阅读说明：本技术 一种含有噁虫酮和啶虫脒的杀虫组合物及其应用 (Insecticidal composition containing famoxadone and acetamiprid and application thereof ) 是由 田大军 李安明 贾炜 章超 王宝林 于 2019-10-29 设计创作，主要内容包括：本发明公开了一种含有噁虫酮和啶虫脒的杀虫组合物及其应用,有效成分为噁虫酮和啶虫脒,有效成分的总含量为2％-80％,余量为辅料；辅料为助剂,或者助剂和特殊成分；特殊成分为桉叶油、D-柠烯或樟脑醇。该二元组合物解决了卫生害虫对拟除虫菊酯类的抗性问题,提高了防效,降低了用药量,降低了施药刺激性。啶虫脒作为致死剂,本身还具备较好的击倒性能,因而也提高了对卫生害虫的击倒效果。两者不同作用机理的杀虫剂复配也能延缓抗性产生,为防治卫生害虫提供了一种新的思路和方法。(The invention discloses an insecticidal composition containing famoxadone and acetamiprid and application thereof, wherein the active ingredients are famoxadone and acetamiprid, the total content of the active ingredients is 2-80%, and the balance is auxiliary materials; the auxiliary material is an auxiliary agent, or the auxiliary agent and a special component; the special component is eucalyptus oil, D-limonene or camphorol. The binary composition solves the problem of resistance of sanitary pests to pyrethroids, improves the control effect, reduces the dosage and reduces the irritation of pesticide application. The acetamiprid serving as a lethal agent also has better knockdown performance, so that the knockdown effect on sanitary pests is improved. The insecticide with different action mechanisms can also delay the generation of resistance, and provides a new idea and method for preventing and controlling sanitary pests.)

1. An insecticidal composition containing famoxadone and acetamiprid, which is characterized in that: the active ingredients are the famoxadone and the acetamiprid, the total content of the active ingredients is 2% -80%, and the balance is auxiliary materials.

2. The insecticidal composition of claim 1, wherein: the weight ratio of the famoxadone to the acetamiprid is 1: 40-40: 1.

3. The insecticidal composition of claim 1, wherein: the auxiliary material is an auxiliary agent or an auxiliary agent and a special component; when the auxiliary materials are the auxiliary agents and the special components, the content of the special components in the insecticidal composition is 1% -2%, and the balance is the auxiliary agents.

4. The insecticidal composition of claim 3, wherein: the special component is any one of eucalyptus oil, D-limonene and camphorol, or a mixture of two or more than two of the eucalyptus oil, the D-limonene and the camphorol which are mixed in any proportion.

5. The insecticidal composition of claim 3, wherein: the auxiliary agent is any one of dispersing agent, emulsifier, antifreezing agent, thickening agent, preservative, defoaming agent, solvent, wetting agent, disintegrating agent, water and filler, or a mixture of two or more of the dispersing agent, the emulsifying agent, the antifreezing agent, the thickening agent, the preservative, the defoaming agent, the solvent, the wetting agent, the disintegrating agent, the water and the filler.

6. The insecticidal composition of claim 1, wherein: the formulation of the insecticidal composition is missible oil, aqueous emulsion, microemulsion, soluble liquid, suspending agent, wettable powder, water dispersible granule and dry suspending agent.

7. Use of a pesticidal composition according to any one of claims 1 to 6 for controlling sanitary pests.

8. Use according to claim 7, characterized in that: the sanitary pests refer to culex pipiens pallens, culex fatigues, culex tritaeniorhynchus, aedes albopictus, aedes aegypti, anopheles sinensis, aedes infestans, midge, houseflies, city flies, chrysomyia megacephala, lucilia sericata, lucilia cuprina, lucilia, latrine flies, metalatus flies, german cockroaches, american cockroaches, bed bugs, fleas, mangrove ticks, Chinese hard ticks, prairie hard ticks, small cattle ticks, spider mites and scabies.

9. Use according to claim 7, characterized in that: when the insecticidal composition is used for preventing and controlling sanitary pests, the insecticidal composition is diluted by 200-fold and 400-fold with water and is sprayed on the surfaces of walls, doors, windows, ceilings, houses and the like, so that binary sanitary insecticide is remained on the surfaces of the objects, the sanitary pests are knocked down and die, and the applicable formulations of the insecticidal composition are suspending agents, wettable powder, water dispersible granules and dry suspending agents.

10. Use according to claim 7, characterized in that: when the insecticidal composition is used for preventing and controlling sanitary pests, the insecticidal composition is diluted by 20-40 times by using water, and is uniformly sprayed into a space by using spraying equipment such as an ultralow-volume sprayer, a smoke sprayer and a constant-volume sprayer, so that the sanitary pests can contact with a medicament when moving in a pesticide application space, the purpose of knocking down and killing the sanitary pests is achieved, and the sanitary pests are controlled.

Technical Field

The invention relates to a binary sanitary insecticidal composition and application thereof, in particular to an insecticidal composition containing famoxadone and acetamiprid and application thereof.

Background

For a long time, the retention spraying and space spraying agents used for the public health pests are mostly single agents or compound agents of pyrethroid products, and the long-term use of the pyrethroid agents causes the health pests such as mosquitoes, flies, cockroaches and the like to generate different degrees of drug resistance to certain pyrethrins, so that the control effect is greatly reduced.

The oxadixic ketone has contact poisoning and stomach poisoning effects, and has good knockdown activity. It has the dual properties of inhibiting acetylcholinesterase and acting on nerve axons.

Acetamiprid belongs to a nicotine compound, acts on a nicotine acetylcholine receptor of insects, interferes with stimulation conduction of the nervous system of the insects, and causes paralysis and death of the insects.

We consider the development of a novel non-pyrethroid composition for controlling sanitary pests to address the problem of resistance of sanitary pests to pyrethroids. Tests show that the compounding of the famoxadone and the acetamiprid can solve the resistance problem, on one hand, in terms of the action mechanism, because the compounding of the famoxadone and the acetamiprid has no cross resistance with the existing pyrethroid insecticide, the problem of the resistance of sanitary pests such as mosquitoes, flies, cockroaches and the like to the pyrethroid insecticide is solved, the control effect is improved, and the dosage is reduced; on the other hand, the irritation of the famoxadone and the acetamiprid is small, so that the safety of the pesticide applying personnel is improved; in addition, the acetamiprid serving as a lethal agent has better knockdown performance, so that the control effect is improved; the insecticide compound with the two different action mechanisms can also delay the generation of pest resistance.

Disclosure of Invention

The invention aims to solve the technical problem of providing an insecticidal composition containing famoxadone and acetamiprid and application thereof aiming at the defects in the prior art, the composition is a binary sanitary insecticidal composition, the active ingredients are famoxadone and acetamiprid, on one hand, the compounding of the famoxadone and acetamiprid can solve the drug resistance of sanitary pests to pyrethroid insecticides, improve the control effect and reduce the dosage, on the other hand, the stimulation of the famoxadone and the acetamiprid is small, the safety of a pesticide applicator is improved, and the compounding of insecticides with different action mechanisms can delay the generation of resistance.

In order to achieve the purpose, the invention adopts the following technical scheme:

an insecticidal composition containing famoxadone and acetamiprid comprises active ingredients of famoxadone and acetamiprid, wherein the total content (mass percentage) of the active ingredients is 2% -80%, and the balance is auxiliary materials.

In the technical scheme, the weight ratio of the famoxadone to the acetamiprid is 1: 40-40: 1.

In the above technical scheme, the weight ratio of the famoxadone to the acetamiprid is preferably 2: 1-1: 20.

In the technical scheme, the auxiliary material is an auxiliary agent or an auxiliary agent and a special component.

In the technical scheme, when the auxiliary materials are the auxiliary agent and the special component, the content of the special component in the insecticidal composition is 1% -2%, and the balance is the auxiliary agent.

In the technical scheme, the special component is any one of eucalyptus oil, D-limonene and camphorol or a mixture of two or more of the eucalyptus oil, the D-limonene and the camphorol which are mixed in any proportion, and the special component is added to improve the knockdown speed of the mosquito and fly.

In the technical scheme, the auxiliary agent is any one of a dispersing agent, an emulsifying agent, an antifreezing agent, a thickening agent, a preservative, a defoaming agent, a solvent, a wetting agent, a disintegrating agent, water and a filler, or a mixture of two or more of the dispersing agent, the emulsifying agent, the antifreezing agent, the thickening agent, the preservative, the defoaming agent, the solvent, the wetting agent, the disintegrating agent, the water and the filler in any proportion.

In the above technical scheme, the dispersant is selected from any one of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene formaldehyde condensate, sulfate, alkylbenzene sulfonate calcium salt, naphthalene sulfonic acid formaldehyde condensate sodium salt, alkylphenol polyoxyethylene, fatty amine polyoxyethylene, fatty acid polyoxyethylene ester, and glycerin fatty acid ester polyoxyethylene ether, or a mixture of two or more thereof mixed at any ratio.

In the above technical scheme, the emulsifier is selected from: polyoxyethylene ether formaldehyde condensate sulfate, lignosulfonate dispersant, calcium dodecyl benzene sulfonate, nonionic hydroxy polyethylene oxide block copolymer, alkylphenol polyoxyethylene, fatty amine polyoxyethylene ether, phenethyl phenol polyoxyethylene ether phosphate ether, piperonyl tertiary butyl ether, fatty acid polyoxyethylene ether and glycerin fatty acid ester polyoxyethylene ether.

In the technical scheme, the antifreezing agent is any one of ethylene glycol, propylene glycol, glycerol and urea, or a mixture of two or more of the ethylene glycol, the propylene glycol, the glycerol and the urea in any proportion.

In the above technical scheme, the thickener is any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, organic bentonite and white carbon black, or a mixture of two or more of the components mixed in any proportion.

In the technical scheme, the preservative is any one of sodium benzoate, benzoic acid, potassium sorbate and kasong, or a mixture of two or more of the sodium benzoate, the benzoic acid, the potassium sorbate and the kasong which are mixed in any proportion.

In the technical scheme, the defoaming agent is any one of a silicone compound, silicone oil, a C8-10 fatty alcohol compound and a C10-20 saturated fatty acid compound, or a mixture of two or more of the silicone compound, the silicone oil, the C8-10 fatty alcohol compound and the C10-20 saturated fatty acid compound in any proportion.

In the above technical scheme, the solvent is selected from: one or more of odorless kerosene, isopropyl myristate, diisopropyl adipate, tributyl citrate, acetyl tributyl citrate, dodecyl benzene, N-dimethyl pelargoniamide and N, N-dimethyl caprylamide.

In the above technical solution, the wetting agent is selected from: the formaldehyde condensate sulfate of alkylphenol polyoxyethylene ether, phosphate of alkylbenzene polyoxyethylene ether, phosphate of phenethyl phenol polyoxyethylene ether, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate, sodium dodecyl sulfate, nekal BX, wetting penetrant F and dodecyl benzene sulfonic acid, or a mixture of two or more of them mixed in any proportion.

In the above technical scheme, the disintegrating agent is selected from: any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate and sodium sulfate, or a mixture of two or more of them in any proportion.

In the above technical solution, the filler is selected from: any one of kaolin, corn starch, attapulgite, calcium carbonate and diatomite, or a mixture of two or more of the above in any proportion.

In the technical scheme, the insecticidal composition is in the dosage form of missible oil, aqueous emulsion, microemulsion, soluble liquid, suspending agent, wettable powder, water dispersible granule and dry suspending agent. The preparation method can be carried out according to the conventional method in the field or the prior art.

The invention also provides application of the insecticidal composition in the aspect of controlling sanitary pests.

In the above technical solution, the sanitary insect pests refer to culex pipiens pallens, culex fatigues, culex tritaeniorhynchus, aedes albopictus, aedes aegypti, anopheles sinensis, aedes infestans, midge, houseflies, city flies, chrysomyia megacephala, lucilia cuprina, lucilia glauca, latrine flies, metazoa flies, cockroaches germanica, periplaneta americana, bed bugs, fleas, mangrove ticks, dursban recited ticks, prairie ticks, mini cattle ticks, spider mites, and scabies.

In the above technical scheme, the sanitary insect pests are preferably culex pipiens pallens, aedes albopictus, aedes aegypti, anopheles sinensis, houseflies, city flies, lucilia sericata, lucilia cuprina, german cockroaches, periplaneta americana, bed bugs, dursban china, spider mites and mange mites which are resistant to pyrethroid insecticides.

In the technical scheme, when the insecticidal composition is used for preventing and treating sanitary pests, the insecticidal composition is diluted by 200-fold and 400-fold with water and sprayed on the surfaces of walls, doors, windows, ceilings, houses and the like, so that the binary sanitary insecticide is remained on the surfaces of the objects, the sanitary pests are knocked down and die, and the applicable formulations of the insecticidal composition are suspending agents, wettable powder, water dispersible granules and dry suspending agents.

In the technical scheme, when the insecticidal composition is used for preventing and controlling sanitary pests, the insecticidal composition is diluted by 20-40 times by using water, and is uniformly sprayed to a space by using spraying equipment such as an ultralow-volume sprayer, a smoke sprayer and a constant-volume sprayer, so that the sanitary pests can contact with a medicament when moving in a pesticide application space to knock down and die and control the sanitary pests, and the applicable formulations of the insecticidal composition are missible oil, aqueous emulsion, microemulsion and soluble liquid.

According to the invention, the insecticidal composition solves the problem of resistance of sanitary pests to pyrethroids, improves the control effect, reduces the dosage and reduces the application irritation. The acetamiprid serving as a lethal agent also has better knockdown performance, so that the knockdown effect on sanitary pests is improved. The insecticide with different action mechanisms can also delay the generation of resistance, and provides a new idea and method for preventing and controlling sanitary pests. The insecticidal composition can well control Culex pipiens and houseflies in Guangzhou pale color.

Detailed Description

The following detailed description of the embodiments of the present invention is provided, but the present invention is not limited to the following descriptions:

the preparation method of the dosage form in each embodiment of the invention is as follows:

the laboratory preparation method of the missible oil comprises the following steps: weighing the emulsifier, the solvent, the famoxadone and the acetamiprid according to the proportion, heating and mixing the mixture in a beaker uniformly to obtain the product.

The laboratory preparation method of the aqueous emulsion comprises the following steps: weighing the famoxadone, the acetamiprid, the emulsifier and the solvent according to the proportion, heating and dissolving to obtain an oil phase, weighing the antifreezing agent, the antifoaming agent and the water according to the proportion to obtain a water phase, and slowly adding the water phase into the oil phase under a shearing condition to obtain the aqueous emulsion.

The laboratory preparation method of the microemulsion comprises the following steps: weighing the famoxadone, the acetamiprid, the emulsifier, the solvent and the water according to the proportion, and heating and fully dissolving to obtain the microemulsion.

Soluble liquid agent: weighing the famoxadone, the acetamiprid, the emulsifier and the solvent according to the proportion, and heating to fully dissolve the materials to obtain the soluble liquid.

The laboratory preparation method of the suspending agent comprises the following steps: weighing wetting agent, dispersant, antifreeze, preservative, defoamer and water according to the proportion, adding into a beaker, uniformly mixing, adding famoxadone and acetamiprid into the beaker, transferring to a sand mill, adding zirconia beads into the sand mill, grinding for 2-3h, adding thickener, and continuously grinding for 0.5h to obtain a particle size D₉₅Controlling the particle size below 5 microns, and filtering to remove zirconia beads to obtain the product.

The laboratory preparation method of the wettable powder comprises the following steps: adding the famoxadone, the acetamiprid, the wetting agent, the dispersing agent and the filler into a food processor, uniformly mixing, and then crushing in a jet mill to obtain the pesticide composition.

The laboratory preparation method of the water dispersible granule comprises the following steps: adding the famoxadone, the acetamiprid, the wetting agent, the dispersing agent, the disintegrating agent and the filler into a food processor, uniformly mixing, then crushing in a jet mill, mixing again in the food processor, adding a proper amount of water, and finally extruding and granulating by a granulator to obtain the product.

The laboratory preparation method of the dry suspending agent comprises the following steps: weighing wetting agent, dispersant, defoamer, filler and water according to the proportion, adding the wetting agent, the dispersant, the defoamer, the filler and the water into a beaker, uniformly mixing, adding the famoxadone and the acetamiprid into the beaker, transferring the beaker to a sand mill, adding zirconia beads into the sand mill, and grinding for 2-3h to enable the particle diameter D to be D₉₅Controlling the particle size below 5 microns, filtering to remove zirconia beads, and drying the obtained material by a spray dryer to obtain the product.

The invention will now be illustrated with reference to specific examples:

formulation example 1: 25% oxadilone acetamiprid suspending agent

2g of famoxadone, 23g of acetamiprid, 2g of sodium dodecyl sulfate, 5g of lignosulfonate, 2g of propylene glycol, 3g of ethylene glycol, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.

Formulation example 2: 15% oxadilone acetamiprid suspending agent

1g of famoxadone, 14g of acetamiprid, 1g of alkyl sulfate, 2g of alkyl sulfonate, 1g of polycarboxylate, 6g of lignosulfonate, 2g of propylene glycol, 0.5g of potassium sorbate, 3g of urea, 0.5g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.

Formulation example 3: 40% oxadilone acetamiprid suspending agent

20g of famoxadone, 20g of acetamiprid, 2g of alkyl benzene polyoxyethylene ether phosphate, 1g of sodium naphthalene sulfonic acid formaldehyde condensate, 4g of lignosulfonate, 2g of glycerol, 3g of urea, 0.5g of sodium benzoate, 0.5g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.

Formulation example 4: 80% oxadixolone and acetamiprid water dispersible granule

40g of famoxadone, 40g of acetamiprid, BX2g, 3g of alkyl sulfate, 4g of lignosulfonate, 3g of sodium salt of a naphthalene sulfonic acid formaldehyde condensate, 1g of sodium sulfate, 3g of ammonium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.

Formulation example 5: water dispersible granule containing 40% oxadixolone and acetamiprid

30g of famoxadone, 10g of acetamiprid, 5g of nekal BX5g, 5g of sodium dodecyl sulfate, 10g of sodium naphthalenesulfonic acid-formaldehyde condensate, 3g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.

Formulation example 6: water dispersible granule containing 50% oxadixolone and acetamiprid

10g of famoxadone, 40g of acetamiprid, BX8g, 5g of lignosulfonate, 10g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 3g of sodium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.

Formulation example 7: wettable powder of 42% oxadixic ketone and acetamiprid

22g of famoxadone, 20g of acetamiprid, 3g of alkyl sulfate, 5g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 2g of lignosulfonate, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.

Formulation example 8: 30% oxadilone acetamiprid wettable powder

20g of famoxadone, 10g of acetamiprid, 3g of alkyl sulfate, 5g of sodium salt of a naphthalene sulfonic acid formaldehyde condensate, 2g of fatty amine polyoxyethylene ether, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.

Formulation example 9: 41% oxadixic ketone acetamiprid wettable powder

1g of famoxadone, 40g of acetamiprid, 2g of alkyl sulfate, 2g of sodium naphthalenesulfonic acid-formaldehyde condensate, 10g of fatty amine polyoxyethylene ether, 3g of white carbon black and the balance of kaolin to 100 g. The wettable powder is prepared by the method.

Formulation example 10: 21% oxadilone acetamiprid wettable powder

1g of famoxadone, 20g of acetamiprid, 5g of polyoxyethylene fatty acid ester, 5g of sodium naphthalene sulfonic acid formaldehyde condensate, 10g of fatty amine polyoxyethylene ether, 3g of white carbon black and the balance of corn starch to 100 g. The wettable powder is prepared by the method.

Formulation example 11: 10% oxadixon acetamiprid suspending agent

2g of famoxadone, 8g of acetamiprid, 3g of sodium dodecyl sulfate, 5g of lignosulfonate, 3g of propylene glycol, 3g of ethylene glycol, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.2g of silicone oil and water which are complemented to 100 g. The suspending agent is prepared by the method.

Formulation example 12: 41% oxadixolone and acetamiprid water dispersible granule

40g of famoxadone, 1g of acetamiprid, 5g of nekal BX5g, 5g of sodium dodecyl sulfate, 10g of sodium naphthalenesulfonic acid-formaldehyde condensate, 3g of ammonium sulfate and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.

Formulation example 13: 5% oxadilone acetamiprid missible oil

1g of famoxadone, 4g of acetamiprid, 3g of calcium dodecyl benzene sulfonate, 4g of nonionic hydroxy polyethylene oxide block copolymer, 2g of alkylphenol polyoxyethylene, 20g of acetyl tributyl citrate and the balance of dodecyl benzene to 100 g. The missible oil is prepared by the method.

Formulation example 14: 15% oxadilone acetamiprid missible oil

3g of famoxadone, 12g of acetamiprid, 4g of calcium dodecyl benzene sulfonate, 4g of fatty amine polyoxyethylene ether, 2g of alkylphenol polyoxyethylene ether, 2g of piperonyl tert-butyl ether, 10g of tributyl citrate and the balance of dodecylbenzene to 100 g. The missible oil is prepared by the method.

Formulation example 15: 8% oxadilone acetamiprid missible oil

3g of famoxadone, 5g of acetamiprid, 4g of calcium dodecyl benzene sulfonate, 4g of fatty alcohol-polyoxyethylene ether, 2g of alkylphenol ethoxylate, 10g of isopropyl myristate and the balance of dodecylbenzene to 100 g. The missible oil is prepared by the method.

Formulation example 16: aqueous emulsion of 6% oxadixolone and acetamiprid

1g of famoxadone, 5g of acetamiprid, 4g of calcium dodecyl benzene sulfonate, 8g of fatty alcohol-polyoxyethylene ether, 2g of alkylphenol polyoxyethylene, 1g of piperonyl tert-butyl ether, 20g of dodecylbenzene, 5g of ethylene glycol, 0.2g of silicone compound and water which are complemented to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 17: aqueous 12% oxadilone/acetamiprid emulsion

3g of famoxadone, 9g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 8g of fatty alcohol-polyoxyethylene ether, 2g of alkylphenol polyoxyethylene, 5g of diisopropyl adipate, 15g of dodecylbenzene, 3g of ethylene glycol, 2g of propylene glycol, 0.2g of silicone compound and water, wherein the balance is up to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 18: aqueous emulsion of 5% oxadixolone and acetamiprid

1.5g of famoxadone, 3.5g of acetamiprid, 2.5g of calcium dodecyl benzene sulfonate, 8g of fatty alcohol-polyoxyethylene ether, 2g of alkylphenol ethoxylate, 20g of tributyl citrate, 5g of dodecylbenzene, 4g of ethylene glycol, 2g of propylene glycol, 0.2g of silicone compound and water, wherein the balance is up to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 19: 8% oxadilone acetamiprid microemulsion

1g of famoxadone, 7g of acetamiprid, 5.5g of calcium dodecyl benzene sulfonate, 20g of fatty acid polyoxyethylene ether, 50g of N, N-dimethyl pelargonide and water, wherein the balance is 100 g. The microemulsion is prepared by the method.

Formulation example 20: microemulsion of 11% oxadixone and acetamiprid

3g of famoxadone, 8g of acetamiprid, 5.5g of calcium dodecyl benzene sulfonate, 20g of alkylphenol polyoxyethylene, 5g of phenethyl phenol polyoxyethylene ether phosphate ether, 2g of piperonyl tertiary butyl ether, 30g of N, N-dimethyl pelargoniamide, 10g of N, N-dimethyl caprylamide and water, wherein the balance is up to 100 g. The microemulsion is prepared by the method.

Formulation example 21: 13% oxadilone acetamiprid microemulsion

1g of famoxadone, 12g of acetamiprid, 5.5g of calcium dodecyl benzene sulfonate, 20g of alkylphenol polyoxyethylene, 30g of N, N-dimethyl pelargoniamide, 10g of dodecyl benzene and water, wherein the balance is up to 100 g. The microemulsion is prepared by the method.

Formulation example 22: microemulsion of 18% oxadixon and acetamiprid

3g of famoxadone, 15g of acetamiprid, 5.5g of calcium dodecyl benzene sulfonate, 20g of phenethyl phenol polyoxyethylene ether phosphate ether, 30g of N, N-dimethyl pelargoniamide, 15g of acetyl tributyl citrate and water, wherein the balance is up to 100 g. The microemulsion is prepared by the method.

Formulation example 23: 6% oxadilone-acetamiprid soluble liquid agent

2g of famoxadone, 4g of acetamiprid, 5.5g of calcium dodecyl benzene sulfonate, 20g of phenethyl phenol polyoxyethylene ether phosphate ether and the balance of N, N-dimethyl pelargonide to 100 g. The soluble liquid is prepared by the method.

Formulation example 24: 18% oxadilone-acetamiprid soluble liquid agent

2g of famoxadone, 16g of acetamiprid, 2.5g of calcium dodecyl benzene sulfonate, 15g of nonionic hydroxy polyethylene oxide block copolymer and the balance of N, N-dimethyl caprylamide to 100 g. The soluble liquid is prepared by the method.

Formulation example 25: 10% oxadilone-acetamiprid soluble liquid agent

1g of famoxadone, 9g of acetamiprid, 3.5g of calcium dodecyl benzene sulfonate, 15g of nonionic hydroxy polyethylene oxide block copolymer, 10g of fatty acid polyoxyethylene ether, 20g of diisopropyl adipate and the balance of N, N-dimethyl caprylamide to 100 g. The soluble liquid is prepared by the method.

Formulation example 26: 2% oxadilone-acetamiprid soluble liquid agent

1g of famoxadone, 1g of acetamiprid, 3.5g of calcium dodecyl benzene sulfonate, 12g of nonionic hydroxy polyethylene oxide block copolymer, 8g of alkylphenol polyoxyethylene, 10g of N, N-dimethyl pelargoniamide and the balance of N, N-dimethyl caprylamide to 100 g. The soluble liquid is prepared by the method.

Formulation example 27: 8% oxadilone-acetamiprid soluble liquid agent

1g of famoxadone, 7g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 12g of nonionic hydroxy polyethylene oxide block copolymer, 8g of phenethyl phenol polyoxyethylene ether phosphate ether, 10g of N, N-dimethyl pelargonamide and N, N-dimethyl caprylamide, wherein the balance is up to 100 g. The soluble liquid is prepared by the method.

Formulation example 28: 6% oxadilone-acetamiprid soluble liquid agent

1g of famoxadone, 5g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 8g of nonionic hydroxy polyethylene oxide block copolymer, 10g of N, N-dimethyl pelargoniamide and N, N-dimethyl caprylamide, wherein the balance is up to 100 g. The soluble liquid is prepared by the method.

Formulation example 29: aqueous emulsion of 8% oxadixolone and acetamiprid

1g of famoxadone, 7g of acetamiprid, 4g of calcium dodecyl benzene sulfonate, 8g of fatty acid oxyethylene ether, 1g of nonionic hydroxyl polyethylene oxide block copolymer, 20g of dodecyl benzene, 5g of ethylene glycol, 0.2g of silicone compound and water which are complemented to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 30: 8% oxadilone acetamiprid missible oil

1g of famoxadone, 7g of acetamiprid, 3g of calcium dodecyl benzene sulfonate, 4g of nonionic hydroxy polyethylene oxide block copolymer, 2g of piperonyl tert-butyl ether, 20g of acetyl tributyl citrate and the balance of dodecylbenzene to 100 g. The missible oil is prepared by the method.

Formulation example 31: wettable powder of 10% oxadixic ketone and acetamiprid

2g of famoxadone, 8g of acetamiprid, 3g of alkyl sulfate, 4g of polycarboxylate, 2g of lignosulfonate, 3g of white carbon black and kaolin which are complemented to 100 g. The wettable powder is prepared by the method.

Formulation example 32: water dispersible granule containing 50% oxadixolone and acetamiprid

40g of famoxadone, 10g of acetamiprid, 5g of polycarboxylate, 5g of sodium dodecyl sulfate, 13g of sodium naphthalene sulfonate formaldehyde condensate, 3g of ammonium sulfate, 20g of corn starch and the balance of kaolin to 100 g. The water dispersible granule is prepared by the method.

Formulation example 33: 10% oxadixolone and acetamiprid water dispersible granule

2g of famoxadone, 8g of acetamiprid, 8g of polycarboxylate, 5g of sodium dodecyl sulfate, 3g of sodium naphthalene sulfonate formaldehyde condensate, 2g of ammonium sulfate and the balance of corn starch to 100 g. The water dispersible granule is prepared by the method.

Formulation example 34: 8% oxadilone acetamiprid missible oil

1g of famoxadone, 7g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 6g of nonionic hydroxy polyethylene oxide block copolymer, 2g of alkylphenol polyoxyethylene, 5g of odorless kerosene, 1g of piperonyl tertiary butyl ether and the balance of dodecyl benzene to 100 g. The missible oil is prepared by the method.

Formulation example 35: 8% oxadilone acetamiprid missible oil

1g of famoxadone, 8g of acetamiprid, 3g of calcium dodecyl benzene sulfonate, 2g of nonionic hydroxy polyethylene oxide block copolymer, 2g of alkylphenol polyoxyethylene, 3g of fatty acid polyoxyethylene, 1g of piperonyl tertiary butyl ether and the balance of dodecyl benzene to 100 g. The missible oil is prepared by the method.

Formulation example 36: 10% oxadilone-acetamiprid dry suspending agent

2g of famoxadone, 8g of acetamiprid, 5g of alkyl sulfate, 5g of sodium dodecyl sulfate, 3g of sodium naphthalene sulfonate formaldehyde condensate, 1g of silicone oil and the balance of corn starch to 100 g. The dry suspending agent is prepared by the method.

Formulation example 37: aqueous emulsion of 3% oxadixolone and acetamiprid

2g of famoxadone, 1g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 8g of fatty acid polyoxyethylene ether, 2g of nonionic hydroxyl polyoxyethylene block copolymer, 2g of fatty amine polyoxyethylene ether, 10g of dodecylbenzene, 4g of piperonyl tertiary butyl ether, 5g of ethylene glycol, 3g of propylene glycol, 0.2g of silicone compound and the balance of water to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 38: water dispersible granule containing 50% oxadixolone and acetamiprid

10g of famoxadone, 40g of acetamiprid, BX8g, 5g of lignosulfonate, 10g of sodium salt of naphthalene sulfonic acid formaldehyde condensate, 3g of sodium sulfate, 1g of eucalyptus oil, 1g of D-limonene and corn starch in a balance of 100 g. The water dispersible granule is prepared by the method.

Formulation example 39: aqueous emulsion of 6% oxadixolone and acetamiprid

1g of famoxadone, 5g of acetamiprid, 4g of calcium dodecylbenzene sulfonate, 8g of fatty amine polyoxyethylene ether, 2g of alkylphenol polyoxyethylene ether, 1g of piperonyl tert-butyl ether, 2g of D-limonene, 20g of dodecylbenzene, 5g of ethylene glycol, 0.2g of silicone compound and water, wherein the balance is up to 100 g. The aqueous emulsion is prepared by the method.

Formulation example 40: 2% oxadilone acetamiprid missible oil

1g of famoxadone, 1g of acetamiprid, 2g of calcium dodecyl benzene sulfonate, 8g of fatty alcohol-polyoxyethylene ether, 2g of fatty amine polyoxyethylene ether, 10g of dodecylbenzene, 4g of piperonyl tertiary butyl ether, 30g of N, N-dimethyl sunflower amide and tasteless kerosene, wherein the total amount is up to 100 g. The missible oil is prepared by the method.

The products obtained from the formulation examples of the present invention were tested for validation, comparing the ratio of formulation 1: 10% lambda-cyhalothrin wettable powder (commercially available), control 2: 10% wettable powder of beta-cypermethrin (commercially available), control 3: 0.71% of S-bioallethrin-16.15% of permethrin water emulsion (commercially available).

Verification test 1: determination of resistance level of Guangzhou wild culex pipiens and houseflies

(1) Test subjects: laboratory breeding of Culex pipiens, laboratory breeding of Culex pipiens in light color, laboratory breeding of Musca domestica

(2) The test method comprises the following steps: reference to indoor bioassay test criteria for pesticides part one: and (3) a contact killing activity test, namely performing an activity determination test on culex pipiens pallens and houseflies by adopting a dropping method NY/T1154.1-2006.

(3) Test agents: high-efficiency cypermethrin technical

(4) And (3) test results:

TABLE 1 Activity data of Culex pipiens, Musca domestica in the laboratory and Guangzhou field

As can be seen from the table above, the times of resistance of Culex pipiens in Guangzhou field to beta-cypermethrin are 135 times of that in the laboratory, and the times of resistance of Musca domestica in Guangzhou field to beta-cypermethrin are 82 times of that in the laboratory. The culex pipiens pallens and houseflies collected from the guangzhou field are hereinafter referred to as field resistant strains.

Verification test 2:

(1) test subjects: laboratory breeding of Culex pipiens, laboratory breeding of Culex pipiens in light color, laboratory breeding of Musca domestica

(2) The test method comprises the following steps: refer to GB/T13919.1-2009 pesticide registration sanitary insecticide indoor pesticide effect test and evaluation, retention spray test.

(3) Test agents: 10% efficient cypermethrin wettable powder

(4) And (3) test results:

TABLE 2 laboratory and Guangzhou field culex pipiens pallens, houseflies retention spray data

As can be seen from the retention spray test data of table 2: KT of culex pallens and houseflies in Guangzhou field₅₀Is obviously higher than the strain in the laboratory, and also proves that the field strain generates resistance to the beta-cypermethrin.

Verification test 3: cotoxicity coefficient of famoxadone and acetamiprid to culex pipiens pallens

(1) Test subjects: light culex (laboratory feeding)

(2) The test method comprises the following steps: reference to indoor bioassay test criteria for pesticides part one: and (3) a contact killing activity test, namely performing an activity determination test on culex pipiens pallens by adopting a dropping method NY/T1154.1-2006.

(3) And (3) data statistics: the activity of the combination of the two on culex pipiens pallens is evaluated by adopting a co-toxicity coefficient method. Then calculating toxicity regression equation by DPS statistical software to obtain LD of each medicine₅₀And calculating the virulence index and the cotoxicity coefficient of the medicament according to the Sun cloud Pepper method. The co-toxicity coefficient is more than 120 to show the synergistic effect, the co-toxicity coefficient is between 80 and 120 to show the additive effect, and the co-toxicity coefficient is less than 80 to show the antagonistic effect. The results of the measurements are shown in the following table:

TABLE 3 Cotoxicity coefficient of famoxadone and acetamiprid against Culex pipiens pallens

As can be seen from table 3: oxadilone: the co-toxicity coefficients of the acetamiprid are all larger than 120 at a ratio of 2: 1-1: 20, and the acetamiprid is synergistic.

Verification test 4: pesticide effect test for preventing and controlling mosquito and fly spray

(1) Test subjects: culex pipiens pallens and housefly (first generation of field resistant line breeding)

(2) The test method comprises the following steps: refer to GB/T13919.1-2009 pesticide registration sanitary insecticide indoor pesticide effect test and evaluation, spray test.

(3) Test agents: formulation examples 13, 15, 16, 17, 19, 21, 27, 29, 34, 39 were all diluted to 1500ppm with water, and control 3 was diluted to 1500ppm with water.

(4) And (3) data statistics:

TABLE 4 data of several treatments for efficacy tests against culex pipiens pallens and houseflies

As can be seen from the above table, several examples of the combination of famoxadone and acetamiprid are against KT of culex pipiens pallens and houseflies₅₀The values are all less than 8 minutes, and the 24-hour mortality rate is all more than 95%, while the control medicament 3 is lightKT of culex and housefly₅₀Values were all greater than 16 minutes and 24 hour mortality was 90%. Therefore, the acetamiprid and the famoxadone have good control effect on the culex pipiens pallens and the houseflies with pyrethroid resistance by adopting a space spraying mode.

Verification test 5: drug effect test for preventing and controlling retention of mosquitoes and flies

(1) Test subjects: culex pipiens pallens and housefly (first generation of field resistant line breeding)

(2) The test method comprises the following steps: refer to GB/T13919.1-2009 pesticide registration sanitary insecticide indoor pesticide effect test and evaluation, retention spray test.

(3) Test agents: formulation examples 1, 2, 3, 4, 6, 8, 10, 11, 31, 33, 36, 38 were all diluted to 800ppm with water, and control agents 1 and 2 were diluted to 800ppm with water.

(4) And (3) data statistics:

TABLE 5 data of several treatments for efficacy tests against culex pipiens pallens and houseflies

As can be seen from the above table, several examples of the combination of famoxadone and acetamiprid are against KT of culex pipiens pallens and houseflies₅₀Values were less than 7 minutes and 24 hours mortality was greater than 90%, while controls 1 and 2 KT against resistant culex pipiens pallens and houseflies₅₀Values were all greater than 19 minutes and 24 hour mortality was less than 85%. Therefore, the acetamiprid and the famoxadone have good control effect on the culex pipiens pallens and the houseflies with pyrethroid resistance by adopting a retention spraying mode.

The above examples are only for illustrating the technical concept and features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.