阅读说明：本技术 一种薄膜包衣粉的配方及制备方法 (Formula and preparation method of film coating powder ) 是由 丁一 于 2020-04-16 设计创作，主要内容包括：本发明涉及薄膜包衣粉技术领域,尤其涉及一种薄膜包衣粉的配方及制备方法,包括步骤：步骤S1,对羟丙甲纤维素、聚维酮k30、二氧化钛、硬脂酸镁、滑石粉、色淀粉碎并过120目筛；步骤S2,取45-55份羟丙甲纤维素加入反应釜；步骤S3,取4-6份聚维酮k30加入反应釜；步骤S4,取8-12份聚乙二醇-4000加入反应釜；步骤S5,取4-6份聚乙二醇-400加入反应釜；步骤S6,取8-12份二氧化钛加入反应釜；步骤S7,取8-12份硬脂酸镁加入反应釜；步骤S8,取8-12份滑石粉倒入反应釜；步骤S9,取1.5-2.5份色淀加入反应釜；步骤S10,以上物料混合,本发明的薄膜包衣粉配料、加工方法简单。(The invention relates to the technical field of film coating powder, in particular to a formula and a preparation method of film coating powder, which comprises the following steps: step S1, crushing hydroxypropyl methylcellulose, povidone k30, titanium dioxide, magnesium stearate, talcum powder and lake and sieving the crushed powder with a 120-mesh sieve; step S2, adding 45-55 parts of hydroxypropyl methylcellulose into a reaction kettle; step S3, adding 4-6 parts of povidone k30 into a reaction kettle; step S4, adding 8-12 parts of polyethylene glycol-4000 into a reaction kettle; step S5, adding 4-6 parts of polyethylene glycol-400 into a reaction kettle; step S6, adding 8-12 parts of titanium dioxide into a reaction kettle; step S7, adding 8-12 parts of magnesium stearate into a reaction kettle; step S8, pouring 8-12 parts of talcum powder into a reaction kettle; step S9, adding 1.5-2.5 parts of lake into a reaction kettle; and step S10, mixing the materials, and the film coating powder has simple ingredients and processing method.)

1. The formula and the preparation method of the film coating powder are characterized in that: the method comprises the following steps:

step S1, respectively crushing the hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake, sieving the crushed hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake by a 120-mesh sieve, and placing the sieved hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake in a classified manner;

step S2, adding 45-55 parts of hydroxypropyl methylcellulose into a reaction kettle;

step S3, adding 4-6 parts of povidone k30 into a reaction kettle;

step S4, adding 8-12 parts of polyethylene glycol-4000 into a reaction kettle;

step S5, adding 4-6 parts of polyethylene glycol-400 into a reaction kettle;

step S6, adding 8-12 parts of titanium dioxide into a reaction kettle;

step S7, adding 8-12 parts of magnesium stearate into a reaction kettle;

step S8, pouring 8-12 parts of talcum powder into a reaction kettle;

step S9, adding 1.5-2.5 parts of lake into a reaction kettle;

and step S10, fully mixing the materials, and then adjusting the PH value to 6.5-7.5 to obtain the film coating powder.

2. The formulation and preparation method of film coating powder according to claim 1, wherein in step S10, the above materials are mixed thoroughly for 40-60 minutes.

3. The formulation and preparation method of film-coated powder according to claim 1, wherein no Escherichia coli is detected in the film-coated powder in step S10, and if Escherichia coli is contained, the film-coated powder is sterilized at high temperature, and the process returns to step S10 to repeat the process.

4. The formulation and the preparation method of the film coating powder according to claim 1, wherein the total number of the microbial colonies in the film coating powder is less than or equal to 15CPU/g in step S10.

5. The formulation and preparation method of film coating powder of claim 1, wherein in step S10, the heavy metal content in the film coating powder is less than or equal to twenty parts per million.

Technical Field

The invention relates to the technical field of film coating powder, in particular to a formula and a preparation method of film coating powder.

Background

In the process of treating diseases in western medicine, concentrated medicines are used for treating diseases, tablet medicines are invented for accurate medicine taking measurement and convenient carrying, transportation and taking, different diseases require different parts of tablets in stomach and intestine of a human body to release medicine effects, and in order to distinguish the tablets directly through the appearance colors of the tablet medicines, people invent that film coating powder is coated outside the tablet medicines, so that the problem to be solved by the invention is how to prepare the formula and the preparation method of the film coating powder.

Disclosure of Invention

In view of the above, the present invention aims to provide a formula and a preparation method of a film coating powder.

In order to solve the problems, the invention provides a formula of film coating powder and a preparation method thereof, wherein the formula comprises the following steps:

step S1, respectively crushing the hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake, sieving the crushed hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake by a 120-mesh sieve, and placing the sieved hydroxypropyl methylcellulose, the povidone k30, the titanium dioxide, the magnesium stearate, the talcum powder and the lake in a classified manner;

step S2, adding 45-55 parts of hydroxypropyl methylcellulose into a reaction kettle;

step S3, adding 4-6 parts of povidone k30 into a reaction kettle;

step S4, adding 8-12 parts of polyethylene glycol-4000 into a reaction kettle;

step S5, adding 4-6 parts of polyethylene glycol-400 into a reaction kettle;

step S6, adding 8-12 parts of titanium dioxide into a reaction kettle;

step S7, adding 8-12 parts of magnesium stearate into a reaction kettle;

step S8, pouring 8-12 parts of talcum powder into a reaction kettle;

step S9, adding 1.5-2.5 parts of lake into a reaction kettle;

and step S10, fully mixing the materials, and then adjusting the PH value to 6.5-7.5 to obtain the film coating powder.

Preferably, in step S10, the above materials are thoroughly mixed for 40-60 minutes.

Preferably, in step S10, escherichia coli is not detected in the film-coated powder, and if escherichia coli is contained, the film-coated powder is sterilized at high temperature, and the process is returned to step S10 to repeat the operation.

Preferably, in step S10, the total number of microbial colonies in the film coating powder is 15CPU/g or less.

Preferably, in step S10, the heavy metal content in the film coating powder is less than or equal to twenty parts per million.

The film coating powder prepared by the invention is simple in selected ingredients, the effective production method is stirring and mixing, the production method is simple, the yield is high, the moisture resistance is good, the production cost is low, the film coating powder can be stored at normal temperature, the performance is stable, and the film coating powder is convenient to store and transport.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.