阅读说明：本技术 一种磁珠分析杯、抓杯系统、凝血分析仪以及抓杯方法 (Magnetic bead analysis cup, cup grabbing system, blood coagulation analyzer and cup grabbing method ) 是由 吴绍勇 肖清文 尚添 于 2019-10-24 设计创作，主要内容包括：本发明适用于医疗器械技术领域,提供了一种磁珠分析杯、抓杯系统、凝血分析仪以及抓杯方法。磁珠分析杯,用于与光学杯配合使用的抓杯系统,包括杯体,杯体的杯底设有供磁力可驱动粒子做往返滚动的弧道,杯体上设有用于供抓杯系统抓取的待夹持部,待夹持部包括与抓杯系统的抓取部相适配的凸出部。本发明提供的磁珠分析杯,能够和光学杯适配同一套抓杯系统,省略掉了原始磁珠分析杯的抓杯系统,简化了凝血分析仪的结构,降低了抓杯系统的控制复杂性,从而降低了故障率；此外,磁珠分析杯生产成本低,且更易于加工生产,可大批量生产。(The invention is applicable to the technical field of medical instruments, and provides a magnetic bead analysis cup, a cup grabbing system, a blood coagulation analyzer and a cup grabbing method. Magnetic bead analysis cup for with optics cup cooperation use grab a cup system, including the cup, the bottom of cup is equipped with and supplies magnetic force can drive the particle and do the arc way that comes and goes the roll, be equipped with on the cup to be used for supplying to grab the portion of treating that the cup system snatched, treat that the clamping part includes and grab the bulge of the looks adaptation of the portion of snatching of cup system. The magnetic bead analysis cup provided by the invention can be matched with an optical cup to form a cup grabbing system, so that the cup grabbing system of the original magnetic bead analysis cup is omitted, the structure of a blood coagulation analyzer is simplified, the control complexity of the cup grabbing system is reduced, and the failure rate is reduced; in addition, the magnetic bead analysis cup has low production cost, is easier to process and produce and can be produced in large batch.)

1. A magnetic bead analysis cup is used for being matched with a cup grabbing system of an optical cup and is characterized by comprising a cup body, an arc channel for magnetic force to drive particles to roll back and forth is arranged at the bottom of the cup body, a to-be-clamped portion for the cup grabbing system to grab is arranged on the cup body, and the to-be-clamped portion comprises a protruding portion matched with the grabbing portion of the cup grabbing system.

2. The magnetic bead analysis cup of claim 1, wherein the protrusion is disposed on one side of the cup wall or on opposite sides of the cup wall, and the protrusion has a curved surface.

3. The magnetic bead analysis cup of claim 1, wherein the protrusion is disposed on a top of the cup body, the protrusion is a hollow cylinder, an outer side of the cylinder is a curved surface, and a bottom of the cylinder is integrally connected and communicated with a rim of the cup body.

4. The analysis cup for magnetic beads of any of claims 1 to 3, wherein the portion to be clamped further comprises a flange disposed on the protrusion.

5. The analysis cup for magnetic beads according to any of claims 1 to 3, wherein the cup body has a square flat shape, and the walls of the cup body and the side surfaces of the slide that are perpendicular to the direction in which the particles are driven to roll are smoothly curved.

6. The magnetic bead analysis cup of any one of claims 1-3, wherein the magnetic bead analysis cup further comprises magnetically actuable particles.

7. A magnetic bead analysis cup according to claim 2 or 3, wherein the portion to be gripped is provided with stoppers on opposite sides of the protrusion, the stoppers abutting against the gripping portion of the gripping system when the gripping system grips the protrusion.

8. A cup grasping system for a coagulation analyzer, comprising the magnetic bead analysis cup according to any one of claims 1 to 7, an optical cup, and a gripper mechanism that can grasp the magnetic bead analysis cup or the optical cup.

9. The coagulation analyzer of claim 8, wherein the grasping mechanism comprises a mounting member, grasping fingers movably disposed opposite to the mounting member, and elastic members connected to the grasping fingers, wherein the opposing grasping fingers form grasping portions for grasping the protrusions, and the elastic members provide tightening pretension to the opposing grasping fingers.

10. The coagulation analyzer as claimed in claim 9, wherein the portion to be clamped comprises a cambered protrusion arranged on one side or two opposite sides of the cup wall of the cup body, a flange is arranged outside the protrusion, and the grabbing finger is provided with a clamping groove matched with the flange;

or, treat the clamping part including set up in the cavity cylinder at cup top, the lateral surface of cylinder is the cambered surface, the bottom of cylinder with the rim of a cup body coupling, the outside flange of cylinder, snatch the finger be equipped with flange assorted draw-in groove.

11. A coagulation analyzer comprising the cup grasping system according to any one of claims 8 to 10.

12. A cup gripping method applied to the cup gripping system according to any one of claims 8 to 10, comprising the steps of:

s1: the gripper mechanism grips the magnetic bead analysis cup/the optical cup;

s2: the driving device drives the hand grab mechanism to drive the magnetic bead analysis cup/the optical cup to move to an incubation position of the blood coagulation analyzer to incubate the sample in the magnetic bead analysis cup/the optical cup;

s3: the driving device of the cup grabbing system drives the grabbing mechanism to drive the magnetic bead analysis cup/optical cup to move from the incubation position to the test reagent loading position of the coagulation analyzer, and a reagent loading module of the coagulation analyzer loads a test reagent to the magnetic bead analysis cup/optical cup;

s4: the mixing mechanism of the cup grabbing system is used for mixing the liquid in the magnetic bead analysis cup or the optical cup;

s5: the driving device drives the gripper mechanism to drive the magnetic bead analysis cup/optical cup to move from the incubation position to the measurement position of the blood coagulation analyzer so as to measure the liquid in the analysis cup;

s6: the driving gripper mechanism drives the magnetic bead analysis cup/optical cup to move from the measurement position to the waste disposal cup position, and then the magnetic bead analysis cup/optical cup is discarded.

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a magnetic bead analysis cup, a cup grabbing system, a blood coagulation analyzer and a cup grabbing method.

Background

The development of medical equipment and biotechnology, the basic theory of hemostasis and thrombosis and the application thereof are gradually improved, and the automatic blood coagulation analyzer is rapidly developed and applied to the diagnosis and treatment process.

Among the blood coagulation tests, the magnetic bead method and the optical method are the mainstream in the market at present, but in the blood coagulation test, when interfering substances such as hemolysis, jaundice and blood fat exist in a sample, the measurement result of the optical method is influenced. The magnetic bead method is to drive a demagnetizing steel bead to move in a sample by using magnetic force, and when the sample is solidified, the movement of the demagnetizing steel bead is gradually stopped. The steel ball particle displacement sensing device is used for receiving the movement of the demagnetized steel ball and calculating the blood coagulation time, so that the optical interference of hemolysis, jaundice and blood fat on blood coagulation detection is avoided.

The existing blood coagulation analyzer with both an optical method and a magnetic bead method is completed by adopting the optical method through most tests, so that the characteristics of low cost, high precision and high reliability of the optical method instrument are reserved, and the test economy is greatly improved; a few interference samples are tested by a magnetic bead method, and the anti-interference advantage of the magnetic bead method is taken into consideration. However, the bottom of the magnetic bead analysis cup is provided with a slideway with a certain stroke for the magnetic bead to move back and forth, so that the overall size of the magnetic bead analysis cup is large, the optical analysis cup does not contain particles, and only needs to have a light transmission function, under the condition that the magnetic bead analysis cup needs to have the slideway function and the optical analysis cup only needs to be light-transmitting, the overall sizes of the shapes of the cup bodies of the magnetic bead analysis cup and the optical analysis cup are large, and the magnetic bead analysis cup has different geometrical structural characteristics.

Disclosure of Invention

The embodiment of the invention provides a magnetic bead analysis cup, and aims to solve the technical problems that in the related art, a coagulation analyzer with an optical method and a magnetic bead method needs to be provided with two sets of cup grabbing systems independently, so that the structural complexity of the analyzer is increased, the control complexity is high, the failure rate is high, and the two sets of cup grabbing systems are easy to interfere with each other.

The embodiment of the invention is realized in such a way that the magnetic bead analysis cup is used for a cup grabbing system matched with an optical cup, the magnetic bead analysis cup comprises a cup body, an arc channel for enabling magnetic force to drive particles to roll back and forth is arranged at the bottom of the cup body, a part to be clamped for grabbing by the cup grabbing system is arranged on the cup body, and the part to be clamped comprises a protruding part matched with the grabbing part of the cup grabbing system.

Furthermore, the bulge is arranged on one side of the cup wall of the cup body or on two opposite sides of the cup wall and protrudes out of the bulge of the cup wall of the cup body, and the bulge is of an arc-shaped structure.

Further, the bulge is arranged at the top of the cup body and is a hollow cylinder, the outer side surface of the cylinder is an arc surface, and the bottom of the cylinder is communicated with the cup body.

Further, the part to be clamped also comprises a flange arranged on the protruding part.

Furthermore, the cup body is in a square flat shape, and the arc surfaces of the cup wall of the cup body and the side surface of the slide way, which is vertical to the rolling direction of the drivable particles, are in smooth transition.

Further, the magnetic bead analysis cup further comprises magnetically actuable particles.

Furthermore, the part to be clamped is provided with limiting blocks on two opposite sides of the protruding part, and the limiting blocks are abutted against the grabbing part of the grabbing system when the cup grabbing system grabs the protruding part.

The invention also provides a cup grabbing system which comprises the magnetic bead analysis cup, the optical cup and the hand grab mechanism, wherein the hand grab mechanism can grab the magnetic bead analysis cup or the optical cup.

Further, the grabbing mechanism comprises an installation part, grabbing fingers movably and oppositely arranged on the installation part and elastic pieces connected with the grabbing fingers, the grabbing fingers oppositely arranged form grabbing parts for grabbing the protruding parts, and the elastic pieces provide tightening pretightening force for the grabbing fingers oppositely arranged.

Furthermore, the part to be clamped comprises an arc-shaped protruding part arranged on one side or two opposite sides of the cup wall of the cup body, a flange is arranged outside the protruding part, and a clamping groove matched with the flange is formed in the grabbing finger;

or, treat the clamping part including setting up in the cavity cylinder at cup top, the lateral surface of cylinder is the cambered surface, the bottom of cylinder and the rim of a cup body coupling, the outside flange of cylinder snatchs the finger and is equipped with the draw-in groove with flange assorted.

The invention also provides a coagulation analyzer which comprises the cup grabbing system.

The invention also provides a cup grabbing method which is applied to the cup grabbing system and is characterized by comprising the following steps of:

s1: the gripper mechanism grips the magnetic bead analysis cup/optical cup;

s2: the driving device drives the gripper mechanism to drive the magnetic bead analysis cup/the optical cup to move to an incubation position of the blood coagulation analyzer to incubate the sample in the magnetic bead analysis cup/the optical cup;

s3: a driving device of the cup grabbing system drives a grabbing hand mechanism to drive the magnetic bead analysis cup/the optical cup to move from the incubation position to a test reagent loading position of the coagulation analyzer, and a reagent loading module of the coagulation analyzer loads a test reagent to the magnetic bead analysis cup/the optical cup;

s4: a mixing mechanism of the cup grabbing system is used for mixing liquid in the magnetic bead analysis cup or the optical cup;

s5: the driving device drives the gripper mechanism to drive the magnetic bead analysis cup/optical cup to move from the incubation position to the measurement position of the blood coagulation analyzer so as to measure the liquid in the analysis cup;

s6: the driving and driving gripper mechanism is driven to drive the magnetic bead analysis cup/optical cup to move from the measurement position to the waste cup throwing position, and then the magnetic bead analysis cup/optical cup is discarded.

The invention achieves the following beneficial effects: the cup body of the magnetic bead analysis cup is provided with the to-be-clamped part matched with the cup grabbing system of the optical cup, so that the purpose of matching the same set of cup grabbing system with the optical cup is achieved, the cup grabbing system of the original magnetic bead analysis cup is omitted, the structure of the blood coagulation analyzer is simplified, the control complexity of the cup grabbing system is reduced, and the failure rate is reduced; in addition, the magnetic bead analysis cup has low production cost, is easier to process and produce and can be produced in large batch.

Drawings

FIG. 1 is a schematic structural diagram of an embodiment of a magnetic bead analysis cup according to the present invention;

FIG. 2 is a schematic diagram of another embodiment of a magnetic bead analysis cup according to the present invention;

FIG. 3 is a schematic diagram of another embodiment of a magnetic bead analysis cup according to the present invention;

FIG. 4 is a schematic diagram of a magnetic bead analysis cup grabbed by the cup grabbing system of the blood coagulation analyzer provided by the present invention;

FIG. 5 is a schematic diagram of a grasping optical cup of the cup grasping system of the coagulation analyzer according to the present invention;

fig. 6 is a schematic structural diagram of a gripper mechanism of a cup gripping system of a coagulation analyzer according to the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The existing magnetic bead analysis cup needs to be provided with an arc channel which can drive particles to roll back and forth by magnetic force, so that the size and the structure of the magnetic bead analysis cup are both larger and more complex compared with an optical cup, and the optical cup only needs to meet the light transmission function, so that the size and the shape of the optical cup are small and exquisite and simple. The existing coagulation analyzer has the analysis functions of a magnetic bead method and an optical method, so that two sets of independent cup grabbing systems are arranged to respectively adapt to an optical cup and a magnetic bead analysis cup, but the two sets of cup grabbing systems are arranged, the structural complexity of the instrument is greatly increased, the complexity of the cup grabbing control process of the cup grabbing systems is increased, the fault rate is high, the practicability of the coagulation analyzer with the optical method and the magnetic bead method is reduced, and the two sets of cup grabbing systems easily cause mutual interference. The invention provides a magnetic bead analysis cup, which can be matched with an optical cup through improving the structure of the magnetic bead analysis cup, saves a cup grabbing system of an original magnetic bead analysis cup, simplifies the structure of a blood coagulation analyzer, reduces the control complexity of the cup grabbing system, and reduces the failure rate.