阅读说明：本技术 厚朴酚和/或和厚朴酚在家禽养殖中的应用 (Application of magnolol and/or honokiol in poultry breeding ) 是由 陈芳 杜恩存 张昊 樊启文 魏金涛 赵娜 郭万正 黄少文 张巍 于 2019-10-06 设计创作，主要内容包括：本发明公开了厚朴酚和/或和厚朴酚在家禽养殖中的应用,属于畜禽养殖技术领域。厚朴酚和/或和厚朴酚在家禽日粮中应用,可以促进家禽肠道绒毛发育,提高肠绒毛高度和绒毛/隐窝比值；并可显著改善家禽常见肠道致病菌感染、应激等对鸡肠道和生产性能造成的不良影响；本发明还公开了一种厚朴酚和/或和厚朴酚为主要成分的替代抗生素的饲料添加剂。(The invention discloses application of magnolol and/or honokiol in poultry breeding, and belongs to the technical field of livestock breeding. The magnolol and/or honokiol is applied in daily ration of domestic fowl, and can promote intestinal villus development of fowl, and improve intestinal villus height and ratio of villus/crypt; and can obviously improve the adverse effects of common intestinal pathogenic bacteria infection, stress and the like of the poultry on the intestinal tract and the production performance of the chicken; the invention also discloses a feed additive which takes magnolol and/or honokiol as main components and replaces antibiotics.)

1. Application of magnolol and/or honokiol in poultry breeding is characterized in that: the magnolol and/or honokiol is applied to the feed additive for promoting intestinal villus development and improving the oxidation resistance of intestinal mucosa.

2. Application of magnolol and/or honokiol in poultry breeding is characterized in that: the magnolol and/or honokiol is applied to the feed additive for relieving intestinal tract pathogenic bacteria infection of poultry, intestinal tract injury caused by stress and production performance reduction.

3. Application of magnolol and/or honokiol in poultry breeding is characterized in that: the magnolol and/or honokiol is applied to the feed additive for reducing the feed conversion ratio of meat to meat or the feed conversion ratio of eggs.

4. Use of magnolol and/or honokiol according to any one of claims 1-3 in poultry farming, characterized in that: the feed additive containing magnolol and honokiol is used for daily ration of broiler chickens, wherein the weight ratio of magnolol to honokiol is 1: 2-3.

5. Use of magnolol and/or honokiol according to any one of claims 1-3 in poultry farming, characterized in that: the feed additive containing magnolol and honokiol is used for daily ration of laying hens, and the weight ratio of magnolol to honokiol is 1: 0.5-1.

6. A magnolol and/or honokiol-containing feed additive according to any one of claims 1 to 3, wherein: the feed additive and the weight portion are 0-30 portions of magnolol, 0-30 portions of honokiol, 5-10 portions of organic acid, 5-10 portions of functional oligosaccharide, 5-10 portions of probiotics, 1-5 portions of vitamin E and 40-75 portions of carrier.

7. The magnolol and/or honokiol-containing feed additive according to claim 6, wherein: the feed additive contains magnolol and/or honokiol total phenol 20-30%.

8. The magnolol and/or honokiol-containing feed additive according to claim 6, wherein: the mass concentration of the feed additive in the feed is 0.5-1 kg/t.

9. The magnolol and/or honokiol-containing feed additive according to claim 6, wherein: the organic acid is any one or more of lactic acid, formic acid, propionic acid, butyric acid, citric acid, fumaric acid and salts thereof;

the functional oligosaccharide is any one or more of mannan oligosaccharide, chitosan oligosaccharide and fructooligosaccharide;

the probiotics are any one or more of bacillus coagulans, bacillus subtilis, clostridium butyricum and lactobacillus;

the carrier is any one of wheat bran, defatted rice bran and rice hull powder.

Technical Field

The invention belongs to the technical field of livestock and poultry breeding, and particularly relates to application of magnolol and/or honokiol in a feed additive in poultry breeding.

Background

Since the 40 th of the 20 th century, antibiotics are widely applied to livestock and poultry breeding as feed additives, can reduce the diarrhea rate of animals under certain conditions, regulate intestinal microbial flora, inhibit pathogenic bacteria and host competitive nutrient substances, and accordingly improve the growth performance of the animals and the utilization rate of the feed.

Statistically, among the currently used feed antibiotics in the world, 42% of the growth-promoting antibiotics account for the growth, and only 18% of the antibiotics account for the treatment. The phenomenon of antibiotic abuse is widespread. The long-term use of antibiotics can cause the drug resistance problem of pathogenic bacteria, also can destroy the micro-ecological balance in the intestinal tracts of livestock and poultry, and cause endogenous infection or double infection, so that the cellular immunity and the humoral immunity of the livestock and poultry are reduced, and the production performance is influenced; antibiotics generate residues in livestock and poultry products such as meat, eggs and milk, directly threaten the health and safety of human bodies, and have adverse effects on public health.

With the increasing concern of human beings on food safety, safety problems such as antibiotic and chemical drug residues become more and more prominent, and the development of the feed industry and the breeding industry is seriously hindered.

The intestinal health is the most important factor for the healthy growth of livestock and poultry. Therefore, the nutrition regulation and control means can promote the intestinal health degree, the immunologic function and the nutrition absorption function, improve the intestinal microecology, and is an important means for ensuring the organism health of livestock and poultry and improving the production performance of livestock and poultry.

Magnolol and honokiol are main active ingredients of cortex magnoliae officinalis, and have multiple physiological functions of resisting oxidation, inflammation and tumor. Previous research results prove that magnolol and honokiol have the following effects on common intestinal pathogens of chickens in vitro: the escherichia coli, the salmonella pullorum and the clostridium perfringens have obvious inhibiting effect; magnolol and honokiol can also be used for improving livestock and poultry intestinal immunity, promoting intestinal mucosa development, maintaining digestive tract microecological balance, and improving tissue antioxidant ability to ensure livestock and poultry intestinal health. Therefore, the development of the feed additive which takes magnolol and honokiol as main active ingredients and can replace antibiotics is of great significance for promoting the healthy development of the livestock industry.

Disclosure of Invention

The invention aims to provide a method for effectively promoting the development of intestinal mucosa, improving the oxidation resistance of the intestinal tract and effectively relieving the intestinal injury caused by pathogenic bacteria in the intestinal tract of poultry aiming at the health of the intestinal tract of the poultry. The invention relates to an application of magnolol and/or honokiol in preparing a feed additive for improving the intestinal health of poultry.

In order to achieve the purpose, the invention provides the following technical scheme: application of magnolol and/or honokiol in poultry breeding, and application of magnolol and/or honokiol in feed additives for promoting intestinal villus development and improving intestinal mucosa oxidation resistance.

Preferably, the magnolol and/or honokiol is applied to poultry breeding, and the magnolol and/or honokiol is applied to feed additives for relieving poultry intestinal pathogenic bacteria infection, stress-caused intestinal injury and production performance reduction.

Preferably, the magnolol and/or honokiol is applied to poultry breeding, and the magnolol and/or honokiol is applied to feed additives for reducing feed conversion ratio.

Preferably, the magnolol and/or honokiol are/is applied to poultry breeding, and the feed additive containing magnolol and honokiol is used for daily ration of broiler chickens, wherein the weight ratio of magnolol to honokiol is 1: 2-3.

Preferably, the magnolol and/or honokiol are/is applied to poultry breeding, the feed additive containing magnolol and honokiol is used for daily ration of laying hens, and the weight ratio of magnolol to honokiol is 1: 0.5-1.

Preferably, the feed additive containing magnolol and/or honokiol comprises, by weight, 0-30 parts of magnolol, 0-30 parts of honokiol, 5-10 parts of organic acid, 5-10 parts of functional oligosaccharide, 5-10 parts of probiotics, 1-5 parts of vitamin E and 40-75 parts of a carrier.

Preferably, the feed additive containing magnolol and/or honokiol as described above has a content of magnolol and/or honokiol of 20-30%.

Preferably, the feed additive containing magnolol and/or honokiol as described above has a mass concentration of 0.5-1kg/t in the feed.

Preferably, the feed additive containing magnolol and/or honokiol as described above, wherein the organic acid is any one or more of lactic acid, formic acid, propionic acid, butyric acid, citric acid, fumaric acid and salts thereof;

the functional oligosaccharide is any one or more of mannan oligosaccharide, chitosan oligosaccharide and fructooligosaccharide;

the probiotics are any one or more of bacillus coagulans, bacillus subtilis, clostridium butyricum and lactobacillus;

the carrier is any one of wheat bran, defatted rice bran and rice hull powder.

Depending on the purpose of use, magnolol and/or honokiol, when applied to a pharmaceutical or feed additive for improving the intestinal health of poultry, may contain, in addition to the compositions of the preferred embodiments listed above, other natural or synthetic substances having a synergistic effect on their basic active ingredients.

Compared with the prior art, the invention has the following advantages:

(1) the invention discovers new application of known compounds magnolol and honokiol in promoting intestinal development and ensuring intestinal health, and develops new application fields.

(2) The invention is a safe and efficient feed additive, improves the production performance of livestock and poultry by regulating and controlling the intestinal health, has no side effect on the livestock and poultry, and is not easy to generate drug resistance.

(3) According to the invention, appropriate amounts of organic acid, functional oligosaccharide, vitamin E and probiotics cooperate with magnolol and honokiol to exert biological activity, so that intestinal villus development is promoted, and poultry production performance is improved.

Detailed Description

In order to better understand the essence of the present invention, the following examples are given in more detail, but the following examples are only illustrative, and the present invention is not limited by these examples. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.