阅读说明：本技术 一种氰霜唑·烯酰吗啉悬浮剂及其加工方法 (Cyazofamid-dimethomorph suspending agent and processing method thereof ) 是由 徐益峰 方润 徐金娇 宁早霞 刘明浩 吴兵 王震 张帆 袁成军 季汪洋 安林峰 于 2019-10-15 设计创作，主要内容包括：本发明涉及一种氰霜唑·烯酰吗啉悬浮剂,包括以下重量份的原料：氰霜唑原药(95％)100-110份、烯酰吗啉原药(95％)310-320份、脂肪醇硫酸钠28-32份、高效非离子氟表面活性剂28-32份、含tsp基团的特殊类型阴离子表面活性剂28-32份、消泡剂4.5-5.5份、乙二醇48-52份、黄原胶1.4-1.6份、白炭黑9-11份、苯甲酸钠2.5-3.5份、水410-420份。本发明制备的40％氰霜唑·烯酰吗啉水悬浮剂一种安全性好、综合性能俱佳和应用前景好的环保剂型。其粒径较微细,粘度适宜,流动性良好,不易析水和沉降,可长期保持良好的外观,尤其是经54℃、14d的热贮后稳定性合格,且无结块,粘度基本保持不变。(The invention relates to a cyazofamid-dimethomorph suspending agent which comprises the following raw materials in parts by weight: 100-110 parts of cyazofamid (95%), 310-320 parts of dimethomorph (95%), 28-32 parts of fatty alcohol sodium sulfate, 28-32 parts of high-efficiency nonionic fluorosurfactant, 28-32 parts of special anionic surfactant containing tsp groups, 4.5-5.5 parts of defoaming agent, 48-52 parts of ethylene glycol, 1.4-1.6 parts of xanthan gum, 9-11 parts of white carbon black, 2.5-3.5 parts of sodium benzoate and 410-420 parts of water. The 40 percent cyazofamid-dimethomorph aqueous suspension prepared by the invention is an environment-friendly preparation with good safety, good comprehensive performance and good application prospect. The product has fine particle size, proper viscosity, good fluidity, and good appearance, and can be stored at 54 deg.C for 14 days without agglomeration and viscosity unchanged.)

1. A cyazofamid-dimethomorph suspending agent is characterized in that: the feed comprises the following raw materials in parts by weight:

wherein the content of cyazofamid in cyazofamid bulk drug is 95 percent, and the content of dimethomorph in dimethomorph bulk drug is 95 percent.

2. The cyazofamid-dimethomorph suspension according to claim 1, characterized in that: the feed comprises the following raw materials in parts by weight:

Wherein the content of cyazofamid in cyazofamid bulk drug is 95 percent, and the content of dimethomorph in dimethomorph bulk drug is 95 percent.

3. The cyazofamid-dimethomorph suspension according to claim 1, characterized in that: the high-efficiency nonionic fluorine surfactant is one of DX-3070SF, perfluoroalkyl phosphate, DuPont fluorine surfactant FS-60 and FCS-005.

4. the cyazofamid-dimethomorph suspension according to claim 1, characterized in that: the special type of anionic surfactant containing the tsp group is one of trisodium phosphate anionic surfactant, sodium hexametaphosphate anionic surfactant and sodium tripolyphosphate anionic surfactant.

5. The cyazofamid-dimethomorph suspension according to claim 1, characterized in that: the defoaming agent is one of AT-882D organosilicon defoaming agent, LS-6220 organosilicon defoaming agent and QQ-20186 high-performance organosilicon emulsion type defoaming agent.

6. a process for the preparation of the suspension concentrate of cyazofamid dimethomorph according to any one of claims 1 to 5, characterized in that: the method comprises the following specific steps: adding each raw material into a shearing kettle for shearing, feeding into a sand mill after the raw materials are uniformly dispersed and sheared, sanding for 2 times, feeding into a homogeneous shearing kettle for shearing and mixing, pumping into a storage tank after sampling detection is qualified, and packaging by a filling machine to obtain the product.

Technical Field

The invention relates to the field of pesticides, and particularly relates to a cyazofamid-dimethomorph suspending agent and a processing method thereof.

Background

dimethomorph (dimethomorph) is a broad-spectrum systemic bactericide developed by BASF company, has the action characteristic of destroying the formation of cell wall membranes, and is widely used for disease control caused by oomycetes fungi of dinoflagellate phylum, such as vegetable downy mildew, epidemic disease, seedling damping-off, tobacco black shank and the like. Dimethomorph belongs to a low-toxicity bactericide, has no cross resistance with phenylamide medicaments, is harmless to natural enemies and beneficial organisms, is a broad-spectrum bactericide with good environmental compatibility, and has increasingly large dosage in China in recent years.

Cyazofamid is a novel protective bactericide, has high activity on oomycete pathogenic bacteria such as phytophthora, downy mildew, pseudodowny mildew, pythium and the like, and has the action mechanism that the effective components are combined with the inner membrane of plant pathogenic bacteria cell mitochondria to block the electron transfer in the membrane and interfere the energy supply, so that the effect of killing the pathogenic bacteria is achieved.

The suspending agent is a water-based preparation which does not use any solvent, does not generate dust, and has low toxicity and irritation to human and animals. The dosage form is not flammable, explosive and dust-generating during packaging, storage and transportation.

Disclosure of Invention

The invention aims to: provides a cyazofamid-dimethomorph suspending agent and a processing method thereof.

In order to achieve the above purpose, the invention provides the following technical scheme:

The cyazofamid-dimethomorph suspending agent comprises the following raw materials in parts by weight:

Wherein the content of cyazofamid in cyazofamid bulk drug is 95 percent, and the content of dimethomorph in dimethomorph bulk drug is 95 percent.

Preferably, the cyazofamid-dimethomorph suspending agent comprises the following raw materials in parts by weight:

Wherein the content of cyazofamid in cyazofamid bulk drug is 95 percent, and the content of dimethomorph in dimethomorph bulk drug is 95 percent.

Preferably, the high-efficiency nonionic fluorine surfactant is one of DX-3070SF, perfluoroalkyl phosphate, DuPont fluorine surfactant FS-60 and FCS-005.

preferably, the specific type of anionic surfactant containing a tsp group is one of trisodium phosphate anionic surfactant, sodium hexametaphosphate anionic surfactant and sodium tripolyphosphate anionic surfactant.

Preferably, the defoaming agent is one of AT-882D silicone defoaming agent, LS-6220 silicone defoaming agent and QQ-20186 high-performance silicone emulsion type defoaming agent.

A processing method of a cyazofamid-dimethomorph suspending agent comprises the following specific steps: adding each raw material into a shearing kettle for shearing, feeding into a sand mill after the raw materials are uniformly dispersed and sheared, sanding for 2 times, feeding into a homogeneous shearing kettle for shearing and mixing, pumping into a storage tank after sampling detection is qualified, and packaging by a filling machine to obtain the product.

The invention has the beneficial effects that:

the invention has a unique ternary substituted core structure by using special anionic surface activity containing a tsp group, and can have good interaction with active ingredients of cyazofamid and dimethomorph. The colloidal stability is excellent, the firm colloidal structure provides strong steric hindrance and electrostatic repulsion interaction, the colloidal structure is easily adsorbed on a newly formed surface in the sanding process, the strong repulsion prevents tiny favorable re-polymerization and clustering, and the steric hindrance of the tsp macromolecular structure prevents the estradiol cage from being wrapped, so the colloidal structure is harmless to estrogen and is safer to mammals. Meanwhile, the suspension rate of the pesticide active ingredients is improved, the pesticide active ingredients can be dispersed rapidly, and the auxiliary agents can promote the preparation to form a film on the surface of a plant, so that the adhesiveness of the preparation is enhanced, and the preparation is resistant to rain wash.

The 40 percent cyazofamid-dimethomorph aqueous suspension prepared by the invention is an environment-friendly preparation with good safety, good comprehensive performance and good application prospect. The product has fine particle size, proper viscosity, good fluidity, and good appearance, and can be stored at 54 deg.C for 14 days, with qualified stability, suspension rate of above 90%, no agglomeration, and unchanged viscosity.

In the process of storing the suspending agent, the medicine particles are settled under the action of gravity, serious water separation and layering occur, and the product quality is influenced. Not only can improve the viscosity of a dispersion medium and reduce the sedimentation velocity of particles, but also has the dispersing function and greatly improves the storage stability of the preparation. The good fluidity of the preparation is ensured while the good stability of the preparation is ensured.

By reasonably controlling the proportion and the adding amount of the thickening agent, the viscosity of the suspending agent is controlled to be 600-800 mPa & s (25 ℃), so that the suspending agent meets the stability requirement (no layering, no precipitation, no caking and fluidity) during the storage period.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

The raw material ratio for producing 1 ton of 40 percent cyazofamid-dimethomorph suspending agent is as follows:

wherein the high-efficiency nonionic fluorine surfactant is selected from DX-3070SF (New chemical materials, Inc., Daxi, Guangzhou), perfluoroalkyl phosphate (Colocao, Inc., Guangzhou), Dupont fluorine surfactant FS-60, and FCS-005 (Nippon Seng).

The special type of anionic surfactant containing the tsp group is one of trisodium phosphate anionic surfactant, sodium hexametaphosphate anionic surfactant and sodium tripolyphosphate anionic surfactant.

The defoaming agent is one of AT-882D organosilicon defoaming agent, LS-6220 organosilicon defoaming agent and QQ-20186 high-performance organosilicon emulsion type defoaming agent.

the production process comprises the following steps:

During production, the original medicine, the dispersing agent, the wetting agent, the antifreezing agent, the thickening agent and the functional auxiliary agent are added into a shearing kettle for shearing, the mixture enters a sand mill after being uniformly dispersed and sheared, sand grinding is carried out for 2 times, the mixture enters a homogeneous shearing kettle for shearing and mixing, the mixture is injected into a storage tank after sampling and detection are qualified, and the product is packaged by a filling machine.

Under the operating conditions, the whole preparation process is about 3 hours, 3 batches can be produced in each shift, the shift yield is 1 ton, and the monthly yield can reach more than 60 tons in 2 shifts per day.

The technical indexes of the product of the invention are as follows in table 1:

Table 1 shows the technical indices of the products

The surface tension of the 40% cyazofamid/dimethomorph suspension prepared according to the present invention after dilution with water is shown in the following table 2:

Table 2 shows the surface tension at different dilution times

dilution factor	100	300	500	800	1500
						Surface tension (mN/m)	26.42	27.79	28.85	30.52	31.23

It is known that: the critical surface tension of a plant is an important parameter for the application of pesticides, and when the surface tension of a liquid medicine is less than the critical surface tension of a certain plant, the medicine can be wetted and spread on the surface of the plant. The critical surface tension value for plants which are difficult to wet (waxy layers), such as cabbage, rice and wheat, is approximately 35 mN/m. The invention can reduce the surface tension of the product to below 32mN/m by adding the functional auxiliary agent high-efficiency non-ionic fluorine surfactant.

Testing of Heat storage stability

The heat storage stability is measured and 5 batches of heat storage is carried out according to the method of GB/T19136-2003-2.3, and the obtained 40 percent cyazofamid-dimethomorph aqueous suspension has good heat storage stability, the decomposition rate of the effective components is less than 5 percent, the reduction range of the suspension rate is less than 5 percent, and the requirements of performance indexes are met.

TABLE 3 Heat storage stability test results

TABLE 4 Heat storage stability test results

From tables 3 and 4, it can be seen that the 40% cyazofamid-dimethomorph aqueous suspension product prepared according to the formula meets the technical index required by the suspension agent, and the decomposition rate of the effective components is less than 5%.