阅读说明：本技术 有机化合物 (Organic compounds ) 是由 D·勒列夫尔 A·阿尔舍伯格 H·科克 于 2018-05-14 设计创作，主要内容包括：公开了包含环己酸乙酯的香料组合物。(Perfume compositions comprising ethyl cyclohexanoate are disclosed.)

1. A perfume composition comprising ethyl cyclohexanecarboxylate and at least one perfume ester.

2. The fragrance composition of claim 1, wherein the fragrance ester is a compound of formula (I)

Having a molecular weight of at most 300 (e.g. 130- & lt250-), and wherein

ii)R¹Selected from methyl, ethyl, C₃-C₆Alkyl and C₂-C₆Alkenyl radical, and

R²is a hydrocarbyl radical comprising up to 14C-atoms, optionally comprising 1,2 or 3 functional groups selected from-OH, -C (O) and-O-; or

ii)R¹Is a hydrocarbyl radical comprising up to 14C-atoms, optionally comprising 1,2 or 3 functional groups selected from-OH, -C (O) and-O-, and

R²selected from methyl, ethyl, C₃-C₆Alkyl and C₂-C₆An alkenyl group; or

iii)R¹And R²Together with the atoms to which they are attached form a cyclic ester comprising 5 or 6 ring atoms, wherein the ring is optionally substituted with 1,2 or more groups selected from alkyl and alkenyl.

3. The perfume composition according to any of the preceding claims, wherein the weight ratio between the ethyl cyclohexanecarboxylate and the at least one perfume ester is from 1:10 '000' 000 to 1:100 (ethyl cyclohexanecarboxylate: ester).

4. The perfume composition of any of the preceding claims, wherein said composition comprises up to 1 wt% ethyl cyclohexanecarboxylate.

5. A perfume composition comprising at least one ester of formula (I) as defined in claim 2, having "enhanced" fragrance characteristics obtained by admixing thereto ethyl cyclohexanecarboxylate.

6. A perfume composition according to claim 5 obtained by mixing up to 1% by weight of ethyl cyclohexanecarboxylate.

7. Perfumed article comprising a perfume composition as defined in one of the preceding claims.

8. A method of enhancing the fruity character of an ester comprising the step of adding ethyl cyclohexanecarboxylate to a composition comprising at least one flavor ester.

9. The method of claim 8, wherein the fragrance ester is a compound of formula (I)

Having a molecular weight of at most 300 (e.g. 130- & lt250-), and wherein

iii)R¹Selected from methyl, ethyl, C₃-C₆Alkyl and C₂-C₆Alkenyl radical, and

R²is a hydrocarbyl radical comprising up to 14C-atoms, optionally comprising 1,2 or 3 functional groups selected from-OH, -C (O) and-O-; or

ii)R¹Is a hydrocarbyl radical comprising up to 14C-atoms, optionally comprising 1,2 or 3 functional groups selected from-OH, -C (O) and-O-, and

R²selected from methyl, ethyl, C₃-C₆Alkyl and C₂-C₆An alkenyl group; or

iii)R¹And R²Together with the atoms to which they are attached form a cyclic ester comprising 5 or 6 ring atoms, wherein the ring is optionally substituted with 1,2 or more groups selected from alkyl and alkenyl.

10. The method of claim 7 or 8, wherein the weight ratio between the ethyl cyclohexanecarboxylate and the at least one fragrance ester is from 1:10 '000' 000 to 1:100 (ethyl cyclohexanecarboxylate: ester).

11. The method of any of claims 8-10, wherein up to 0.1 wt% of ethyl cyclohexanecarboxylate is added to the composition, based on the total amount of the composition.

Example 1: synthesis of ethyl cyclohexanoate

Cyclohexanecarboxylic acid (64g, 0.50mol) and p-toluenesulphonic acid (1.0g, 0.01mol) in cyclohexane (64g) were heated to 73 ℃. Ethanol (64g, 1.39mol) was added over 90min, and the reaction mixture was stirred under reflux for another 90min while the aqueous phase was gradually eliminated over time. After cooling the reaction mixture to r.t., H was used₂O、4％Na₂CO₃Aqueous solution and H₂O wash the organic phase. The organic phase was concentrated and distilled to give 73g (93%) of ethyl cyclohexanecarboxylate as a colorless oil.

¹H NMR(CDCl₃，400MHz)：δ＝4.09(q，J＝7.1Hz，2H)，2.25(tt，J＝11.3，3.7Hz，1H)，1.90-1.83(m，2H)，1.78-1.70(m，2H)，1.64-1.58(m，1H)，1.46-1.36(m，2H)，1.31-1.17(m，3H)，1.22(t，J＝7.1Hz，3H)ppm。

¹³C-NMR(CDCl₃，100MHz)：δ＝176.0(s)，59.9(t)，43.2(d)，29.0(2t)，25.7(t)，25.4(2t)，14.2(q)ppm。

MS (EI，tR＝4.89min)：156(43，[M]^+·)，128(21)，115(16)，111(41)，110(23)，101(68)，88(21)，83(100)，82(17)，81(17)，73(21)，68(15)，67(16)，55(79)，54(11)，41(38)，39(20)，29(30)，27(20)。