阅读说明：本技术 一种免洗消毒液及其制备方法与应用 (No-clean disinfectant and preparation method and application thereof ) 是由 丁兴龙 盖中涛 马万山 陈振 寇宗阳 朱之炜 于 2020-04-17 设计创作，主要内容包括：本发明公开了一种免洗消毒液,是由聚六亚甲基胍盐酸盐、甘草酸、甘油、纯化水组成。本发明的免洗消毒液利用聚六亚甲基胍盐酸盐、病毒蛋白受体ACE2)抑制剂甘草酸为主要杀菌、抗病毒成分,在抗菌和抗病毒中发挥作用。该产品克服了市售多数消毒剂存在刺激性强、微毒等缺点,成为一种广谱性杀菌消毒、作用速度快、稳定性好、毒性低、无腐蚀性、刺激性小的高效环保型消毒剂,尤其使用该产品时特别易于在人体手部形成一层“液体手套”,起到消毒防护的作用,应用前景广阔。(The invention discloses a no-clean disinfectant, which consists of polyhexamethylene guanidine hydrochloride, glycyrrhizic acid, glycerol and purified water. The washing-free disinfectant disclosed by the invention utilizes polyhexamethylene guanidine hydrochloride and a virus protein receptor ACE2) inhibitor glycyrrhizic acid as main sterilization and antiviral components, and plays a role in sterilization and antivirus. The product overcomes the defects of strong irritation, slight toxicity and the like of most disinfectants sold in the market, becomes a high-efficiency environment-friendly disinfectant with broad-spectrum sterilization and disinfection, high action speed, good stability, low toxicity, no corrosiveness and small irritation, particularly easily forms a layer of 'liquid gloves' on hands of a human body when the product is used, plays a role in disinfection and protection, and has wide application prospect.)

1. A washing-free disinfectant consists of polyhexamethylene guanidine hydrochloride, glycyrrhizic acid, glycerol and purified water, and is characterized in that: the pH value of the no-clean disinfectant is 5.5-7, the components of the no-clean disinfectant are calculated by 100ml of solution, and the no-clean disinfectant comprises 1.5 ml-3 ml of polyhexamethylene guanidine hydrochloride solution with the mass concentration of 25%, 0.05 ml-0.2 ml of glycyrrhizic acid, 3 ml-6 ml of glycerol and the balance of purified water.

2. The no-clean disinfectant as set forth in claim 1, wherein: the pH value of the no-clean disinfectant is 6.0-6.8, and the components of the no-clean disinfectant are calculated by 100ml of solution, and the no-clean disinfectant comprises 2ml of poly (hexamethylene guanidine hydrochloride) solution with the mass concentration of 25%, 0.1ml of glycyrrhizic acid, 5ml of glycerol and 92.9ml of purified water.

3. The method for preparing the no-clean disinfectant as claimed in claim 1 or 2, comprising the steps of:

(1) adding 70-80% of purified water and 25% of polyhexamethylene guanidine hydrochloride solution at the mass concentration at the formula amount into a stirring tank at normal temperature, and stirring until the mixture is completely uniform for later use;

(2) adding glycyrrhizic acid and glycerol in formula amount and purified water in balance at normal temperature, and stirring uniformly;

(3) testing pH value, determining whether the pH value reaches 5.5-7, and filling if the pH value is between 5.5-7; if the pH value does not reach the standard, the pH value is adjusted by citric acid.

4. The method for preparing a no-clean disinfectant as claimed in claim 3, wherein the method comprises the following steps:

(1) adding 70ml of purified water and 2ml of poly (hexamethylene guanidine) hydrochloride solution with the mass concentration of 25% into a stirring tank at normal temperature based on 100ml of prepared disinfectant, and stirring until the mixture is completely uniform for later use;

(2) adding glycyrrhizic acid 0.1ml, glycerin 5ml and purified water 22.9ml at normal temperature, and stirring;

(3) testing the pH value, determining whether the pH value reaches 6.0-6.8, and filling if the pH value is 6.0-6.8; if the pH value does not reach the standard, the pH value is adjusted by citric acid.

5. The use of the leave-on disinfectant of claim 1 or 2 for antimicrobial and antiviral purposes.

6. Use according to claim 5, characterized in that: the bacteria are Escherichia coli 8099, Staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC15442 and Candida albicans ATCC 10231; the virus is a novel coronavirus.

7. Use according to claim 6, characterized in that: the virus refers to a novel coronavirus SARS-CoV-2 and a novel coronavirus 2019-nCoV.

Technical Field

The invention relates to a disinfectant, a preparation method and application thereof, in particular to a washing-free virus-killing disinfectant, and a preparation method and application thereof. Belongs to the technical field of chemical disinfectants.

Background

Hospitals, banks, supermarkets, organs, enterprises and public institutions, movie theaters, troops, entertainment venues, schools, kindergartens, families, hotels, restaurants, airports, docks, railway stations and other places are very easy to cause the spread of bacteria and viruses, thereby causing public cross infection. The presence of harmful microorganisms can cause a number of diseases and, in severe cases, can endanger human life. Disinfection and sterilization are effective measures for maintaining the life safety of human beings. In daily life, various disinfectants are often used.

At present, the active ingredients of the commonly used disinfectants mainly comprise the following substances: oxidizing substances, aldehydes, phenols, alcohols, alkali salts, halogens, surfactants, and the like, but all have disadvantages. The ideal disinfectant has the characteristics of wide bactericidal spectrum, strong bactericidal capacity, high action speed, good stability, low toxicity, corrosiveness, small irritation (no toxicity, no residue, no corrosion or no irritation), easy water dissolution, safety to human and animals, low price, easy obtainment, low environmental pollution degree and the like. Therefore, there is an urgent need to develop such disinfectants that are more rapidly effective and non-toxic.

Railings, door handles, handrails in a carriage, money bills and the like which are used for daily hand holding or hand touching are important factors causing public cross infection. In this case, the leave-on disinfectant takes place at the end of life. The hand-washing-free disinfectant can save precious water resources while ensuring health of people, and does not need to use towels, water and soaps. At present, related washing-free disinfectants have been reported or products, but the principle of sterilization and disinfection of polyhexamethylene guanidine hydrochloride is utilized, and glycyrrhizic acid and glycerol reagents are matched, so that the defect that the conventional polyhexamethylene guanidine hydrochloride has certain corrosivity to aluminum and carbon steel is overcome, and the prepared high-efficiency environment-friendly disinfectant has the advantages of broad-spectrum sterilization, high acting speed, good stability, low toxicity, no corrosivity and small irritation, is particularly easy to form a layer of 'liquid gloves' on hands of a human body, and has a disinfection and protection effect.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a washing-free virus-killing disinfectant and a preparation method and application thereof.

The washing-free disinfectant disclosed by the invention consists of polyhexamethylene guanidine hydrochloride, glycyrrhizic acid, glycerol and purified water, and is characterized in that: the pH value of the no-clean disinfectant is 5.5-7, the components of the no-clean disinfectant are calculated by 100ml of solution, and the no-clean disinfectant comprises 1.5 ml-3 ml of polyhexamethylene guanidine hydrochloride solution with the mass concentration of 25%, 0.05 ml-0.2 ml of glycyrrhizic acid, 3 ml-6 ml of glycerol and the balance of purified water.

Wherein: the pH value of the no-clean disinfectant is preferably 6.0-6.8, and the components of the no-clean disinfectant are preferably 2ml of a 25% polyhexamethylene guanidine hydrochloride solution, 0.1ml of glycyrrhizic acid, 5ml of glycerol and 92.9ml of purified water in terms of 100ml of solution.

The preparation method of the no-clean disinfectant comprises the following steps:

(1) adding 70-80% of purified water and 25% of polyhexamethylene guanidine hydrochloride solution at the mass concentration at the formula amount into a stirring tank at normal temperature, and stirring until the mixture is completely uniform for later use;

(2) adding glycyrrhizic acid and glycerol in formula amount and purified water in balance at normal temperature, and stirring uniformly;

(3) testing pH value, determining whether the pH value reaches 5.5-7, and filling if the pH value is between 5.5-7; if the pH value does not reach the standard, the pH value is adjusted by citric acid.

The preparation method of the no-clean disinfectant comprises the following steps:

(1) adding 70ml of purified water and 2ml of poly (hexamethylene guanidine) hydrochloride solution with the mass concentration of 25% into a stirring tank at normal temperature based on 100ml of prepared disinfectant, and stirring until the mixture is completely uniform for later use;

(2) adding glycyrrhizic acid 0.1ml, glycerin 5ml and purified water 22.9ml at normal temperature, and stirring;

(3) testing the pH value, determining whether the pH value reaches 6.0-6.8, and filling if the pH value is 6.0-6.8; if the pH value does not reach the standard, the pH value is adjusted by citric acid.

The washing-free disinfectant disclosed by the invention is applied to antibiosis and antivirus.

Wherein: the bacteria are preferably Escherichia coli 8099, Staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC15442 and Candida albicans ATCC 10231; the virus preferably refers to a novel coronavirus, specifically a novel coronavirus SARS-CoV-2 and a novel coronavirus 2019-nCoV.

The no-clean disinfectant provided by the invention can be applied to sterilization and disinfection of skin, hand disinfection, air disinfection and other various environmental aspects.

In the components of the no-clean disinfectant disclosed by the invention, polyhexamethylene guanidine hydrochloride is a sterilization component, methyl guanidine has high activity per se, so that a polymer is electropositive, the sterilization mechanism of the no-clean disinfectant is the combined action of chemistry and physics, firstly, the no-clean disinfectant can strongly act with a microbial cell membrane which usually has negative charges, and the ion gradient necessary for storing energy and transporting nutrients of the microbe is destroyed, so that the cell membrane is broken; meanwhile, the substance is positive and can be easily adsorbed on the surfaces of various negatively charged bacteria and viruses, the division function of the bacteria and the viruses is inhibited, the bacteria and the viruses lose the reproductive capacity, and the polymers form to block the breathing channel of the microorganisms, so that the microorganisms are suffocated. Therefore, at an extremely low concentration (10ppm), the polyhexamethylene guanidine hydrochloride can kill cotton fabric bacteria catalase and fungi, acanthamoeba keratitis pathogenic bacteria, escherichia coli, staphylococcus aureus and candida albicans, skin natural bacteria, inactivated viruses, bacterial spores, bacterial propagules and the like. Glycyrrhizic acid is a novel inhibitor of a coronavirus (SARS-CoV-2) protein receptor ACE2, can be combined with angiotensin converting enzyme 2(ACE2) to block combination of a virus S protein and an ACE2 receptor, and reduces invasion of viruses into epidermal cells of a human body, so that harm of the viruses to the human body is reduced. Neurosurgery of the medical college of Stanford university in USA and the college of traditional Chinese medicine of hong Kong university in United states together published papers, and it was also confirmed that glycyrrhizic acid can bind to ACE2, and thus it can be concluded that glycyrrhizic acid is a potential anti-SARS-CoV-2 compound, and has important value for preventing novel coronavirus (SARS-CoV-2) infection and treating SARS. In medicine, glycerin is generally used for preparing various preparations, solvents, moisture absorbents, antifreezes and sweeteners, and formulating ointments or suppositories for external use, etc. Because glycerin has water absorption, it is commonly used as a moisture absorbent and moisturizer for cosmetics, foods, and textiles. The glycyrrhizic acid and the glycerol are added into the no-clean disinfectant, and the polyhexamethylene guanidine hydrochloride is coordinated, so that the product is convenient to use and easy to paint, can form a better 'film' after being dried, forms 'invisible gloves' on the surfaces of objects or hands, and plays a role in inhibiting bacteria for a long time.

The invention provides a washing-free virus-killing disinfectant and a preparation method and application thereof. Wherein the disinfectant is a hydrophilic solution consisting of polyhexamethylene guanidine hydrochloride, glycyrrhizic acid and glycerol. The disinfectant has the remarkable advantages that: 1. broad-spectrum antibiosis; 2. the action speed is high, and the effect is achieved within 5 minutes; 3. the effect lasts for 4-5 hours, and the maximum time can reach 6 hours; 4. the liquid gloves are formed, have the functions of gentle skin care, preventing skin damage and moistening and caring hand skin; 5. completely non-toxic, degradable and good in environmental protection property; 6. is suitable for disinfection and sterilization of object surfaces, water, air and other environments.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples are merely illustrative of the preferred embodiments of the present invention and are not intended to limit the present invention in any way, and any simple modifications, equivalent changes and modifications made to the embodiments according to the technical spirit of the present invention fall within the scope of the technical solution of the present invention.