阅读说明：本技术 一种治疗牙龈肿痛和口腔溃疡的中药组合物及其制备方法 (A Chinese medicinal composition for treating gingival swelling and pain and oral ulcer, and its preparation method ) 是由 李德昌 于 2019-09-29 设计创作，主要内容包括：本发明属于生物医药领域,具体涉及一种治疗牙龈肿痛和口腔溃疡的中药组合物及其制备方法。一种治疗牙龈肿痛和口腔溃疡的中药组合物包括桂皮和吴茱萸。桂皮和吴茱萸协同作用,对牙龈肿痛和口腔溃疡均具有较好的疗效,从根本上实现对上述两种病症的治疗。本中药组合物使用醋作为辅料,可以加强局部炎症的收敛作用。本方案的中药组合物具有药味数量少和副作用小等特点,对牙龈肿痛和口腔溃疡有较好的临床疗效。本发明可以应用于牙龈肿痛和口腔溃疡的临床治疗当中。(The invention belongs to the field of biological medicines, and particularly relates to a traditional Chinese medicine composition for treating gum swelling and pain and oral ulcer and a preparation method thereof. A Chinese medicinal composition for treating gingival swelling and pain and oral ulcer comprises cortex Cinnamomi Japonici and fructus evodiae. The cinnamon and the fructus evodiae have a synergistic effect, have good curative effects on the gum swelling and pain and the dental ulcer, and fundamentally realize the treatment of the two diseases. The traditional Chinese medicine composition uses vinegar as an auxiliary material, and can strengthen the convergence of local inflammation. The traditional Chinese medicine composition has the characteristics of small quantity of medicinal materials, small side effect and the like, and has better clinical curative effects on gum swelling and pain and oral ulcer. The invention can be applied to the clinical treatment of the swelling and aching of gum and the dental ulcer.)

1. A traditional Chinese medicine composition for treating swelling and aching of gum and oral ulcer is characterized by comprising cassia bark and fructus evodiae.

2. The traditional Chinese medicine composition for treating swelling and aching of gum and dental ulcer as claimed in claim 1, wherein the mass ratio of cinnamon to evodia rutaecarpa is 1: 1.

3. The traditional Chinese medicine composition for treating swelling and aching of gums and oral ulcers according to claim 2, wherein the traditional Chinese medicine composition further comprises pharmaceutically acceptable excipients.

4. The Chinese medicinal composition for treating swelling and aching of gum and dental ulcer according to claim 3, wherein the auxiliary material is vinegar.

5. The traditional Chinese medicine composition for treating swelling and aching of gum and oral ulcer according to claim 4, wherein the dosage form of the traditional Chinese medicine composition is a clinically acceptable external dosage form.

6. The method for preparing a Chinese medicinal composition for treating gingival swelling and pain and oral ulcer according to any one of claims 1-5, wherein cortex cinnamomi japonici (ramulus Cinnamomi) powder and fructus evodiae (fructus evodiae) powder are obtained by respectively micronizing cortex cinnamomi japonici (ramulus Cinnamomi) and fructus evodiae (fructus evodiae); mixing cortex Cinnamomi powder and fructus evodiae powder to obtain mixed powder, adding vinegar into the mixed powder, and mixing to obtain the Chinese medicinal composition.

7. The preparation method of claim 6, wherein the mass ratio of vinegar to cinnamon to evodia rutaecarpa is 4:1: 1.

8. The preparation method of claim 7, wherein the cinnamon powder and the fructus evodiae powder are mixed and then sieved through a 300-mesh sieve to obtain mixed powder.

Technical Field

The invention belongs to the field of biological medicines, and particularly relates to a traditional Chinese medicine composition for treating gum swelling and pain and oral ulcer and a preparation method thereof.

Background

the swelling and aching of gum is mainly caused by inflammation such as gingivitis, and the poor oral hygiene can cause dental plaque, dental calculus and soft scale to deposit on the tooth surface near the gingival margin, thereby inducing gingivitis and causing the swelling and aching of gum. The clinical manifestations of swelling and pain of gum are swelling and hypertrophy of gum, deep red or dark red, soft tissue, easy bleeding in probing. Canker sores are a common ulcerative lesion occurring in the mucous membranes of the mouth. The gum swelling and pain and the dental ulcer are oral diseases which are easy to recur, the clinical incidence rate is high, and the oral diseases tend to gradually rise, the gum swelling and pain and the dental ulcer can directly influence the normal eating of patients, the chewing function of the patients is influenced, and the life quality of the patients is greatly reduced.

The coptis bolus for clearing away heat is a medicament which is frequently used clinically for treating gum swelling and pain and oral ulcer. The coptis chinensis pill for clearing away the upper heat comprises the following components: coptis root, gardenia (processed by ginger), fructus forsythiae, fructus viticis (fried), radix sileris, schizonepeta spike, radix angelicae, scutellaria baicalensis, chrysanthemum, mint, wine-processed rhubarb, golden cypress (fried with wine), platycodon grandiflorum, ligusticum wallichii, gypsum, inula flower and liquorice. The prior art has the following defects: (1) the coptis chinensis shangqing pills are large in medicinal taste, so that the pharmacological action mechanism of the medicine is very complex, and the large medicinal taste also means that the medicine has stronger toxic effect and brings higher risk of side effect to a user; (2) the coptis bolus for clearing the upper heat is an oral medicine, and before the medicine is absorbed and enters blood circulation, the medicine is rapidly degraded and metabolized in the digestive tract, and the amount of the medicine finally entering the blood circulation is reduced, so that the medicine effect is reduced. There is a need to develop a Chinese medicinal composition with less medicinal ingredients, clear pharmacological action and no first-pass effect, which can be used for relieving and treating gingival swelling and pain and oral ulcer.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating swelling and aching of gum and oral ulcer, which has the characteristics of small quantity of medicinal ingredients, small side effect and the like, and has better clinical curative effect on the swelling and aching of gum and the oral ulcer.

In order to solve the technical problems, the technical scheme of the invention provides a traditional Chinese medicine composition for treating gum swelling and pain and oral ulcer, and the traditional Chinese medicine composition comprises cassia bark and fructus evodiae.

The technical principle and the beneficial effects of the scheme are as follows:

Congealing cold, qi stagnation, blood stasis and swelling, and a large amount of allergic factors released by local tissues can cause swelling and pain of gums and oral ulcer. Cinnamon, with great heat in nature and pungent and sweet flavor, can dispel wind-cold, promote blood circulation and can guide fire to return to original origin; evodia rutaecarpa, fructus evodiae, pungent and warm in flavor, warms spleen and stomach, enters large intestine meridian, induces heat to descend stomach, and large intestine meridian runs along gum. The cinnamon and the fructus evodiae have synergistic effect, achieve the effects of diminishing inflammation and easing pain by warming and dredging channels and collaterals, and treat dental ulcer at the same time. The excessive fire can cause the swelling and pain of gum and the occurrence of canker sore, the fire is divided into excess fire and deficient fire, the cassia bark enters the kidney channel, the function of leading the fire to the origin is in line with the pathogenic mechanism, and the cassia bark also has the functions of promoting the circulation of qi and reducing the phlegm, and activating blood and dissolving stasis; evodia rutaecarpa has the effects of calming the liver and strengthening the spleen, and the liver pertains to earth and wood spleen, and can induce heat to descend, so as to synergistically enhance the fire-reducing effect of cinnamon. The two medicines are used together, and have better curative effect on various types of swelling and aching of gum. And because the oral ulcer and the swelling and aching of gum have the same etiology and pathogenesis, the combination of the two medicinal materials of the evodia and the cassia bark can achieve the curative effect of treating the different diseases at the same time. However, in the prior art, the medicines for treating the swelling and aching of gum and the dental ulcer are mainly medicines for clearing away heat and toxic materials and nourishing yin and clearing heat (such as coptis chinensis pill for clearing away heat and notopterygium root pill for treating bad taste, etc.), even anesthesia and analgesia medicines are used, and the medicines cannot fundamentally treat the swelling and aching of gum and the dental ulcer.

Mouse in vivo experiments prove that the cinnamon and the fructus evodiae both have certain anti-inflammatory effects, the combined anti-inflammatory effect of the cinnamon and the fructus evodiae is better than that of the cinnamon and the fructus evodiae, and the two medicines have synergistic effect on the anti-inflammatory effect. In addition, clinical experiments also prove the synergistic effect phenomenon of the combination of the cinnamon and the fructus evodiae.

In this scheme, cortex Cinnamomi Japonici (Bark of Cinnamon) is Bark of Cinnamomum japonicum, Cinnamomum cassia, Cinnamomum tenuipilum or Cinnamomum cassia of Lauraceae. Fructus evodiae (fructus evodiae) is dry near-mature fruit of Rutaceae plant fructus evodiae, caulis Seu folium Ampelopsis Brevipedunculatae or Rutaceae fructus evodiae.

To sum up, this scheme's beneficial effect lies in:

(1) The cinnamon and the fructus evodiae have a synergistic effect, have good curative effects on the gum swelling and pain and the dental ulcer, and fundamentally realize the treatment of the two diseases.

(2) The scheme can realize the treatment of the gum swelling and pain and the dental ulcer by only using two medicinal flavors, has small quantity of medicinal flavors, correspondingly reduces the toxic effect on patients and increases the safety of the medicament. The traditional Chinese medicine composition has small quantity of medicines and simultaneously reduces the difficulty of researching the pharmacological mechanism of the traditional Chinese medicine composition.

(3) The traditional Chinese medicine composition is low in price and easy to obtain, treatment cost can be reduced, and economic burden of patients is reduced.

Further, the mass ratio of the cinnamon to the fructus evodiae is 1: 1.

By adopting the technical scheme, better synergistic effect between the two medicinal materials can be obtained.

Further, the traditional Chinese medicine composition also comprises pharmaceutically acceptable auxiliary materials.

By adopting the technical scheme, the medicine can be prepared into various dosage forms by adding the auxiliary materials, and the stability and the efficacy of the main medicine can be enhanced by adding the auxiliary materials.

further, the auxiliary material is vinegar.

By adopting the technical scheme, the vinegar can strengthen the convergence of local inflammation.

Furthermore, the dosage form of the traditional Chinese medicine composition is a clinically acceptable external dosage form.

By adopting the technical scheme, the external preparation has the advantages of high efficiency, low toxicity, safety, convenience and the like, can avoid the first pass effect of the liver and avoid the damage of the medicine to the gastrointestinal tract.

The Chinese medicinal composition can be administered transdermally at acupoints to obtain good therapeutic effect. The acupoint transdermal drug delivery system is a new drug delivery system developed on the basis of acupoint application in traditional Chinese medicine. The medicine effect is improved by utilizing the meridian effect of the acupuncture points, the autoimmune function of the organism is activated, and the comprehensive treatment effect is achieved. The side effects of the medicine can be reduced by external application of the medicine, and the purpose of quick treatment can be achieved by applying the traditional Chinese medicine composition on specific acupuncture points. Especially, the medicine is taken at the Yongquan point, has good treatment effect, is taken from the upper part of the body, and can more quickly achieve the effect of inducing fire to return to the origin.

Further, a preparation method of the traditional Chinese medicine composition for treating swelling and aching of gum and dental ulcer comprises the steps of respectively carrying out superfine grinding on cassia bark and evodia rutaecarpa to obtain cassia bark powder and evodia rutaecarpa powder; mixing cortex Cinnamomi powder and fructus evodiae powder to obtain mixed powder, adding vinegar into the mixed powder, and mixing to obtain the Chinese medicinal composition.

by adopting the technical scheme, the ultrafine crushed cinnamon powder and the fructus evodiae powder are matched with vinegar for use, the contact area of the crushed Chinese medicinal materials and the surface of human skin is large, functional ingredients in the Chinese medicinal material powder can be dissolved out by the vinegar and can be infiltrated, the powder is prevented from being scattered when the medicine is taken, and the vinegar has the function of astringing local inflammation, so that the treatment effect of the Chinese medicinal composition is enhanced.

Further, the mass ratio of the vinegar to the cinnamon to the fructus evodiae is 4:1: 1.

By adopting the technical scheme, the optimal treatment effect can be obtained by adopting the dosage ratio, and the optimal scheme is provided.

Further, the cinnamon powder and the fructus evodiae powder are mixed and then sieved by a 300-mesh sieve to obtain mixed powder.

By adopting the technical scheme, the uniform degree and the particle size of the mixed powder are ensured by sieving the mixed powder by a 300-mesh sieve, and the prepared traditional Chinese medicine composition can be stably externally applied to acupuncture points and release functional substances.

Detailed Description

the following is further detailed by way of specific embodiments: