阅读说明：本技术 一种医用可吸收生物材料长丝 (Medical absorbable biomaterial filament ) 是由 袁春雅 于 2019-09-29 设计创作，主要内容包括：本发明公开了一种医用可吸收生物材料长丝,是将胶原类原料经酸性液体中搅拌均匀、过滤除去颗粒杂质、去除气体,得到原料液,利用湿法纺丝技术将原料液注入凝固液中,使原料液定型,再经晾干、搓捻/或不搓捻、交联工艺获得胶原长丝,所得长丝可根据临床需要制作为多种形态产品,如丝线状、膜片状、卷筒状、柱状、球状、块状等。其优点是延长胶原纤维长度、提升胶原纤维强度、获得可完全吸收的胶原长丝,制得产品用于体内或体表,无毒副作用。本发明可实现获得胶原类长丝,并根据市场需要制作成多种产品,整体具有成本低、操作方便、可降解吸收、无毒副作用、纤维长度可控、强度可控的特点。(The invention discloses a medical absorbable biomaterial filament, which is prepared by uniformly stirring collagen raw materials in acidic liquid, filtering to remove particle impurities and gas to obtain raw material liquid, injecting the raw material liquid into coagulating liquid by using a wet spinning technology to shape the raw material liquid, and then carrying out air drying, twisting/or non-twisting and crosslinking processes to obtain the collagen filament. Its advantages are long length of collagen fibres, high strength of collagen fibres, and high absorbability of collagen filaments. The invention can obtain collagen filaments, can be made into various products according to market demands, and has the characteristics of low cost, convenient operation, degradability and absorption, no toxic or side effect, controllable fiber length and controllable strength.)

1. A medical absorbable biomaterial filament, its characterized in that: the raw material may be pure collagen, a complex of collagen and mucopolysaccharide, or a combination of various substances such as collagen and chitosan.

2. The medical absorbable biomaterial filament according to claim 1, wherein: soaking the raw materials in an acidic solution for 6h, stirring for 10-120min or directly stirring for 10-180min until uniform, filtering to remove particle impurities and remove gas to obtain 0.3% -1.0% raw material solution.

3. The medical absorbable biomaterial filament according to claim 2, wherein: the preferable stirring time is 30-90 min; the most preferred stirring time is 30-80 min.

4. The medical absorbable biomaterial filament according to claim 1, wherein:

(1) injecting raw material liquid into coagulating liquid by using a wet spinning technology to obtain monofilaments, multifilaments or specific shapes;

(2) the solidification liquid is a mixture of alcohols, ketones and ammonia water;

(3) after shaping by a coagulating liquid, obtaining collagen filaments by airing, twisting or non-twisting and crosslinking processes;

(4) the length of the filament can be arbitrarily made according to the requirement;

(5) the strength of the filament can be freely made according to the requirement;

(6) the crosslinking process can adopt physical crosslinking, chemical crosslinking and physical-chemical crosslinking, and the crosslinking time is set according to the needs of the product;

(7) the obtained filament can be used for making products such as silk thread clothes, film, reel, column, ball and block.

5. The medical absorbable biomaterial filament as claimed in claim 1, wherein the velocity of the raw material liquid injected into the coagulating liquid is 0.5-20 cm/s.

6. The medical absorbable biomaterial filament according to claim 5, wherein: the preferred rate of injection of the raw material liquid into the coagulation liquid is 4 to 15cm/s, and the most preferred rate of injection of the raw material liquid into the coagulation liquid is 5 cm/s.

7. The medical absorbable biomaterial filament according to claim 1, wherein the physical crosslinking method comprises ultraviolet irradiation, thermal crosslinking; the chemical crosslinking method comprises aldehyde crosslinking, imine crosslinking, diisocyanate crosslinking, genipin crosslinking, azido diphenylphosphine crosslinking and procyanidine crosslinking; and physical-chemical crosslinking methods.

8. A solidification liquid, when the solidification liquid is alcohol, the concentration of the alcohol is 50% -100%; when the solidification liquid is ketone, the concentration of the ketone is 70-100%; when the solidification liquid is a mixture of ketones and ammonia water, the volume ratio is as follows: ketones: ammonia water: 50-150% of water: 3-10: 0.5-1.5.

9. A solidification liquid as claimed in claim 8, wherein: the solidification liquid can also be used for solidification and shaping for manufacturing the medical absorbable material by a 3D printing technology.

Technical Field

The invention relates to the technical field of medical instruments and 3D printing, in particular to a medical absorbable biomaterial filament.

Background

At present, in the technical field of long fibers of collagen products, solutions of the collagen products have different degrees of viscosities, so that the long fibers are difficult to manufacture, and short fibers or entangled long fibers can be obtained by long-time operation such as pH adjustment. In order to manufacture collagen filaments with certain length and strength and meet the requirements of markets on collagen multi-component products, the invention provides the collagen filaments with low investment, convenient operation, degradability and absorption, no toxic or side effect, controllable fiber length and controllable strength.

Disclosure of Invention

In view of the above, the invention provides a collagen filament with low cost, convenient operation, degradability and absorption, no toxic or side effect, controllable fiber length and controllable strength, and various clinically-required products such as silk threads, membranes, rolls, columns, spheres, blocks and the like can be prepared by using the collagen filament.

In order to achieve the purpose, the invention provides the following technical scheme:

a medical absorbable biomaterial filament, characterized by that, the raw material used can be pure collagen, compound of collagen and mucopolysaccharide or combination of collagen and chitosan; uniformly stirring the raw materials by using an acid solution, filtering to remove particle impurities and gas to obtain a raw material solution; injecting raw material liquid into coagulating liquid by using a wet spinning technology to obtain monofilaments, multifilaments or specific shapes; the solidification liquid is a mixture of alcohols, ketones and ammonia water; after shaping by a coagulating liquid, obtaining collagen filaments by airing, twisting or non-twisting and crosslinking processes; the length of the filament can be arbitrarily made according to the requirement; the strength of the filament can be freely made according to the requirement; the crosslinking process can adopt physical crosslinking, chemical crosslinking and physical-chemical crosslinking, and the crosslinking time is set according to the needs of the product; the obtained filament can be used for making products such as silk thread clothes, film, reel, column, ball and block.

In the above medical absorbable biomaterial filament, the raw material may be pure collagen, a compound of collagen and mucopolysaccharide, or a combination of a plurality of substances such as collagen and chitosan.

In the medical absorbable biomaterial filament, when the coagulating liquid is alcohol, the stirring time is 60-90 min; the most preferred stirring time is 20-80 min. The concentration of the alcohol is 50% -100%; when the solidification liquid is ketone, the concentration of the ketone is 70-100%; when the solidification liquid is a mixture of ketones and ammonia water, the volume ratio is as follows: ketones: ammonia water: 50-150% of water: 3-10: 0.5-1.5.

Preferably, in the medical absorbable biomaterial filament, the speed of injecting the raw material liquid into the coagulating liquid is 0.5-20 cm/s.

The preferred rate of injection of the raw material liquid into the coagulation liquid is 4 to 15cm/s, and the most preferred rate of injection of the raw material liquid into the coagulation liquid is 5 cm/s.

Preferably, in the above one medical absorbable biomaterial filament, the physical crosslinking method includes ultraviolet irradiation, thermal crosslinking; the chemical crosslinking method comprises aldehyde crosslinking, imine crosslinking, diisocyanate crosslinking, genipin crosslinking, azido diphenylphosphine crosslinking and procyanidine crosslinking; and physical-chemical crosslinking methods.

According to the technical scheme, the invention discloses a medical absorbable biomaterial filament, collagen raw materials are uniformly stirred in acidic liquid, particle impurities are removed through filtration, gas is removed, raw material liquid is obtained, the raw material liquid is injected into coagulating liquid through a wet spinning technology to be shaped, the collagen filament is obtained through processes of airing, twisting and crosslinking, and the obtained filament can be manufactured into products in various shapes such as thread shape, membrane shape, reel shape, column shape, sphere shape, block shape and the like according to clinical needs.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The embodiment of the invention discloses a method for manufacturing a medical absorbable biomaterial filament with low investment, convenient operation, degradability, absorption, no toxic or side effect, controllable fiber length and controllable strength.