阅读说明：本技术 2-巯基吡啶-n-氧化物三价钴盐配合物的抗菌应用 (Antibacterial application of 2-mercaptopyridine-N-oxide trivalent cobalt salt complex ) 是由 袁福根 卢慧 陈宏伟 于 2019-08-30 设计创作，主要内容包括：本发明涉及2-巯基吡啶-N-氧化物三价钴盐配合物的抗菌应用。本发明公开2-巯基吡啶-N-氧化物三价钴盐配合物对铜绿假单胞菌、大肠杆菌和枯草芽孢杆菌均具有优异的抗菌活性。该抗菌剂制备工艺简单,反应条件温和,产率高,具有重大应用价值。(The invention relates to an antibacterial application of a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex. The invention discloses a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex which has excellent antibacterial activity on pseudomonas aeruginosa, escherichia coli and bacillus subtilis. The antibacterial agent has the advantages of simple preparation process, mild reaction conditions, high yield and great application value.)

The antibacterial application of the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex is characterized in that the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex has the following molecular structure:

2. the antibacterial use of a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex according to claim 1, characterized in that it is highly effective in inhibiting the growth of pseudomonas aeruginosa, escherichia coli and bacillus subtilis.

3. The antibacterial application of the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex according to claim 1, wherein the concentration of the complex is 0.3-1.36 mg/mL.

Technical Field

The invention belongs to the field of biology, and particularly relates to an antibacterial application of a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex.

Background

With the continuous improvement of the living standard of people, people have higher requirements on healthy and sanitary living environments, and the demand of antibacterial materials is more and more increased. The core of the antibacterial material is an antibacterial agent, a substance with antibacterial and bactericidal properties. Antibacterial agents can be classified into inorganic antibacterial agents and organic antibacterial agents. Inorganic antibacterial agents represented by metallic silver ions have a strong antibacterial and bactericidal ability, but have the disadvantages of poor selectivity and easy deterioration. Organic antibacterial agents, such as antibiotics, have the advantage of good selectivity of sterilization, but after a large amount of use, bacteria are liable to develop resistance to drugs. For this reason, we considered to prepare an inorganic-organic composite antibacterial agent combining the advantages of the inorganic antibacterial agent and the organic antibacterial agent.

The 2-mercaptopyridine-N-oxide sodium salt is an efficient, safe and broad-spectrum bactericide, is used for preventing and treating apple scab and leaf curl disease in agriculture, has an inhibiting effect on yeast and mould in foods, and is used for treating body surface diseases such as seborrheic dermatitis, tinea versicolor and the like in medicine. The cobalt element is an important trace element in the human body, and for example, the cobalt element is a component of vitamin B12 and can promote the synthesis of hemoglobin and the like. 2-mercaptopyridine-N-oxide and cobalt metal are coordinately combined, and the complex is friendly to human bodies and the environment.

Although the coordination reaction of 2-mercaptopyridine-N-oxide and cobalt metal ions has been reported, the application research of the 2-mercaptopyridine-N-oxide in the aspect of antibacterial materials has not been reported. It is worth noting that cobalt has two valence states, divalent and trivalent, and the invention discloses trivalent cobalt salt complexes. The antibacterial agent complex has the advantages of simple preparation process, mild reaction conditions, high yield and great application value.

Disclosure of Invention

The invention provides an antibacterial application of a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex.

The specific technical scheme is as follows:

the antibacterial application of the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex is that the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex has the following molecular structure:

the antibacterial objects comprise pseudomonas aeruginosa, escherichia coli and bacillus subtilis; the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex can effectively inhibit the growth of pseudomonas aeruginosa, escherichia coli and bacillus subtilis.

The concentration of the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex is preferably 0.3-1.36 mg/mL.

Drawings

FIG. 1 is a crystal structure diagram of a 2-mercaptopyridine-N-oxide trivalent cobalt salt complex

FIG. 2 is a graph of 2-mercaptopyridine-N-oxide Ni (II), Co (III), Ag (I) complex inhibiting the growth of Pseudomonas aeruginosa

FIG. 3 is a graph of 2-mercaptopyridine-N-oxide Ni (II), Co (III), Ag (I) complexes inhibiting the growth of E.coli

FIG. 4 is a graph of 2-mercaptopyridine-N-oxide Ni (II), Co (III), Ag (I) complexes inhibiting the growth of Bacillus subtilis

Detailed Description

The present invention will be further described with reference to specific examples, but the embodiments of the present invention are not limited thereto.

The experimental methods in the following examples, which are not specified under specific conditions, are generally performed under conventional conditions. The reagents are all common reagents sold in the market, and the solvents used for preparing the 2-mercaptopyridine-N-oxide trivalent cobalt salt complex solution are all dimethyl sulfoxide (DMSO).

The trivalent cobalt salt complex of 2-mercaptopyridine-N-oxide referred to in the present invention can be synthesized by reference to and modification of literature methods (D.X.West, C.A.Brown, J.P.Jasinski, J.M.Jasinski, R.M.Heathwaite, D.G.Forster, R.J.Staples, and R.J.Butcher, Crystal structures of the cobalt (III), nickel (II), copper (II), and zinc (II) complexes of 2-thio-6-pyridine N-oxide, Journal of Chemical crystallization, 1998, 28 (12): 853-: