阅读说明：本技术 一种治疗乙型病毒性肝炎的中药制剂及制备方法 (Chinese medicinal preparation for treating viral hepatitis B and preparation method thereof ) 是由 陈安芬 周芳 周廷全 周芸锋 朱书岑 朱纹静 于 2019-12-30 设计创作，主要内容包括：本发明公开了一种治疗乙型病毒性肝炎的中药制剂及制备方法,中药制剂包括以下按质量配比的中药组分：蟾蜍20～28、白花蛇舌草8～12、半枝莲8～12、虫草2～4、夏枯草8～12、木香15～22、龙胆草、金钱草、柴胡、茵陈。本发明以蟾蜍为主药,蟾蜍具有破破症结,行水湿,化毒,杀虫,定痛,治恶疮疽、阴疽瘰疬的功效,加以清热利湿、解毒的白花蛇舌草,清肝散结行肝气、开肝郁、补养血脉的夏枯草,清热解毒的半枝莲,行气止痛温中和胃的木香,益精气、补虚损的虫草等重要辅助,能够达到清肝、利湿、解毒、补虚、益精气等药效对乙肝型病毒性肝炎、肝硬化肝腹水肝癌等具有很好的治疗效果。(The invention discloses a traditional Chinese medicine preparation for treating viral hepatitis B and a preparation method thereof, wherein the traditional Chinese medicine preparation comprises the following traditional Chinese medicine components in parts by mass: 20-28 parts of toad, 8-12 parts of spreading hedyotis herb, 8-12 parts of barbed skullcap herb, 2-4 parts of cordyceps sinensis, 8-12 parts of selfheal, 15-22 parts of costustoot, gentian, desmodium, radix bupleuri and oriental wormwood. The invention takes toad as main drug, the toad has the efficacy of breaking symptom knots, moving water dampness, transforming toxin, killing insects, relieving pain, treating malignant ulcer and scrofula, and the toad is added with the important assistance of spreading hedyotis herb for clearing heat, promoting diuresis and detoxifying, selfheal for clearing liver, dissipating knots, moving liver qi, opening liver depression and nourishing blood vessels, barbed skullcap for clearing heat and detoxifying, costustoot for promoting qi circulation, relieving pain, warming middle-jiao and stomach, cordyceps for benefiting vital essence and qi and tonifying deficiency and the like, so that the drug effects of clearing liver, removing dampness, detoxifying, tonifying deficiency, benefiting vital essence and the like have good treatment effects on viral hepatitis type B, liver cirrhosis, liver ascites and the like.)

1. The traditional Chinese medicine preparation for treating viral hepatitis B is characterized by comprising the following traditional Chinese medicine components in parts by mass: 20-28 parts of toad, 8-12 parts of spreading hedyotis herb, 8-12 parts of barbed skullcap herb, 2-4 parts of cordyceps, 8-12 parts of selfheal, 15-22 parts of costustoot, 10-15 parts of gentian, 10-20 parts of desmodium, 10-15 parts of radix bupleuri and 10-15 parts of oriental wormwood.

2. The traditional Chinese medicine preparation for treating viral hepatitis B according to claim 1, which is characterized by comprising the following traditional Chinese medicine components in parts by mass: 25 parts of toad, 10 parts of oldenlandia diffusa, 10 parts of sculellaria barbata, 3 parts of cordyceps sinensis, 10 parts of selfheal, 18 parts of costustoot, 12 parts of gentian, 15 parts of desmodium, 12 parts of radix bupleuri and 12 parts of oriental wormwood.

3. A preparation method of a traditional Chinese medicine preparation for treating viral hepatitis B is characterized by comprising the following steps:

s1, preparing materials: cleaning and drying required traditional Chinese medicine raw materials;

s2, crushing: pulverizing and sieving the components respectively;

s3, mixing: weighing the crushed traditional Chinese medicine materials according to the mass ratio, and then placing the weighed traditional Chinese medicine materials in a mixer for uniformly mixing;

s4, weighing and subpackaging: packaging the uniformly mixed traditional Chinese medicine materials into small bags or capsules, or decocting the prepared traditional Chinese medicines into water for taking.

Technical Field

The invention belongs to the technical field of Chinese patent medicines and preparation methods thereof, and particularly relates to a Chinese medicinal preparation for treating viral hepatitis B and a preparation method thereof.

Background

Chronic hepatitis b is caused by infection with Hepatitis B Virus (HBV), which is the main source of infection in patients with hepatitis b and HBV carriers, and can be transmitted by mother and baby, blood and blood products, damaged skin mucosa and sexual contact. After HBV infection, different outcomes and clinical types can occur due to the influence of virus factors, host factors, environmental factors and the like, and the common reasons for the development of chronic viral hepatitis B are as follows:

1. familial transmission

The main reason for the high incidence of hepatitis B in China is familial transmission, wherein mother-infant vertical transmission is taken as the main reason, and if the hepatitis B E antigen of mothers is positive, the born and child are not injected with hepatitis B vaccine and are mostly hepatitis B virus carriers. Hepatitis B virus can be detected in semen, and thus can be transmitted by sex. This is the main reason for the family gathering characteristics of hepatitis B in our country.

2. Infant stage infectious virus

The age of the initial hepatitis B infection is closely related to chronic viral hepatitis B. Once the fetus and the newborn are infected with the hepatitis B virus, about 90 to 95 percent of the fetus and the newborn become chronic virus carriers; children are infected with hepatitis B virus, about 20% of which become chronic hepatitis B virus carriers; only 3-6% of adult infected hepatitis B virus develops into chronic hepatitis B virus carrying state.

3. Lack of prevention consciousness

The hepatitis B vaccine is a measure for blocking the vertical transmission of hepatitis B, and due to the limitation of economic conditions and the lack of prevention consciousness, the vaccination work of the hepatitis B vaccine is not ideal enough, so that the prevention of the hepatitis B is difficult to implement, and more chronic cases exist.

4. Missed diagnosis

Acute latent icteric hepatitis is more likely to develop into chronic hepatitis than acute icteric hepatitis, which is related to the fact that the icteric hepatitis is easy to be misdiagnosed or misdiagnosed, and is not diagnosed and treated in time and has a rest.

5. Patients with low immune function are infected with virus

The hepatitis B virus is easy to develop into chronic viral hepatitis B for patients with kidney transplantation, tumor, leukemia, AIDS and hemodialysis. In the acute stage of hepatitis B, patients are treated with immunosuppressive agents such as glucocorticoid, etc., so that the immune balance in the body of the patients is destroyed, and the acute hepatitis is easily changed into chronic hepatitis.

It is known that once suffering from hepatitis B, not only can work and life of the individual be greatly affected, causing the patient to be perplexing, but also certain mental burden can be brought to family and relatives and friends, so that the family and friends can take a far-away attitude towards the patient. Although the research on the traditional Chinese medicine liver diseases is active in recent years, great progress is made from the theoretical basis to the clinical treatment of the viral hepatitis seriously harming the labor production, but the traditional Chinese medicine liver diseases still feel troublesome to the treatment of the hepatitis B. In the western medicine treatment process at home and abroad, no specific medicine is available for treating hepatitis B, in recent years, mostly used are ribonucleic acid injection, some are breast milk liver injection, and the levo-imipramol hydrochloride tablets and other medicines appear later, but the curative effect is not ideal. And the medicine is expensive and has long treatment time. Therefore, many patients with hepatitis B have the option of abandoning the treatment by smelling price and generating fear.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine preparation for treating viral hepatitis type B and a preparation method thereof, wherein the traditional Chinese medicine preparation takes toads as a main drug, can achieve the drug effects of clearing liver, removing dampness, detoxifying, tonifying deficiency, benefiting vital essence and qi and the like, and has a better treatment effect on hepatitis type B.

The purpose of the invention is realized by the following technical scheme: a traditional Chinese medicine preparation for treating viral hepatitis B comprises the following traditional Chinese medicine components in parts by mass: 20-28 parts of toad, 8-12 parts of spreading hedyotis herb, 8-12 parts of barbed skullcap herb, 2-4 parts of cordyceps, 8-12 parts of selfheal, 15-22 parts of costustoot, 10-15 parts of gentian, 10-20 parts of desmodium, 10-15 parts of radix bupleuri and 10-15 parts of oriental wormwood.

Preferably, the traditional Chinese medicine preparation for treating viral hepatitis B comprises the following traditional Chinese medicine components in parts by mass: 25 parts of toad, 10 parts of oldenlandia diffusa, 10 parts of sculellaria barbata, 3 parts of cordyceps sinensis, 10 parts of selfheal, 18 parts of costustoot, 12 parts of gentian, 15 parts of desmodium, 12 parts of radix bupleuri and 12 parts of oriental wormwood.

The invention also discloses a preparation method of the traditional Chinese medicine preparation for treating viral hepatitis B, which comprises the following steps:

s1, preparing materials: cleaning and drying required traditional Chinese medicine raw materials;

s2, crushing: pulverizing and sieving the components respectively;

s3, mixing: weighing the crushed traditional Chinese medicine materials according to the mass ratio, and then placing the weighed traditional Chinese medicine materials in a mixer for uniformly mixing;

s4, weighing and subpackaging: packaging the uniformly mixed traditional Chinese medicine materials into small bags or capsules, or decocting the prepared traditional Chinese medicines into water for taking.

The invention has the beneficial effects that: the invention takes toad as main drug, the toad has the efficacy of breaking symptom knots, removing dampness by water, transforming toxin, killing insects, relieving pain, treating malignant sore and scrofula, and the toad is added with capillary artemisia which can promote bile flow and remove jaundice, gentian which can promote liver and gallbladder to remove liver heat, longhairy antenoron herb which can promote diuresis and reduce edema and remove liver and gallbladder damp heat, bupleurum which can purge liver fire, sooth liver and regulate qi, eliminate mass, promote qi circulation, remove stasis, oldenlandia which can clear heat and promote diuresis, detoxify, liver-clearing and disperse stagnation and remove liver-qi, prunella which can nourish blood vessels, sculellaria barbata which can clear heat and detoxify, elecampane which can promote qi circulation and relieve pain and warm middle warmer and stomach, cordyceps which can benefit essence and qi and deficiency, and the like, and the invention can achieve the drug effects of clearing liver, promoting diuresis, detoxifying, tonifying deficiency, benefiting essence and qi, and the like, and has good treatment effect on hepatitis B type viral hepatitis, liver ascites.

Detailed Description

The technical scheme of the invention is further explained by combining specific examples.