阅读说明：本技术 一种生物力型下颌骨支架和微纳分级通透性的钛铌表面的制备方法 (Preparation method of biological force type mandible scaffold and micro-nano graded permeable titanium-niobium surface ) 是由 韩婧 金明江 刘剑楠 周子疌 于 2020-03-25 设计创作，主要内容包括：本发明公开了一种生物力型下颌骨支架和微纳分级通透性的钛铌表面的制备方法,所述下颌骨支架的材料为梯度结构,包括合金基体和多孔表面；所述合金基体为钛-铌基β系合金材料；所述多孔表面为微纳分级通透性的钛-铌表面。本发明的生物力型下颌骨支架,具有高强度低模量的合金基体和多孔表面,且多孔结构进一步降低模量及形成利于成骨细胞粘附的形貌,使构建的下颌骨支架更符合生物力学特征并具有表面成骨活性。(The invention discloses a biological force type mandible support and a preparation method of a micro-nano graded permeable titanium-niobium surface, wherein the mandible support is made of a gradient structure and comprises an alloy matrix and a porous surface, the alloy matrix is a titanium-niobium-based β series alloy material, and the porous surface is a micro-nano graded permeable titanium-niobium surface.)

1. The biological force type mandible scaffold is characterized in that the mandible scaffold is made of a gradient structure and comprises an alloy matrix and a porous surface, wherein the alloy matrix is made of a titanium-niobium-based β series alloy material, and the porous surface is a micro-nano graded permeable titanium-niobium surface.

2. The biomechanical mandible brace of claim 1, wherein the material of the alloy base further comprises at least one of tin and zirconium.

3. The biomechanical mandible scaffold according to claim 1, wherein the pore size in the micro-nano graded permeable titanium-niobium surface is in the range of 100-300 nanometers; preferably, the thickness of the porous surface is 5-30 microns.

4. A method for preparing a micro-nano graded permeable titanium-niobium surface on the surface of an alloy matrix of a mandible scaffold is characterized by comprising the following steps:

an alloy coating is deposited on the surface of the alloy matrix of the mandible support, and the alloy coating is dealloyed, so that a micro-nano graded permeable titanium-niobium surface can be prepared on the surface of the alloy matrix of the mandible support.

5. The method for preparing the micro-nano graded permeable titanium-niobium surface on the surface of the alloy matrix of the mandible scaffold according to claim 4, wherein the material of the alloy coating comprises a 'Ti-Nb + Ti-Fe' two-phase system.

6. The method for preparing the micro-nano graded permeable titanium-niobium surface on the alloy matrix surface of the mandible scaffold according to claim 5, wherein the volume ratio of the Ti-Fe phase is 30-70%.

7. The method for preparing the micro-nano graded permeable titanium-niobium surface on the surface of the alloy matrix of the mandible scaffold according to claim 4 or 5, wherein the thickness of the alloy coating is 5-30 micrometers.

8. The method for preparing the micro-nano graded permeable titanium-niobium surface on the surface of the alloy matrix of the mandibular scaffold according to claim 7, wherein the alloy coating is deposited on the surface of the alloy matrix by magnetron sputtering.

9. The method for preparing the micro-nano graded permeable titanium-niobium surface on the surface of the alloy matrix of the mandible scaffold according to claim 4, wherein the preparation steps of the alloy matrix are as follows: and mixing and smelting the metal powder to obtain the alloy matrix.

10. The method for preparing a micro-nano graded permeable titanium-niobium surface on the alloy matrix surface of a mandibular scaffold according to claim 9, where the metal powder comprises titanium, niobium, tin and zirconium.

Technical Field

The invention relates to the technical field of restoration and reconstruction of oral and maxillofacial surfaces, in particular to a biological force type mandible scaffold and a method for preparing a micro-nano graded permeable titanium-niobium surface on the surface of an alloy matrix of the mandible scaffold.

Background

The existing methods for repairing the mandibular defect comprise autologous bone transplantation, heterogeneous material transplantation and the like, but the simple autologous bone transplantation and the full-heterogeneous material transplantation have defects. The simple autologous bone transplantation has the problems of insufficient autologous bone mass, damage to supply areas, high operation difficulty and the like. Pure titanium materials are the most widely studied in the transplantation of fully heterogeneous materials.

However, pure titanium has a heterogeneous mandible, which has a poor binding ability with surrounding bone tissues and soft tissues due to a high elastic modulus of the material, and thus, has problems of exposure of the implant to the oral cavity, poor osseointegration, implant failure and the like in a clinical process. In the mandibular reconstruction process, the titanium plate fixes the bone graft and the mandibular stump, however, the elastic modulus of pure titanium is significantly higher than the mandible, which easily results in stress shielding, and thus results in insufficient stress of the bone graft for absorption.

In order to overcome the defects of insufficient autologous bone mass and mechanical and biocompatibility defects of a pure metal material, researchers study and design a special titanium mesh to combine with ilium or fibula cancellous bone particles and bone marrow to reconstruct the mandible, the scheme can avoid the stress shielding effect, but the obvious defects of the scheme comprise: due to the high biological stress characteristic of the mandible, the structural design strength of the titanium mesh is insufficient, and the titanium mesh is easy to deform in the stress process; and the free non-vascularized cancellous bone has high postoperative absorption rate, poor anti-infection capability and poor long-term effect.

Therefore, it is desirable to provide a scaffold for reconstructing a jaw bone, which not only meets biomechanical characteristics of the jaw bone, but also promotes osteogenesis at a material-bone interface, and reduces stress shielding, so as to solve the above problems.

Disclosure of Invention

The invention aims to provide a biological material type mandible support which has an alloy matrix with high strength and low modulus and a porous surface, and the porous structure further reduces the modulus and forms a morphology beneficial to adhesion of osteoblasts, so that the constructed mandible support is more consistent with biomechanical characteristics and has surface osteogenesis activity.

In order to achieve the purpose, the invention adopts the following technical scheme.

The invention provides a biological force type mandible support which is made of a gradient structure and comprises an alloy matrix and a porous surface, wherein the alloy matrix is made of a Ti-Nb-based β series alloy material, and the porous surface is a micro-nano graded permeable titanium-niobium surface.

Further, the alloy matrix further includes at least one of tin (Sn) and zirconium (Zr).

Further, the range of the aperture in the titanium-niobium surface with micro-nano hierarchical permeability is 100-300 nanometers.

Further, the thickness of the porous surface is 5-30 microns.

The invention also provides a method for preparing the micro-nano graded permeable titanium-niobium surface on the surface of the alloy matrix of the mandible support, which comprises the following steps:

an alloy coating is deposited on the surface of the alloy matrix of the mandible support, and the alloy coating is dealloyed, so that a micro-nano graded permeable titanium-niobium surface can be formed on the surface of the alloy matrix of the mandible support.

Further, the material of the alloy coating comprises a Ti-Nb + Ti-Fe dual-phase system.

Further, the volume ratio of the Ti-Fe phase is 30-70%; for example, the Ti-Fe phase may be 30%, 50%, and 70% by volume.

Further, the thickness of the alloy coating is 5-30 microns. For example, the thickness of the coating layer described in the present invention may be 5 μm, 10 μm, 15 μm, 20 μm, 25 μm, and 30 μm.

Further, the preparation of the alloy coating specifically comprises the following steps: and depositing a deposition material on the surface of the alloy matrix by adopting a magnetron sputtering method to obtain the alloy coating.

Further, the deposition material comprises a Ti-Nb + Ti-Fe dual-phase system; the volume ratio of the Ti-Fe phase is 30-70%.

Further, the preparation steps of the alloy matrix are as follows: and mixing and smelting the metal powder to obtain the alloy matrix.

Further, the metal powder includes titanium (Ti), niobium (Nb), tin (Sn), and zirconium (Zr).

In the invention, the structure of the biological material type mandible support is determined according to the actual condition.

The invention has the beneficial effects that:

the biological force type mandible support not only accords with the biomechanical characteristics of the mandible, reduces stress shielding, but also can promote osteogenesis of a material-bone interface, accords with the biomechanical characteristics and has surface osteogenesis activity.

The biological force type mandible scaffold provided by the invention has a high-strength low-modulus titanium-niobium alloy material matrix which is prepared from elements with good biocompatibility such as Ti, Nb, Sn, Zr and the like, so that the mandible scaffold matrix has an elastic modulus close to that of the cortex of the mandible and has higher mechanical strength.

According to the invention, a micro-nano transparent porous structure is formed on the surface of the alloy matrix by utilizing the magnetron sputtering and dealloying technology, so that the elastic modulus of the surface of the stent is further reduced, and osteoblasts are favorably adhered, so that the surface bone forming material has excellent surface bone forming activity. According to the invention, the initial two-phase volume ratio and the tissue structure of the alloy coating are regulated and controlled, so that the pore size distribution, porosity and permeability of the surface of the material obtained after dealloying are effectively controlled, the surface modulus of the alloy is further reduced, and a micro-nano permeable porous surface is formed.

The bracket of the invention can be well applied to oral and maxillofacial reconstruction surgery, meets the performance requirement of being used as a mandible reconstruction bracket, and has good mechanical property and biocompatibility.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.

Fig. 1 is a schematic structural view of a biomaterial-type mandible scaffold material according to the present invention.

FIG. 2a is an alloy matrix according to the present invention; FIG. 2b is an alloy substrate with an alloy coating deposited thereon according to the present invention; FIG. 2c shows an alloy substrate with micro-nano graded permeability on the surface of titanium-niobium in the invention.

The reference numerals in the figures are respectively:

1. an alloy matrix;

2. an alloy coating;

3. a micro-nano graded permeable titanium-niobium surface.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.