dimethylaminoethyl) amine or copper (II) bis (2-aminomethylpyridine) -propionate.

5. A nitric oxide generation apparatus according to any of claims 1-4, wherein said electrodes comprise at least one electrode sheet;

preferably, the electrode comprises at least two electrode sheets which are closely stacked;

preferably, the number of electrode sheets constituting the anode electrode is the same as or different from the number of electrode sheets constituting the cathode electrode;

preferably, the electrode plate is of a net structure;

preferably, the electrode plate is made of a material selected from gold, platinum, carbon or stainless steel;

preferably, the electrode sheet material constituting the anode electrode is the same as or different from the electrode sheet material constituting the cathode electrode.

6. The nitric oxide generating device according to any one of claims 1 to 5, further comprising a housing, wherein the gas-liquid separation device, the gas mixing module and the gas concentration control module are integrally arranged inside the housing, and the electrolytic cell is detachably arranged outside the housing;

preferably, the shell is provided with a groove for fixing an electrolytic cell, and the electrolytic cell is connected with a gas-liquid separation device positioned in the shell through an external liquid hose;

preferably, a human-computer interaction interface is embedded in the shell;

preferably, the human-computer interaction section comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device and used for realizing real-time data transmission and interaction; the control panel is electrically connected with the flow control device and used for manually operating the flow control device.

7. A method of using a nitric oxide generation apparatus according to any of claims 1 to 6, comprising:

NO gas generated by the electrolytic cell enters the gas-liquid separation device along with electrolyte, and the NO gas obtained by separation enters the gas mixing device to be mixed with air introduced from an air source.

8. The use method according to claim 7, characterized in that the use method specifically comprises the following steps:

NO gas generated by an electrolytic cell enters a gas-liquid separation device along with electrolyte, the NO gas obtained by separation of a membrane module is discharged under the drive of carrier gas, and part of mixed gas formed by the NO and the carrier gas enters a gas mixing device;

(II) the air source leads air into the gas mixing device, the air is mixed with part of mixed gas entering the gas mixing device in the step (I) to obtain therapeutic gas, the therapeutic gas is sampled by a sampling pump and then is sent to the gas concentration sensing device, the gas concentration sensing device detects the NO concentration in the sampled gas and compares the NO concentration with a preset NO concentration range, when the actual measured value of the NO concentration in the sampled gas exceeds the preset concentration range, the flow control device is fed back and controlled, and when the detected actual measured value of the NO concentration in the sampled gas falls into the preset range, the therapeutic gas is discharged for the patient to inhale.

9. The use method as claimed in claim 8, wherein in the step (I), 200-300 mA of current is applied to the anode electrode and the cathode electrode in the electrolytic cell;

preferably, the flow rate of the carrier gas introduced into the gas-liquid separation device is 0.5-1.5L/min;

preferably, the carrier gas is air;

preferably, the total flow of the mixed gas discharged by the gas-liquid separation device is 0.5-1.5L/min;

preferably, the flow rate of part of the mixed gas entering the gas mixing device accounts for 0.1-80% of the total flow rate of the mixed gas discharged by the gas-liquid separation device.

10. The use method according to claim 8 or 9, wherein in the step (II), the air flow rate of the air source introduced into the gas mixing device is 1-10L/min;

preferably, the preset NO concentration range is 5-40 ppm;

preferably, the process of logically controlling the flow control device by the gas concentration sensing device specifically includes the following steps:

when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device is higher than the upper limit of the preset NO concentration range, sending a feedback signal to the flow control device to reduce the production flow of the first mixed gas;

and when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device is lower than the lower limit of the preset NO concentration range, sending a feedback signal to the flow control device to increase the flow rate of the first mixed gas.

Technical Field

The invention belongs to the technical field of medical instruments, and relates to a portable nitric oxide generating device and a using method thereof.

Background

Nitric oxide is an endogenous, small molecule substance with important physiological functions. The main functions include: increase vasodilation, prevent platelet adhesion, promote wound healing and angiogenesis, and can be released by macrophages and nasal epithelial cells as an effective antimicrobial agent. Direct inhalation nitric oxide therapy is approved by the U.S. food and drug administration as a therapeutic means for treating neonatal persistent pulmonary hypertension, and has been shown to improve body oxygenation and reduce the risk of high-risk extracorporal cardiopulmonary support therapy. Nitric oxide inhalation therapy not only dilates the pulmonary blood vessels and reduces pulmonary vascular resistance, but also is helpful in the treatment of other diseases including pneumonia, stroke, acute respiratory distress syndrome, and the like. Recent studies have reported that nitric oxide acts as an inhaled antibacterial agent in the treatment of cystic fibrosis, tuberculosis and as an anti-inflammatory agent to modulate the immune response and improve the survival of malaria patients. Nitric oxide inhalation therapy has also been shown to provide neuroprotection and reduce brain damage. Another potential reuse clinical application area of gaseous nitric oxide scanning gas in oxygenators used in extracorporeal circuits for cardiopulmonary bypass surgery, as well as cardiotomy air, can cause severe systemic inflammation in some patients, associated with inflammation and various organ failures, the severity of which is related to the length of the surgery time. The anti-inflammatory properties of nitric oxide may also be beneficial in reducing the occurrence of complications of these diseases.

CN110101946A discloses a portable nitric oxide therapeutic instrument, which comprises a housin, the casing internal fixation has NO control assembly, detection module, power supply module and control module, control module and power supply module electric connection, be provided with the handle on the casing, NO control assembly includes mass flow controller, detection module includes the air pump, detect sensor and three way solenoid valve, three way solenoid valve outlet pipeline divide into and detects the gas circuit and sets for the gas circuit, it links breather pump and detection sensor to detect the gas circuit, set for gas circuit and atmosphere intercommunication, detect the sensor, mass flow controller and three way solenoid valve all with control module electric connection, power supply module includes rechargeable battery group.

CN208193356U discloses a nitric oxide therapeutic apparatus, comprising: breathing machine, gaseous monitoring devices, gas mixing device and sampling device, breathing machine and gas monitoring devices all are connected with gas mixing device, and sampling device passes through the L type and connects and set up the sampling port on gas mixing device output and be connected, and wherein the confession human breathing's that the breathing machine produced mixes gas and the NO gas that gas monitoring devices produced form the treatment gas in mixing device, and gas monitoring devices is sent into with the treatment gas of gathering to sampling device.

CN110872714A discloses a portable nitric oxide maker, which comprises an air pump, a nitric oxide generator, a reduction module, wherein the nitric oxide generator is further connected with a nitric oxide concentration regulator and a numerical display; the nitric oxide generator is a closed container and is provided with electrolyte and electrodes, wherein the electrodes comprise an electrode cathode and an electrode anode, and the electrode anode and the electrode cathode are connected with a power supply; the closed container is provided with an air inlet pipe and an air outlet pipe, one end of the air inlet pipe is connected with an air pump, and the other end of the air inlet pipe extends into the electrolyte and is close to the cathode of the electrode; one end of the air outlet pipe is connected with the reduction module, and the other end of the air outlet pipe is positioned above the electrolyte.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a portable nitric oxide generating device and a using method thereofThe floor area is less, and the operation is more nimble, and the integrated level is higher, carries more conveniently, uses safelyr. The invention separates NO gas from the electrolyte by arranging the gas-liquid separation device, realizes the high-efficiency separation of the NO gas, generates NO with higher purity, and generates by-product NO₂The content of (A) is low.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the present invention provides a portable nitric oxide generating device, which comprises a nitric oxide generating module and a gas mixing module connected in sequence.

The nitric oxide generation module comprises an electrolytic cell and a gas-liquid separation device which are connected in a circulating manner.

The gas mixing module comprises a gas mixing device connected with the gas-liquid separation device, the gas mixing device is externally connected with an air source, and NO discharged by the gas-liquid separation device enters the gas mixing device and then is mixed with air introduced from the air source to obtain therapeutic gas.

The invention generates NO through electrolysis of the electrolytic cell, can realize the instant generation of NO gas according to the use requirement, and compared with the NO steel cylinder adopted in the prior art, the invention has the advantages of smaller occupied area of equipment, more flexible operation, higher integration level, more convenient carrying and safer use. The invention separates NO gas from the electrolyte by arranging the gas-liquid separation device, realizes the high-efficiency separation of the NO gas, generates NO with higher purity, and generates by-product NO₂The content of (A) is low.

As a preferred technical scheme of the present invention, the gas-liquid separation device includes a housing and a membrane module disposed inside the housing along an axial direction of the housing, a gas accommodating chamber of an annular columnar structure is formed between an inner wall of the housing and an outer wall of the membrane module, NO gas generated by the electrolytic cell enters the membrane module along with the electrolyte, NO gas in the electrolyte passes through the membrane holes to enter the gas accommodating chamber in the process of flowing through the membrane module, and the electrolyte from which NO gas is filtered flows back to the electrolytic cell.

Preferably, a liquid pump is arranged on a connecting pipeline between the liquid outlet of the membrane module and the liquid return port of the electrolytic cell, and the electrolyte with NO gas filtered is returned to the electrolytic cell through the liquid pump.

Preferably, the outer wall of the shell is provided with an air inlet and an air outlet which are communicated with the gas containing cavity, the air inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas into the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the air outlet is divided into two paths, and one path is connected with an NO gas inlet of the gas mixing device.

In the invention, the concentration of NO generated by the electrolytic cell is high, and the NO can not be completely utilized and inhaled by a patient, and only part of NO can be extracted and utilized by the device; therefore, the invention is provided with two pipelines at the air outlet, part of the NO/carrier gas mixed gas is led out, and the other part of the NO/carrier gas mixed gas is optionally discharged into the atmosphere or recycled.

Preferably, the carrier gas source is a first air pump, and the first air pump delivers air into the gas accommodating chamber as carrier gas for driving discharge of NO gas.

As a preferable technical solution of the present invention, the nitric oxide generating apparatus further includes a gas concentration control module, and the gas concentration control module is configured to detect a concentration of NO in the mixed gas and feedback-control a production flow rate of the NO gas.

Preferably, the gas concentration control module includes a gas concentration sensing device and a flow control device connected with the gas concentration sensing device in a feedback manner, the flow control device is disposed on a connection pipeline between the gas-liquid separation device and the gas mixing device, the gas concentration sensing device is connected to a sampling port of the gas mixing device, and the gas concentration sensing device is used for detecting the concentration of NO in the sampled gas.

Preferably, a sampling pump is arranged on a connecting pipeline between the gas concentration sensing device and the sampling port of the gas mixing device.

Preferably, a second air pump is arranged on a connecting pipeline between the gas-liquid separation device and the flow control device.

Preferably, the therapeutic gas outlet of the gas mixing device is connected to a patient inhalation device.

Preferably, the patient inhalation device is an oronasal mask.

As a preferable technical scheme of the invention, the electrolytic cell is a closed container filled with electrolyte, two electrodes arranged at intervals are inserted into the electrolyte, and the two electrodes are respectively an anode electrode of an external power supply anode and a cathode electrode of an external power supply cathode.

Preferably, the electrolyte comprises a buffer, a nitrite and a copper-based catalyst.

Preferably, the concentration of the buffer solution is 0.01 to 3mol/L, and may be, for example, 0.01mol/L, 0.2mol/L, 0.4mol/L, 0.6mol/L, 0.8mol/L, 1.0mol/L, 1.2mol/L, 1.4mol/L, 1.6mol/L, 1.8mol/L, 2.0mol/L, 2.2mol/L, 2.4mol/L, 2.6mol/L, 2.8mol/L or 3.0mol/L, but is not limited to the values listed, and other values not listed in the range of the values are also applicable.

Preferably, the buffer solution comprises 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, 3-morpholine propanesulfonic acid buffer solution, phosphate buffer solution or organic buffer solution.

Preferably, the nitrite is present in a concentration of 0.01 to 5mol/L, for example 0.01mol/L, 1mol/L, 1.5mol/L, 2mol/L, 2.5mol/L, 3mol/L, 3.5mol/L, 4mol/L, 4.5mol/L or 5mol/L, but not limited to the recited values, and other values not recited in the numerical ranges are equally applicable.

Preferably, the copper-based catalyst has a concentration of 1 to 7mmol/L, for example, 1mmol/L, 1.5mmol/L, 2mmol/L, 2.5mmol/L, 3mmol/L, 3.5mmol/L, 4mmol/L, 4.5mmol/L, 5mmol/L, 5.5mmol/L, 6mmol/L, 6.5mmol/L or 7mmol/L, but not limited to the values listed, and other values not listed in the range of values are equally applicable.

Preferably, the copper-based catalyst is selected from one or a combination of at least two of copper (II) tris (2-pyridylmethyl) amine, copper (II) 1, 4, 7-triazacyclononane, copper (II) 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane, copper (II) tris (2-aminoethyl) amine, copper (II) tris (2-dimethylaminoethyl) amine or copper (II) bis (2-aminomethylpyridine) -propionate.

As a preferable technical solution of the present invention, the electrode includes at least one electrode sheet.

Preferably, the electrode comprises at least two electrode sheets stacked closely, for example, 2, 3, 4, 5, 6, 7, 8, 9 or 10 electrode sheets, but not limited to the values listed, and other values not listed in the range of the values are also applicable.

Preferably, the number of electrode sheets constituting the anode electrode is the same as or different from the number of electrode sheets constituting the cathode electrode.

Preferably, the electrode plate is of a net structure.

Preferably, the electrode plate is made of a material selected from gold, platinum, carbon or stainless steel.

Preferably, the electrode sheet material constituting the anode electrode is the same as or different from the electrode sheet material constituting the cathode electrode.

As a preferable technical solution of the present invention, the nitric oxide generating apparatus further comprises a housing, the gas-liquid separating apparatus, the gas mixing module and the gas concentration control module are integrally disposed inside the housing, and the electrolytic cell is detachably disposed outside the housing.

Preferably, the shell is provided with a groove for fixing the electrolytic cell, and the electrolytic cell is connected with a gas-liquid separation device positioned in the shell through an external liquid hose.

Preferably, a man-machine interaction interface is embedded in the shell.

Preferably, the human-computer interaction section comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device and used for realizing real-time data transmission and interaction; the control panel is electrically connected with the flow control device and used for manually operating the flow control device.

In a second aspect, the present invention provides a method for using the nitric oxide generating apparatus according to the first aspect, the method comprising:

NO gas generated by the electrolytic cell enters the gas-liquid separation device along with electrolyte, and the NO gas obtained by separation enters the gas mixing device to be mixed with air introduced from an air source.

As a preferred technical solution of the present invention, the using method specifically comprises the following steps:

NO gas generated by an electrolytic cell enters a gas-liquid separation device along with electrolyte, the NO gas obtained by separation of a membrane component is led out of the gas-liquid separation device under the drive of carrier gas, the mixed gas of the NO and the carrier gas is divided into a first mixed gas and a second mixed gas, the first mixed gas enters a gas mixing device through a flow control device, and the second mixed gas is emptied or recycled;

(II) the air source leads air into the gas mixing device, the air is mixed with the first mixed gas in the step (I) to obtain the therapeutic gas, the therapeutic gas is sampled by the sampling pump and then is sent to the gas concentration sensing device, the gas concentration sensing device detects the NO concentration in the sampled gas and compares the NO concentration with the preset NO concentration range, when the actual NO concentration value in the sampled gas exceeds the preset concentration range, the flow control device is fed back, and the therapeutic gas is discharged for the patient to inhale until the detected actual NO concentration value in the sampled gas falls into the preset range.

In a preferred embodiment of the present invention, in step (I), 200 to 300mA of current, for example, 200mA, 210mA, 220mA, 230mA, 240mA, 250mA, 260mA, 270mA, 280mA, 290mA or 300mA is applied to the anode electrode and the cathode electrode in the electrolytic cell, but the current is not limited to the values listed, and other values not listed in the numerical range are also applicable.

Preferably, the flow rate of the carrier gas introduced into the gas-liquid separator is 0.5 to 1.5L/min, for example, 0.5L/min, 0.6L/min, 0.7L/min, 0.8L/min, 0.9L/min, 1.0L/min, 1.1L/min, 1.2L/min, 1.3L/min, 1.4L/min or 1.5L/min, but is not limited to the values listed, and other values not listed in the range of values are also applicable.

Preferably, the carrier gas is air.

Preferably, the total flow rate of the mixed gas discharged from the gas-liquid separator is 0.5 to 1.5L/min, for example, 0.5L/min, 0.6L/min, 0.7L/min, 0.8L/min, 0.9L/min, 1.0L/min, 1.1L/min, 1.2L/min, 1.3L/min, 1.4L/min or 1.5L/min, but not limited to the values listed, and other values not listed in the range of the values are also applicable.

Preferably, the flow rate of the first mixed gas is 0.1-80% of the total flow rate of the mixed gas, for example, 0.1%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75% or 80%, but is not limited to the listed values, and other values not listed in the range of the values are also applicable.

In a preferred embodiment of the present invention, in the step (II), the air flow rate of the air from the air source into the gas mixing device is 1 to 10L/min, for example, 1L/min, 2L/min, 3L/min, 4L/min, 5L/min, 6L/min, 7L/min, 8L/min, 9L/min or 10L/min, but is not limited to the values listed, and other values not listed in the range of the values are also applicable.

It should be noted that the air flow rate defined by the present invention is intermittently adjusted or continuously adjusted in a stepless manner, and if intermittent adjustment is adopted, optionally, every 1L/min is one gear, and the total speed is 10 gears.

Preferably, the predetermined NO concentration is in the range of 5 to 40ppm, such as 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm or 40ppm, but not limited to the recited values, and other values not recited in the range of values are also applicable.

It should be noted that the NO concentration defined by the present invention is intermittently adjusted, specifically, the range of the NO concentration knob on the adjustment control panel is 5-40 ppm, each 5ppm is provided with an adjustment gear, after an operator determines a certain adjustment gear, the NO concentration in the output therapeutic gas is the concentration corresponding to the gear after multiple sampling detection and logic control.

Preferably, the process of logically controlling the flow control device by the gas concentration sensing device specifically includes the following steps:

and when the measured value of the concentration of NO in the sampled gas detected by the gas concentration sensing device is higher than the upper limit of the preset concentration range of NO, sending a feedback signal to the flow control device to reduce the flow of the first mixed gas.

And when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device is lower than the lower limit of the preset NO concentration range, sending a feedback signal to the flow control device to increase the flow rate of the first mixed gas.

It should be noted that, in the actual operation process of the nitric oxide generating device provided by the present invention, only an operator needs to adjust the NO concentration knob to a certain value gear, and control of the NO concentration in the therapeutic gas is realized through an internal program, so that the NO concentration reaches the NO concentration of the set value gear, and how to realize regulation and control of the NO concentration inside the nitric oxide generating device is not specifically limited and has special requirements, and optionally, the purpose of regulating the NO concentration in the produced therapeutic gas is achieved in the mixing stage by adjusting the mixing ratio between the NO/carrier gas mixture and the air (mainly realized by matching the gas concentration sensing device and the flow control device); or the NO generation rate is increased or reduced from the NO generation source by adjusting the current so as to achieve the purpose of regulating the NO concentration in the produced therapeutic gas; or the two ways are adopted simultaneously, so long as the NO concentration of the gear with the output NO concentration being the set value can be finally achieved.

The system refers to an equipment system, or a production equipment.

Compared with the prior art, the invention has the beneficial effects that:

(1) the invention generates NO through electrolysis of the electrolytic cell, can realize the instant generation of NO gas according to the use requirement, and compared with the NO steel cylinder adopted in the prior art, the invention has the advantages of smaller occupied area of equipment, more flexible operation, higher integration level, more convenient carrying and safer use.

(2) The invention separates NO gas from the electrolyte by arranging the gas-liquid separation device, realizes the high-efficiency separation of the NO gas, generates NO with higher purity, and generates by-product NO₂The content of (A) is low.

(3) The NO gas concentration is feedback controlled by the sensing device, is not influenced by the change of environmental factors such as temperature, pressure and the like in the system, and has the advantages of rapid response, convenient control, safety and reliability.

Drawings

Fig. 1 is a schematic structural diagram of a nitric oxide generating apparatus according to an embodiment of the present invention;

fig. 2 is a design diagram of an appearance of a nitric oxide generating apparatus according to an embodiment of the present invention;

wherein, 1-an electrolytic cell; 2-an anode electrode; 3-a cathode electrode; 4-a gas-liquid separation device; 5-liquid pump; 6-a first air pump; 7-a second air pump; 8-a flow control device; 9-a source of air; 10-a gas mixing device; 11-a sampling pump; 12-a gas concentration sensing device; 13-oronasal mask; 14-human-computer interaction interface.

Detailed Description

It is to be understood that in the description of the present invention, the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be taken as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

It should be noted that, in the description of the present invention, unless otherwise explicitly specified or limited, the terms "disposed," "connected" and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.

In one embodiment, the present invention provides a portable nitric oxide generating apparatus, which includes a nitric oxide generating module and a gas mixing module connected in sequence, as shown in fig. 1.

The nitric oxide generating module comprises an electrolytic cell 1 and a gas-liquid separation device 4 which are connected in a circulating manner. The electrolytic cell 1 is a closed container filled with electrolyte, two electrodes arranged at intervals are inserted into the electrolyte, and the two electrodes are respectively an anode electrode 2 of an external power supply anode and a cathode electrode 3 of an external power supply cathode. The gas-liquid separation device 4 comprises a shell and a membrane assembly arranged in the shell along the axial direction, a gas containing cavity with an annular columnar structure is formed between the inner wall of the shell and the outer wall of the membrane assembly, NO gas generated by the electrolytic cell 1 enters the membrane assembly along with electrolyte, the NO gas in the electrolyte passes through membrane holes to enter the gas containing cavity in the process of flowing through the membrane assembly, and the electrolyte with the NO gas filtered out flows back to the electrolytic cell 1. A liquid pump 5 is arranged on a connecting pipeline between the liquid outlet of the membrane component and the liquid return port of the electrolytic cell 1, and the electrolyte with NO gas filtered is returned to the electrolytic cell 1 through the liquid pump 5. The outer wall of the shell is provided with an air inlet and an air outlet which are communicated with the gas containing cavity, the air inlet is externally connected with a carrier gas source, the carrier gas source conveys carrier gas into the gas containing cavity for driving NO gas to be discharged out of the gas containing cavity, the air outlet is divided into two paths, and one path is connected with an NO gas inlet of the gas mixing device 10. Specifically, the carrier gas source is a first air pump 6, and the first air pump 6 delivers air into the gas accommodating cavity as carrier gas for driving the discharge of NO gas.

The gas mixing module comprises a gas mixing device 10 connected with the gas-liquid separation device 4, the gas mixing device 10 is externally connected with an air source 9, and NO discharged by the gas-liquid separation device 4 enters the gas mixing device 10 and then is mixed with air introduced from the air source 9 to obtain therapeutic gas.

The nitric oxide generating device also comprises a gas concentration control module, and the gas concentration control module is used for detecting the concentration of NO in the mixed gas and controlling the extraction flow of NO gas in a feedback mode. The gas concentration control module comprises a gas concentration sensing device 12 and a flow control device 8 connected with the gas concentration sensing device 12 in a feedback mode, the flow control device 8 is arranged on a connecting pipeline between the gas-liquid separation device 4 and the gas mixing device 10, and a second air pump 7 is arranged on the connecting pipeline between the gas-liquid separation device 4 and the flow control device 8. The gas concentration sensing device 12 is connected to a sampling port of the gas mixing device 10, the gas concentration sensing device 12 is used for detecting the concentration of NO in the sampled gas, and a sampling pump 11 is arranged on a connecting pipeline between the gas concentration sensing device 12 and the sampling port of the gas mixing device 10. The therapeutic gas outlet of the gas mixing device 10 is connected to a patient inhalation device, in particular optionally an oronasal mask 13.

The nitric oxide generating device further comprises a shell, the gas-liquid separation device 4, the gas mixing module and the gas concentration control module are integrally arranged inside the shell, and the electrolytic cell 1 is detachably arranged outside the shell. The shell is provided with a groove (shown in figure 2) for fixing the electrolytic cell 1, and the electrolytic cell 1 is connected with a gas-liquid separation device 4 positioned in the shell through an external liquid hose. A human-computer interaction interface 14 (shown in fig. 2) is embedded in the shell, the human-computer interaction section comprises a display screen and a control panel which are matched and suitable, and the display screen is electrically connected with the gas concentration sensing device 12 and used for realizing real-time data transmission and interaction; the control panel is electrically connected to the flow control device 8 and is used for manually operating the flow control device 8.

In another embodiment, the present invention provides a method for using the above nitric oxide generating apparatus, the method comprising the steps of:

(1) applying a current of 200-300 mA to an anode electrode 2 and a cathode electrode 3 in an electrolytic cell 1, wherein the anode electrode 2 and the cathode electrode 3 are composed of at least one electrode plate with a net structure, the number of the electrode plates for forming the anode electrode 2 and the number of the electrode plates for forming the cathode electrode 3 can be the same or different, the electrode plates are made of a material selected from gold, platinum, carbon or stainless steel, and the electrode plate material for forming the anode electrode 2 and the electrode plate material for forming the cathode electrode 3 can be the same or different;

the electrolyte comprises a buffer solution, nitrite and a copper-based catalyst, the concentration of the buffer solution is 0.01-3 mol/L, the buffer solution comprises a 4-hydroxyethyl piperazine ethanethiosulfonic acid buffer solution, a 3-morpholine propanesulfonic acid buffer solution, a phosphate buffer solution or an organic buffer solution, the concentration of the nitrite is 0.01-5 mol/L, the concentration of the copper-based catalyst is 1-7 mmol/L, and the copper-based catalyst is selected from one or a combination of at least two of tris (2-pyridylmethyl) amine copper (II), 1, 4, 7-triazacyclononane copper (II), 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane copper (II), tris (2-aminoethyl) amine copper (II), tris (2-dimethylaminoethyl) amine copper (II) or bis (2-aminomethyl pyridine) -propionic acid copper (II) (ii) a

NO gas generated by electrolysis enters a gas-liquid separation device 4 along with electrolyte, the electrolyte containing the NO gas is separated by a membrane component to obtain NO gas, and the NO gas enters a gas accommodating cavity for temporary storage;

the first air pump 6 is used for introducing 0.5-1.5L/min of air into the air accommodating cavity; the NO gas temporarily stored in the gas containing cavity is driven by air to be discharged out of the gas-liquid separation device 4, the mixed gas formed by the NO and the carrier gas is discharged out of the gas-liquid separation device at the speed of 0.5-1.5L/min, part of the mixed gas enters the gas mixing device 10 through the flow control device 8, and the flow of the part of the mixed gas entering the gas mixing device accounts for 0.1-80% of the total flow of the mixed gas discharged by the gas-liquid separation device;

(2) the air source 9 introduces 1-10L/min of air into the gas mixing device 10, the air is mixed with part of mixed gas entering the gas mixing device in the step (1) to obtain treatment gas, the treatment gas is sampled by the sampling pump 11 and then sent to the gas concentration sensing device 12, the gas concentration sensing device 12 detects the NO concentration in the sampled gas, the control panel is provided with an NO concentration knob, 8 gears including 5ppm, 10ppm, 15ppm, 20ppm, 25ppm, 30ppm, 35ppm and 40 are arranged on the knob in a circle, an operator determines the concentration of the NO gas to be output by rotating the knob, and after the operator determines a certain adjusting gear, the concentration of the NO in the output treatment gas is the NO concentration corresponding to the gear after multiple sampling detection and logic control;

the specific logic control process comprises the following steps: when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is higher than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to reduce the flow rate of the first mixed gas; when the measured value of the NO concentration in the sampled gas detected by the gas concentration sensing device 12 is lower than the NO concentration set gear determined by the operator, a feedback signal is sent to the flow control device 8 to increase the flow rate of the first mixed gas.