阅读说明：本技术 用于***的中药组合物 (Traditional Chinese medicine composition for treating tumors ) 是由 殷永华 于 2019-10-31 设计创作，主要内容包括：本发明公开了一种用于治疗肿瘤的中药组合物,由如下组分组成：半支莲、白花蛇舌草、玄巴虫、半边莲。与现有技术相比,本发明组合物用于治疗肝癌、肺癌、胃癌和结肠癌,疗效显著、副作用小。(The invention discloses a traditional Chinese medicine composition for treating tumors, which comprises the following components: herba Scutellariae Barbatae, herba Hedyotidis Diffusae, XUANGBIAN, and herba Lobeliae chinensis. Compared with the prior art, the composition provided by the invention is used for treating liver cancer, lung cancer, gastric cancer and colon cancer, and has the advantages of remarkable curative effect and small side effect.)

1. The traditional Chinese medicine composition for treating the tumor is characterized by comprising the following components: herba Scutellariae Barbatae, herba Hedyotidis Diffusae, XUANGBIAN, and herba Lobeliae chinensis.

2. The traditional Chinese medicine composition for treating tumors as claimed in claim 1, wherein the weight parts of each of the components are respectively as follows: 20-80 parts of barbat skullcap, 20-80 parts of spreading hedyotis herb, 5-40 parts of Xuanba insect and 20-80 parts of Chinese lobelia.

3. The traditional Chinese medicine composition for treating tumors as claimed in claim 1, wherein the weight parts of each of the components are respectively as follows: 40-60 parts of barbat skullcap, 40-60 parts of spreading hedyotis herb, 10-30 parts of myxocypris and 40-60 parts of Chinese lobelia.

4. The traditional Chinese medicine composition for treating tumors as claimed in claim 1, wherein the weight parts of each of the components are respectively as follows: 50 parts of Chinese lobelia, 50 parts of spreading hedyotis herb, 20 parts of myxoma longituba and 50 parts of Chinese lobelia.

5. The use of the Chinese medicinal composition for treating tumor according to any one of claims 1 to 4 in the preparation of medicaments for treating liver cancer, lung cancer, stomach cancer and colon cancer.

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating tumors.

Background

Liver cancer, lung cancer, stomach cancer and colon cancer are common tumor diseases in clinic, the incidence and mortality of the cancers are on the rising trend year by year in recent years, and the health and life of human beings are seriously influenced. Common treatment modalities include surgery, radiation, chemotherapy, immunization, molecular targeted therapy, etc., but overall the prognosis remains poor, depending on the ability to detect early and treat in time. However, cancer is difficult to find in early stage, the treatment effect is poor in middle and late stages, cancer patients are painful in the treatment process, particularly, the chemotherapy method can kill part of tumor cells, but can also damage healthy cells, so that the effect of killing one thousand of cells and eight hundred of cells is caused, the phenomena of hemogram reduction, immune function inhibition and the like are caused in the chemotherapy process, and the side effect is great.

The traditional Chinese medicine considers that the main pathological factors of the tumor include healthy qi deficiency, phlegm coagulation, blood stasis, cancer toxin and the like, wherein the heat toxin is an important pathological factor of the tumor, the heat toxin is accumulated in the interior, the fluid is burnt into phlegm, and qi and blood phlegm are stagnated to block meridians and viscera to form the tumor, which is recorded in Huangdi's internal classic: "pain, itching and sore all belong to the heart" and "the heart governs fire"; 'Yi Zong jin Jian' is characterized by: the former is the generation of fire toxin and the blockage of meridians and collaterals by qi and blood coagulation.

Disclosure of Invention

The invention aims to overcome the defect of great side effect of the method for treating liver cancer, lung cancer, stomach cancer and colon cancer in the prior art, and provides a traditional Chinese medicine composition for treating tumor, which is used for treating liver cancer, lung cancer, stomach cancer and colon cancer and has remarkable curative effect and small side effect.

The purpose of the invention is mainly realized by the following technical scheme:

the traditional Chinese medicine composition for treating the tumor comprises the following components: herba Scutellariae Barbatae, herba Hedyotidis Diffusae, XUANGBIAN, and herba Lobeliae chinensis.

The traditional Chinese medicine formula is an important means for treatment based on syndrome differentiation and administration based on a theoretical method in traditional Chinese medicine, and the theory of traditional Chinese medicine considers that the medicines have unique characteristics and the formulas have combined wonderful effects, and the compatibility is the characteristic of the traditional Chinese medicine based on syndrome differentiation, and has the characteristics of purposiveness, dynamics, environmental adaptability and the like. The traditional Chinese medicine formula is a process of organically combining medicines with different properties and efficacies for treating a certain disease by applying a certain theory under the guidance of the traditional Chinese medicine theory. The traditional Chinese medicine emphasizes the difference of monarch, minister, assistant and guide on the medication, different medicines have antagonism or synergy and the like, different medicine dosages are combined, different medicine effect changes also exist, the medicine combination can reduce the toxic and side effect of the medicine, enhance the curative effect of the medicine and is more suitable for the comprehensive medication of complex diseases; if the compatibility and flavor of herbs are different, the curative effect of herbs will also change. The unique rule and the effect of the compatibility of monarch, minister, assistant and messenger in the traditional Chinese medicine formula are proved by the clinical practice of the long years. The principal drug is the principal drug of one party, and the principal cause and principal symptom of one disease are mainly acted, namely the principle drugs in the book of the Nei Jing: the principal disease is known as jun; the so-called minister, the "internal classic" says: the assistant and monarch drugs are the ministers. Ministerial refers to a drug assisting and strengthening the efficacy of monarch drugs; the adjuvant is called as adjuvant under the ministerial, and the adjuvant is a compatible medicine close to the ministerial medicine, and can assist the monarch medicine to relieve certain secondary symptoms except for assisting the monarch medicine; the so-called "envoy" refers to a kind of adjuvant drug for ministerial drugs, and the term "internal classic" states that: should be regarded as guide.

The traditional Chinese medicine holds that the main pathological factors of the tumor comprise healthy energy deficiency, phlegm coagulation, blood stasis, cancer toxin and the like, the tumor treatment is divided into two aspects of eliminating pathogenic factors and strengthening healthy energy, the eliminating pathogenic factors refer to clearing heat and detoxicating, promoting blood circulation and removing blood stasis, eliminating phlegm and removing dampness, attacking toxic materials with poison and the like, and the strengthening healthy energy is to tonify qi, blood and yin and yang. Many traditional Chinese medicines in the traditional Chinese medicine can achieve the effects of eliminating pathogenic factors and strengthening body resistance, but different traditional Chinese medicines have different medicinal properties, and the combination of the traditional Chinese medicines in different formulas can cause the traditional Chinese medicines to express in different degrees and different levels, so that the traditional Chinese medicines have different effects when acting on diseases. Therefore, the prescription for treating the liver cancer, the lung cancer, the stomach cancer and the colon cancer is not realized by simply combining a plurality of traditional Chinese medicines and can be obtained by long-term repeated tests according to the drug properties of the medicines. Through deep research on the drug properties of a plurality of traditional Chinese medicines, the inventor finds that the combination of Chinese lobelia, oldenlandia diffusa, babassu and Chinese lobelia has good curative effect on liver cancer, lung cancer, gastric cancer and colon cancer by adopting the combination of Chinese lobelia, oldenlandia diffusa, Chinese lobelia and Chinese lobelia after long-term experimental research on different traditional Chinese medicine combinations aiming at tumor symptoms.

According to the technical scheme, the barbat skullcap, the spreading hedyotis herb, the Xuanba worm and the Chinese lobelia are used in a compatible mode, the barbat skullcap is used as a monarch drug, the spreading hedyotis herb is used as a ministerial drug, the Xuanba worm is used as a ministerial drug, the Chinese lobelia is used as a conductant drug, and the spreading hedyotis herb is used as a ministerial drug, and belongs to the fields of one-phase treatment, one-rigidity and one-flexibility treatment, one-walking and one-guard treatment, the two drugs mutually control and complement each other, the treatment effect of the composition is enhanced, channels of various drugs are combined, the drug treatment and a pathological change part are better combined, and treatment factors are blocked more.

The technical scheme has the following functions of the components: the barbat skullcap, pungent and mild, enters heart, small intestine and lung channels and has the effects of clearing away heat and toxic materials, inducing diuresis and reducing edema; the oldenlandia diffusa is bitter, bland and cold in nature, enters heart, liver and spleen channels, and has the effects of clearing heat, removing toxicity and promoting diuresis; the Xuanba insect, namely the slug, is salty and cold, enters liver, spleen and lung channels, and has the effects of clearing heat, dispelling wind, reducing swelling, detoxifying, breaking phlegm and dredging channels; lobelia chinensis, pungent, bitter and cold in flavor, enters lung, liver and kidney meridians, and has the effects of clearing away heat and toxic materials, eliminating tinea and inducing diuresis. In terms of efficacy, the oldenlandia diffusa, the barbat skullcap, the Chinese lobelia and the Xuanba insect have the main effects of clearing away heat and toxic materials, have the effects of diminishing inflammation, sterilizing, abating fever, enhancing immunity and the like, and also have better anticancer activity; the Chinese lobelia, the barbat skullcap and the Xuanba insect also have the functions of removing blood stasis and activating blood circulation, and the three medicines are used together, similar to the mutual reinforcement in seven-emotion compatibility of the traditional Chinese medicines, and can enhance the functions of inhibiting cancer, expelling toxin, sterilizing and diminishing inflammation; the Chinese lobelia and the barbat skullcap have the effects of removing blood stasis and promoting blood circulation, prevent and treat the penetration of cancer cells to blood vessel walls by changing the viscosity of whole blood and the platelet aggregation capability, weaken the platelet aggregation, and ensure that the cancer cells are not easy to stay, aggregate and plant in the blood, thereby reducing the metastasis and the relapse of tumors.

The inventor also finds that the monarch drug of the Chinese lobelia in the composition plays a main treatment role, the property of the Chinese lobelia can be greatly promoted by matching the ministerial drug of the oldenlandia diffusa with the Chinese lobelia, and the Chinese lobelia can treat partial diseases of liver cancer, lung cancer, stomach cancer and colon cancer by being supplemented with the ministerial drug of the Chinese lobelia, but the effect is not ideal; in contrast, the inventor discovers that the adding of the Xuanba worm can obviously improve the drug property of the composition, the Xuanba worm is a traditional Chinese medicine which is rarely used as a medicine, but has outstanding effects on treating liver cancer, lung cancer, gastric cancer and colon cancer by being matched with barbat skullcap, spreading hedyotis herb and Chinese lobelia; when the Xuanbachong is compatible with the barbat skullcap, the spreading hedyotis herb and the Chinese lobelia herb, the Xuanbachong and the spreading hedyotis herb are used as ministerial drugs, but the spreading hedyotis herb is mainly used for assisting monarch drugs to strengthen the main treatment symptoms, the Xuanbachong mainly plays a role in treating accompanied symptoms, the combination of the Xuanbachong and the spreading hedyotis herb greatly improves the Chinese lobelia herb, and the Chinese lobelia is used for assisting the prescription regulation of the Chinese lobelia herb and guiding the Chinese drugs to reach the disease centers, so that the combination of the technical scheme has an unexpected treatment effect on liver cancer, lung cancer, stomach.

The existing treatment means focuses on eliminating tumor, and particularly chemotherapy has strong tumor killing effect, but has the side effects of digestive tract stimulation, bone marrow inhibition, heart, liver, renal function damage and the like on the organism due to high toxicity; the traditional Chinese medicine composition in the technical scheme is beneficial to eliminating tumor, has the treatment effect of strengthening body resistance and consolidating constitution, can correct the spleen deficiency, kidney deficiency and qi deficiency symptoms of patients, improves the immunity of organisms, promotes recovery and has small side effect. Therefore, the technical scheme adopts the compatibility of the barbat skullcap, the oldenlandia diffusa, the babassu and the Chinese lobelia, is used for treating liver cancer, lung cancer, stomach cancer and colon cancer, and has remarkable curative effect and small side effect.

It is further noted that the Xuanba insect in the technical scheme is baked and dried, and the barbed skullcap herb, the spreading hedyotis herb and the Chinese lobelia herb are all used as whole seedlings. The composition has obvious anti-tumor effect on treating liver cancer, lung cancer, stomach cancer and colon cancer, and because the yin and yang of a cancer patient are imbalanced in the body, qi is easy to flow, blood circulation is not smooth, and the spleen and the stomach are damaged, medicaments which are mutually reinforced or matched with barbat skullcap, spreading hedyotis herb, Xuanba worm and Chinese lobelia can be added into the composition to strengthen the body resistance and tonify deficiency, enhance the efficacy of the composition for strengthening the spleen and regulating qi, reinforce the spleen and the kidney, and improve the body constitution of the patient, for example, Chinese yam is added to reinforce the spleen and the stomach to prevent pathogen attachment, coix seed is used for nourishing yin and relieving diarrhea, spleen and yin are used for improving the body condition of the patient, glossy privet fruit is used for tonifying the liver and kidney, calming the.

Further, the weight parts of each component are respectively as follows: 20-80 parts of barbat skullcap, 20-80 parts of spreading hedyotis herb, 5-40 parts of Xuanba insect and 20-80 parts of Chinese lobelia.

The Chinese Lobelia herb, the spreading hedyotis herb, the Indian bread worm and the Chinese Lobelia herb of the composition have different efficacies in the treatment of liver cancer, lung cancer, gastric cancer and colon cancer, and the dosage of each component influences the efficacy of the composition due to the difference of the effects and actions of each component. The inventor finds that the four cancers can be better treated by adopting the mixture ratio and the side effect is small by long-term research.

Further, the weight parts of each component are respectively as follows: 40-60 parts of barbat skullcap, 40-60 parts of spreading hedyotis herb, 10-30 parts of myxocypris and 40-60 parts of Chinese lobelia.

The composition in the technical scheme provides a better choice for the distribution of each component of the composition.

Further, the weight parts of each component are respectively as follows: 50 parts of Chinese lobelia, 50 parts of spreading hedyotis herb, 20 parts of myxoma longituba and 50 parts of Chinese lobelia.

The technical scheme provides the optimal proportion of the composition, and the inventor finds that the composition with the proportion has better treatment effect on liver cancer, lung cancer, stomach cancer and colon cancer in the research process.

The invention also provides application of the traditional Chinese medicine composition for treating tumors in preparation of medicines for treating liver cancer, lung cancer, gastric cancer and colon cancer.

Due to the difference of the properties of various Chinese herbs, the dissolution rate of the effective components of the herbs can be influenced by the preparation method of the herbs. In order to enable the composition to achieve better drug effect, the inventor continuously tries at different temperatures, time, solvent types, solvent dosage and extraction steps in the preparation process, finally finds that the barbat skullcap in the composition is extracted independently, the spreading hedyotis herb and the barbat skullcap are mixed and then extracted, and the extracted mixture is mixed with the myxobolus powder, decompressed, concentrated and freeze-dried, and through the mode, the types, the solvent dosage, the temperature and the time of the solvent selected by the inventor can extract the effective components of the components to the maximum extent, if the used solvent is too much, the temperature is too high and the time is too long, the effective components of the components can be volatilized, the drug effect is reduced, if the used solvent is too little, the soaking temperature is too low and the time is too short, the finally obtained effective components are few, and the drug effect is low. The preparation method of the traditional Chinese medicine composition comprises the following steps:

the preparation method of the traditional Chinese medicine composition comprises the following steps:

1. crushing the barbat skullcap, adding water for soaking, and performing suction filtration to obtain first filter residue and a first extracting solution; adding the first filter residue into an ethanol water solution, performing ultrasonic extraction, and performing suction filtration to obtain a second filter residue and a second extracting solution;

2. crushing herba Hedyotidis Diffusae and herba Lobeliae chinensis respectively, mixing, soaking in water, and vacuum filtering to obtain third residue and third extractive solution; adding the third filter residue into an ethanol water solution, performing ultrasonic extraction, and performing suction filtration to obtain a fourth filter residue and a fourth extracting solution;

3. grinding the myxobolus, adding the first extracting solution, the second extracting solution, the third extracting solution and the fourth extracting solution, heating, refluxing and concentrating under reduced pressure to obtain an extract;

4. and (4) carrying out vacuum freeze drying on the extract to obtain the traditional Chinese medicine composition.

Preferably, the barbat skullcap in the step 1 is crushed and then sieved by a 40-100-mesh sieve, 1-4 times of water by weight is added, the soaking time is 30-80 min, the soaking temperature is 20-40 ℃, 1-4 times of ethanol water by weight is added, the concentration of an ethanol water solution is 60-95 wt%, the ultrasonic extraction temperature is 30-60 ℃, and the ultrasonic extraction time is 30-70 min.

Preferably, in the step 2, the oldenlandia diffusa and the Chinese lobelia are crushed, respectively pass through the crushed oldenlandia diffusa and the Chinese lobelia, pass through a sieve of 40-100 meshes, add 2-4 times of water by weight, soak for 50-150 min at the soaking temperature of 20-40 ℃, add 2-4 times of ethanol water by weight, the concentration of the ethanol water solution is 60-95 wt%, the ultrasonic extraction temperature is 30-60 ℃, and the ultrasonic extraction time is 30-60 min.

Preferably, the myxobolus in the step 3 is ground into powder and then sieved by a 150-300-mesh sieve, the heating reflux time is 30-100 min, the reduced pressure concentration condition is-0.06 Kp-0.1 Kp vacuum degree, the temperature is 50-80 ℃, and the combined extracting solution is concentrated to the relative density of 1.05-1.2.

Preferably, the freeze-drying condition in the step 4 is vacuum freeze-drying for 12-20 h at-78 to-60 ℃.

Preferably, the preparation method of the traditional Chinese medicine composition is as follows:

1. crushing the barbat skullcap, sieving with a 80-mesh sieve, adding 2 times of water by weight, soaking at 30 ℃ for 60min, and performing suction filtration to obtain first filter residue and a first extracting solution; adding the first filter residue into 2 times of 85 wt% ethanol aqueous solution by weight, performing ultrasonic extraction at 45 ℃ for 50min, and performing suction filtration to obtain a second filter residue and a second extracting solution;

2. crushing herba Hedyotidis Diffusae and herba Lobeliae chinensis respectively, sieving with 60 mesh sieve, mixing, adding 2.5 times of water, soaking at 30 deg.C for 120min, and vacuum filtering to obtain third residue and third extractive solution; adding the third filter residue into 85 wt% ethanol aqueous solution in an amount which is 3 times the weight of the third filter residue, performing ultrasonic extraction at 45 ℃ for 40min, and performing suction filtration to obtain a fourth filter residue and a fourth extracting solution;

3. grinding the myxobolus, sieving with a 200-mesh sieve, adding the first extract, the second extract, the third extract and the fourth extract, heating and refluxing for 60min, concentrating under reduced pressure at-0.08 Kp vacuum degree and 65 deg.C, and concentrating to relative density of 1.1 to obtain extract;

4. and (4) carrying out vacuum freeze drying on the extract at the temperature of-70 ℃ for 16h to obtain the traditional Chinese medicine composition.

It is further noted that the heating reflux temperature in step 3 is between 78 ℃ and 100 ℃ because the boiling point of ethanol is 78 ℃ and the boiling point of water is 100 ℃.

Furthermore, in order to be convenient to store and take, the traditional Chinese medicine composition obtained by the preparation method is added with auxiliary materials and preparations; the auxiliary material is one or a mixture of more than one of starch, dextrin and glucan; the preparation can be powder, pills or granules. Wherein, the traditional Chinese medicine composition particles are prepared by the following method:

1. adding 0.25 times of the auxiliary materials into the traditional Chinese medicine composition obtained by the preparation method, and uniformly mixing;

2. adding 95 wt% ethanol as adhesive, wherein the weight ratio of ethanol to the Chinese medicinal composition is 1:1, mixing, extruding, sieving with 20 mesh sieve, and granulating;

3. and (3) drying the granules obtained in the step (2) at 40 ℃ for 1h, finishing the granules, and drying at 50 ℃ to obtain the traditional Chinese medicine composition granules.

In the preparation method, in the step 1, the preferable auxiliary materials are a mixture of starch and dextrin in a weight ratio of 2: 1.

In conclusion, compared with the prior art, the invention has the following beneficial effects:

1. the invention uses the compatibility of the barbat skullcap, the oldenlandia diffusa, the Chinese yam and the Chinese lobelia, the barbat skullcap is monarch drug in the compatibility of medicines, the spreading hedyotis herb is ministerial drug, the Chinese yam is ministerial drug, the Chinese lobelia is messenger drug, and the spreading hedyotis herb is ministerial drug, and belongs to the category of one-phase drugs, one-rigid-one-soft drugs and one-walking-one-guard drugs, the two drugs can mutually control and complement each other, so that the treatment effect of the composition is enhanced, and the channel tropism of various drugs is combined, so that the drug treatment is better combined with the pathological change part, and the treatment factors are more easily blocked. When the Xuanbachong is compatible with the barbat skullcap, the spreading hedyotis herb and the Chinese lobelia herb, the Xuanbachong and the spreading hedyotis herb are used as ministerial drugs, but the spreading hedyotis herb is mainly used for assisting monarch drugs to strengthen the main treatment symptoms, the Xuanbachong mainly plays a role in treating accompanied symptoms, the combination of the Xuanbachong and the spreading hedyotis herb greatly improves the Chinese lobelia herb, and the Chinese lobelia is used for assisting the prescription regulation of the Chinese lobelia herb and guiding the Chinese drugs to reach the disease centers, so that the combination has an unintended treatment effect on liver cancer, lung cancer, stomach cancer and colon.

2. The traditional Chinese medicine composition disclosed by the invention is beneficial to eliminating tumor, has the treatment effect of strengthening body resistance and consolidating the constitution, can correct the spleen deficiency, kidney deficiency and qi deficiency symptoms of a patient, improves the immunity of an organism, promotes recovery and has small side effect. The invention adopts the compatibility of the sun plant, the oldenlandia diffusa, the babesia diffusa and the Chinese lobelia, is used for treating liver cancer, lung cancer, gastric cancer and colon cancer, and has remarkable curative effect and small side effect.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.