阅读说明：本技术 一种治疗鼻炎的药物组合物及其制备方法和应用 (Pharmaceutical composition for treating rhinitis and preparation method and application thereof ) 是由 邱丙玉 邱登阶 于 2019-11-05 设计创作，主要内容包括：本发明公开了一种治疗鼻炎的药物组合物及其制备方法和应用,属于药物技术领域。该治疗鼻炎的药物组合物,包括以下按照重量份计的组分：猪胆汁150~500份、黄连10~60份、皂角刺10~60份、穿山甲5~30份、冰片5~20份。本发明实施例提供的一种治疗鼻炎的药物组合物,通过以猪胆汁、黄连、皂角刺、穿山甲和冰片等中药材作为主要成分,并通过添加麻油进行制备,可以制得油状的药物组合物,其无毒副作用,可有效治疗鼻炎等病症且药效快。(The invention discloses a pharmaceutical composition for treating rhinitis, and a preparation method and application thereof, and belongs to the technical field of medicaments.)

1. The pharmaceutical composition for treating rhinitis is characterized by comprising the following components in parts by weight: 150-500 parts of pig bile, 10-60 parts of coptis chinensis, 10-60 parts of spina gleditsiae, 5-30 parts of pangolin and 5-20 parts of borneol.

2. The pharmaceutical composition for treating rhinitis according to claim 1, wherein the pharmaceutical composition comprises the following components in parts by weight: 250-350 parts of pig bile, 20-40 parts of coptis chinensis, 20-40 parts of spina gleditsiae, 10-20 parts of pangolin and 10-15 parts of borneol.

3. The pharmaceutical composition for treating rhinitis according to claim 1, wherein the pharmaceutical composition comprises the following components in parts by weight: 300 parts of pig bile, 30 parts of coptis, 30 parts of Chinese honeylocust spine, 15 parts of pangolin and 12 parts of borneol.

4. A process for the preparation of a pharmaceutical composition according to any one of claims 1 to 3, comprising the steps of:

(1) weighing pig bile, coptis chinensis, spina gleditsiae, pangolin scales and borneol according to the weight parts of the components for later use;

(2) mixing and grinding the weighed coptis chinensis, spina gleditsiae and pangolin to obtain mixed powder;

(3) mixing the mixed powder with the pig bile, and performing cooking treatment to obtain a cooking solution;

(4) filtering the cooking liquor, and adding sesame oil into filtrate obtained by filtering to soak to obtain soaking liquor;

(5) filtering the soaking solution, adding sesame oil and the borneol into the filtrate obtained by filtering, and soaking to obtain the medicinal composition.

5. The preparation method of the pharmaceutical composition for treating rhinitis according to claim 4, wherein in the step (4), the mass ratio of the added sesame oil to the filtrate is (1-3) to 1, and the soaking time is 20-40 days.

6. The preparation method of the pharmaceutical composition for treating rhinitis according to claim 5, wherein in the step (5), the mass ratio of the added sesame oil to the filtrate is (1-3) to 1, and the soaking time is 20-40 days.

7. A pharmaceutical composition prepared by the preparation method of any one of claims 4 to 6.

8. Use of a pharmaceutical composition as claimed in any one of claims 1 to 3 and claim 7 in the manufacture of a medicament for the treatment of rhinitis.

Technical Field

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating rhinitis and a preparation method and application thereof.

Background

Rhinitis, an inflammatory disease of the nasal cavity, is inflammation of the mucous membrane of the nasal cavity caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of the nasal mucosa.

At present, most of the medicines for treating rhinitis on the market adopt medicines such as oxymetazoline hydrochloride spray or normal saline, and although the medicines can play a certain effect on cleaning nasal cavities, the medicines still have the problems of poor curative effect, slow effect and the like.

Disclosure of Invention

The embodiment of the invention aims to provide a pharmaceutical composition for treating rhinitis, so as to solve the problems in the background technology.

In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:

a pharmaceutical composition for treating rhinitis comprises, by weight, 150 parts of pig bile 150 ~ 500, 10 ~ 60 parts of coptis chinensis, 10 ~ 60 parts of spina gleditsiae, 5 parts of pangolin scales 5 ~ 30, and 5 parts of borneol 5 ~ 20.

Preferably, the pharmaceutical composition comprises the following components, by weight, 250 ~ 350 parts of pig bile, 20 ~ 40 parts of coptis chinensis, 20 ~ 40 parts of spina gleditsiae, 10 ~ 20 parts of pangolin and 10 ~ 15 parts of borneol.

Preferably, the pharmaceutical composition comprises the following components in parts by weight: 300 parts of pig bile, 30 parts of coptis, 30 parts of Chinese honeylocust spine, 15 parts of pangolin and 12 parts of borneol.

Another object of the embodiments of the present invention is to provide a method for preparing the above pharmaceutical composition, which comprises the following steps:

(1) weighing pig bile, coptis chinensis, spina gleditsiae, pangolin scales and borneol according to the weight parts of the components for later use;

(2) mixing and grinding the weighed coptis chinensis, spina gleditsiae and pangolin to obtain mixed powder;

(3) mixing the mixed powder with the pig bile, and performing cooking treatment to obtain a cooking solution;

(4) filtering the cooking liquor, and adding sesame oil into filtrate obtained by filtering to soak to obtain soaking liquor;

(5) filtering the soaking solution, adding sesame oil and the borneol into the filtrate obtained by filtering, and soaking to obtain the medicinal composition.

Preferably, in the step (4), the mass ratio of the added sesame oil to the filtrate is (1 ~ 3):1, and the soaking time is 20 ~ 40 days.

Preferably, in the step (5), the mass ratio of the added sesame oil to the filtrate is (1 ~ 3):1, and the soaking time is 20 ~ 40 days.

Another object of the embodiments of the present invention is to provide a pharmaceutical composition prepared by the above preparation method.

The embodiment of the invention also aims to provide application of the pharmaceutical composition in preparing a medicine for treating rhinitis.

Wherein, the pharmacology of the components is as follows:

the pig bile mainly contains bile acids, bile pigment, mucin, lipid, inorganic substances, etc. Nature and taste: bitter, salty and cold. Meridian tropism: enter liver, gallbladder, lung, heart and large intestine meridians. The functions are as follows: resolve phlegm and stop cough. The main treatment is as follows: benefiting lung, invigorating spleen, moistening dryness; it can be used for treating diabetes, constipation, jaundice, pertussis, asthma, diarrhea, dysentery, conjunctival congestion, pharyngitis, ear infection, and carbuncle.

Coptis root, nature and taste: bitter and cold. Meridian tropism: gallbladder channel, stomach channel, spleen channel, large intestine channel, liver channel, heart channel. The functions are as follows: clear heat and dry dampness, purge fire and remove toxicity. The main treatment is as follows: can be used for treating damp-heat distention, fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, coma, excessive heart-fire, vexation, insomnia, hematemesis, hemorrhage, conjunctival congestion, toothache, diabetes, carbuncle, furuncle, etc.; the external treatment of eczema, eczema and ear canal pus discharge, the wine coptis is good at clearing heat in upper jiao, conjunctival congestion, aphtha, the ginger coptis is good at clearing stomach and regulating stomach and stopping vomiting, cold and heat are combined, damp-heat is blocked in middle energizer, fullness and vomiting, the coptis chinensis is good at soothing liver, stomach and vomiting, liver and stomach disharmony is caused, vomiting and acid regurgitation are caused.

Spina gleditsiae, nature and taste: pungent and warm. Meridian tropism: it enters liver and stomach meridians. The functions are as follows: detumescence, expelling toxin, expelling pus and killing parasites. The main treatment is as follows: can be used for treating early carbuncle and cellulitis or suppurative abscess; it is indicated for external treatment of scabies and leprosy.

Squama Manis is squama Manis of Manitis of dace family. Nature and taste: salty and slightly cold. Meridian tropism: it enters liver and stomach meridians. The functions are as follows: dredge meridians and promote lactation, relieve swelling and expel pus, dispel wind and dredge collaterals. The main treatment is as follows: can be used for treating amenorrhea and abdominal mass, galactostasis, carbuncle, swelling, sore, arthralgia, numbness and contracture.

Borneol, nature and taste: cold in nature, pungent and bitter in flavor. Meridian tropism: they enter heart, spleen and lung meridians. The functions are as follows: inducing resuscitation, refreshing mind, clearing heat and relieving pain. The main treatment is as follows: it is indicated for heat block coma, phlegm-heat block, summer-heat stroke syncope, infantile convulsions, various sores and abscess, swelling and pain, unhealing after ulceration, scald, fire injury, swelling and pain in throat, sore throat, conjunctival congestion, swelling and pain, aphtha of the mouth and tongue, etc.

Compared with the prior art, the embodiment of the invention has the beneficial effects that:

according to the pharmaceutical composition for treating rhinitis provided by the embodiment of the invention, the oily pharmaceutical composition can be prepared by taking pig bile, coptis chinensis, spina gleditsiae, pangolin scales, borneol and other traditional Chinese medicinal materials as main components and adding sesame oil, has no toxic or side effect, can effectively treat rhinitis and other diseases, and has a quick drug effect.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.