阅读说明：本技术 可溶性和免疫反应性寨卡病毒ns1多肽 (Soluble and immunoreactive Zika virus NS1 polypeptide ) 是由 E.法茨 M.格勒克 P.明希 A.里德尔 C.舒尔茨 G.塔巴雷斯 于 2018-04-23 设计创作，主要内容包括：本发明涉及适合于检测分离的生物样品中的针对寨卡病毒的抗体的多肽,其包含寨卡病毒NS1侧翼结构域特异性氨基酸序列及其变体,其中没有另外的寨卡病毒特异性氨基酸序列存在于所述多肽中。该多肽不与针对来自蜱传脑炎病毒、登革病毒1-4、西尼罗病毒、黄热病毒或日本脑炎病毒的结构相关抗原产生的抗体免疫交叉反应,但与针对全长寨卡病毒NS1抗原产生的抗体免疫反应。还公开了产生可溶性和免疫反应性寨卡病毒NS1多肽的方法以及用于检测分离的样品中的对于寨卡病毒特异性的抗体的方法和试剂盒。(The present invention relates to polypeptides suitable for detecting antibodies to Zika virus in an isolated biological sample comprising Zika virus NS1 flanking domain-specific amino acid sequences and variants thereof, wherein no additional Zika virus-specific amino acid sequences are present in the polypeptides. The polypeptide does not immunologically cross-react with antibodies raised against structurally related antigens from tick-borne encephalitis virus, dengue virus 1-4, west nile virus, yellow fever virus or japanese encephalitis virus, but is immunologically reactive with antibodies raised against the full-length zika virus NS1 antigen. Also disclosed are methods of producing soluble and immunoreactive Zika virus NS1 polypeptides and methods and kits for detecting antibodies specific for Zika virus in an isolated sample.)