阅读说明：本技术 一种含有石墨烯的医学工程材料 (Medical engineering material containing graphene ) 是由 王文彬 张晓梦 田小军 于 2020-04-10 设计创作，主要内容包括：本发明公开了一种含有石墨烯的医学工程材料,包括以下重量份的原料组成：聚氧丙烯聚氧乙烯嵌段共聚物10～30份,羟基磷灰石5～15份,透明质酸钠12～25份,魔芋葡甘聚糖15～32份,聚氧丙烯聚氧乙烯无规共聚物20～45份,微晶纤维素18～30份,明胶30～60份,石墨烯水分散液10～25份,交联剂3～8份。本发明通过上述等结构的配合,解决了现有的组织工程支架材料存在强度弱或脆性大,难以满足承力骨修复的要求,同时不易为细胞提供好的增殖和生长环境,难以促进了骨组织修复,且生物相容性差,使用的过程中容易给患者产生不良反应的问题。(The invention discloses a medical engineering material containing graphene, which comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent. Through the matching of the structures, the invention solves the problems that the existing tissue engineering scaffold material has weak strength or large brittleness, is difficult to meet the requirement of bearing bone repair, is difficult to provide good proliferation and growth environment for cells, is difficult to promote bone tissue repair, has poor biocompatibility and is easy to cause adverse reaction to patients in the using process.)

1. A medical engineering material containing graphene is characterized in that: the composite material comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent.

2. The graphene-containing medical engineering material according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: 20-30 parts of polyoxypropylene polyoxyethylene block copolymer, 9-15 parts of hydroxyapatite, 15-25 parts of sodium hyaluronate, 21-32 parts of konjac glucomannan, 30-45 parts of polyoxypropylene polyoxyethylene random copolymer, 22-30 parts of microcrystalline cellulose, 45-60 parts of gelatin, 18-25 parts of graphene water dispersion and 5-8 parts of cross-linking agent.

3. The graphene-containing medical engineering material according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 26 parts of polyoxypropylene polyoxyethylene block copolymer, 13 parts of hydroxyapatite, 22 parts of sodium hyaluronate, 29 parts of konjac glucomannan, 40 parts of polyoxypropylene polyoxyethylene random copolymer, 28 parts of microcrystalline cellulose, 55 parts of gelatin, 22 parts of graphene aqueous dispersion and 6 parts of cross-linking agent.

4. The graphene-containing medical engineering material according to claim 1, wherein: the cross-linking agent is sodium alginate oxide, and the microcrystalline cellulose is nano microcrystalline cellulose.

5. The graphene-containing medical engineering material according to claim 1, wherein: the graphene aqueous dispersion is graphene oxide aqueous dispersion.

Technical Field

The invention relates to the technical field of medical engineering materials, in particular to a medical engineering material containing graphene.

Background

Tissue engineering is an emerging discipline for constructing tissues or organs in vitro or in vivo by combining cell biology and material science, in the process of tissue engineering construction, tissue engineering materials are needed, for example, tissue engineering scaffold materials refer to materials which can be combined with tissue living cells and implanted into different tissues of organisms, and according to functions of specific substitute tissues, in order to proliferate and differentiate the seed cells, it is necessary to provide a tissue engineering scaffold composed of a biomaterial, the scaffold material is equivalent to an artificial extracellular matrix, engineering scaffolds are often needed in the process of repairing bone injury, the repair of bone defects has been the key subject of continuous and deep research for centuries, and with the continuous progress of biomedical and tissue engineering research, the research on materials of tissue engineering scaffolds is concerned by researchers. The existing tissue engineering scaffold material has weak strength or high brittleness, is difficult to meet the requirement of bearing bone repair, is difficult to provide good proliferation and growth environment for cells, is difficult to promote bone tissue repair, has poor biocompatibility, and is easy to generate adverse reaction for patients in the using process, so the improvement is needed.

Disclosure of Invention

The invention aims to provide a medical engineering material containing graphene, which has the advantages that the degradability of a tissue engineering scaffold in vivo is enhanced and the absorption is facilitated by the arrangement of a polyoxypropylene polyoxyethylene block copolymer, hydroxyapatite and a polyoxypropylene polyoxyethylene random copolymer, the repair of bone defects caused by bone wax can be promoted by the addition of the hydroxyapatite, the solubility and the mechanical property of insoluble drugs in water are increased by adopting nano microcrystalline cellulose, the regeneration of bones and the mineralization of bones can be promoted by sodium hyaluronate, in addition, the physical property of the hydroxyapatite can be improved by the addition of the graphene, and a better material can be provided for the tissue engineering scaffold, so that a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and the manufacturing process flow of the engineering material comprises the steps of firstly, mixing the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite and the polyoxypropylene polyoxyethylene random copolymer, The polyoxypropylene polyoxyethylene random copolymer and the gelatin are subjected to hot melting stirring, then hydroxyapatite, nano microcrystalline cellulose, sodium hyaluronate and graphene water dispersion are added to be stirred and mixed uniformly, the mixture after mixing is placed in a mold or a split charging bottle, and is placed at normal temperature for curing and forming, and then packaging and sealing are performed.

In order to achieve the purpose, the invention provides the following technical scheme: a medical engineering material containing graphene comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent.

Preferably, the medical engineering material containing graphene comprises the following raw materials in parts by weight: 20-30 parts of polyoxypropylene polyoxyethylene block copolymer, 9-15 parts of hydroxyapatite, 15-25 parts of sodium hyaluronate, 21-32 parts of konjac glucomannan, 30-45 parts of polyoxypropylene polyoxyethylene random copolymer, 22-30 parts of microcrystalline cellulose, 45-60 parts of gelatin, 18-25 parts of graphene water dispersion and 5-8 parts of cross-linking agent.

Preferably, the medical engineering material containing graphene comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 26 parts of polyoxypropylene polyoxyethylene block copolymer, 13 parts of hydroxyapatite, 22 parts of sodium hyaluronate, 29 parts of konjac glucomannan, 40 parts of polyoxypropylene polyoxyethylene random copolymer, 28 parts of microcrystalline cellulose, 55 parts of gelatin, 22 parts of graphene aqueous dispersion and 6 parts of cross-linking agent.

Preferably, the cross-linking agent is sodium alginate oxide, and the microcrystalline cellulose is nano microcrystalline cellulose.

Preferably, the graphene aqueous dispersion is a graphene oxide aqueous dispersion.

Compared with the prior art, the invention has the following beneficial effects:

the invention enhances the degradability of the tissue engineering scaffold in vivo and is beneficial to absorption through the arrangement of the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite and the polyoxypropylene polyoxyethylene random copolymer, the addition of the hydroxyapatite can promote the repair of bone wax to bone defects, and the solubility and the mechanical property of insoluble drugs in water are increased by adopting the nanocrystalline cellulose.

The konjac glucomannan has excellent forming performance and mechanical performance, and the defects of poor formability and mechanical strength of hydroxyapatite can be improved by compounding the konjac glucomannan with hydroxyapatite.

The graphene is arranged, so that the hydroxyapatite material performance can be improved, a better material can be provided for the tissue engineering support, a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and meanwhile, the graphene has low cost and lower toxicity to people and the environment, has a certain antibacterial property, promotes bone tissue repair to a certain extent, and enables patients to recover better.

Fourthly, in conclusion, through the cooperation of the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite, the polyoxypropylene polyoxyethylene random copolymer, the sodium hyaluronate, the konjac glucomannan and the graphene, a better material can be provided for a tissue engineering scaffold, so that a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and meanwhile, the tissue engineering scaffold has a certain antibacterial property, bone tissue repair is promoted to a certain extent, and a patient can be better recovered.

Drawings

FIG. 1 is a diagram of a raw material composition ratio chart in an embodiment of the present invention;

FIG. 2 is a composition ratio table of the second raw material in the example of the present invention;

FIG. 3 is a composition ratio table of three raw materials in the embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1, the present invention provides a technical solution: