阅读说明：本技术 用于IgE介导过敏性疾病治疗的靶向膜结合型IgE的肽免疫原及其剂型 (Peptide immunogen of targeting membrane-bound IgE for treating IgE-mediated allergic diseases and dosage form thereof ) 是由 王长怡 林峰 陈君伯 于 2017-12-31 设计创作，主要内容包括：本公开关于用于IgE介导过敏性疾病治疗的IgE EMPD肽免疫原构建体及其剂型。IgE EMPD肽免疫原构建体具有超过20个氨基酸的B细胞表位肽,以环状为优选,其经任选间隔子连接衍生自病原体蛋白的异源性T辅助细胞(Th)表位。肽免疫原构建体及其剂型能够在接种的宿主中刺激高特异性抗体产生,其针对IgE EMPD肽,并与定向分化为分泌IgE的B淋巴细胞上的膜结合型IgE交叉反应。肽免疫原构建体及其剂型诱导的抗体在接种的宿主诱导表达IgE的B细胞凋亡,并介导抗体依赖性细胞毒性作用(ADCC),导致接种的宿主抗体特异性IgE和总IgE水平下降以有效治疗IgE介导过敏性病理学。(The present disclosure relates to IgE EMPD peptide immunogen constructs and dosage forms thereof for the treatment of IgE-mediated allergic diseases. The IgE EMPD peptide immunogen constructs have a B cell epitope peptide of more than 20 amino acids, preferably cyclic, which is linked via an optional spacer to a heterologous T helper cell (Th) epitope derived from the pathogen protein. The peptide immunogen constructs and dosage forms thereof are capable of stimulating the production of highly specific antibodies in vaccinated hosts, which are directed against the IgE EMPD peptides and cross-react with membrane-bound IgE directed to differentiate into IgE-secreting B lymphocytes. The peptide immunogen constructs and dosage forms thereof induce antibodies that induce apoptosis of IgE-expressing B-cells in the vaccinated host and mediate antibody-dependent cellular cytotoxicity (ADCC), resulting in a reduction in the levels of IgE specific and total IgE of the vaccinated host antibodies for effective treatment of IgE-mediated allergic pathologies.)