阅读说明：本技术 红毛丹果皮提取物在皮肤和/或粘膜保湿中的用途 (Use of extract of rambutan peel for moisturizing skin and/or mucous membranes ) 是由 I·博内 S·卡道 L·达努斯 C·德尔策维耶 S·莱欧缇-欧卡姆毕 于 2018-08-01 设计创作，主要内容包括：本发明涉及植物红毛丹的果皮提取物在维持和/或增加皮肤和/或粘膜的保湿作用和/或屏障作用中的美容化妆用途。该果皮提取物增加外皮蛋白合成、透明质酸含量、ATP和牛磺酸转运蛋白TAUT的合成。本发明还涉及美容化妆护理方法,该方法包括局部应用红毛丹的果皮提取物。最后,本发明涉及所述果皮提取物在治疗和/或预防皮肤和/或粘膜异常干燥状态导致的病理状况中的用途,特别是皮肤病学用途。(The present invention relates to the cosmetic use of extracts of the pericarp of the plant rambutan for maintaining and/or increasing the moisturization and/or barrier action of the skin and/or mucous membranes. The pericarp extract increases involucrin synthesis, hyaluronic acid content, ATP and taurine transporter TAUT synthesis. The invention also relates to a cosmetic makeup care method comprising the topical application of an extract of the peel of rambutan. Finally, the invention relates to the use of said extract of the fruit peel for treating and/or preventing pathological conditions resulting from an abnormal dry state of the skin and/or mucous membranes, in particular for dermatological use.)

1. Cosmetic use of extract of the pericarp of rambutan for maintaining and/or increasing the moisturization and/or barrier action of healthy skin and/or healthy mucous membranes, advantageously of healthy dry skin and/or healthy dry mucous membranes.

2. Cosmetic use as claimed in claim 1, characterized in that the extract of the pericarp increases the synthesis of involucrin and/or the hyaluronic acid content in the skin and/or mucous membranes.

3. Use as claimed in any one of claims 1 and 2, wherein the extract is obtained by extraction in a solvent or solvent mixture, such as water, alcohol, glycol, polyol, water/alcohol, water/glycol or water/polyol mixtures (e.g. water mixed with ethanol, glycerol and/or butylene glycol and/or other glycols such as xylitol and/or propylene glycol), in a ratio of 99/1-1/99 (w/w).

4. The use as claimed in any one of claims 1 to 3, wherein the extract is obtained by extraction in water as the sole solvent.

5. Cosmetic use as claimed in any one of claims 1 to 4, by topical or oral application, preferably by topical application.

6. Cosmetic use as claimed in any one of claims 1 to 5, characterized in that the extract is applied to healthy dry skin and/or healthy dry mucous membranes.

7. Cosmetic use as claimed in any one of claims 1 to 6, characterized in that the extract increases the radiance of the skin complexion.

8. Cosmetic use as claimed in claim 7, wherein the extract increases the synthesis of the ATP and/or taurine transporter TAUT.

9. Cosmetic use as claimed in any one of claims 1 to 8, characterized in that the extract is dissolved in an aqueous solution comprising glycerol, advantageously present in a concentration of 60% to 90% by weight, more advantageously in a concentration of 70% to 85% by weight, very advantageously in a concentration of 80% by weight, relative to the total weight of the aqueous solution comprising the extract.

10. Cosmetic use as claimed in any one of claims 1 to 9, characterized in that, in a cosmetic composition comprising at least one acceptable cosmetic vehicle, the extract is present at 1 x 10-⁴-10% by weight, preferably 1X 10-⁴-5% by weight and more preferably 1X 10-³-3% by weight is present in the composition.

11. Cosmetic makeup care process comprising the application, preferably topical application, of an extract as defined in any one of claims 1 to 6 or of a cosmetic makeup composition comprising it, for maintaining and/or increasing the moisturizing effect and/or barrier effect of healthy skin and/or healthy mucous membranes, advantageously of healthy dry skin and/or healthy dry mucous membranes, and/or for increasing the radiance of the skin complexion.

12. Cosmetic makeup method as claimed in claim 11, for increasing involucrin synthesis and/or hyaluronic acid content in the skin and/or mucous membranes, and/or for increasing synthesis of the ATP and/or taurine transporter TAUT in the skin.

13. Cosmetic makeup care process as claimed in any one of claims 11 and 12, wherein it comprises the topical application of an extract as defined in any one of claims 1 to 6, or of a cosmetic makeup composition comprising it, to all or part of the body and/or face and/or mucous membranes, advantageously selected from the group consisting of legs, feet, axilla, hands, thighs, stomach, chest, neck, arms, trunk, back, lip mucous membranes, face and/or scalp, more advantageously the chest and/or face, even more advantageously the face.

14. Extract of the pericarp of rambutan or a pharmaceutical, preferably dermatological, composition comprising it, for use in the prevention and/or treatment of pathological conditions resulting from an abnormally dry state of the skin and/or mucous membranes, such as atopic dermatitis, fissures, eczema and/or ichthyosis, preferably dermatological use.

15. Extract as claimed in claim 14, characterized in that it is present at 1 x 10-⁴A concentration of% -10% by weight, advantageously 1X 10-³-3% by weight, more advantageously 0.01% to 3% by weight relative to the total weight of the composition.

16. An extract as claimed in any one of claims 14 or 15, as defined in claim 3 or 4.

Example 1: method for preparing rambutan extract according to the invention