阅读说明：本技术 用于递送核酸的新型羰基脂质和脂质纳米颗粒制剂 (Novel carbonyl lipid and lipid nanoparticle formulations for delivery of nucleic acids ) 是由 杜新曜 史蒂文·M·安塞尔 于 2018-04-27 设计创作，主要内容包括：提供了具有以下结构(I)或(II)中的一种的化合物：<Image he="304" wi="700" file="DDA0002335743290000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>或者其药学上可接受的盐、互变异构体或立体异构体,其中R3a、R3b、L1、L2、G1a、G1b、G2a、G2b和G3如本文所限定。还提供了所述化合物作为脂质纳米颗粒制剂的组分以用于递送治疗剂的用途、包含所述化合物的组合物及其使用和制备方法。(Provided are compounds having one of the following structures (I) or (II): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b, and G3 are as defined herein. Also provided are uses of the compounds as components of lipid nanoparticle formulations for the delivery of therapeutic agents, compositions comprising the compounds, and methods of use and preparation thereof.)