阅读说明：本技术 生物医用可降解材料及其制备方法 (Biomedical degradable material and preparation method thereof ) 是由 李扬德 于 2019-10-24 设计创作，主要内容包括：本发明公开一种生物医用可降解材料,包括镁或镁合金基体,镁或镁合金基体的表面构筑有活性涂层,活性涂层表面通过磁控溅射机溅射出一层铁/锌离子膜,铁/锌离子膜的厚度为1-5μm,因此,既保持了镁及镁合金基体的力学性能,在增加生物相容性的基础上,控制镁及镁合金基体的降解速度,有效地延长了生物医用可降解材料的使用寿命,满足临床的需要。另外,本发明还公开了一种生物医用可降解材料的制备方法,通过该方法制备生物医用可降解材料,活性涂层增加了生物医用支架的生物相容性,生物医用支架表面沉积铁/锌离子膜有助于控制镁或镁合金生物医用支架的降解速度,有效地延长了生物医用支架的使用寿命。(The invention discloses a biomedical degradable material, which comprises a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, a layer of iron/zinc ion film is sputtered on the surface of the active coating by a magnetron sputtering machine, and the thickness of the iron/zinc ion film is 1-5 mu m, so that the mechanical property of the magnesium or magnesium alloy matrix is maintained, the degradation speed of the magnesium or magnesium alloy matrix is controlled on the basis of increasing the biocompatibility, the service life of the biomedical degradable material is effectively prolonged, and the clinical requirement is met. In addition, the invention also discloses a preparation method of the biomedical degradable material, the active coating layer of the biomedical degradable material prepared by the method increases the biocompatibility of the biomedical bracket, and the iron/zinc ionic membrane deposited on the surface of the biomedical bracket is beneficial to controlling the degradation speed of the magnesium or magnesium alloy biomedical bracket, thereby effectively prolonging the service life of the biomedical bracket.)

1. The biomedical degradable material is characterized by comprising a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, a layer of iron/zinc ion film is sputtered on the surface of the active coating through a magnetron sputtering machine, and the thickness of the iron/zinc ion film is 1-5 mu m.

2. The biomedical degradable material of claim 1, wherein the magnesium or magnesium alloy matrix is a biomedical scaffold with a specific shape, and the active coating is a granular hydroxyapatite coating.

3. A preparation method of a biomedical degradable material is characterized by comprising the following steps:

(1) providing a magnesium or magnesium alloy matrix, and processing the magnesium or magnesium alloy matrix into a biomedical stent with a specific shape;

(2) constructing an active coating on the surface of the biomedical stent;

(3) feeding the biomedical bracket into a magnetron sputtering machine by taking iron/zinc metal as a target material;

(4) depositing an iron/zinc ion film on the surface of the biomedical scaffold by using a low-temperature sputtering method.

4. The method for preparing a biodegradable material for biomedical use according to claim 3, characterized in that the low temperature condition is from room temperature to 100 ℃.

5. The method for preparing the biomedical degradable material according to the claim 3 is characterized in that the method further comprises the step of cleaning the magnesium or magnesium alloy matrix before the step (1).

Technical Field

The invention relates to the technical field of biomedical materials, in particular to a biomedical degradable material and a preparation method thereof.

Background

In recent years, biomaterials are widely used in the medical field and have been clinically successful, providing a material basis for the development of artificial organs and some medical instruments. During medical procedures, sometimes temporary materials are required, such as internal fixation of fractures, which require the implant material to be biodegradable during wound healing or drug release.

Biomedical degradable materials are used for medical purposes, and some materials are implanted into the interior of an animal or human body for a long time, so that the requirements on the materials are relatively severe. Firstly, the degradable material needs to have good biocompatibility, the time for degradation needs to be controlled by controlling certain conditions, and the final material can be ensured to be discharged out of the body through the metabolic system or the excretory system of the human body. Magnesium and magnesium alloy are widely applied in the medical field, and magnesium has the function of inducing bone growth, accelerates the healing of bones, has good biocompatibility and can be automatically degraded in vivo. However, magnesium and magnesium alloy are very easy to corrode in a weak acid environment for a long time after being implanted into a human body, excessive magnesium ions are generated to cause diseases if the corrosion speed is too high, and the disappearance of an implant before the body is completely recovered causes treatment failure.

Therefore, there is an urgent need for a biodegradable biomedical material with controlled degradation rate and good biocompatibility and a preparation method thereof.

Disclosure of Invention

The invention aims to provide a biomedical degradable material which can control the degradation speed and keep good biocompatibility.

The invention also aims to provide a preparation method of the biomedical degradable material, and the biomedical degradable material with good biocompatibility and controllable degradation rate is prepared by the method.

In order to achieve the purpose, the invention provides a biomedical degradable material which comprises a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, an iron/zinc ion film is sputtered on the surface of the active coating through a magnetron sputtering machine, and the thickness of the iron/zinc ion film is 1-5 mu m.

Compared with the prior art, the biomedical degradable material comprises a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, a layer of iron/zinc ion film is sputtered on the surface of the active coating through a magnetron sputtering machine, and the thickness of the iron/zinc ion film is 1-5 mu m, so that the mechanical property of the magnesium or magnesium alloy matrix is maintained, the degradation speed of the magnesium or magnesium alloy matrix is controlled on the basis of increasing the biocompatibility, the service life of the biomedical degradable material is effectively prolonged, and the clinical requirement is met.

Specifically, the magnesium or magnesium alloy substrate is a biomedical stent with a specific shape, and the active coating is a granular hydroxyapatite coating. The hydroxyapatite is alkalescent and has good biocompatibility and bioactivity, and the hydroxyapatite particles stabilize the degradation rate of the material and enable the corrosion to be more uniformly carried out.

The invention provides a preparation method of a biomedical degradable material, which comprises the following steps:

(1) providing a magnesium or magnesium alloy matrix, and processing the magnesium or magnesium alloy matrix into a biomedical stent with a specific shape;

(2) constructing an active coating on the surface of the biomedical stent;

(3) feeding the biomedical bracket into a magnetron sputtering machine by taking iron/zinc metal as a target material;

(4) depositing an iron/zinc ion film on the surface of the biomedical bracket by using a low-temperature sputtering method.

Compared with the prior art, the preparation method of the biomedical degradable material has the advantages that an active coating is constructed on the surface of the biomedical stent, iron/zinc metal is used as a target material, the biomedical stent is sent into a magnetron sputtering machine, and an iron/zinc ion film is deposited on the surface of the biomedical stent by using a low-temperature sputtering method. The active coating increases the biocompatibility of the biomedical stent, and the iron/zinc ion film deposited on the surface of the biomedical stent is beneficial to controlling the degradation speed of the magnesium or magnesium alloy biomedical stent. Therefore, the mechanical property of the magnesium and magnesium alloy biomedical stent is maintained, the degradation speed of the magnesium and magnesium alloy matrix is controlled on the basis of increasing the biocompatibility, the service life of the biomedical stent is effectively prolonged, and the clinical requirement is met.

Specifically, the low temperature condition is room temperature to 100 ℃.

Preferably, step (1) is preceded by a step of cleaning the magnesium or magnesium alloy substrate.

Detailed Description

The present invention will be described in detail with reference to the following embodiments.

The biomedical degradable material comprises a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, a layer of iron/zinc ion film is sputtered on the surface of the active coating through a magnetron sputtering machine, the thickness of the iron/zinc ion film is 1-5 mu m, and the thickness of the active coating is 10-20 nm.

Preferably, the magnesium alloy matrix contains rare earth elements. Not only can effectively enhance the corrosion resistance and the mechanical property, but also is beneficial to improving the anticoagulation behavior of the biomedical bracket. Specifically, the magnesium alloy matrix contains Cu, Al, MgO, rare earth elements, and the balance of Mg and inevitable impurities. The rare earth elements are added into the magnesium alloy, so that the harmful influence of impurity elements in a magnesium alloy matrix can be reduced, the corrosion resistance of the magnesium alloy is improved, and the mechanical property of the magnesium alloy is enhanced.

Specifically, the magnesium or magnesium alloy substrate is a biomedical stent with a specific shape, and the active coating is a granular hydroxyapatite coating. The hydroxyapatite is alkalescent and has good biocompatibility and bioactivity, and the hydroxyapatite particles stabilize the degradation rate of the material and enable the corrosion to be more uniformly carried out.

The invention provides a preparation method of a biomedical degradable material, which comprises the following steps:

(1) providing a magnesium or magnesium alloy matrix, and processing the magnesium or magnesium alloy matrix into a biomedical stent with a specific shape;

(2) constructing an active coating on the surface of the biomedical stent;

(3) feeding the biomedical bracket into a magnetron sputtering machine by taking iron/zinc metal as a target material;

(4) depositing an iron/zinc ion film on the surface of the biomedical bracket by using a low-temperature sputtering method.

Preferably, step (1) is preceded by a step of cleaning the magnesium or magnesium alloy substrate.

Depositing a hydroxyapatite coating on the surface of the biomedical scaffold by a bionic method. When the magnetron sputtering machine is used for depositing the iron/zinc ion film on the surface of the biomedical bracket, the vacuum degree of the magnetron sputtering machine is adjusted to 5 multiplied by 10^-4Pa, filling high-purity argon to stabilize the air pressure in the vacuum device at about 0.5 Pa; starting a power supply, gradually increasing current, controlling the heating temperature below 100 ℃, cleaning the biomedical bracket with the hydroxyapatite coating, putting the biomedical bracket into a magnetron sputtering machine, taking iron and zinc metals as target materials, respectively placing the target materials on a target table in a vacuum chamber, depositing a layer of iron/zinc ion film on the surface of the biomedical bracket, and adjusting the thickness of the iron/zinc ion film by adjusting the sputtering time (10-20min) and the current (2-5A). It can be understood that a plurality of targets can be used for sputtering, including single-target sputtering, double-target co-sputtering and the like, and parameters such as sputtering time, current and the like can be adjusted according to the thickness and the type of the ionic film to be deposited, so that the iron/zinc ionic film can be deposited on the surface of the biomedical stent.

Compared with the prior art, the biomedical degradable material comprises a magnesium or magnesium alloy matrix, wherein an active coating is constructed on the surface of the magnesium or magnesium alloy matrix, a layer of iron/zinc ion film is sputtered on the surface of the active coating through a magnetron sputtering machine, and the thickness of the iron/zinc ion film is 1-5 mu m, so that the mechanical property of the magnesium or magnesium alloy matrix is maintained, the degradation speed of the magnesium or magnesium alloy matrix is controlled on the basis of increasing the biocompatibility, the service life of the biomedical degradable material is effectively prolonged, and the clinical requirement is met. The biomedical degradable material is prepared by the preparation method of the biomedical degradable material, the biocompatibility of the biomedical stent is increased by the active coating, and the iron/zinc ion film deposited on the surface of the biomedical stent is beneficial to controlling the degradation speed of the magnesium or magnesium alloy biomedical stent.

The above disclosure is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent changes and modifications made according to the contents of the claims of the present invention should be included in the claims of the present invention.