阅读说明：本技术 一种高形状回复率水凝胶及其制备方法 (hydrogel with high shape recovery rate and preparation method thereof ) 是由 关爽 宫宇宁 郭佩佩 傅海 于 2019-09-22 设计创作，主要内容包括：本发明公开了一种高形状回复率水凝胶,它是由下列组分组成：丙烯酸、壳聚糖、CaCl<Sub>2</Sub>、0~5%阿拉伯胶、过硫酸铵、余量为水的溶液；制备方法包括：将丙烯酸和壳聚糖混合,加壳聚糖8~10倍重量的水,搅拌0.5~1.5h；加入CaCl<Sub>2</Sub>,搅拌25~35min；加入阿拉伯胶和过硫酸铵,加水稀释,搅拌均匀；除气泡,在55~65℃下加热6~8h；取出,清洗,再在55~65℃下干燥45~50h,得到高形状回复率水凝胶；水凝胶在聚合过程中,形成氢键,以及壳聚糖上的氨基和钙离子的配位作用,相互协同,形成了凝胶网络；本发明制备的高回复率水凝胶属于纯物理交联,具有高强度、耐疲劳、导电的性能。(the invention discloses a high-shape-recovery-rate hydrogel which is a solution of acrylic acid, chitosan, CaCl 2 , 0 ~% of Arabic gum, ammonium persulfate and the balance of water, and the preparation method comprises the steps of mixing the acrylic acid and the chitosan, adding water accounting for 8 ~ times of the weight of the chitosan, stirring for 0.5 ~.5 h, adding CaCl 2 , stirring for 25 ~ min, adding the Arabic gum and the ammonium persulfate, diluting with the water, uniformly stirring, removing bubbles, heating at 55 5638 ℃ for 6 ~ h, taking out, cleaning, drying at 55 3565 ℃ for 45 ~ h to obtain the high-shape-recovery-rate hydrogel, forming hydrogen bonds in the polymerization process of the hydrogel, and forming a gel network through the coordination effect of amino groups and calcium ions on the chitosan, wherein the gel network is formed through the coordination of the amino groups and the calcium ions.)

1. A hydrogel with high shape recovery rate is a solution which comprises, by weight, 18 ~ 22% of acrylic acid, 1 ~ 4% of chitosan, 0.5 ~ 1.5, 1.5% of 1M CaCl ₂, 0 ~ 5% of Arabic gum, 0.1 ~ 0.3, 0.3% of 0.7mmol of ammonium persulfate and the balance of water.

2. The high shape recovery hydrogel of claim 1, wherein: 20% of acrylic acid, 4% of chitosan and 3% of Arabic gum.

3. a method for preparing a hydrogel with high shape recovery rate, which comprises the following steps:

1) weighing the acrylic acid, the chitosan, the CaCl ₂, the Arabic gum and the ammonium persulfate as described in claim 1, mixing the acrylic acid and the chitosan, adding water with the weight being 10 times that of the chitosan 8 ~, stirring for 0.5 ~.5 h, adding the CaCl ₂, stirring for 25 ~ min, adding the Arabic gum and the ammonium persulfate, diluting with water, stirring uniformly, removing bubbles, and heating at 55 ~ ℃ for 6 ~ h;

2) Taking out, washing, and drying at 55 ~ 65 deg.C for 45 ~ 50h to obtain hydrogel with high shape recovery rate.

4. The method for preparing the hydrogel with high shape recovery rate according to claim 3, wherein the hydrogel with high shape recovery rate obtained in the step 2) is put into an aqueous solution containing an active substance for 40 ~ 50 h.

5. The method for preparing a hydrogel with high shape recovery rate according to claim 4, wherein the method comprises the following steps: heating at 60 ℃ for 7h as described in step 1).

6. the method for preparing a hydrogel with high shape recovery rate according to claim 5, wherein the method comprises the following steps: drying at 60 ℃ for 48h as described in step 2).

Technical Field

The invention belongs to the technical field of high polymer materials, and particularly relates to a hydrogel with high shape recovery rate and a preparation method thereof.

background

Chitosan (chitosan), also known as chitosan, is obtained by deacetylation of chitin (chitin) widely existing in nature, and is chemically named polyglucosamine (1-4) -2-amino-B-D glucose. Such natural polymers have been widely used in various industries for their excellent properties such as biological functionality, compatibility, blood compatibility, safety, and biodegradability, and have made great progress in the research of applications in various fields such as medicine, food, chemical engineering, cosmetics, water treatment, metal extraction and recovery, biochemistry, and biomedical engineering. While gum arabic is the oldest, most well-known natural gum in the world. Arabic gum contains high molecular polysaccharides and its calcium, magnesium and potassium salts. Mainly comprises arabinose, galactose, glucuronic acid and the like. However, natural polysaccharide molecules often have the defects of strong crystallinity, difficult processing and forming, poor mechanical properties, poor material recovery and the like.

Hydrogel is a hydrophilic three-dimensional network high molecular polymer, can absorb a large amount of water, is soft, is similar to a living tissue material, has good biocompatibility, and is widely applied. Can be used in the fields of biomedicine, tissue engineering and the like, such as tissue fillers, drug sustained release agents, enzyme embedding, protein electrophoresis, contact lenses, artificial blood plasma, artificial skin, tissue engineering scaffold materials and the like. In addition, based on the molecular unit structure of the polysaccharide, a large number of hydrogen bonds exist in the molecule and among the molecules, and specific functional groups possessed by different kinds of polysaccharides enable the gel to have different structural properties. However, the properties of single polysaccharide molecules are single, and most of the existing polysaccharide hydrogel products have the problems of complex preparation process and poor mechanical properties, thereby greatly limiting the wide application of the polysaccharide hydrogel products. Therefore, the development of the polysaccharide-based hydrogel which is simple to prepare and excellent in material performance has far-reaching significance.

Both hydrogels and elastomers have similar properties as polymeric materials, such as softness and stretchability, and are widely used in many similar fields, such as machinery, biology, medical treatment, etc. However, the different structures of the two make both hydrogels and elastomers unique for specific applications. The elastomer has unique characteristics such as stability under various environments, high mechanical strength, excellent recovery and the like, and the hydrogel has unique characteristics including high water content, good biocompatibility and the like. Similarly, the disadvantages of both are quite obvious, and the biocompatibility and the ion permeability of the elastomer are not strong, so that the application in the medical field is limited. Whereas hydrogels have poor mechanical strength compared to elastomers and recovery speed are far apart compared to elastomers. Therefore, combining the advantages of both elastomers and hydrogels to compensate for their deficiencies is a popular direction in the current field of hydrogel research.

To achieve the above object, there are two methods today, one is to improve the strength and recovery of the gel by adhering the hydrogel to the elastomer by means of a combination of the hydrogel and the elastomer. However, the gel prepared by the method is greatly dependent on the strength of adhesion between the gel and the elastomer, and the application range is limited, so that the gel is generally used for wound dressings and is difficult to apply to in vivo environments. Another approach is to increase the strength and recovery of the gel. The crosslinking mode in the gel is classified into chemical crosslinking and physical crosslinking. However, today's gels still need to overcome the problems of low recovery rate and long recovery time.

disclosure of Invention

The invention aims to solve the problems of low recovery rate and long recovery time of the existing hydrogel, and provides the hydrogel with high shape recovery rate and the preparation method thereof.

A hydrogel with high shape recovery rate comprises (by weight) acrylic acid 18 ~ 22%, chitosan 1 ~ 4%, CaCl ₂ with concentration of 1M 0.5 ~ 1.5.5%, acacia gum 0 ~ 5%, ammonium persulfate 0.1 ~ 0.3.3% with concentration of 0.7mmol, and water in balance;

20% of acrylic acid, 4% of chitosan and 3% of Arabic gum.

A method for preparing a hydrogel with high shape recovery rate, which comprises the following steps:

1) Weighing the acrylic acid, the chitosan, the CaCl ₂, the Arabic gum and the ammonium persulfate, mixing the acrylic acid and the chitosan, adding water with the weight being 8 ~ 10 times that of the chitosan, stirring for 0.5 ~ 1.5.5 h, adding the CaCl ₂, stirring for 25 ~ 35min, adding the Arabic gum and the ammonium persulfate, adding water for diluting, uniformly stirring, removing bubbles, and heating for 6 ~ 8h at 55 ~ 65 ℃;

2) Taking out, cleaning, and drying at 55 ~ 65 deg.C for 45 ~ 50h to obtain hydrogel with high shape recovery rate;

Putting the hydrogel with high shape recovery rate obtained in the step 2) into an aqueous solution containing an active substance for 40 ~ 50 h;

Heating at 60 ℃ for 7h as described in step 1);

Drying at 60 ℃ for 48h as described in step 2).

The invention provides a high shape recovery rate hydrogel which is prepared from the following components in percentage by weight, 18 ~ 22% of acrylic acid, 1 ~ 4% of Chitosan, 0.5 ~ 1.5, 1.5% of 1M CaCl ₂, 0 ~ 5% of Arabic gum, 0.1 ~ 0.3, 0.3% of 0.7mmol ammonium persulfate and the balance of water, wherein the preparation method comprises the steps of mixing acrylic acid and Chitosan, adding 8 ~ 10 times of the weight of the Chitosan, stirring for 0.5 ~ 1.5.5 h, adding CaCl ₂, stirring for 25 ~ 35min, adding Arabic gum and ammonium persulfate, diluting with water, stirring uniformly, removing bubbles, heating for 6 ~ 8h at 55 ~ 65 ℃, taking out, cleaning, drying for 45 ~ 50h at 55 ~ 65 ℃, obtaining the high shape recovery rate hydrogel, and the hydrogel is synthesized by Acrylic Acid (AA), Chitosan (Chitosan) and Arabic Gum (AG), and is prepared as a monomer in the polymerization process, the PAA is used as a dry gel, and the PAA hydrogel is prepared, and has the high shape recovery rate of the carboxyl on carboxyl groups, and the carboxyl groups of carboxyl groups, and the carboxyl groups on the carboxyl groups of the carboxyl groups, and the Chitosan, and the hydrogel has the synergistic effect of the high physical recovery rate of the carboxyl groups, and the high-resistant hydrogel, and the high-chain-based hydrogel has the synergistic effect of the.

Drawings

FIG. 1 is a schematic diagram of the hydrogel preparation procedure;

FIG. 2 shows the results of the mechanical strength test of the hydrogel;

FIG. 3 results of cyclic stretching experiments; a is a first, fifth and tenth cyclic stretch diagram; b is the maximum mechanical strength of the ten-cycle stretching; c, ten-cycle stretching deformation conditions of the gel; d is visual comparison of shape change after cyclic stretching;

FIG. 4 effect of chitosan addition on gels;

FIG. 5 Effect of gum arabic addition on gels.

Detailed Description