阅读说明：本技术 一种冻干机及其灭菌降温装置 (Freeze dryer and sterilization and cooling device thereof ) 是由 张景芝 丁立新 徐秀芝 王卫东 于威 郭海洋 刘强 蒋殿家 于 2021-08-23 设计创作，主要内容包括：本发明公开一种冻干机及其灭菌降温装置,灭菌降温装置包括换热器和控制器,换热器内设有供油通道和紧贴供油通道设置的水冷通道,供油通道的进油口设有用于检测油温的油温检测件,水冷通道的进水口设有进水阀,油温检测件及进水阀均与控制器相连。当油温检测件检测到供油通道的进油口油温大于预设温度时,油温检测反馈指令至控制器,控制器控制进水阀打开,水冷通道注入的冷却水与供油通道内的热硅油进行热交换,流动的冷却水持续带走热硅油的热量,自动对热硅油进行降温,替换传统的以空气对流为主的降温方式,有效缩短冻干机的降温周期,提升生产效率。(The invention discloses a freeze dryer and a sterilization and cooling device thereof, wherein the sterilization and cooling device comprises a heat exchanger and a controller, an oil supply channel and a water cooling channel arranged close to the oil supply channel are arranged in the heat exchanger, an oil temperature detection piece for detecting the oil temperature is arranged at an oil inlet of the oil supply channel, a water inlet valve is arranged at a water inlet of the water cooling channel, and the oil temperature detection piece and the water inlet valve are both connected with the controller. When the oil temperature detection piece detects that the oil temperature of an oil inlet of the oil supply channel is higher than the preset temperature, the oil temperature detection feedback instruction is sent to the controller, the controller controls the water inlet valve to be opened, cooling water injected into the water cooling channel exchanges heat with hot silicone oil in the oil supply channel, flowing cooling water continuously carries away heat of the hot silicone oil, the hot silicone oil is automatically cooled, the traditional cooling mode mainly based on air convection is replaced, the cooling period of the freeze dryer is effectively shortened, and the production efficiency is improved.)

1. The sterilization and cooling device of the freeze dryer is characterized by comprising a heat exchanger (1), wherein an oil supply channel (11) and a water cooling channel (12) tightly attached to the oil supply channel (11) are arranged in the heat exchanger (1), an oil temperature detection piece for detecting the oil temperature is arranged at an oil inlet of the oil supply channel (11), and a water inlet valve (21) is arranged at a water inlet of the water cooling channel (12); the oil temperature detection part and the water inlet valve (21) are both connected with a controller, the controller is used for controlling the water inlet valve (21) to be opened when the oil temperature of the oil inlet is higher than a preset temperature according to a high oil temperature instruction fed back by the oil temperature detection part, and cooling water injected into the water cooling channel (12) exchanges heat with hot silicon oil in the oil supply channel (11).

2. The sterilization and cooling device of a freeze dryer according to claim 1, wherein a water outlet valve (31) is disposed at a water outlet of the water cooling channel (12), a circulating pump (61) is disposed at the oil inlet, the water outlet valve (31) and the circulating pump (61) are both connected to the controller, and the controller is configured to control the water outlet valve (31) to open according to the received high oil temperature command, and control the water inlet valve (21) to open and start the circulating pump (61) after a first preset time delay.

3. The sterilization and cooling device of a freeze dryer according to claim 2, wherein the controller is configured to control the water inlet valve (21) to close when the oil temperature at the oil inlet is less than or equal to the preset temperature according to a low oil temperature command fed back by the oil temperature detecting element, and to control the water outlet valve (31) and the circulation pump (61) to close after delaying a second preset time.

4. The sterilization and cooling device of the freeze dryer according to claim 3, wherein a drain valve (41) is arranged at a drain port of the water cooling channel (12), the drain valve (41) is connected with the controller, and the controller is configured to control the drain valve (41) to open after delaying a third preset time according to a water outlet closing instruction fed back when the water outlet valve (31) is closed.

5. The sterilization and cooling device of the freeze dryer according to claim 4, wherein an air inlet valve (51) is arranged at an air inlet of the water cooling channel (12), the air inlet valve (51) is connected with the controller, and the controller is used for controlling the air inlet valve (51) to be opened after delaying a fourth preset time according to a drainage starting instruction fed back when the drainage valve (41) is opened.

6. The sterilization and cooling device of the freeze dryer according to claim 5, further comprising a drain pipe (4) provided with the drain valve (41) and communicated with the water cooling channel (12), wherein the drain pipe (4) is provided with a flow detection piece (42) for detecting flow, the flow detection piece (42) is connected with the controller, and the controller is used for controlling the drain valve (41) and the air inlet valve (51) to be closed according to a zero flow instruction fed back by the flow detection piece (42).

7. The sterilization and cooling device for the freeze dryer according to any one of claims 1 to 6, wherein an oil inlet and an oil outlet of the oil supply channel (11) are respectively provided with an oil inlet pipeline (6) and an oil outlet pipeline (7) correspondingly, and sealing members are respectively provided between the oil supply channel (11) and the oil inlet pipeline (6) and between the oil supply channel (11) and the oil outlet pipeline (7).

8. The sterilization and cooling device of a freeze dryer according to any one of claims 1 to 6, wherein a plurality of layers of the oil supply channels (11) are arranged in the heat exchanger (1), and any two adjacent layers of the oil supply channels (11) are separated by the water cooling channel (12).

9. The sterilization and cooling device of a freeze dryer according to claim 8, wherein a plurality of aluminum partition plates for separating the oil supply channel (11) from the water cooling channel (12) are fixedly arranged in the heat exchanger (1).

10. A freeze dryer comprising the sterilization and cooling device of any one of claims 1 to 9.

Technical Field

The invention relates to the technical field of freeze drying, in particular to a freeze dryer and a sterilization and cooling device thereof.

Background

In the field of biological product production technology, most biological products are usually freeze-dried by a freeze dryer, so that the biological products which are pre-frozen into solid state are directly sublimated into gas state under vacuum, main components in the biological products such as protein and microorganism are ensured not to be denatured or lose biological activity, the original properties are maintained, and the application is common.

The freeze dryer is usually located in a production area with temperature regulation, and after sterilization is completed, hot air in a box body of the freeze dryer and cold air in a machine room exchange heat in a convection mode to cool the freeze dryer. However, the traditional cooling method consumes 24 hours to cool the freeze dryer after each batch of products are sterilized, which results in an excessively long production period of the products and seriously affects the production efficiency.

Disclosure of Invention

In view of the above, an object of the present invention is to provide a freeze dryer and a sterilization and cooling device thereof, wherein when the oil temperature at an oil inlet of an oil supply channel is too high, a water inlet valve is controlled to be automatically opened, cooling water injected into a water cooling channel automatically cools hot silicone oil in the oil supply channel, and replaces air for convection cooling, so that the cooling period is shortened, and the production efficiency is improved.

The sterilization cooling device of the freeze dryer comprises a heat exchanger, wherein an oil supply channel and a water cooling channel which is arranged to be attached to the oil supply channel are arranged in the heat exchanger, an oil temperature detection piece for detecting the oil temperature is arranged at an oil inlet of the oil supply channel, and a water inlet valve is arranged at a water inlet of the water cooling channel; the oil temperature detection part and the water inlet valve are connected with the controller, the controller is used for controlling the water inlet valve to be opened when the oil temperature of the oil inlet is higher than the preset temperature according to a high oil temperature instruction fed back by the oil temperature detection part, and cooling water injected into the water cooling channel exchanges heat with hot silicon oil in the oil supply channel.

Preferably, a water outlet valve is arranged at a water outlet of the water cooling channel, a circulating pump is arranged at an oil inlet of the water cooling channel, the water outlet valve and the circulating pump are both connected with the controller, and the controller is used for controlling the water outlet valve to be opened according to the received high oil temperature instruction, controlling the water inlet valve to be opened and starting the circulating pump after delaying for a first preset time.

Preferably, the controller is used for controlling the water inlet valve to be closed when the oil temperature of the oil inlet is less than or equal to a preset temperature according to a low oil temperature instruction fed back by the oil temperature detection part, and controlling the water outlet valve and the circulating pump to be closed after delaying for a second preset time.

Preferably, a drain valve is arranged at a drain port of the water cooling channel, the drain valve is connected with the controller, and the controller is used for controlling the drain valve to be opened after delaying for a third preset time according to a water outlet closing instruction fed back when the water outlet valve is closed.

Preferably, an air inlet valve is arranged at an air inlet of the water cooling channel, the air inlet valve is connected with the controller, and the controller is used for controlling the air inlet valve to be opened after delaying the fourth preset time according to a drainage starting instruction fed back when the drainage valve is opened.

Preferably, the system further comprises a drainage pipeline which is provided with a drainage valve and communicated with the water cooling channel, the drainage pipeline is provided with a flow detection piece for detecting flow, the flow detection piece is connected with a controller, and the controller is used for controlling the drainage valve and the air inlet valve to be closed according to a zero flow instruction fed back by the flow detection piece.

Preferably, an oil inlet and an oil outlet of the oil supply channel are respectively and correspondingly provided with an oil inlet pipeline and an oil outlet pipeline, and sealing elements are arranged between the oil supply channel and the oil inlet pipeline and between the oil supply channel and the oil outlet pipeline.

Preferably, a plurality of layers of oil supply channels are arranged in the heat exchanger, and any two adjacent layers of oil supply channels are separated by a water cooling channel.

Preferably, a plurality of aluminum clapboards for separating the oil supply channel and the water cooling channel are fixedly arranged in the heat exchanger.

The freeze dryer provided by the invention comprises the sterilization cooling device.

Compared with the background art, the sterilization cooling device of the freeze dryer comprises a heat exchanger and a controller, wherein an oil supply channel and a water cooling channel are arranged in the heat exchanger, the water cooling channel is arranged close to the oil supply channel, the water cooling channel is used for cooling water circulation, and the oil supply channel is used for supplying heat silicone oil circulation. An oil temperature detection piece is arranged at an oil inlet of the oil supply channel and used for detecting the oil temperature of the oil inlet. A water inlet valve is arranged at the water inlet of the water cooling channel. The oil temperature detecting part and the water inlet valve are both connected with the controller.

When the oil temperature detection piece detects that the oil temperature of an oil inlet of the oil supply channel is higher than the preset temperature, the oil temperature detection feedback instruction is sent to the controller, the controller controls the water inlet valve to be opened, cooling water injected into the water cooling channel exchanges heat with hot silicone oil in the oil supply channel, flowing cooling water continuously carries away heat of the hot silicone oil, the hot silicone oil is automatically cooled, the traditional cooling mode mainly based on air convection is replaced, the cooling period of the freeze dryer is effectively shortened, and the production efficiency is improved.

The freeze dryer provided by the invention comprises the sterilization cooling device and has the same beneficial effects.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a sterilization and cooling device of a freeze dryer according to an embodiment of the present invention.

The reference numbers are as follows:

the system comprises a heat exchanger 1, a water inlet pipeline 2, a water outlet pipeline 3, a water discharge pipeline 4, a gas inlet pipeline 5, an oil inlet pipeline 6 and an oil outlet pipeline 7;

an oil supply passage 11 and a water cooling passage 12;

a water inlet valve 21;

a water outlet valve 31;

a drain valve 41 and a flow rate detecting member 42;

an intake valve 51;

and a circulation pump 61.

In the drawings, the solid arrows indicate the flow direction of cooling water, and the hollow arrows indicate the flow direction of hot silicone oil.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific examples.

Referring to fig. 1, fig. 1 is a schematic structural diagram of a sterilization and cooling device of a freeze dryer according to an embodiment of the present invention.

The embodiment of the invention discloses a sterilization cooling device of a freeze dryer, which comprises a heat exchanger 1, wherein the heat exchanger 1 is preferably a shell-and-tube heat exchanger, but the type is not limited to the above.

An oil supply channel 11 and a water cooling channel 12 arranged close to the oil supply channel 11 are arranged in the heat exchanger 1, the oil supply channel 11 is used for supplying hot silicone oil to circulate, and the water cooling channel 12 is used for supplying cooling water to circulate. Specifically, a plurality of layers of oil supply channels 11 and a plurality of layers of water cooling channels 12 are arranged in the heat exchanger 1, and any two adjacent layers of oil supply channels 11 are separated by the water cooling channels 12, so that each water cooling channel 12 cools the oil supply channels 11 at two adjacent sides, and uniform heat dissipation of all the oil supply channels 11 is ensured.

All the water cooling channels 12 are arranged in an S shape, so that all the water cooling channels 12 are communicated with each other, and the cooling water is ensured to smoothly circulate in the heat exchanger 1.

A plurality of aluminum partition plates are fixedly arranged in the heat exchanger 1 and used for separating the oil supply channel 11 from the water cooling channel 12, and the good heat conductivity of the aluminum partition plates is utilized to accelerate the heat transfer efficiency between the oil supply channel 11 and the water cooling channel 12, so that the hot silicone oil is rapidly cooled. Of course, the material of the partition plate is not limited to aluminum, and other heat conductive materials may be used.

In addition, a plurality of water-stop bulges can be integrally arranged on the inner wall of each water-cooling channel 12, each water-cooling channel 12 is divided into a plurality of channels with equal width, cooling water uniformly flows through each water-cooling channel 12, and then adjacent oil supply channels 11 uniformly dissipate heat, so that the phenomenon that local oil temperature is too high due to non-uniform flowing of the cooling water is avoided.

An oil temperature detecting piece is arranged at an oil inlet of the oil supply channel 11 and used for detecting the oil temperature, and the oil temperature detecting piece can be specifically a temperature sensor. The water inlet of the water cooling channel 12 is provided with a water inlet valve 21, and the water inlet valve 21 is preferably an electromagnetic valve. The oil temperature detecting part and the water inlet valve 21 are both connected with the controller.

When the temperature detection part detects that the oil temperature of the oil inlet is higher than the preset temperature, a high oil temperature instruction fed back by the oil temperature detection part is sent to the controller, the controller controls the water inlet valve 21 to be automatically opened, and cooling water injected into the water cooling channel 12 exchanges heat with hot silicone oil in the oil supply channel 11, so that the water cooling channel 12 automatically cools the oil supply channel 11 according to the temperature of the hot silicone oil. The preset temperature is the lowest critical temperature required for cooling the hot silicone oil.

In conclusion, the sterilization cooling device of the freeze dryer provided by the invention can automatically cool hot silicone oil by optimizing the structure of the device, replaces the traditional cooling mode mainly based on air convection, effectively shortens the cooling period of the freeze dryer, and improves the production efficiency.

The water inlet of the water cooling channel 12 is provided with a water inlet pipeline 2, the water inlet valve 21 is arranged on the water inlet pipeline 2, and the flow of the water inlet pipeline 2 is adjusted by adjusting the opening degree of the water inlet valve 21. The water outlet of the water cooling channel 12 is provided with a water outlet pipeline 3, the water outlet pipeline 3 is provided with a water outlet valve 31, and the flow of the water outlet pipeline 3 is adjusted by adjusting the opening degree of the water outlet valve 31.

An oil inlet pipe 6 is arranged at an oil inlet of the oil supply channel 11, and an oil outlet pipe 7 is arranged at an oil outlet of the oil supply channel 11. Sealing elements are arranged between the oil supply channel 11 and the oil inlet pipeline 6 and between the oil supply channel 11 and the oil outlet pipeline 7, the sealing elements can be rubber sealing strips or rubber sealing rings, the sealing performance of the oil supply channel 11 is improved, and cooling water is prevented from being mixed into the oil supply channel 11. The oil inlet pipeline 6 is provided with a circulating pump 61, and hot silicone oil in the oil inlet pipeline 6 is pumped into the oil supply channel 11 by the circulating pump 61.

The outlet valve 31 is preferably a solenoid valve, and both the outlet valve 31 and the circulation pump 61 are connected to the controller. When the controller receives a high oil temperature instruction fed back by the oil temperature detection piece, the outlet valve 31 is controlled to be opened firstly, after the first preset time is delayed, the inlet valve 21 is controlled to be opened, the circulating pump 61 is started simultaneously, the outlet valve 31 and the inlet valve 21 are automatically opened according to the time sequence when the temperature is reduced, before cooling water is injected into the water cooling channel 12, the outlet valve 31 is ensured to be opened before the inlet valve 21, residual waste water in the cold water channel is fully emptied, synchronous supply of cooling water and hot silicone oil is ensured, the situation that the residual waste water cannot rapidly reduce the temperature of the hot silicone oil injected firstly due to overhigh temperature is avoided, and the further improvement of the temperature reduction efficiency is facilitated.

The first preset time is a time required for completely emptying the residual wastewater in the water cooling channel 12, and may be 10s, and may be specifically adjusted according to the volume of the heat exchanger 1, which is not specifically limited herein.

When the oil temperature detecting element detects that the oil temperature of the oil inlet is less than or equal to the preset temperature, the oil temperature detecting element feeds a low oil temperature instruction back to the controller, the controller firstly controls the water inlet valve 21 to be closed, and then controls the water outlet valve 31 and the circulating pump 61 to be closed after delaying for a second preset time, so that the water inlet valve 21 and the water outlet valve 31 are automatically closed in sequence when finishing temperature reduction, the water outlet valve 31 is ensured to be closed later than the water inlet valve 21, the stop cycle time of cooling water can be later than that of hot silicon oil, and the insufficient temperature reduction of the hot silicon oil is avoided; the cooling water in the water cooling channel 12 can be drained conveniently, and the influence on the next use caused by the excessive cooling water left in the water cooling channel 12 is avoided.

The second preset time is the time consumed by the cooling water flowing from the water inlet to the water outlet of the water cooling channel 12, and may be 10 seconds, and may be specifically adjusted according to the flow rate of the cooling water channel, which is not specifically limited herein.

The water outlet of the water cooling channel 12 is provided with a water discharge pipeline 4, the water discharge pipeline 4 is provided with a water discharge valve 41, and the flow of the water discharge pipeline 4 is adjusted by adjusting the opening degree of the water discharge valve 41. The drain valve 41 may also be a solenoid valve, and the drain valve 41 is connected to the controller. When the outlet valve 31 is closed, the outlet valve 31 feeds back an outlet closing instruction to the controller, and after a third preset time is delayed, the controller controls the drain valve 41 to be automatically opened to drain the cooling water remaining in the water cooling channel 12, which means that when the temperature reduction is finished, the cooling water is not immediately drained, but the cooling water remaining in the water cooling channel 12 is utilized to continue to exchange heat with the outer wall of the oil supply channel 11, so that the influence of the residual temperature of the oil supply channel 11 on the subsequently flowing silicone oil is avoided.

The third preset time is the time consumed by the cooling water to completely reduce the residual temperature of the oil supply channel 11, and may be 10 seconds, and may be specifically adjusted according to the specification of the oil supply channel 11, which is not specifically limited herein.

An intake duct 5 is provided at an intake port of the water-cooled passage 12, an intake valve 51 is provided in the intake duct 5, and an intake air amount of the intake duct 5 is adjusted by adjusting an opening degree of the intake valve 51. And one end of the air inlet pipeline 5, which is far away from the air inlet, is connected with a vacuum pump to provide negative pressure air for the heat exchanger 1. The intake valve 51 is preferably a solenoid valve, and the intake valve 51 is connected to the controller. When the drain valve 41 is opened, the drain valve 41 feeds back a drain starting instruction controller, and after delaying for a fourth preset time, the controller controls the air inlet valve 51 to be opened again, that is, the heat exchanger 1 fills negative pressure gas into the water cooling channel 12 after draining for a period of time, so that the heat exchanger 1 can drain residual cooling water by means of negative pressure.

The fourth preset time is time consumed by the water cooling channel 12 to initially drain the cooling water, and may be 10s, and may be specifically adjusted according to the flow rate of the water cooling channel 12, which is not specifically limited herein.

The drainage pipeline 4 is provided with a flow detection piece 42 for detecting the flow of the drainage pipeline 4, and can be a photoelectric liquid level switch. When the flow detection part 42 detects that the flow of the drainage pipeline 4 is zero, the heat exchanger 1 is meant to completely empty the cooling water, at the moment, the flow detection part 42 feeds back a zero-flow instruction to the controller, and the controller controls the closing of the drain valve 41 and the air inlet valve 51, so that the drain valve 41 and the air inlet valve 51 can be automatically closed after the cooling water is completely emptied, the manual participation is reduced, the control precision is high, the cooling water residue caused by the fact that whether the cooling water is completely emptied can not be accurately judged is avoided, the phenomenon that overlong invalid waiting time is wasted to wait for the emptying of the cooling water can be avoided, and the time is favorably saved.

It should be noted that the controller includes a signal receiving portion, a signal determining portion and a signal transmitting portion, the signal receiving portion is used for receiving an electrical signal transmitted by a detecting member such as an oil temperature detecting member, the signal determining portion is electrically connected to the receiving portion so that the signal determining portion can determine whether the signal received by the receiving portion is a trigger signal, and the signal transmitting portion is electrically connected to the signal determining portion so that the signal transmitting portion transmits the determination signal generated by the signal determining portion to an executing member such as the water inlet valve 21. The specific arrangement mode of the signal receiving part, the signal judging part and the signal sending part can refer to the prior art; in the invention, the application scenes of the three are only changed, and the three are not substantially improved. Obviously, the controller with the structure is widely applied to the existing automatic control equipment, such as an MCU, a DSP or a single chip microcomputer. The key point of the invention is that the controller correspondingly combines each detection piece and each execution piece in pairs.

The invention also discloses a freeze dryer which comprises the sterilization cooling device and has the same beneficial effects.

The freeze dryer and the sterilization and cooling device thereof provided by the invention are described in detail above, and the principle and the implementation mode of the invention are explained by applying specific examples, and the description of the examples is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.