阅读说明：本技术 用于生成治疗方案的方法和设备 (Method and apparatus for generating a treatment plan ) 是由 G·马斯卡 A·波佩斯库 于 2018-06-08 设计创作，主要内容包括：公开了一种用于生成治疗方案的方法和一种装置。所述方法包括：接收治疗目标(101)和治疗限制输入(109)；接收患者特性输入(102)；生成多个腹膜透析治疗方案(103),每个腹膜透析治疗方案由一系列的第一循环和第二循环并由对应的第一循环的数量和第二循环的数量限定；考虑输入的患者特性,针对所述多个腹膜透析治疗方案中的每一个,模拟腹膜透析治疗结果(104),以生成模拟的治疗结果,并使得待应用于特定治疗的腹膜透析治疗方案能够基于模拟的治疗结果和输入的治疗目标和限制被选择(106)。(A method and an apparatus for generating a treatment plan are disclosed. The method comprises the following steps: receiving a treatment target (101) and a treatment limit input (109); receiving a patient characteristic input (102); generating a plurality of peritoneal dialysis treatment protocols (103), each peritoneal dialysis treatment protocol being defined by a series of first and second cycles and by a corresponding number of first and second cycles; peritoneal dialysis treatment outcomes are simulated (104) for each of the plurality of peritoneal dialysis treatment protocols in view of the input patient characteristics to generate simulated treatment outcomes and to enable a peritoneal dialysis treatment protocol to be applied to a particular treatment to be selected (106) based on the simulated treatment outcomes and the input treatment objectives and limits.)

1. A method (100) for generating a peritoneal dialysis protocol for controlling the operation of a peritoneal dialysis treatment machine to meet a treatment goal or a range of treatment goals, the method comprising:

-receiving a treatment target input (101),

-receiving a patient characteristic input (102),

-generating a plurality of peritoneal dialysis treatment protocols (103), each peritoneal dialysis treatment protocol being defined by a series of first cycles and second cycles, wherein the first cycles are defined by a first inflow volume and a first dwell time, respectively, wherein the second cycles are defined by a second inflow volume and a second dwell time, respectively, each peritoneal dialysis treatment protocol being defined by a number of first cycles and a number of second cycles, the number of first cycles and/or the number of second cycles being variable and/or independent of each other,

-simulating a peritoneal dialysis treatment outcome (104) for each of the plurality of peritoneal dialysis treatment protocols taking into account the inputted patient characteristics to generate a simulated treatment outcome and enabling the peritoneal dialysis treatment protocol to be applied to the specific treatment to be selected (106) based on the simulated treatment outcome and the inputted treatment objective.

2. The method according to claim 1, wherein the method comprises inputting allowed treatment parameter ranges (109), wherein the plurality of peritoneal dialysis treatment protocols (103) are generated taking into account the allowed treatment parameter ranges.

3. A method (100) for generating a peritoneal dialysis solution according to claim 1 or 2, wherein a fixed ratio between the first dwell time and the second dwell time is predetermined.

4. Method (100) for generating a peritoneal dialysis solution according to any of the preceding claims, wherein a fixed ratio between the first inflow volume and the second inflow volume is predetermined.

5. Method (100) for generating a peritoneal dialysis solution according to any of the preceding claims, wherein the first cycle is shorter and smaller than the second cycle.

6. Method (100) for generating a peritoneal dialysis protocol according to claim 5, wherein a first glucose concentration is defined for a first cycle and a second glucose concentration is defined for a second cycle, wherein the first glucose concentration is greater than the second glucose concentration.

7. A method (100) for generating a peritoneal dialysis solution according to claim 4, wherein the first cycle precedes the second cycle.

8. Method (100) for generating a peritoneal dialysis solution according to claim 4, wherein the first and second cycles alternate with each other.

9. An apparatus (2) for generating a peritoneal dialysis protocol for controlling the operation of a peritoneal dialysis treatment machine to meet a treatment target or a range of treatment targets, the apparatus (2) comprising:

a treatment target input unit for inputting a treatment target,

-a patient characteristic input unit for inputting a patient characteristic,

a peritoneal dialysis treatment protocol generation unit configured to generate a plurality of peritoneal dialysis treatment protocols, each peritoneal dialysis treatment protocol being defined by a series of first cycles and second cycles, the first cycles being defined by a first inflow volume and a first dwell time, the second cycles being defined by a second inflow volume and a second dwell time, each peritoneal dialysis treatment protocol being defined by a number of first cycles and a number of second cycles, the number of first cycles and/or the number of second cycles being variable and/or independent of each other,

-a simulation unit configured to be able to simulate a peritoneal dialysis treatment outcome for each of the plurality of peritoneal dialysis treatment protocols to generate a simulated treatment outcome, an

A selection unit configured to be able to select a peritoneal dialysis treatment protocol to be applied for a specific treatment from the plurality of peritoneal dialysis treatment protocols based on the respective simulated treatment results and treatment objectives.

10. An apparatus for generating a peritoneal dialysis solution according to claim 9, wherein the apparatus is adapted to perform the method according to any one of claims 1-8.

11. A peritoneal dialysis machine comprising an apparatus for generating a peritoneal dialysis solution according to claim 9 or claim 10.

12. A database module for a database, the database comprising a device according to claim 9 or claim 10.

13. A peritoneal dialysis system comprising a database having the database module of claim 12 and a peritoneal dialysis machine connected to the database for downloading peritoneal dialysis solutions from the database and adapted to operate in accordance with the downloaded peritoneal dialysis solutions.

14. A peritoneal dialysis protocol generated by applying the method of any one of claims 1-8.

15. A computer program comprising instructions which, when executed by a computer, cause the computer to perform the method according to any one of claims 1 to 8.

16. A computer-readable medium comprising instructions for performing the method of any one of claims 1 to 8 when the instructions are executed on a computer.

Technical Field

The present invention relates to the field of generating treatment protocols, in particular for generating protocols for operating a peritoneal dialysis treatment apparatus.

Background

The proportion of patients performing Automated Peritoneal Dialysis ("APD") is increasing worldwide, in part because APD can be tailored to the specific needs of the patient in terms of their private lives and the patient's therapeutic needs. The two main goals of dialysis, solute removal and Ultrafiltration ("UF": Ultrafiltration), depend on the form or type of APD performed.

Historically, APD devices typically do not have the ability to provide feedback to the patient regarding the effectiveness of his/her recent treatment. Moreover, APD devices are typically run open-loop so that they do not adjust treatment parameters (e.g., form, solution type, treatment time, and fill volume) based on actual measured daily clearance and UF. Thus, there is a great risk that some patients do not reach their goals and develop adverse conditions such as fluid overload and, in some cases, hypertension.

To address the above-mentioned problems, computerized prescription optimization systems have been developed that use patient physiological data in combination with specific treatment goals (e.g., ultrafiltration volume, clearance) and ranges of treatment inputs (e.g., number of exchanges, inflow volume, cycle time, solution selection) to calculate or provide possible solutions that meet the prescribed ranges.

Patient characteristics include Mass Transfer Area Coefficient ("MTAC") data and hydraulic permeability data to classify patient transport and UF characteristics. In order to simulate the results of Peritoneal Dialysis treatments, various algorithms have been developed and described in the literature [ Kinetic modeling in personal analysis, Gotch, Keen, clinical analysis, 4th edition,2005: 385-. One algorithm often used to simulate the results of dialysis treatments employs a three-hole model that adds predicted clearance through three different sized holes in the patient's peritoneum. The flow of toxins through the large, small and micro-pores in the peritoneal vessels is summarized. For example, urea and creatinine are removed from the patient's blood through small pores.

The large pores allow larger protein molecules to pass from the patient's blood to the dialysate. In each case, the osmotic gradient drives toxins from the patient's blood to the dialysate. In a more simplified two-hole model, only two different sizes of holes are considered. Alternatively, a so-called dual-pool peritoneal dialysis dynamics model can be used to predict fluid and solute removal in peritoneal dialysis to simulate treatment outcomes. The dual cell model utilizes a set of differential equations that collectively describe the dispersive and convective mass transfer in the body and dialysate compartments of an "equivalent" membrane core.

Prescription optimization systems typically apply a two-hole, three-hole, or two-pool model or other model to generate a plan using target information and other treatment input information.

The inventors of the present application have found that conventional treatment regimens do not always provide optimal therapeutic results, leading to patients not being able to reach their therapeutic target.

It is therefore an object of the present invention to provide an improved method for generating a peritoneal dialysis solution for controlling a peritoneal dialysis treatment and a corresponding apparatus, which take into account an improved implementation of the treatment objective.

Disclosure of Invention

The above object is solved by a method of generating a peritoneal dialysis solution for controlling the operation of a peritoneal dialysis treatment machine to meet a treatment target or a range of treatment targets. The method comprises the following steps:

a treatment target input is received and a treatment target input is received,

a patient characteristic input is received and a patient characteristic input is received,

generating a plurality of peritoneal dialysis treatment protocols, each peritoneal dialysis treatment protocol defined by a series of first and second cycles and by a corresponding number of first and second cycles,

simulating a peritoneal dialysis treatment outcome for each of the plurality of peritoneal dialysis treatment protocols taking into account the entered patient characteristics to generate a simulated treatment outcome and enabling the peritoneal dialysis treatment protocol to be applied to the particular treatment to be selected based on the simulated treatment outcome and the entered treatment objective.

According to the proposed method, the first cycle is defined by a first inflow volume, a first residence time, the second cycle is defined by a second inflow volume, a second residence time, the number of first cycles and/or the number of second cycles is variable and/or independent of each other.

Advantageously, the method comprises receiving a treatment parameter range input describing an allowed range of one or more treatment parameters, or in other words a set of one or more treatment limits, within which a plurality of peritoneal dialysis solutions are generated.

It is also advantageous to define a first glucose concentration for the first cycle and a second glucose concentration for the second cycle, the second concentration being different from the first concentration.

Furthermore, the above object is solved by the subject matter of the independent claims. The dependent claims provide advantageous embodiments.

Other embodiments

In accordance with the present disclosure, embodiments 1 through 14 are provided to focus on particular aspects of the present disclosure.

Drawings

Fig. 1 depicts a method of generating a peritoneal dialysis treatment protocol and applying the generated treatment to a patient.

Fig. 2 depicts a peritoneal dialysis treatment protocol generation apparatus.

Fig. 3 depicts a peritoneal dialysis machine that includes a treatment protocol generation apparatus.

Fig. 4 depicts a peritoneal dialysis system that includes a database and a peritoneal dialysis machine.

Fig. 5-10 depict graphical representations of candidate sets of peritoneal dialysis treatment protocols.

Example 1: a method of generating a peritoneal dialysis protocol for controlling the operation of a peritoneal dialysis treatment machine to meet a treatment goal or range of treatment goals, the method comprising:

-receiving a treatment target input,

-receiving a patient characteristic input,

generating a plurality of peritoneal dialysis treatment protocols, each peritoneal dialysis treatment protocol being defined by a series of first cycles and second cycles, wherein the first cycles are defined by a first inflow volume and a first dwell time, respectively, wherein the second cycles are defined by a second inflow volume and a second dwell time, respectively, wherein the first cycles are shorter and smaller than the second cycles, wherein a first glucose concentration is defined for the first cycles and a second glucose concentration is defined for the second cycles, wherein the first glucose concentration is greater than the second concentration,

-simulating the peritoneal dialysis treatment outcome for each of the plurality of dialysis treatment protocols taking into account the inputted patient characteristics to generate a simulated treatment outcome, and enabling the peritoneal dialysis treatment protocol to be applied to the specific treatment to be selected based on the simulated treatment outcome and the inputted treatment objective.