阅读说明：本技术 治疗乳腺小叶增生的中药组合物及其制备方法和应用 (Traditional Chinese medicine composition for treating mammary gland lobular hyperplasia and preparation method and application thereof ) 是由 黄文珍 于 2020-05-12 设计创作，主要内容包括：本发明公开了一种治疗乳腺小叶增生的中药组合物及其制备方法和应用。本发明首先公开了一种治疗乳腺小叶增生的中药组合物,包括：溪黄草,白绒草,四籽马蓝和天胡荽。本发明进一步公开了制备所述中药组合物的方法。本发明中药组合物具有消肿解毒、凉血生津之功效,临床疗效观察结果表明,本发明中药组合物对于乳腺增生具有确切的疗效且见效快；安全性观察发现,没有观察到任何临床不良反应,表明本发明中药组合物临床应用安全、无毒副作用。(The invention discloses a traditional Chinese medicine composition for treating mammary gland lobular hyperplasia, and a preparation method and application thereof. The invention firstly discloses a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which comprises the following components: linearstripe rabdosia herb, whiteflower velvet grass, watercress and coriander. The invention further discloses a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of relieving swelling, removing toxicity, cooling blood and promoting the secretion of saliva or body fluid, and clinical curative effect observation results show that the traditional Chinese medicine composition has exact curative effect and quick response on hyperplasia of mammary glands; the safety observation shows that no clinical adverse reaction is observed, which indicates that the traditional Chinese medicine composition is safe in clinical application and has no toxic or side effect.)

1. A traditional Chinese medicine composition for treating hyperplasia of mammary glands is characterized by being prepared from the following raw material medicines: linearstripe rabdosia herb, whiteflower velvet grass, watercress and coriander.

2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 35-50 parts of linearstripe rabdosia herb, 20-30 parts of velvetplant, 10-18 parts of Sizima blue and 2-8 parts of lawn pennywort herb.

3. The traditional Chinese medicine composition according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 45 parts of linearstripe rabdosia herb, 25 parts of velvetplant, 14 parts of Sizima blue and 6 parts of lawn pennywort herb.

4. The Chinese medicinal composition according to any one of claims 1 to 3, which is prepared into any one of clinically acceptable oral preparations by a conventional Chinese medicinal preparation method.

5. The composition of claim 4, wherein the oral formulation is selected from the group consisting of tablets, granules, capsules, powders, pills, oral liquids, and syrups.

6. A method of preparing a Chinese medicinal composition of any one of claims 1 to 3, comprising: weighing the raw materials according to the weight parts, crushing, sieving and uniformly mixing to obtain the traditional Chinese medicine.

7. A method of preparing a Chinese medicinal composition of any one of claims 1 to 3, comprising:

(1) weighing the raw material medicines according to the parts by weight;

(2) decocting the raw materials in water, and filtering the decoction; concentrating the filtrate into fluid extract, drying, adding medicinal adjuvants or vehicle for forming preparation, and mixing.

8. Use of a Chinese medicinal composition according to any one of claims 1 to 3 in the manufacture of a medicament for the treatment of mammary lobular hyperplasia.

Technical Field

The invention relates to a traditional Chinese medicine composition for treating hyperplasia of mammary glands, and also relates to a preparation method and application of the traditional Chinese medicine composition, belonging to the field of traditional Chinese medicine treatment of hyperplasia of mammary glands.

Background

The mammary gland hyperplasia refers to hyperplasia of mammary epithelium and fibrous tissue, degenerative changes of mammary tissue ducts and mammary lobules on the structure and growth of progressive connective tissue, is the most common breast disease of women, and the incidence rate of the mammary gland hyperplasia accounts for the first place of the mammary gland disease; the incidence of the disease has been increasing year by year in recent years, and the age has been getting lower. Fasciitis refers to aseptic inflammatory reaction of muscles and fascia, which can occur in various parts of the whole body, and when the body is stimulated by external adverse factors such as wind-cold invasion, fatigue, trauma or improper sleeping position, acute attack of muscle fasciitis can be induced, fibrosis change can occur after fascia injury, and acute or chronic injury and strain of muscles, ligaments and joint capsules at the shoulder, neck and waist are the basic causes of the disease.

The existing traditional Chinese medicine for treating the hyperplasia of mammary glands has slow effect and unsatisfactory treatment effect. Therefore, the development of a traditional Chinese medicine composition which has an exact treatment effect on the hyperplasia of mammary glands and takes effect quickly is urgently needed.

Disclosure of Invention

The invention aims to solve the technical problem of providing the traditional Chinese medicine composition for treating the hyperplasia of mammary glands, and the traditional Chinese medicine composition has exact treatment effect on the hyperplasia of mammary glands and quick response.

In order to solve the technical problems, the technical scheme adopted by the invention is as follows:

the invention firstly discloses a traditional Chinese medicine composition for treating hyperplasia of mammary glands, which is prepared from the following raw material medicines: linearstripe rabdosia herb, whiteflower bluegrass, watercress and coriander;

preferably, the weight parts of the raw material medicines are as follows: 35-50 parts of linearstripe rabdosia herb, 20-30 parts of velvetplant, 10-18 parts of tetrasperma blue and 2-8 parts of lawn pennywort herb;

more preferably, the raw material medicines comprise the following components in parts by weight: 45 parts of linearstripe rabdosia herb, 25 parts of velvetplant, 14 parts of Sizima blue and 6 parts of lawn pennywort herb.

Rabdosia lophanthide: rabdosia serra (Maxim.) Hara, commonly known as golden thread, and others: rabdosia lophanthide, goat face, bear gall grass, herb of glabrous greenbrier, yellow juice grass, rabdosia lophanthide, Rabdosia trichocarpa and the like, and the rabdosia lophanthide of Labiatae has the effects of clearing heat and promoting diuresis, removing jaundice and clearing damp, cooling blood and dissipating blood stasis.

The plant edelweiss is prepared from the whole plants of the edelweiss, Yunnan, Guangxi western and Guizhou western, Nipol, India, Srilanka, Burmese, Thailand, Vietnamese to Malaysia and Indonesia, and has the effects of clearing lung-heat, relieving cough and stopping hemoptysis chest pain.

The Chinese medicinal composition is prepared from herba seu radix Caesalpiniae Japonicae (Dicliptera chinensis (L.) Thunb.) Makinsis, also called herba Cibotii, which is the whole herb of dicotyledonous plant herba seu radix Kalimeridis (Acanthaceae), including herba Centipedae, herba corydalis Bungeanae, hepar Sus Domestica vegetable, green snake, Arisaema cum uncis, herba Erigerontis, herba Melastomatis Canadensis, Zanthoxylum schlegelii, herba Capparis Sprensis, herba Eupatorii, herba Asteris Nomalae, herba Lasiocladi, herba Melastomatis Cannabinae, and herba Elephantopi Heterophyllae.

Lawn pennywort herb: the name learning: hydrocotylie sibthorpioides, belonging to the genus Hydrocotyle of the family Umbelliferae. The whole herb is used as a medicine and has the effects of clearing heat, promoting urination, reducing swelling and detoxifying, and treating jaundice, red and white dysentery, nebula, throat swelling, carbuncle, deep-rooted carbuncle, furuncle and traumatic injury.

The traditional Chinese medicine composition is prepared according to a formula of a traditional Chinese medicine theory and a certain weight ratio, and the traditional Chinese medicine composition is prepared by combining cold and warm in the formula, performing purgation and reinforcement simultaneously and has the effects of strengthening body resistance and eliminating pathogenic factors.

The raw materials used in the invention can be purchased in medical shops.

The traditional Chinese medicine composition can be applied to preparing medicines for treating hyperplasia of mammary glands, and proper auxiliary materials or carriers are added on the basis of the traditional Chinese medicine composition with therapeutically effective amount. Wherein the dosage form of the medicine is an oral preparation and comprises the following components: powder, tablet, granule, pill, emulsion, granule, soft capsule, hard capsule or microcapsule.

The adjuvant or carrier of the present invention refers to the conventional adjuvants or carriers in the pharmaceutical field, such as: diluents, disintegrants, lubricants, excipients, binders, glidants, fillers, surfactants, and the like; in addition, other adjuvants such as flavoring agents and sweeteners may be added to the composition. The diluent may be one or more components for increasing the weight and volume of the tablet, and commonly used diluents include lactose, starch, pregelatinized starch, microcrystalline cellulose, sorbitol, mannitol, and inorganic calcium salts. The disintegrant can be one or more of crosslinked polyvinylpyrrolidone (with a total weight ratio of 2-6%), crosslinked sodium carboxymethylcellulose (with a total weight ratio of 2-6%), alginic acid (with a total weight ratio of 2-5%), and microcrystalline cellulose (with a total weight ratio of 5-15%). The lubricant comprises one or a mixture of stearic acid, sodium stearate, magnesium stearate, calcium stearate, polyethylene glycol, talcum powder and hydrogenated vegetable oil. The amount of lubricant used is generally in the range of 0.25 to 0.75% by weight. The binder may be one or more ingredients useful for granulation, and may be starch slurry (10-30% by weight of the total binder), hydroxypropyl methylcellulose (2-5% by weight of the total binder), and polyvinylpyrrolidone (2-20% by weight of the total binder). The glidant can be one or a mixture of more of superfine silica gel powder, talcum powder and magnesium trisilicate. The surfactant may be one or more ingredients that improve wetting and increase drug dissolution, such as sodium lauryl sulfate (usually in the range of 0.2-6% by weight relative to the total weight).

The invention also discloses a method for preparing the traditional Chinese medicine composition, which comprises the following steps: weighing the raw materials according to the weight parts, crushing and uniformly mixing to obtain the composite material. The invention has no special limitation on the crushing, can be adjusted according to actual needs and is used as reference for crushing to 200-300 meshes.

Preferably, a method for preparing the traditional Chinese medicine composition for treating hyperplasia of mammary glands comprises the following steps:

(1) weighing the raw materials in parts by weight;

(2) decocting the raw materials in water, and filtering the decoction; concentrating the filtrate into fluid extract, drying, adding medicinal adjuvants or vehicle for forming preparation, and mixing.

Wherein, preferably, the decoction in the step (2) is added with water for decoction for 1 to 3 times, and more preferably for 2 times; wherein 6 to 12 times of water by weight is added for the first time, and the decoction is carried out for 1 to 3 hours; adding 4-10 times of water for the second time, and decocting for 0.5-2 hours; mixing decoctions, filtering, concentrating the filtrate to fluid extract with relative density of 1.12-1.18 at 75 deg.C, and drying to obtain dry powder.

The use method and the dosage of the traditional Chinese medicine composition are as follows: the dosage of the traditional Chinese medicine composition depends on factors such as specific dosage forms, age of patients, health conditions and the like. For oral preparation, the effective dose is 1-2g per time and 3 times a day, calculated by the crude drug contained in the traditional Chinese medicine composition.

The observation result of clinical curative effect shows that the traditional Chinese medicine composition has exact curative effect and quick response (on the 7 th day of treatment, the pain and other symptoms of the patients in the test group are obviously relieved); the safety observation shows that no clinical adverse reaction is observed, which indicates that the traditional Chinese medicine composition is safe in clinical application and has no toxic or side effect.

Detailed Description

The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. It is to be understood that the described embodiments are exemplary only and are not limiting upon the scope of the invention. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be within the scope of the invention.