阅读说明：本技术 一种皮肤外用药膏及其制备方法 (External ointment for skin and preparation method thereof ) 是由 李生林 于 2019-10-24 设计创作，主要内容包括：本发明提供了一种皮肤外用药膏及其制备方法,涉及中药技术领域。本发明提供的皮肤外用药膏,由包括以下质量份的原料制备而成：曲咪新膏8～12份、尿素膏18～22份、克霉唑膏18～22份、红霉素膏8～12份、獾油8～12份、氯霉素针1～1.4份、甲硝唑片2.2～2.6份、冰片2～4份和轻粉4～8份。本发明提供的外用药膏效果奇特,无毒副作用,且使用后皮肤会更加细腻有护肤的作用。(The invention provides an external ointment for skin and a preparation method thereof, relating to the technical field of traditional Chinese medicines. The invention provides an external ointment for skin, which is prepared from the following raw materials in parts by mass: 8-12 parts of tramadol ointment, 18-22 parts of urea ointment, 18-22 parts of clotrimazole ointment, 8-12 parts of erythromycin ointment, 8-12 parts of badger fat, 1-1.4 parts of chloramphenicol, 2.2-2.6 parts of metronidazole tablets, 2-4 parts of borneol and 4-8 parts of calomel. The external ointment provided by the invention has unique effect and no toxic or side effect, and the skin can be more delicate after use, thereby having the function of skin care.)

1. The skin external ointment is characterized by being prepared from the following raw materials in parts by mass: 8-12 parts of tramadol ointment, 18-22 parts of urea ointment, 18-22 parts of clotrimazole ointment, 8-12 parts of erythromycin ointment, 8-12 parts of badger fat, 1-1.4 parts of chloramphenicol, 2.2-2.6 parts of metronidazole tablets, 2-4 parts of borneol and 4-8 parts of calomel.

2. The external ointment for skin as claimed in claim 1, which is prepared from the following raw materials in parts by mass: 10 parts of tramadol ointment, 20 parts of urea ointment, 20 parts of clotrimazole ointment, 10 parts of erythromycin ointment, 10 parts of badger fat, 1.25 parts of chloramphenicol, 2.4 parts of metronidazole tablets, 3 parts of borneol and 6 parts of calomel.

3. The method for preparing an ointment for external application to skin according to claim 1 or 2, comprising the steps of:

(1) respectively and independently crushing the borneol, the calomel and the metronidazole tablets into powder and then mixing to obtain powder;

(2) mixing the triamcinolone acetonide ointment, the urea ointment, the clotrimazole ointment and the erythromycin ointment to obtain an ointment;

(3) mixing the powder obtained in the step (1), the ointment obtained in the step (2), the badger fat and the chloramphenicol needle to obtain an external ointment;

there is no chronological definition between steps (1) and (2).

4. The preparation method according to claim 3, wherein the particle size of the powder in the step (1) is 80-120 meshes.

5. The preparation method according to claim 3, wherein the mixing time in the step (3) is 15-20 min.

6. Use of the ointment for external use for skin according to claim 1 or 2 for the preparation of a medicament for preventing and treating psoriasis.

7. The use of claim 6, wherein said psoriasis comprises psoriasis, tinea manus, tinea pedis, tinea versicolor, tinea capitis, and tinea cruris.

8. Use of the ointment for external use for skin according to claim 1 or 2 for the preparation of a medicament for the treatment of allergic inflammatory dermatoses.

9. The use according to claim 8, wherein said allergic inflammatory skin diseases include eczema, eczema and urticaria.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to an external skin ointment and a preparation method thereof.

Background

Skin disorders are a general term for disorders occurring in the skin and skin appendages. The skin is used as the first physiological defense line and the largest organ of the human body, constantly participates in the functional activities of the body, maintains the unity of opposition between the body and the natural environment, and the abnormal conditions of the body can be reflected on the surface of the skin. The skin has nearly perfect physiological protection function: such as barrier function, sensory function, body temperature regulation, absorption function, secretion and excretion function, etc., and plays an important role in maintaining the health of the body. The physiological function of the skin is impaired, causing skin diseases.

The most common pathogenic factors in skin diseases are infectious diseases and allergic dermatitis, and most of the medicines for treating the skin diseases in the prior art generate toxic and side effects.

Disclosure of Invention

In view of the above, the present invention aims to provide an ointment for external use on skin and a preparation method thereof. The external ointment provided by the invention has unique effect and no toxic or side effect, and the skin can be more delicate after use, thereby having the function of skin care. The elasticity and vitality of the skin are increased, the local microcirculation of the skin is improved to be normal, and therefore the skin is softer and glossy and can be kept for a long time without rebounding.

In order to achieve the above object, the present invention provides the following technical solutions:

the invention provides an external ointment for skin, which is prepared from the following raw materials in parts by mass: 8-12 parts of tramadol ointment, 18-22 parts of urea ointment, 18-22 parts of clotrimazole ointment, 8-12 parts of erythromycin ointment, 8-12 parts of badger fat, 1-1.4 parts of chloramphenicol, 2.2-2.6 parts of metronidazole tablets, 2-4 parts of borneol and 4-8 parts of calomel.

Preferably, the feed additive is prepared from the following raw materials in parts by mass: 10 parts of tramadol ointment, 20 parts of urea ointment, 20 parts of clotrimazole ointment, 10 parts of erythromycin ointment, 10 parts of badger fat, 1.25 parts of chloramphenicol, 2.4 parts of metronidazole tablets, 3 parts of borneol and 6 parts of calomel.

The invention also provides a preparation method of the external ointment in the technical scheme, which comprises the following steps:

(1) respectively and independently crushing the borneol, the calomel and the metronidazole tablets into powder and then mixing to obtain powder;

(2) mixing the triamcinolone acetonide ointment, the urea ointment, the clotrimazole ointment and the erythromycin ointment to obtain an ointment;

(3) mixing the powder obtained in the step (1), the ointment obtained in the step (2), the badger fat and the chloramphenicol needle to obtain an external ointment;

there is no chronological definition between steps (1) and (2).

Preferably, the particle size of the powder in the step (1) is 80-120 meshes.

Preferably, the mixing time in the step (3) is 15-20 min.

The invention also provides application of the external ointment for skin in the technical scheme in preparing a medicine for preventing and treating psoriasis.

Preferably, the psoriasis includes psoriasis, tinea manus, tinea pedis, tinea versicolor, tinea capitis, and tinea cruris.

The invention also provides application of the external ointment for skin in the technical scheme in preparing a medicament for treating allergic inflammatory dermatosis.

Preferably, the allergic inflammatory skin disease includes eczema, urticaria and the like.

The invention provides an external ointment for skin and a preparation method thereof. The external ointment provided by the invention has the functions of resisting inflammation, fungi and allergy, inhibiting the synthesis of fungal cell membranes, influencing the metabolic process of the fungal cell membranes and resisting various fungi at shallow parts and deep parts. Moreover, the external ointment has unique effect and no toxic or side effect, and the skin can be more delicate after the external ointment is used, so that the external ointment has the skin care effect.

Detailed Description

The invention provides an external ointment for skin, which is prepared from the following raw materials in parts by mass: 8-12 parts of tramadol ointment, 18-22 parts of urea ointment, 18-22 parts of clotrimazole ointment, 8-12 parts of erythromycin ointment, 8-12 parts of badger fat, 1-1.4 parts of chloramphenicol, 2.2-2.6 parts of metronidazole tablets, 2-4 parts of borneol and 4-8 parts of calomel.

The external ointment for skin provided by the invention comprises 8-12 parts by mass of tramadol ointment, and preferably 10 parts by mass of tramadol ointment. In the invention, the tramadol ointment is preferably purchased from Guangzhou Baiyunshan He Ji pharmaceutical factory, Guangzhou Baiyunshan pharmaceutical group GmbH, and the product is No. 6 Tongyitai street in Guangzhou Baiyunshan, and the product type is 10g per bottle and 1 per small box. In the invention, the tramadol ointment has the functions of resisting inflammation, resisting allergy and relieving itching by external application.

The external ointment for skin provided by the invention comprises 18-22 parts by mass of urea ointment, and preferably 20 parts by mass of urea ointment. In the invention, the urea paste is preferably purchased from the pharmaceutical Likang pharmaceutical preparation of Tangshan Jichuan, the address is West river and West river in ancient therapy area of Tangshan city, the product type is 10g per bottle, and 1 bottle is used. In the invention, the urea cream has the functions of resisting inflammation, relieving itching and resisting allergy, thereby softening the skin, preventing chapping and the like.

The external ointment for skin provided by the invention comprises 18-22 parts by mass of clotrimazole ointment, and preferably 20 parts by mass of clotrimazole ointment. In the invention, the clotrimazole cream is preferably purchased from the Sanyi pharmaceutical industry of the national medicine group, the address is the scientific and technical park of the biological pharmaceutical industry of Jiuhua North road in the dove river region of the turnip lake city, the product type is 10g per bottle, and 1 per small box. In the invention, the clotrimazole cream has the function of resisting various fungi at shallow parts and deep parts.

The skin external ointment provided by the invention comprises 8-12 parts by mass of erythromycin ointment, and preferably 10 parts by mass of erythromycin ointment. In the invention, the erythromycin ointment is preferably purchased from Sanyi pharmaceutical industry of the national medicine group, the address is Jiuhua North road biological pharmaceutical industry scientific and technological park in the Vernonia region of the Wu lake city, and the product type is 10g per bag and 1 per box. In the invention, the erythromycin ointment has the functions of diminishing inflammation, moistening skin and resisting bacteria.

The external ointment for skin provided by the invention comprises 8-12 parts by mass of badger fat, preferably 10 parts by mass of badger fat. The source of the badger fat is not specially limited, and the badger fat can be prepared by adopting a conventional commercially available product. In the invention, the badger fat has the functions of clearing away heat and toxic materials, diminishing inflammation, lubricating, nourishing yin, promoting granulation and protecting skin.

The ointment for external use on skin provided by the invention comprises 1-1.4 parts by mass of chloramphenicol needle, preferably 1.25 parts by mass. In the invention, the chloramphenicol needle is preferably purchased from the group of national medicine, the family of pharmacy, Inc., the address of the middle section of the east tricyclic road of Wu\38495, Henan province, and the product model is 2 ml. In the invention, the chloramphenicol needle has the functions of diminishing inflammation, resisting bacteria and moistening skin.

The external ointment for skin provided by the invention comprises 2.2-2.6 parts by mass of metronidazole tablets, and preferably 2.4 parts by mass of metronidazole tablets. In the invention, the metronidazole tablets are preferably purchased from Huazhou medicine industry GmbH, address Hubei Xiangyang city 23704c, Shanlu 118 and product model number 0.2 g. In the invention, the metronidazole tablet has the functions of interfering the growth and reproduction of bacteria and finally causing the death of the bacteria.

The external ointment for skin provided by the invention comprises 2-4 parts by mass of borneol, and preferably 3 parts by mass of borneol. The source of the borneol is not particularly limited, and the borneol can be obtained by adopting a conventional commercial product. In the invention, the borneol has the functions of cooling and allaying fever, diminishing inflammation, promoting tissue regeneration and relieving itching.

The external ointment for skin provided by the invention comprises 4-8 parts by mass of calomel, and preferably 6 parts by mass of calomel. The source of the calomel is not particularly limited, and the common commercial product is adopted. In the invention, the calomel has the function of absorbing into blood to drive plum and astringe.

The invention also provides a preparation method of the external ointment in the technical scheme, which comprises the following steps:

(1) respectively and independently crushing the borneol, the calomel and the metronidazole tablets into powder and then mixing to obtain powder;

(2) mixing the triamcinolone acetonide ointment, the urea ointment, the clotrimazole ointment and the erythromycin ointment to obtain an ointment;

(3) mixing the powder obtained in the step (1), the ointment obtained in the step (2), the badger fat and the chloramphenicol needle to obtain an external ointment;

there is no chronological definition between steps (1) and (2).

The borneol, the calomel and the metronidazole tablets are respectively and independently prepared into powder and then mixed to obtain the powder. The method for grinding is not particularly limited, the grinding mode is preferably adopted, and the grain diameter after grinding is preferably 80-120 meshes. The mixing method is not particularly limited, and a conventional mixing method can be adopted.

The invention mixes the trimazole cream, urea cream, clotrimazole cream and erythromycin cream to obtain the cream. The mixing mode is not particularly limited, and the materials are uniformly mixed by adopting a conventional mixing method.

The powder and the ointment are mixed with badger fat and chloramphenicol needle to obtain the external ointment. The mixing method is not particularly limited, and the conventional mixing method for preparing the external ointment is adopted. In the invention, the mixing time is preferably 15-20 min.

The invention also provides application of the external ointment for skin in the technical scheme in preparing a medicine for preventing and treating psoriasis. In the present invention, the psoriasis preferably includes psoriasis, tinea manus and pedis, tinea erythematous, tinea capitis and tinea cruris.

The invention also provides application of the external ointment for skin in the technical scheme in preparing a medicament for treating allergic inflammatory dermatosis. In the present invention, the allergic inflammatory skin disease preferably includes eczema, urticaria and the like.

The application method of the external ointment is not particularly limited, the ointment is preferably applied to an affected part, and after the ointment is applied, the affected part is preferably covered by a preservative film for 2-4 hours. In the invention, the application frequency of the ointment is preferably 1-3 times per day, and more preferably 2 times per day.

In the invention, the ointment is used for treating diseases such as psoriasis, tinea manuum, tinea pedis, tinea versicolor, tinea capitis, tinea cruris, chapped skin, desquamation pruritus, ichthyosis, folliculitis, dermatitis, eczema, soaking diagnosis, urticaria, whelk, acne, rosacea, rhinitis, paronychia, beriberi, lymph nodes, lumps, pruritus ani and vagina.

The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.