阅读说明：本技术 一种制备抗菌医用高分子材料的方法 (Method for preparing antibacterial medical high polymer material ) 是由 颜勇 于 2018-05-30 设计创作，主要内容包括：本发明公开了一种制备抗菌医用高分子材料的方法,将医用高分子材料浸在清洗溶剂中进行超声清洗；然后将医用高分子材料固定在等离子体设备的真空室处理台上,利用等离子体的气体,和紫外灯,激活医疗用高分子材料表面的活性基团；然后置于于偶联剂中,最后用化学镀的方法,将抗感染剂结合在已活化的医用高分子材料表面,即可制得抗菌医用高分子材料；本发明本发明采用紫外照射-自组装单层膜与化学镀相结合以及采用等离子体-自组装单层膜与化学镀相结合的技术处理医用高分子材料,这种复合技术的处理方式能最大限度激活医用高分子材料表面的活性基团,使得原材料的供应范围进一步扩大,选料的选择性大幅降低,生产受原料的限制最小化。(the invention discloses a method for preparing an antibacterial medical high polymer material, which comprises the steps of immersing the medical high polymer material in a cleaning solvent for ultrasonic cleaning; then fixing the medical polymer material on a vacuum chamber treatment table of plasma equipment, and activating active groups on the surface of the medical polymer material by using gas of plasma and an ultraviolet lamp; then placing the medical polymer material in a coupling agent, and finally combining an anti-infective agent on the surface of the activated medical polymer material by a chemical plating method to obtain the antibacterial medical polymer material; the invention adopts the technology of combining ultraviolet irradiation with the self-assembled monolayer film and chemical plating and adopting the technology of combining plasma with the self-assembled monolayer film and chemical plating to treat the medical polymer material, and the treatment mode of the composite technology can activate the active groups on the surface of the medical polymer material to the maximum extent, thereby further expanding the supply range of raw materials, greatly reducing the selectivity of material selection and minimizing the limitation of the production by the raw materials.)

1. A method for preparing an antibacterial medical high polymer material is characterized by comprising the following steps:

Soaking the medical polymer material in a cleaning solvent for ultrasonic cleaning for 40-60min to remove surface attachments, and then drying by using cold air to ensure that the medical polymer is dry and clean for later use;

Fixing the cleaned dry medical polymer material on a vacuum chamber treatment table of plasma equipment, then sealing the vacuum chamber, vacuumizing and injecting gas suitable for plasma, then switching on a power supply, and simultaneously irradiating the medical polymer material by using an ultraviolet lamp to activate active groups on the surface of the medical polymer material;

Soaking a medical high polymer material with an active group on the surface in a coupling agent for 5-7h, and cleaning the medical high polymer material with deionized water after the medical high polymer material is not soaked, so as to obtain an intermediate sample;

And reacting the intermediate sample for 1.5-2.5h by using a chemical plating method, and combining the anti-infective agent on the surface of the activated medical high polymer material to obtain the antibacterial medical high polymer material.

2. The method of claim 1, wherein the cleaning solvent is acetone solution, acid solution, alkali solution or deionized water.

3. the method of claim 1, wherein the temperature of the cooling air is 10-20 ℃.

4. The method for preparing an antibacterial medical polymer material according to claim 1, wherein the degree of vacuum after the gas suitable for plasma introduction is maintained at 1.0 ~ 1.0 x 10 Pa, the gas suitable for plasma is nitrogen, methane or ethane, and the power of plasma is 100 ~ 1500W.

5. The method of claim 1, wherein the vacuum chamber processing table is provided with a separate ultraviolet lamp.

6. the method of claim 1, wherein the coupling agent has the formula Y (CH2) nSiX3, wherein n =0 ~ 3, X is a hydrolyzable group, typically chloro, methoxy, methoxyethoxy, acetyl, etc., and Y is an organic functional group, typically amino, epoxy, methacryloxy, mercapto, ureido.

7. The method of claim 1, wherein the anti-infective agent is an inorganic silver anti-infective agent containing Ag + as an effective anti-infective ingredient.

Technical Field

The invention relates to the technical field of medical high polymer materials, in particular to a method for preparing an antibacterial medical high polymer material.

Background

A polymer material is a material based on a polymer compound. The polymer material is a material composed of compounds with relatively high molecular mass, and comprises rubber, plastics, fibers, paint, an adhesive and a polymer-based composite material, and the polymer is a life existing form. All living organisms can be regarded as a collection of macromolecules.

The polymer materials are classified into natural, semisynthetic (modified natural polymer materials) and synthetic polymer materials according to their sources. Natural macromolecules are the basis of life origin and evolution. The human society has utilized natural polymer materials as living materials and production materials from the beginning, and has mastered its processing technology. Such as weaving fabric with silk, cotton and wool, and making paper with wood, cotton and hemp. At the end of the 30 s in the 19 th century, a semi-synthetic polymer material appeared in the modification stage of natural polymer chemistry. In 1907, synthetic high molecular phenol formaldehyde resin appeared, which marks the beginning of the application of synthetic high molecular materials by human beings. In modern times, high molecular materials are the same as metal materials and inorganic non-metal materials, and become important materials in scientific, technical and economic construction.

The structure of the high polymer material determines the performance of the high polymer material, and the high polymer material with different characteristics can be obtained by controlling and modifying the structure. The polymer material has unique structure, easy modification and easy processing, so that the polymer material has excellent performance incomparable and irreplaceable with other materials, is widely applied to the fields of science and technology, national defense construction and national economy, and becomes an indispensable material for various aspects of clothes, food and housing in modern social life.

many natural materials are generally composed of high molecular materials, such as natural rubber, cotton, human organs, etc. As are synthetic chemical fibers, plastics, rubbers, and the like. Generally, a polymer which is widely used in life and has already been industrially produced is a general-purpose polymer material, and a functional polymer having a special purpose and function is referred to.

The medical polymer material is used for manufacturing human internal organs, external organs, drug dosage forms and medical appliances, and the source of the medical polymer material comprises natural biological polymer materials and synthetic biological polymer materials. The natural medical polymer material comes from nature and comprises cellulose, chitin, hyaluronic acid, collagen, gelatin, sodium alginate and the like; the synthetic medical polymer material is a polymer material artificially synthesized by a chemical method and used for medical purposes, and currently, polyurethane, silicon rubber, polyester fiber, polyvinylpyrrolidone, polyether ether ketone, polymethyl methacrylate, polyvinyl alcohol, polylactic acid, polyethylene and the like are commonly used.

The medical polymer material is mainly used for human bodies, is directly related to human life and health, and generally has the following requirements on the performance: safety: it must be non-toxic or have minimal side effects. This requires high purity of the polymer, very clean production environment, low residue of the polymerization aid, ppm level of impurities, and ensures disease-free and nontoxic propagation conditions. Meanwhile, the macromolecular compound and monomer impurities, degradation or abrasion products do not have adverse effects on the body. And the physical, chemical and mechanical properties need to meet the requirements of medical design and functions. Such as hardness, elasticity, mechanical strength, fatigue strength, creep, abrasion, water absorption, elution, enzyme resistance, in vivo aging resistance, and the like. In the case of heart valves, the valves are preferably usable for 25 ten thousand hours, and particularly good fatigue resistance is required. In addition, the material is required to be convenient for sterilization and disinfection, and can resist damp heat disinfection (120-140 ℃), dry heat disinfection (160-190 ℃), radiation disinfection or chemical treatment disinfection without reducing the performance of the material. Medical high polymer materials with different properties can select a proper sterilization mode according to the specific situation. Adaptability: including adaptability to other materials in medical supplies, biocompatibility of the materials with the human body, hemocompatibility, and tissue compatibility. After the material is implanted into a human body, no influence on body fluid is required for a long time; the compatibility with blood is good, no damage is caused to blood components, blood coagulation and hemolysis are avoided, and thrombosis is avoided; has no foreign body reaction, does not damage tissues in human body, does not cause cancer and teratogenesis, and does not cause inflammation necrosis, tissue hyperplasia and the like. Fourthly, special functions: different application fields require materials with certain special functions respectively. For example: a filtration membrane for artificial kidney having a separation and dialysis function, a gas exchange membrane for artificial lung, a substance for artificial blood which adsorbs and desorbs gas, and the like are required to have respective special separation and permeation functions. In most cases, the chemical composition and structure of the surface of the existing polymer material hardly meet the above requirements, and surface modification treatment such as graft copolymerization is usually performed to improve the properties such as anticoagulation property. In addition, medical polymer materials are required to have excellent processability and to be easily processed into a desired complicated shape.

At present, the polymer material has the wide application technology in the medical field, so that the medical convenience is greatly improved, but the application of the existing medical polymer material in the aspect of antibiosis is still very narrow, the manufacturing mode is limited, and the production requirement at the present stage is difficult to meet.

Disclosure of Invention

The invention aims to provide a method for preparing an antibacterial medical high polymer material, which aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

A method for preparing an antibacterial medical high polymer material comprises the following steps:

1) soaking the medical polymer material in a cleaning solvent for ultrasonic cleaning for 40-60min to remove surface attachments, and then drying by using cold air to ensure that the medical polymer is dry and clean for later use;

2) Fixing the cleaned dry medical polymer material on a vacuum chamber treatment table of plasma equipment, then sealing the vacuum chamber, vacuumizing and injecting gas suitable for plasma, then switching on a power supply, and simultaneously irradiating the medical polymer material by using an ultraviolet lamp to activate active groups on the surface of the medical polymer material;

3) Soaking a medical high polymer material with an active group on the surface in a coupling agent for 5-7h, and cleaning the medical high polymer material with deionized water after the medical high polymer material is not soaked, so as to obtain an intermediate sample;

4) And reacting the intermediate sample for 1.5-2.5h by using a chemical plating method, and combining the anti-infective agent on the surface of the activated medical high polymer material to obtain the antibacterial medical high polymer material.

Further, the cleaning solvent is acetone solution, acid solution, alkali solution and deionized water.

Further, the temperature of the cold air is 10-20 ℃.

further, the degree of vacuum after the gas suitable for plasma was introduced was maintained at 1.0 ~ 1.0.0 × 10 Pa, the gas suitable for plasma was nitrogen, methane or ethane, and the power of plasma was 100 ~ 1500W.

Furthermore, an independent ultraviolet lamp is arranged on the vacuum chamber treatment table.

Further, the coupling agent has the general formula Y (CH2) nSiX3, wherein n =0 ~ 3, X is a hydrolyzable group, typically chloro, methoxy, methoxyethoxy, acetyl, etc., and Y is an organic functional group, typically amino, epoxy, methacryloxy, mercapto, ureido.

Further, the anti-infective agent is an inorganic silver anti-infective agent which takes Ag + as an effective anti-infective component.

Compared with the prior art, the invention adopts the technology of combining ultraviolet irradiation with the self-assembled monolayer film and chemical plating and adopting the technology of combining plasma with the self-assembled monolayer film and chemical plating to process the medical polymer material, and the processing mode of the composite technology can activate the active groups on the surface of the medical polymer material to the maximum extent, so that the supply range of raw materials is further enlarged, the selectivity of material selection is greatly reduced, the production is minimized by the limitation of the raw materials, and the invention is suitable for the requirement of large-scale production; the surface structure of the antibacterial medical high polymer material obtained after treatment is stable, the physical and chemical properties of the material are not influenced, and the antibacterial medical high polymer material has long-acting and broad-spectrum antibacterial performance; the operation is simple, the cost of the light source and the equipment for ultraviolet irradiation is low, and the continuous operation is easy.

Detailed Description

it should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

A method for preparing an antibacterial medical high polymer material comprises the following steps:

The method comprises the steps of immersing a medical high polymer material in a cleaning solvent for ultrasonic cleaning for 40-60min, removing surface attachments, drying by using cold air to ensure that the medical high polymer is dried and clean for later use, wherein the cleaning solvent is acetone solution, acid solution, alkali solution and deionized water, the temperature of the cold air is 10-20 ℃, fixing the cleaned and dried medical high polymer material on a vacuum chamber treatment table of plasma equipment, sealing the vacuum chamber, vacuumizing and injecting gas suitable for plasma, switching on a power supply, irradiating the medical high polymer material by using an ultraviolet lamp to activate active groups on the surface of the medical high polymer material, wherein the vacuum degree after the gas suitable for the plasma is introduced is maintained at 1.0 ~.0X 10 Pa, the gas suitable for the plasma is nitrogen or methane or ethane, the power of the plasma is 100 ~ W, the vacuum chamber treatment table is provided with an independent ultraviolet lamp, immersing the medical high polymer material with the active groups on the surface in a hydrolysable coupling agent for 5-7h, cleaning by using deionized water to obtain an intermediate ureido coupling agent with the general formula of SiY = 32, the chemical ureido coupling agent, the chemical coupling agent is prepared by using an anti-acetoxy chemical reaction method, an anti-acetoxy group-silver group-acrylate coupling agent, and an anti-acrylate coupling agent, wherein the anti-acrylate-.