Measurement control method of sample analyzer and sample analyzer

文档序号:1671892 发布日期:2019-12-31 浏览:38次 中文

阅读说明:本技术 一种样本分析仪的测量控制方法和样本分析仪 (Measurement control method of sample analyzer and sample analyzer ) 是由 陈志民 李爱博 田志超 舒雪燕 于 2019-08-29 设计创作,主要内容包括:本申请实施例公开了一种样本分析仪的测量控制方法和样本分析仪,测量控制方法用于提供两种供测量程序选择的测量模式,以满足不同样本测试指标要求。本申请实施例方法包括:获取待测量样本的样本测量需求;在该样本测量需求指示样本检测周转时间测量模式时,采用样本检测周转时间测量模式测量该待测量样本得到测量结果,该样本检测周转时间测量模式用于实现先进入的样本优先出测量结果;在该样本测量需求指示批量测量模式时,采用批量测试模式测量该待测量样本得到该测量结果,该批量测试模式用于实现整体样本同时出测量结果。(The embodiment of the application discloses a measurement control method of a sample analyzer and the sample analyzer. The method in the embodiment of the application comprises the following steps: acquiring a sample measurement requirement of a sample to be measured; when the sample measurement requirement indicates a sample detection turnaround time measurement mode, measuring the sample to be measured by adopting the sample detection turnaround time measurement mode to obtain a measurement result, wherein the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample; and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.)

1. A measurement control method of a sample analyzer, comprising:

acquiring a sample measurement requirement of a sample to be measured;

when the sample measurement requirement indicates a sample detection turnaround time measurement mode, measuring the sample to be measured by adopting the sample detection turnaround time measurement mode to obtain a measurement result, wherein the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample;

and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

2. The method of claim 1, wherein the measuring the sample to be measured in the batch test mode to obtain the measurement result comprises:

carrying out sample grouping on the samples to be measured according to a sample grouping rule to obtain a sample group set, wherein the sample grouping rule comprises dividing the samples to be measured with the same measurement items according to the number of samples;

and taking the sample group in the sample group set as a unit, and carrying out online measurement on the sample analyzer to obtain the measurement result, wherein after a reagent dispensing mechanism of the sample analyzer injects a test reagent for the same measurement item of the same sample group, the reagent dispensing mechanism is cleaned.

3. The method of claim 2, further comprising:

acquiring inter-group connection of sample groups, wherein the inter-group connection of the sample groups is used for indicating a principle that the samples in the sample groups are measured by the sample analyzer in an online mode;

and measuring the sample group set according to the inter-group connection of the sample group to obtain a measurement result.

4. The method of claim 3, wherein the inter-group join of the sample sets indicates that a second sample set of the sample set is online after measurements of all measurement items of a first sample set of the sample set are obtained;

or the like, or, alternatively,

the inter-group join of the sample groups is used for indicating that after the last measurement item of the first sample group in the sample group set is on line, if available resources exist, the first measurement item of the second sample group in the sample group set is on line.

5. The method of claim 4, wherein the inter-group join of the sample groups is used to indicate that after a last measurement item of a first sample group in the sample group set is on-line, if there is available resource, then when a first measurement item of a second sample group in the sample group set is on-line, the measuring the sample group set according to the inter-group join of the sample groups to obtain the measurement result comprises:

determining a first measurement item of a first sample group and a second measurement item of a second sample group in the sample to be measured, wherein the first measurement item is the last measurement item of the first sample group, and the second measurement item is the first measurement item of the second sample group;

sequentially injecting the samples corresponding to the first measurement items into corresponding first measurement cups, and then starting incubation;

transferring the first overtime measuring cup exceeding the incubation duration in the first measuring cup to a testing area for measurement to obtain a first measuring result;

after the first overtime measuring cup is transferred to the testing area, loading the second measuring cup of the second sample group to the position of the first overtime measuring cup in the preheating area so as to enable the first measuring item of the second sample group to be online to the sample analyzer and obtain a second measuring result;

outputting the first measurement result and the second measurement result as the measurement results.

6. The method of claim 5, further comprising:

acquiring inter-group links of measurement items, wherein the inter-group links of the measurement items are used for indicating the principle that a plurality of measurement items need to be tested in a target sample group in the sample set and all the measurement items are on-line to the sample analyzer;

and measuring the target sample group according to the inter-group connection of the measurement items to obtain a target measurement result.

7. The method of claim 6, wherein the inter-group join of the measurement items is used to indicate that after obtaining a measurement result of a third measurement item in the target sample group, a fourth measurement item of the target sample group is brought online to the sample analyzer, and the fourth measurement item is brought online after the third measurement item;

or the like, or, alternatively,

the inter-group join of the measurement items is used for indicating that after a third measurement item in the target sample group comes on line, if available resources exist, a fourth measurement item of the target sample group comes on line to the sample analyzer, and the fourth measurement item comes on line after the third measurement item.

8. The method of claim 7, wherein after the inter-group join of the measurement items is used to indicate that a third measurement item in a sample group is on-line, if there is available resource, then when a fourth measurement item of the sample group is on-line to the sample analyzer, the obtaining a target measurement result by measuring the target sample group according to the inter-group join of the measurement items comprises:

determining the third measurement item and the fourth measurement item of a target sample group in the sample to be measured;

sequentially injecting the samples corresponding to the third measurement items into corresponding third measurement cups and then starting incubation;

transferring the second overtime measuring cup exceeding the incubation duration in the third measuring cup to a testing area for measurement to obtain a third measuring result;

after the second overtime measuring cup is transferred to the testing area, loading the fourth measuring cup of the fourth measuring item to the position of the second overtime measuring cup in the preheating area so as to enable the fourth measuring item to be online to the sample analyzer and obtain a fourth measuring result;

outputting the third measurement result and the fourth measurement result as the target measurement result.

9. The method of any one of claims 2 to 8, wherein the number of samples is determined by the processing power of the sample analyzer, the processing power of the sample analyzer being indicative of the number of samples processed by the sample analyzer over a sample incubation period.

10. The method of claim 9, further comprising:

the processing power of the sample analyzer is obtained.

11. The method of claim 10, wherein the obtaining processing power of the sample analyzer comprises:

acquiring the minimum incubation time of each item to be measured in the sample to be measured and the injection time of a single sample and a sample buffer solution of the single sample;

and obtaining the processing capacity of the sample analyzer according to the minimum incubation time and the injection time.

12. The method according to any one of claims 2 to 8, further comprising:

and acquiring an item sequence of each measurement item in the sample to be measured, wherein the item sequence is used for indicating an online sequence of each measurement item in the sample group.

13. The method according to any one of claims 2 to 8, further comprising:

and configuring delay time, wherein the delay time is used for indicating the online time interval between the measurement items in the same sample group.

14. A sample analyzer, comprising:

the input equipment is used for acquiring the sample measurement requirement of the sample to be measured;

the processor is used for measuring the sample to be measured by adopting a sample detection turnaround time measurement mode to obtain a measurement result when the sample measurement requirement indicates a sample detection turnaround time measurement mode, and the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample; and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

15. The sample analyzer of claim 14, further comprising a cup transport mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, a washing mechanism, a sample area, a pre-temperature area, a test area, a cup entry area, a reagent area;

the processor is specifically configured to perform sample grouping on the samples to be measured according to a sample grouping rule to obtain a sample group set, where the sample grouping rule includes dividing the samples to be measured with the same measurement items according to the number of samples; and controlling the cup transporting mechanism to carry out online measurement on the preheating region and the test region by taking the sample group in the sample group set as a unit to obtain the measurement result, wherein after the reagent separate-injection mechanism injects a test reagent for the same measurement item of the same sample group, the cleaning mechanism is controlled to clean the reagent separate-injection mechanism.

16. The sample analyzer of claim 15, wherein the processor is further configured to obtain an inter-group join of sample sets, the inter-group join of sample sets being configured to indicate a principle of an up-line measurement to the sample analyzer between sample sets; and measuring the sample group set according to the inter-group connection of the sample group to obtain a measurement result.

17. The sample analyzer of claim 16, wherein the inter-group join of the sample sets indicates that a second sample set of the sample set is online after measurements for all measurements of a first sample set of the sample set are obtained;

or the like, or, alternatively,

the inter-group join of the sample groups is used for indicating that after the last measurement item of the first sample group in the sample group set is on line, if available resources exist, the first measurement item of the second sample group in the sample group set is on line.

18. The sample analyzer of claim 17, wherein the inter-group join of the sample set is configured to indicate that, after a last measurement item of a first sample set in the sample set is brought online, if there is available resource, a first measurement item of a second sample set in the sample set is brought online, the processor is specifically configured to determine a first measurement item of the first sample set and a second measurement item of the second sample set in the sample to be measured, where the first measurement item is the last measurement item of the first sample set, and the second measurement item is the first measurement item of the second sample set;

controlling the sample dispensing mechanism to sequentially pour the samples corresponding to the first measurement items into the corresponding first measurement cups from the sample areas, and then starting incubation;

controlling the cup conveying mechanism to transfer the first overtime measuring cup exceeding the incubation time length in the first measuring cup to the testing area for measurement to obtain a first measuring result;

after the first overtime measuring cup is transferred to the testing area, the cup conveying mechanism is controlled to load the second measuring cup of the second sample group to the position of the first overtime measuring cup in the preheating area, so that the first measuring item of the second sample group is on line to the sample analyzer, and a second measuring result is obtained;

the sample analyzer further includes an output device for outputting the first measurement result and the second measurement result as the measurement result.

19. The sample analyzer of claim 18, wherein the processor is configured to obtain an inter-group join of measurement items, the inter-group join of measurement items being used to indicate a principle that a plurality of measurement items are required to be tested in a target sample group in the sample set, and each measurement item is on-line to the sample analyzer; and measuring the target sample group according to the inter-group connection of the measurement items to obtain a target measurement result.

20. The sample analyzer of claim 19, wherein the inter-group join of the measurement items indicates that after a measurement result of a third measurement item in the target sample group is obtained, a fourth measurement item of the target sample group is brought online to the sample analyzer, and the fourth measurement item is brought online after the third measurement item;

or the like, or, alternatively,

the inter-group join of the measurement items is used for indicating that after a third measurement item in the target sample group comes on line, if available resources exist, a fourth measurement item of the target sample group comes on line to the sample analyzer, and the fourth measurement item comes on line after the third measurement item.

21. The sample analyzer of claim 20, wherein the processor, after inter-group concatenation of the measurement items is used to indicate that a third measurement item in a sample group is on-line, is configured to determine the third measurement item and the fourth measurement item of a target sample group in the sample to be measured when a fourth measurement item of the sample group is on-line to the sample analyzer if available resources are available;

controlling the sample separate injection mechanism to sequentially inject the samples corresponding to the third measurement items into corresponding third measurement cups and then starting incubation;

controlling the cup conveying mechanism to transfer the second overtime measuring cup exceeding the incubation duration in the third measuring cup to the testing area for measurement so as to obtain a third measuring result;

after the second overtime measurement cup is transferred to the test area, controlling the cup conveying mechanism to load the fourth measurement cup of the fourth measurement item to the position of the second overtime measurement cup in the preheating area, so that the fourth measurement item is online to the sample analyzer, and a fourth measurement result is obtained;

the output device is further configured to output the third measurement result and the fourth measurement result as the target measurement result.

22. The sample analyzer of any of claims 15-21, wherein the number of samples is determined by a processing capability of the sample analyzer that is indicative of the number of samples processed by the sample analyzer during a sample incubation period.

23. The sample analyzer of claim 22, wherein the processor is further configured to obtain processing capabilities of the sample analyzer.

24. The sample analyzer of claim 23, wherein the processor is configured to obtain a minimum incubation time of each item to be measured in the sample to be measured, and an injection time of a single sample and a sample buffer solution for the single sample;

and obtaining the processing capacity of the sample analyzer according to the minimum incubation time and the injection time.

25. The sample analyzer of any of claims 15 to 21, wherein the processor is further configured to obtain an item ranking for each measurement item in the sample to be measured, the item ranking being indicative of an order of uplinking of each measurement item in the sample set.

26. The sample analyzer of any of claims 15 to 21, wherein the processor is configured to configure a delay time indicative of an on-line time interval between measurement items in a same sample group.

27. A computer-readable storage medium having stored thereon computer instructions for performing the method of any of the above claims 1-14.

28. A computer program product comprising instructions which, when run on a computer, cause the computer to perform the method of any one of the preceding claims 1 to 14.

Technical Field

The present application relates to the field of medical treatment, and in particular, to a measurement control method for a sample analyzer and a sample analyzer.

Background

When a clinical user uses the existing blood coagulation analysis instrument adopting a fixed sample home position structure to perform sample test, some key technical indexes of the instrument are often emphasized, such as sample value accuracy, sample turn-around time (TAT) time, instrument batch test speed and the like. The sample value making accuracy is the most core technical index of the instrument, and is the guarantee of the blood coagulation function screening and detecting of preoperative patients, prenatal pregnant women, patients with certain blood coagulation factor abnormal diseases and patients with oral anticoagulant drugs, and the TAT time of the sample refers to the time required by the sample from the beginning of sample suction to the result output of the sample during sample testing. The batch test speed refers to the number of samples that can be tested per unit time.

The sample analyzer in the market is a prerequisite foundation on the premise of ensuring the accuracy of sample value making, and the sample analyzer in the middle-low end market is mainly designed for the customer groups with not too large daily sample testing amount, and in consideration of development cost and user sample amount, manufacturers often design the sample analyzer from the aspects of compressor component resource, single component resource sharing, volume ratio miniaturization and the like, so that the resource and control cost are saved, but the clinical customers do not want to rapidly and accurately report the analyzed sample, and the design of the compact saving type analyzer often restricts the technical indexes of TAT time of the sample and the batch testing speed of the instrument, so that how to realize the maximized testing efficiency becomes the key of instrument measuring program design on the premise of not expanding additional resources in the existing compact components.

Disclosure of Invention

The embodiment of the application provides a measurement control method of a sample analyzer and the sample analyzer, which are used for providing two measurement modes for selection of a measurement program so as to meet the requirements of different sample test indexes.

In a first aspect, an embodiment of the present application provides a measurement control method for a sample analyzer, which specifically includes: acquiring a sample measurement requirement of a sample to be measured; when the sample measurement requirement indicates a sample detection turnaround time measurement mode (namely a TAT measurement mode, the same applies hereinafter), measuring the sample to be measured by adopting the sample detection turnaround time measurement mode to obtain a measurement result, wherein the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample;

and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

In a second aspect, an embodiment of the present application provides a sample analyzer, which specifically includes: the input equipment is used for acquiring the sample measurement requirement of the sample to be measured; the processor is used for measuring the sample to be measured by adopting a sample detection turnaround time measurement mode to obtain a measurement result when the sample measurement requirement indicates a sample detection turnaround time measurement mode, and the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample; and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

According to the technical scheme, the embodiment of the application has the following advantages: the sample analyzer provides two measurement modes, one is a sample TAT time mode and one is a batch test mode. The sample TAT time mode is used for realizing that the advanced sample person gives a measurement result in a priority and quick mode; and the batch test mode is used for realizing that the whole sample can output results quickly, so the sample analyzer can meet the requirements of different sample test indexes.

Drawings

FIG. 1 is a schematic block diagram of a sample analyzer according to an embodiment of the present application;

FIG. 2 is a schematic illustration of an area of a sample analyzer in an embodiment of the present application;

FIG. 3 is a schematic block diagram of another embodiment of a sample analyzer;

FIG. 4 is a schematic diagram of a process of measuring a sample by a sample analyzer in an embodiment of the present application;

fig. 5 is a schematic view of an embodiment of a measurement control method of a sample analyzer in the embodiment of the present application;

fig. 6 is a schematic view of another embodiment of a measurement control method of a sample analyzer in the embodiment of the present application;

fig. 7 is a schematic view of another embodiment of a measurement control method of a sample analyzer in the embodiment of the present application;

FIG. 8 is a schematic diagram of one embodiment of a sample analyzer in an embodiment of the present application;

fig. 9 is a schematic view of another embodiment of a sample analyzer in an embodiment of the present application.

Detailed Description

The embodiment of the application provides a measurement control method of a sample analyzer and the sample analyzer, which are used for providing two measurement modes for selection of a measurement program so as to meet the requirements of different sample test indexes.

The terms "first," "second," "third," "fourth," and the like in the description and in the claims of the present application and in the drawings described above, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It will be appreciated that the data so used may be interchanged under appropriate circumstances such that the embodiments described herein may be practiced otherwise than as specifically illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

Fig. 1 is a block diagram illustrating an exemplary structure of a sample analyzer 100 according to an embodiment of the present disclosure. The sample analyzer 100 includes an input device 101, a processor 102, and an output device 103. In this embodiment, the input device 101 may be used to obtain a sample measurement requirement of a sample to be measured; the processor 102 may be configured to measure the sample to be measured using a sample detection turnaround time measurement mode to obtain a measurement result when the sample measurement requirement indicates a sample detection turnaround time measurement mode, where the sample detection turnaround time measurement mode is used to implement a first-in first-out measurement result of the sample; the output device 103 may be used to output the measurement result.

In this embodiment, the output device 103 and the input device 101 of the sample analyzer 100 may be a touch display screen, a liquid crystal display, or the like, or may be independent display devices such as a liquid crystal display, a television, or the like, which are independent of the sample analyzer 100, or may be display screens on electronic devices such as a mobile phone and a tablet computer.

In one example, a schematic of the area of the sample analyzer 100 can be as shown in fig. 2. The areas of the sample analyzer 100 may specifically include a cup entry area, a sample area, a reagent area, a needle wash area, a pre-temperature area, a measurement area, and a waste cup area. In an example, the schematic structure of the sample analyzer 100 can be as shown in fig. 3, and the component mechanisms of the sample analyzer 100 can include: the device comprises a sample dispensing mechanism, a reagent dispensing mechanism, a cup transporting mechanism, a dispensing mechanism traveling assembly and a cup transporting mechanism traveling assembly. The sample dispensing mechanism and the reagent dispensing mechanism can realize X, Y, Z three positive and negative directions of movement under the cooperation of the dispensing mechanism travelling component, the cup transporting mechanism travelling component can realize Y, Z two positive and negative directions of movement, and the cup transporting mechanism can realize that a new measuring cup enters in the X direction. In the sample analyzer 100 shown in fig. 2 and 3, the workflow of this sample application link is as follows: firstly, a cup conveying mechanism grabs a measuring cup from a cup inlet area shown in figure 2 and places a preheating area; then a sample is sucked from the sample area by a sample separate injection mechanism and is injected into a measuring cup positioned in the preheating area; and finally, cleaning the sample dispensing mechanism to the needle washing area. The working flow of the sample incubation link is as follows: the measuring cup filled with the sample waits for a certain period of time in the preheating zone, and other parts of the sample analyzer do not move for the measuring cup for sample incubation. The working flow of the buffer reagent adding link is as follows: and the reagent dispensing mechanism sucks the buffer reagent from the reagent area and injects the buffer reagent into the measuring cup which is positioned in the pre-temperature area and is added with the sample, and finally the reagent dispensing mechanism performs cleaning from the needle washing area. The incubation link of the buffer system is consistent with the incubation link of the sample. The workflow of the test reagent adding link is as follows: the cup transporting mechanism walking assembly transports the incubated measuring cup to a measuring area from the preheating area; then a reagent separate injection mechanism sucks a test reagent from the reagent area and injects the test reagent into a measuring cup positioned in the measuring area; and finally, cleaning the reagent dispensing mechanism to the needle washing area. The working flow of the starting measurement link is as follows: the sample at the measurement zone waits for a period of time for the measurement to take place while the other components of the sample analyzer are not moving with respect to the sample being measured. The working flow of the links of discarding/reporting results is as follows: and the cup conveying mechanism walking assembly conveys the measuring cup from the measuring area to the waste cup area.

In one example, the flow of the measurement performed by the sample analyzer 100 on each sample is shown in fig. 4, and the specific flow is as follows: the measurement stage of the sample is mainly divided into three stages, including a sample adding stage, a buffer reagent adding stage and a test reagent adding stage. In the loading stage, after the measurement cup of the sample analyzer 100 is loaded, the sample is injected into the measurement cup. In this stage, the sample analyzer 100 can selectively add a diluent or correct plasma for different measurement items or measurement samples. After the sample adding stage is completed, the sample analyzer 100 determines whether the sample needs to be incubated according to actual requirements, and if the sample does not need to be incubated, the sample analyzer 100 directly jumps to the stage of adding the test reagent; if sample incubation is desired, the sample analyzer 200 can proceed to a buffer addition stage, and then add different buffers for different measurement items. As shown in fig. 4, the buffer reagent may include, but is not limited to, reagent R1, reagent R2, or reagent R3. It is understood that if the sample analyzer 100 further comprises a stirring region, the sample analyzer 100 may also optionally perform a stirring action during the buffering of the reagents. After the incubation of the sample is completed, the sample analyzer 100 injects a test reagent into the measuring cup, and then starts the optical method to test the sample or starts the magnetic bead method to test the sample to obtain a test result.

In one example, the measurement items may be seven items of conventional coagulation (e.g., Activated Partial Thromboplastin Time (APTT), plasma Prothrombin Time (PT), Thrombin Time (TT), Fibrinogen (FIB), D-Dimer), Fibrinogen Degradation Products (FDP), antithrombin III (AT-III).

Specifically, referring to fig. 5, an embodiment of a measurement control method of a sample analyzer in the embodiment of the present application specifically includes:

501. the sample analyzer acquires sample measurement requirements of a sample to be measured.

In this embodiment, the sample analyzer may obtain a sample measurement requirement of the sample to be measured through an input device. In particular, the input mode of the sample measurement requirements differ according to the different modes of the input device of the sample analyzer. For example, as shown in fig. 6, the input device of the sample analyzer may be a touch screen, and the touch screen displays two options of the sample TAT time measurement and the batch measurement, and then the user inputs the sample measurement requirement by clicking a selection on the touch screen. In this embodiment, the sample measurement requirement may also be input in other manners, for example, a measurement mode key is set, and the sample measurement requirement is selected by the measurement mode key.

502. When the sample measurement requirement indicates a sample TAT time measurement mode, the sample analyzer measures the sample to be measured by adopting the sample TAT time measurement mode to obtain a measurement result.

In this embodiment, the TAT time measurement of the sample is used to realize that "an advanced sample person preferentially and quickly outputs a measurement result", that is, after a single sample enters, the measurement result is obtained by performing sample measurement on the single sample.

503. When the sample measurement needs to indicate a batch measurement mode, the sample analyzer measures the sample to be measured by adopting the batch measurement mode to obtain a measurement result.

In this embodiment, the batch measurement mode is used to realize "fast overall sample output. That is, after entering, a plurality of samples are measured, and the measurement results of the plurality of samples are output simultaneously.

In this embodiment, the sample analyzer provides two measurement modes, one is a sample TAT time mode and one is a batch test mode. The sample TAT time mode is used for realizing that the advanced sample person gives a measurement result in a priority and quick mode; and the batch test mode is used for realizing that the whole sample can output results quickly, so the sample analyzer can meet the requirements of different sample test indexes.

The measurement control method of the sample analyzer is explained in detail below in the batch measurement mode and the sample TAT time measurement mode, respectively.

Specifically, referring to fig. 6, an embodiment of a measurement control method for a sample analyzer in a batch measurement mode in the embodiment of the present application includes:

601. the sample analyzer groups the samples to be measured according to a sample grouping rule to obtain a sample group set, wherein the sample grouping rule comprises dividing the samples to be measured with the same measurement items according to the number of the samples.

In this embodiment, the number of samples is determined based on the processing power of the sample analyzer. The sample analyzer therefore also needs to acquire a corresponding number of samples for different samples to be measured. The specific mode is as follows: the sample analyzer acquires the incubation duration of each measurement item in the sample to be measured, and determines the minimum incubation duration as the minimum incubation duration; obtaining a single sample and the injection duration of a sample buffer solution corresponding to the single sample by the sample analyzer; and obtaining the processing capacity of the sample analyzer according to the minimum incubation time length and the injection time length, namely the number of samples of the sample analyzer in grouping. For example, the sample analyzer currently has 30 samples. Of these, 20 samples have the same measurement items (APTT, PT, TT, and FIB, respectively), and 10 samples have the same measurement items (APTT, PT, and TT, respectively). The sample analyzer now obtains the incubation time for these four measurements separately, which is 30 seconds assuming the APTT is the smallest. And the sample analyzer takes a single sample and the injection time of the sample buffer solution of the single sample is 3 seconds, the sample analyzer can determine that the number of samples is 10 (i.e., each sample group contains 10 samples at most). Therefore, a sample group set obtained by grouping the samples to be measured through a sample grouping rule comprises 3 sample groups, wherein the first sample group comprises 10 samples, and the measurement items of the samples are APTT, PT, TT and FIB; the second sample group comprises 10 samples, and the measurement items of the samples are APTT, PT, TT and FIB; the third sample group contains 10 samples, and the measurement items of the samples are APTT, PT, and TT. Based on this, the parameter configuration of the sample group set can be as shown in table 1:

TABLE 1

Figure BDA0002184872360000071

In table 1, "1" in the cell indicates that the measurement item of the sample group contains the measurement item, and "0" in the cell indicates that the measurement item of the sample group does not contain the measurement item. Table 1 may represent a sample grouping configuration for batch measurement.

602. The sample analyzer takes the sample group in the sample group set as a unit to carry out online measurement by the sample analyzer to obtain a measurement result, wherein the reagent dispensing mechanism of the sample analyzer is cleaned after the reagent dispensing mechanism injects the same test reagent for the same measurement item of the same sample group.

It should be noted that, in the present embodiment, a sample group for measuring the same item is simultaneously brought on line to a sample analyzer for testing, so that, in the reagent adding stage, the same test reagent is respectively injected into the measuring cups corresponding to the samples of the sample group. Since the items tested by each sample are the same and the reagents to be added are also the same, when the same reagent is added to each sample, the reagent needle does not need to be cleaned in the middle. After the test reagent is added to each measurement cup, the reagent needle cleaning is performed to add the next reagent. Therefore, compared with the existing on-line test of samples one by one, the on-line test of the embodiment in the form of sample groups can reduce the time for washing the needle when different reagents are added among the samples. Taking 10 samples in the sample group as an example, each sample needs to be added with 2 reagents, so that the needle only needs to be washed before the 1 st reagent is added, the needle needs to be washed for 1 time after the 1 st reagent is added, and the needle needs to be washed for 3 times after the 2 nd reagent is added. Compared with 10 samples in the prior art, the needle washing process needs to be carried out 21 times, the time for the whole sample to quickly produce results can be greatly shortened, and the whole testing efficiency is improved.

In this embodiment, the sample analyzer may further obtain inter-group connection of the sample group and/or inter-group connection of the measurement items, and then perform measurement on the sample analyzer on line by using the sample group in the sample group set as a unit to obtain a measurement result. Wherein, the inter-group connection of the sample groups is used for indicating the principle that each sample group is on-line to the sample analyzer for measurement; the inter-group join of the measurement items is used for indicating the principle that a plurality of measurement items need to be tested in a target sample group in the sample set, and each measurement item is on-line to the sample analyzer.

Specifically, the principle of the specific indication of the inter-group linkage of the sample group includes: after the inter-group connection of the sample group is used for indicating that the measurement results of all the measurement items of the first sample group in the sample group set are obtained, the second sample group in the sample group set is online; or after the inter-group join of the sample group is used for indicating that the last measurement item of the first sample group in the sample group set is on line, if available resources exist, the first measurement item of the second sample group in the sample group set is on line.

The principle of the specific indication of the inter-group connection of the measurement items comprises the following steps: after the inter-group connection of the measurement items is used for indicating to obtain the measurement result of a third measurement item in the target sample group, a fourth measurement item of the target sample group is online to the sample analyzer, and the fourth measurement item is online after the third measurement item; or after the inter-group join of the measurement items is used for indicating that a third measurement item in the target sample group is on line, if available resources exist, a fourth measurement item of the target sample group is on line to the sample analyzer, and the fourth measurement item is on line after the third measurement item.

Based on the foregoing solution, in an example, if there is available resource after inter-group join of the sample group is used to indicate that the last measurement item of the first sample group in the sample group set is on line, then the sample analyzer is on line with the sample group in the sample group set as a unit, and the specific operation of the sample analyzer performing measurement on the sample analyzer to obtain the measurement result is as follows:

the sample analyzer determines the last measurement item of the first sample group in the samples to be measured;

the sample analyzer loads the first measurement cups in turn according to the number of samples of said first set of samples, which is understood to be 10. For convenience of description, the first measuring cup is identified according to the morning and evening of the loading time, and is respectively the measuring cup 1, the measuring cup 2, the measuring cup 3, the measuring cup 4, the measuring cup 5, the measuring cup 6, the measuring cup 7, the measuring cup 8, the measuring cup 9 and the measuring cup 10, which is not necessarily required in the specific operation process.

Then the sample analyzer uses a sample injection mechanism to suck samples of a first sample group and sequentially injects the samples into the first measuring cup, and the sample injection mechanism is cleaned after the samples in the first sample group are injected; in this practical application, after the sample injection in the measuring cup 1 is completed, the timer of the measuring cup 1 starts, wherein the timing duration of the timer is the incubation duration of the samples in the first sample group. It will be appreciated that after the measuring cup 2 has completed the sample injection, a timer of the measuring cup 2 is started, which timer is timed to the length of the incubation time of the samples of the first set of samples. Similarly, the measurement cups 3 to 10 are also started sequentially by the timer after the sample injection is completed.

After the incubation time in the first measuring cup of the first sample is over, when available resources appear in the pre-temperature region by the sample analyzer, the sample analyzer loads the second measuring cups in sequence according to the number of the samples of the second sample group, and it can be understood that the number of the second measuring cups is 10. For convenience of description, the second measuring cup is identified herein according to the morning and evening of the loading time, and is respectively measuring cup 11, measuring cup 21, measuring cup 31, measuring cup 41, measuring cup 51, measuring cup 61, measuring cup 71, measuring cup 81, measuring cup 91 and measuring cup 101, which is not necessarily required in the specific operation process. The specific loading process may be as follows: the first overtime measuring cup is formed after the timer of the measuring cup 1 is overtime, the sample analyzer transfers the measuring cup 1 to a testing area, and a reagent dispensing mechanism is utilized to inject a corresponding testing reagent into the measuring cup 1 for measurement to obtain a measuring result 1; after the transfer of the measuring cup 1 to the test area, the sample analyzer loads the first measuring cup (i.e. measuring cup 11) of the first measuring item of the second sample group to the position of the measuring cup 1 in the preheating area; after the timer of the measuring cup 2 is overtime, the sample analyzer transfers the measuring cup 2 to a testing area, and a reagent dispensing mechanism is utilized to inject a corresponding testing reagent into the measuring cup 2 for measurement to obtain a measuring result 2; after the transfer of measuring cup 2 to the test area, the sample analyzer loads the 2 nd measuring cup of the first measurement item of the second sample group, i.e. measuring cup 21, to the position of measuring cup 2 in the preheating zone. And so on, after the timer of the measuring cup 3 is overtime, the sample analyzer transfers the measuring cup 3 to the testing area, and injects the corresponding testing reagent into the measuring cup 3 by using the reagent separate injection mechanism to measure and obtain the measuring result 3; after the transfer of the measuring cup 3 to the test area, the sample analyzer loads the 3 rd measuring cup (i.e. measuring cup 31) of the first measuring item of the second sample group to the position of the measuring cup 3 in the preheating zone. I.e. corresponding to the measuring cup of the first measuring item of the second sample set, which can be brought on line in turn by the sample analyzer as long as the pre-temperature zone of the sample analyzer has available empty positions (i.e. available resources). And after the second sample group is on line, measuring each sample of the second sample group according to a measurement process to obtain a measurement result. In this embodiment, the sample groups may be uplinked in an inter-group connection manner between the first sample group and the second sample group, and then the measurement result is obtained by measurement.

In one example, if the inter-group join of the sample group is used to indicate that the measurement results of all the measurement items of the first sample group in the sample group set are obtained, and then the second sample group in the sample group set is online, the sample analyzer performs the measurement on the sample analyzer online by using the sample group in the sample group set as a unit to obtain the measurement results specifically as follows:

the sample analyzer determines the last measurement item of the first sample group in the samples to be measured;

the sample analyzer loads the first measurement cups in turn according to the number of samples of said first set of samples, which is understood to be 10. For convenience of description, the first measuring cup is identified according to the morning and evening of the loading time, and is respectively the measuring cup 1, the measuring cup 2, the measuring cup 3, the measuring cup 4, the measuring cup 5, the measuring cup 6, the measuring cup 7, the measuring cup 8, the measuring cup 9 and the measuring cup 10, which is not necessarily required in the specific operation process.

The sample analyzer then suctions the samples of the first sample group by the sample dispensing mechanism to sequentially inject into the first measuring cup, and the sample dispensing mechanism is cleaned after the samples in the first sample group are injected. After the timer of the measuring cup 1 is overtime, the sample analyzer transfers the measuring cup 1 to a test area, and a reagent dispensing mechanism is utilized to inject a corresponding test reagent into the measuring cup 1 for measurement to obtain a measurement result 1; after the timer of the measuring cup 2 is overtime, the sample analyzer transfers the measuring cup 2 to a test area, and injects a corresponding test reagent into the measuring cup 2 by using a reagent injection mechanism to perform measurement, so as to obtain a measurement result 2. And so on, after the timer of the measuring cup 3 is overtime, the sample analyzer transfers the measuring cup 3 to the testing area, and injects the corresponding testing reagent into the measuring cup 3 by using the reagent separate injection mechanism to measure and obtain the measuring result 3; after the timer of the measuring cup 4 is timed out, the sample analyzer transfers the measuring cup 4 to the testing area, and injects a corresponding testing reagent into the measuring cup 4 by using a reagent injection mechanism to perform measurement, so as to obtain a measuring result 4. After the sample analyzer measures the samples of the first sample group according to the measurement procedure to obtain the measurement results (including measurement results 1 to 10), the sample analyzer measures the samples of the second sample group in the above manner. In this embodiment, the sample groups may be uplinked in an inter-group connection manner between the first sample group and the second sample group, and then the measurement result is obtained by measurement.

In one example, if after the inter-group join of the measurement items is used to indicate that a third measurement item in the target sample group is on-line, if there is available resource, a fourth measurement item of the target sample group is on-line to the sample analyzer, and the fourth measurement item is on-line after the third measurement item, the on-line process of each measurement item in the sample group by the sample analyzer is specifically operated as follows:

the sample analyzer determines a third measurement item of the first sample group in the sample to be measured;

the sample analyzer loads the third measurement cups in turn based on the number of samples of said first set of samples, which is understood to be 10. For convenience of description, the third measuring cup is identified herein according to the morning and evening of the loading time, and is respectively measuring cup 12, measuring cup 22, measuring cup 32, measuring cup 42, measuring cup 52, measuring cup 62, measuring cup 72, measuring cup 82, measuring cup 92 and measuring cup 102, which is not necessarily required in the specific operation process.

Then the sample analyzer uses a sample injection mechanism to suck samples of a first sample group and sequentially injects the samples into the third measuring cup, and the sample injection mechanism is cleaned after the samples in the first sample group are injected; in this embodiment, after the sample is filled into the measuring cup 12, a timer of the measuring cup 12 starts, wherein the timing duration of the timer is the incubation duration of the samples in the first sample group. It will be appreciated that after the measurement cup 22 has completed the sample injection, a timer of the measurement cup 22 is started, which timer is timed to the length of the incubation time of the samples of the first set of samples. Similarly, measurement cups 32-102 also start the timer after the sample injection is completed.

And when available resources appear in the pre-temperature region, the sample analyzer accesses the fourth measurement item of the first sample group, that is, the sample analyzer accesses the fourth measurement cup in sequence according to the number of the samples of the first sample group, and it can be understood that the number of the fourth measurement cups is 10. For convenience of description, the fourth measuring cup is identified according to the morning and evening of the loading time, and is respectively the measuring cup 13, the measuring cup 23, the measuring cup 33, the measuring cup 43, the measuring cup 53, the measuring cup 63, the measuring cup 73, the measuring cup 83, the measuring cup 93 and the measuring cup 103, which is not necessarily required in the specific operation process. The specific loading process may be as follows: after the timer of the measuring cup 12 is overtime, the sample analyzer transfers the measuring cup 12 to a test area, and injects a corresponding test reagent into the measuring cup 12 by using a reagent injection mechanism to measure, so as to obtain a measurement result 12; after the transfer of measuring cup 12 to the test area, the sample analyzer loads the 1 st measuring cup (i.e., measuring cup 13) of the fourth measurement item of the first sample group to the position of measuring cup 12 at the preheating area; after the timer of the measuring cup 22 is overtime, the sample analyzer transfers the measuring cup 22 to a test area, and injects a corresponding test reagent into the measuring cup 22 by using a reagent injection mechanism to measure, so as to obtain a measurement result 22; after the transfer of measuring cup 22 to the test area, the sample analyzer loads the 3 rd measuring cup (i.e. measuring cup 23) of the fourth measurement item of the first sample group to the position of measuring cup 22 at the preheating area. By analogy, after the timer of the measurement cup 32 is overtime, the sample analyzer transfers the measurement cup 32 to the test area, and injects a corresponding test reagent into the measurement cup 32 by using a reagent dispensing mechanism to perform measurement, so as to obtain a measurement result 32; after the transfer of measuring cup 32 to the test area, the sample analyzer loads the 4 th measuring cup (i.e., measuring cup 33) of the fourth measurement item of the first sample group to the position of measuring cup 32 at the preheating area. I.e. corresponding to the measuring cup of the next measuring item of the first sample set that is brought on line in sequence as long as the pre-temperature zone of the sample analyzer has available empty space (i.e. available resources). And after the next measurement item of the first sample group comes on line, measuring each sample of the first sample group according to the measurement flow to obtain a measurement result. In this embodiment, different measurement items in the same sample group can be online in a manner similar to the inter-group connection between the third measurement item and the fourth measurement item, and then the measurement result is obtained by measurement.

In one example, if inter-group concatenation of the measurement items is used to indicate that a measurement result of a third measurement item in the target sample group is obtained, and then a fourth measurement item of the target sample group is online to the sample analyzer, and the fourth measurement item is online after the third measurement item, the online process of each measurement item in the sample group by the sample analyzer is specifically performed as follows:

the sample analyzer determines a third measurement item of the first sample group in the sample to be measured;

the sample analyzer loads the third measurement cups in turn based on the number of samples of said first set of samples, which is understood to be 10. For convenience of description, the third measuring cup is identified herein according to the morning and evening of the loading time, and is respectively measuring cup 12, measuring cup 22, measuring cup 32, measuring cup 42, measuring cup 52, measuring cup 62, measuring cup 72, measuring cup 82, measuring cup 92 and measuring cup 102, which is not necessarily required in the specific operation process.

The sample analyzer then suctions the samples of the first sample group by the sample dispensing mechanism and sequentially injects them into the third measuring cup, and the sample dispensing mechanism is cleaned after the samples in the first sample group are injected. After the timer of the measuring cup 12 is overtime, the sample analyzer transfers the measuring cup 12 to a test area, and injects a corresponding test reagent into the measuring cup 12 by using a reagent injection mechanism to measure, so as to obtain a measurement result 12; after the timer of the measurement cup 22 expires, the sample analyzer transfers the measurement cup 22 to a test area, and injects a corresponding test reagent into the measurement cup 22 by using a reagent injection mechanism to perform measurement, thereby obtaining a measurement result 22. By analogy, after the timer of the measurement cup 32 is overtime, the sample analyzer transfers the measurement cup 32 to the test area, and injects a corresponding test reagent into the measurement cup 32 by using a reagent dispensing mechanism to perform measurement, so as to obtain a measurement result 32; after the timer of the measurement cup 42 expires, the sample analyzer transfers the measurement cup 42 to a test area, and injects a corresponding test reagent into the measurement cup 42 by using a reagent injection mechanism to perform measurement, thereby obtaining a measurement result 42. After the sample analyzer measures the samples of the first sample group according to the measurement flow to obtain the measurement results (including the measurement results 12 to 102), the sample analyzer measures the samples of the next measurement item of the first sample group in the manner described above. In this embodiment, different measurement items in the same sample group can be online in a manner similar to the inter-group connection between the third measurement item and the fourth measurement item, and then the measurement result is obtained by measurement.

It can be understood that, in this embodiment, item ordering may also be performed between the measurement items, specifically, the measurement priority of each measurement item may be preset, and then the online order of the measurement items is arranged from high to low according to the priority. In one example, the ordering of the items in the measurement items may be as shown in table 2:

TABLE 2

Measurement item APTT PT TT FIB D-Dimer FDP AT-III
Priority level 3 4 5 6 2 1 0

In table 2, each number of the priority is used to indicate that the measurement item comes on the next line. For example, "3" indicates that the 3 rd of the measurement item comes on line, and "4" indicates that the 4 th of the measurement item comes on line.

Optionally, in this embodiment, a delay time between sample measurement items may be set, so as to prevent overload of component resources of the sample analyzer caused by accumulation of linear quantities on the sample. In one example, the configuration of the delay time may be as shown in table 3:

TABLE 3

Where table 3 may be used for one exemplary delay time configuration in the batch measurement mode, and the units of time in table 3 are seconds. For example, the delay time of the APTT measurement item in any 4 measurement items is 40 seconds; the APTT measurement item has a delay time of 50 seconds in any 6 measurement items.

In this embodiment, the sample analyzer measures the sample in a batch measurement mode, thereby achieving the effect of "the whole sample simultaneously generates a measurement result". Meanwhile, the sample to be measured is configured with parameters such as sample grouping, item sequencing, delay time, inter-group connection and the like, so that the compression of the measurement time is further realized, and the measurement time is accelerated.

Specifically, referring to fig. 7, an embodiment of a measurement control method for a sample analyzer in an example of a sample TAT time measurement mode in the embodiment of the present application includes:

701. the sample analyzer groups the samples to be measured according to a sample grouping rule to obtain a sample group set, wherein the sample grouping rule is that a single sample is a sample group.

The sample analyzer takes a single sample as a sample group for the sample to be measured. Therefore, in the sample TAT time measurement mode, the configuration of the sample packet can be as shown in table 4:

TABLE 4

Figure BDA0002184872360000141

In table 4, "1" in the cell indicates that the measurement item of the sample includes the measurement item, and "0" in the cell indicates that the measurement item of the sample does not include the measurement item.

702. The sample analyzer takes the single sample as a unit to put the sample to be measured on line to measure the sample analyzer to obtain a measurement result.

In this embodiment, the sample analyzer may further obtain inter-group connection between the single samples and/or inter-group connection between measurement items, and then perform online measurement by using the single sample as a unit to obtain a measurement result. Wherein the inter-group connection of the inter-group connection between the single samples is used for indicating the principle that the samples are up-line to the sample analyzer for measurement; the inter-group linkage of the measurement items is used for indicating the principle that a plurality of measurement items need to be tested in a sample, and each measurement item is on-line to the sample analyzer.

Specifically, the principle of the specific indication of inter-group linkage between the individual samples includes: after the inter-group connection between the single samples is used for indicating that the measurement results of all the measurement items of the first sample are obtained, a second sample is put on line; or, after the inter-group join of the sample group is used to indicate that the last measurement item of the first sample is on line, if there is available resource, the first measurement item of the second sample is on line.

The principle of the specific indication of the inter-group connection of the measurement items comprises the following steps: after the inter-group connection of the measurement items is used for indicating that the measurement result of a third measurement item in a single sample is obtained, a fourth measurement item of the single sample is online to the sample analyzer, and the fourth measurement item is online after the third measurement item; or, after the inter-group join of the measurement items is used to indicate that a third measurement item in the single sample is on-line, if there is available resource, a fourth measurement item of the single sample is on-line to the sample analyzer, the fourth measurement item is on-line after the third measurement item.

Based on the above solution, in an example, if after inter-group connection of the sample group is used to indicate that the last measurement item of the first sample is on line, if there is available resource, then the first measurement item of the second sample is on line, and the sample analyzer is on line with the single sample as a unit to perform measurement, so as to obtain the measurement result, specifically, the following operations are performed:

the sample analyzer determines a last measurement item of the first sample;

the sample analyzer loads a measuring cup A; then the sample analyzer uses a sample injection mechanism to suck a first sample to be injected into the measuring cup A, and the sample injection mechanism is cleaned after the first sample is injected; in this practical application, after the sample injection is completed in the measuring cup a, the timer of the measuring cup a starts, wherein the timing duration of the timer is the incubation duration of the first sample.

And when the incubation time in the measuring cup A is overtime, the measuring cup A becomes a first overtime measuring cup, and when available resources appear in the preheating region, the sample analyzer analyzes the measuring cup B loaded with a second sample. The specific loading process may be as follows: after the timer of the measuring cup A is overtime, the sample analyzer transfers the measuring cup A to a test area, and a reagent dispensing mechanism is utilized to inject a corresponding test reagent into the measuring cup A for measurement to obtain a measurement result 1; after the measurement cup a is transferred to the test area, the sample analyzer loads a second sample measurement cup B to the location of measurement cup a at the pre-warm area. And after the second sample is on-line, measuring each sample of the second sample according to a measurement flow to obtain a measurement result. In this embodiment, the samples may be uplinked in a manner similar to the inter-group linkage between the first sample and the second sample, and then the measurement result is obtained by measurement.

In one example, if the inter-group connection between the single samples is used to indicate that the measurement results of all the measurement items of the first sample are obtained and then the second sample is online, the sample analyzer is online to obtain the measurement results by taking the single sample as a unit, specifically as follows:

the sample analyzer determines a last measurement item of the first sample;

the sample analyzer loads a measuring cup A; then the sample analyzer uses a sample injection mechanism to suck a first sample to be injected into the measuring cup A, and the sample injection mechanism is cleaned after the first sample is injected; after the incubation time in the measuring cup A is overtime, the sample analyzer transfers the measuring cup A to a testing area, and a reagent dispensing mechanism is utilized to inject a corresponding testing reagent into the measuring cup A for measurement to obtain a measuring result 1. After the measurement result 1 is output, the sample analyzer loads the measuring cup B of the second sample and performs measurement to obtain a measurement result 2. And after the second sample is on-line, measuring each sample of the second sample according to a measurement flow to obtain a measurement result. In this embodiment, the samples may be uplinked in a manner similar to the inter-group linkage between the first sample and the second sample, and then the measurement result is obtained by measurement.

In one example, after the inter-group join of the measurement items is used to indicate that a third measurement item in the single sample is on-line, if there is available resource, a fourth measurement item of the single sample is on-line to the sample analyzer, and the fourth measurement item is on-line after the third measurement item, the on-line process of each measurement item in the sample by the sample analyzer is specifically as follows:

the sample analyzer determining a third measurement item of the first sample; the sample analyzer is based on the measuring cup C of the third measurement item of the first sample. The sample analyzer then aspirates a first sample into the measurement cup C using a sample dispensing mechanism, which is cleaned after the first sample is dispensed. In this practical application, after the sample injection is completed in the measurement cup C, the timer of the measurement cup C starts to be started, wherein the timing duration of the timer is the incubation duration of the first sample.

When the timer of the measuring cup C is overtime, a second overtime measuring cup is formed, the sample analyzer transfers the measuring cup C to a test area, and a reagent dispensing mechanism is utilized to inject a corresponding test reagent into the measuring cup C for measurement to obtain a measurement result C; after the measurement cup C is transferred to the test area, the sample analyzer loads the measurement cup D of the fourth measurement item of the first sample; and after the timer of the measuring cup D is overtime, the sample analyzer transfers the measuring cup D to a test area, and injects a corresponding test reagent into the measuring cup D by using a reagent injection mechanism to carry out measurement to obtain a measurement result D. I.e. corresponding to the measuring cup of the next measurement item of the first sample that can be brought on line in sequence by the sample analyzer as long as the pre-temperature zone of the sample analyzer has available empty space (i.e. available resources). After the next measurement item of the first sample comes on line, the first sample is measured according to the measurement flow to obtain the measurement result. In this embodiment, different measurement items in the same sample group can be online in a manner similar to the inter-group connection between the third measurement item and the fourth measurement item, and then the measurement result is obtained by measurement.

In one example, if the inter-group join of the measurement items is used to indicate that a measurement result of a third measurement item in a single sample is obtained, and then a fourth measurement item of the single sample is online to the sample analyzer, and the fourth measurement item is online after the third measurement item, the online process of each measurement item in the sample by the sample analyzer is specifically performed as follows:

the sample analyzer determining a third measurement item of the first sample; the sample analyzer is based on the measuring cup C of the third measurement item of the first sample. Then the sample analyzer uses a sample injection mechanism to suck a first sample to be injected into the measuring cup C, and the sample injection mechanism is cleaned after the first sample is injected; after the incubation of the measuring cup C is finished, the sample analyzer transfers the measuring cup C to a test area, and a reagent dispensing mechanism is utilized to inject a corresponding test reagent into the measuring cup C for measurement to obtain a measurement result C; after obtaining the measurement result C, the sample analyzer loads the measuring cup D of the fourth measurement item of the first sample; and after the timer of the measuring cup D is overtime, the sample analyzer transfers the measuring cup D to a test area, and injects a corresponding test reagent into the measuring cup D by using a reagent injection mechanism to carry out measurement to obtain a measurement result D. The sample analyzer may be brought in sequence to the measuring cup of the next measurement item of the first sample. After the next measurement item of the first sample comes on line, the first sample is measured according to the measurement flow to obtain the measurement result. In this embodiment, different measurement items in the same sample group can be online in a manner similar to the inter-group connection between the third measurement item and the fourth measurement item, and then the measurement result is obtained by measurement.

It can be understood that, in this embodiment, item ordering may also be performed between the measurement items, specifically, the measurement priority of each measurement item may be preset, and then the online order of the measurement items is arranged from high to low according to the priority. In one example, the ordering of the items in the measurement items may be as shown in table 5:

TABLE 5

Measurement item APTT PT TT FIB D-Dimer FDP AT-III
Priority level 3 4 5 6 2 1 0

In table 5, each number of the priority is used to indicate that the measurement item comes on the next line. For example, "3" indicates that the 3 rd of the measurement item comes on line, and "4" indicates that the 4 th of the measurement item comes on line.

Optionally, in this embodiment, a delay time between sample measurement items may be set, so as to prevent overload of component resources of the sample analyzer caused by accumulation of linear quantities on the sample. In one example, the configuration of the delay time may be as shown in table 6:

TABLE 6

Figure BDA0002184872360000181

Where table 6 may be used to represent one exemplary delay time configuration for the sample TAT time measurement mode, and the units of time in table 6 are seconds. For example, the delay time of the APTT measurement item in any of 4 measurement items is 0 second; the delay time of the APTT measurement item in any 6 measurement items is 0 second.

In this embodiment, the sample analyzer measures the sample in the sample TAT time measurement mode, thereby achieving the effect of "advanced sample person gets the measurement result first". Meanwhile, the parameters such as the sequencing of sample configuration items to be measured, the delay time, the inter-group connection and the like are further compressed, and the measurement time is shortened.

The measurement control method in the embodiment of the present application is described above, and the sample analyzer in the embodiment of the present application is described below:

specifically, referring to fig. 8, the sample analyzer 800 in the embodiment of the present application includes: an input device 801, a processor 802, and an output device 803. The sample analyzer 800 may be the sample analyzer of the method embodiments described above, or may be one or more chips within the sample analyzer. The sample analyzer 800 may be used to perform some or all of the functions of the sample analyzer in the method embodiments described above.

For example, the input device 801 may be used to perform step 501 in the above-described method embodiments. For example, the input device 801 acquires sample measurement requirements of a sample to be measured.

The processor 802 may be configured to perform steps 502 to 503, or to perform steps 601 to 602, or to perform steps 701 to 702 in the foregoing method embodiments. For example, when the sample measurement requirement indicates a sample detection turnaround time measurement mode, the processor 802 measures the sample to be measured using a sample detection turnaround time measurement mode to obtain a measurement result, where the sample detection turnaround time measurement mode is used to implement a first-in first-out measurement result of the sample; and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

The output device 803 may be used to output the measurement result.

Optionally, the sample analyzer 800 further comprises a memory module coupled to the processor such that the processor can execute computer executable instructions stored in the memory module to implement the functions of the sample analyzer in the above-described method embodiments. In one example, the memory module optionally included in the sample analyzer 800 may be a memory unit within a chip, such as a register, a cache, etc., and the memory module may also be a memory unit located outside the chip, such as a read-only memory (ROM) or other types of static memory devices that can store static information and instructions, a Random Access Memory (RAM), etc.

It should be understood that the flow executed between the modules of the sample analyzer in the corresponding embodiment of fig. 8 is similar to the flow executed by the sample analyzer in the corresponding method embodiment of fig. 5 to 7, and detailed description thereof is omitted here.

Fig. 9 shows a schematic diagram of a possible structure of a sample analyzer 900 in the above embodiment, and the sample analyzer 900 may be configured as the sample analyzer. The sample analyzer 900 may include: a processor 902, a computer-readable storage medium/memory 903, a transceiver 904, an input device 905 and an output device 906, and a bus 901. Wherein the processor, transceiver, computer readable storage medium, etc. are connected by a bus. The embodiments of the present application do not limit the specific connection medium between the above components.

In one example, the input device 905 acquires sample measurement requirements of a sample to be measured;

when the sample measurement requirement indicates a sample detection turnaround time measurement mode, the processor 902 measures the sample to be measured by using the sample detection turnaround time measurement mode to obtain a measurement result, wherein the sample detection turnaround time measurement mode is used for realizing a first-in first-out measurement result of the sample; and when the sample measurement requirement indicates a batch measurement mode, measuring the sample to be measured by adopting the batch test mode to obtain the measurement result, wherein the batch test mode is used for realizing simultaneous measurement of the whole sample.

In one example, the processor 902 may include baseband circuitry, e.g., may generate control information.

In yet another example, the processor 902 may run an operating system that controls functions between various devices and appliances. The transceiver 904 may include baseband circuitry and radio frequency circuitry.

The input device 905, the output device 906, and the processor 902 may implement corresponding steps in any one of the embodiments of fig. 5 to fig. 7, which are not described herein again.

It is understood that fig. 9 merely illustrates a simplified design of a sample analyzer, and in practical applications, a sample analyzer may comprise any number of transceivers, processors, memories, etc., and all sample analyzers that can implement the present application are within the scope of the present application.

The processor 902 involved in the sample analyzer 900 may be a general-purpose processor, such as a general-purpose Central Processing Unit (CPU), a Network Processor (NP), a microprocessor, etc., an application-specific integrated circuit (ASIC), or one or more integrated circuits for controlling the execution of the program according to the present disclosure. But also a Digital Signal Processor (DSP), a field-programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic device, discrete hardware components. The controller/processor can also be a combination of computing functions, e.g., comprising one or more microprocessors, DSPs, and microprocessors, among others. Processors typically perform logical and arithmetic operations based on program instructions stored within memory.

The bus 901 may be a Peripheral Component Interconnect (PCI) bus, an Extended Industry Standard Architecture (EISA) bus, or the like. The bus may be divided into an address bus, a data bus, a control bus, etc. For ease of illustration, only one thick line is shown in FIG. 9, but this does not indicate only one bus or one type of bus.

The computer-readable storage medium/memory 903 referred to above may also hold an operating system and other application programs. In particular, the program may include program code including computer operating instructions. More specifically, the memory may be a read-only memory (ROM), other types of static storage devices that may store static information and instructions, a Random Access Memory (RAM), other types of dynamic storage devices that may store information and instructions, a disk memory, and so forth. The memory 903 may be a combination of the above memory types. And the computer-readable storage medium/memory described above may be in the processor, may be external to the processor, or distributed across multiple entities including the processor or processing circuitry. The computer-readable storage medium/memory described above may be embodied in a computer program product. By way of example, a computer program product may include a computer-readable medium in packaging material.

Alternatively, embodiments of the present application also provide a general-purpose processing system, such as that commonly referred to as a chip, including one or more microprocessors that provide processor functionality; and an external memory providing at least a portion of the storage medium, all connected together with other supporting circuitry through an external bus architecture. The instructions stored by the memory, when executed by the processor, cause the processor to perform some or all of the steps of the sample analyzer in the measurement control method of the sample analyzer in the embodiments described in fig. 5-7, such as steps 402 and 403 in fig. 5, steps 601-602 in fig. 6, steps 701-702 in fig. 7, and/or other processes for the techniques described herein.

The steps of a method or algorithm described in connection with the disclosure herein may be embodied in hardware or in software instructions executed by a processor. The software instructions may consist of corresponding software modules that may be stored in RAM memory, flash memory, ROM memory, EPROM memory, EEPROM memory, registers, a hard disk, a removable disk, a CD-ROM, or any other form of storage medium known in the art. An exemplary storage medium is coupled to the processor such the processor can read information from, and write information to, the storage medium. Of course, the storage medium may also be integral to the processor. The processor and the storage medium may reside in an ASIC. Additionally, the ASIC may be located in a sample analyzer. Of course, the processor and the storage medium may reside as discrete components in a sample analyzer.

It is clear to those skilled in the art that, for convenience and brevity of description, the specific working processes of the above-described systems, apparatuses and units may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.

In the several embodiments provided in the present application, it should be understood that the disclosed system, apparatus and method may be implemented in other manners. For example, the above-described apparatus embodiments are merely illustrative, and for example, the division of the units is only one logical division, and other divisions may be realized in practice, for example, a plurality of units or components may be combined or integrated into another system, or some features may be omitted, or not executed. In addition, the shown or discussed mutual coupling or direct coupling or communication connection may be an indirect coupling or communication connection through some interfaces, devices or units, and may be in an electrical, mechanical or other form.

The units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, functional units in the embodiments of the present application may be integrated into one processing unit, or each unit may exist alone physically, or two or more units are integrated into one unit. The integrated unit can be realized in a form of hardware, and can also be realized in a form of a software functional unit.

The integrated unit, if implemented in the form of a software functional unit and sold or used as a stand-alone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present application may be substantially implemented or contributed to by the prior art, or all or part of the technical solution may be embodied in a software product, which is stored in a storage medium and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device) to execute all or part of the steps of the method according to the embodiments of the present application. And the aforementioned storage medium includes: a U-disk, a removable hard disk, a Read-only Memory (ROM), a Random Access Memory (RAM), a magnetic disk or an optical disk, and other various media capable of storing program codes.

The above embodiments are only used for illustrating the technical solutions of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions in the embodiments of the present application.

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