阅读说明：本技术 一种环保可降解修复足膜的制备方法 (Preparation method of environment-friendly degradable foot repairing membrane ) 是由 田纹绮 于 2018-06-12 设计创作，主要内容包括：本发明公开了一种环保可降解修复足膜的制备方法,解决了现有皮肤用修复液成份较多且较为复杂,进而增加成本,而且效果不佳,并且应用到足膜本体上后会促进杂菌滋生,造成环境污染的问题。本发明包括(1)采用聚乳酸纤维制成足膜,足膜的厚度为0.2-0.5um；(2)将透明质酸钠、聚谷氨酸钠、杂合褐藻寡糖和天然深层海盐溶解到水中制成修复液；(3)将修复液涂覆在足膜上接触皮肤的一侧,常温干燥；(4)重复步骤(3)2-5次后制成成品。本发明具有环保、可降解,抗菌,消炎,避免造成留疤可能等效果。(The invention discloses a preparation method of an environment-friendly degradable foot repairing membrane, which solves the problems that the existing repairing liquid for skin is more in components and more complex, so that the cost is increased, the effect is poor, and after the repairing liquid is applied to a foot membrane body, the breeding of mixed bacteria is promoted, so that the environment pollution is caused. The invention comprises (1) preparing foot membrane with polylactic acid fiber, wherein the thickness of the foot membrane is 0.2-0.5 um; (2) dissolving sodium hyaluronate, sodium polyglutamate, heterozygotic alginate oligosaccharide and natural deep sea salt in water to prepare a repairing solution; (3) coating the repairing liquid on one side of the foot membrane contacting with the skin, and drying at normal temperature; (4) and (5) repeating the step (3) for 2-5 times to obtain a finished product. The invention has the effects of environmental protection, degradability, antibiosis, antiphlogosis, prevention of scar, and the like.)

1. A preparation method of an environment-friendly degradable foot repairing membrane is characterized by comprising the following steps:

(1) adopting polylactic acid fiber to prepare a foot membrane, wherein the thickness of the foot membrane is 0.2-0.5 um;

(2) dissolving sodium hyaluronate, sodium polyglutamate, heterozygotic alginate oligosaccharide and natural deep sea salt in water to prepare a repairing solution;

(3) coating the repairing liquid on one side of the foot membrane contacting with the skin, and drying at normal temperature;

(4) repeating the step (3) for 2-5 times to obtain a finished product;

the repair liquid comprises 3-5 parts of hyaluronic acid or hyaluronate, 0.01-5 parts of polyglutamic acid or polyglutamate, 0.5-5 parts of alginate oligosaccharide, 2-2.5 parts of sea salt and 10-15 parts of water.

2. The method for preparing the environment-friendly degradable foot membrane according to claim 1, wherein the alginate oligosaccharide is selected from polymannuronate oligosaccharide, polyguluronate oligosaccharide or hybrid alginate oligosaccharide.

3. The method for preparing the environment-friendly degradable foot membrane according to claim 1, wherein the sea salt is natural deep sea salt, dead sea salt or bamboo salt prepared from natural sea salt.

4. The method for preparing the environment-friendly degradable foot repairing membrane according to claim 3, wherein the hyaluronate is selected from hyaluronic acid, sodium hyaluronate, zinc hyaluronate or hyaluronic acid oligosaccharide.

5. The method for preparing the environment-friendly degradable foot membrane according to claim 3, wherein the polyglutamic acid or polyglutamate is polyglutamic acid, sodium polyglutamate or manganese polyglutamate.

Technical Field

The invention relates to a foot membrane, in particular to a preparation method of an environment-friendly degradable foot membrane for repairing.

Background

The skin of people is exposed in the air and often corroded by wind, sand and dust, harmful substances such as bacteria and the like are bred in large quantity, the phenomenon is more and more serious along with the increasing deterioration of the environment, and finally, the skin barrier function is damaged, the skin is dry, the skin is aged, the skin is sensitive, the skin is irritated, the skin is hormone-dependent, the skin is greasy, the seborrheic diseases are caused, and the like.

The existing skin repair liquid has more and more complex components, thereby increasing the cost and having poor effect.

After the existing foot membrane is added with the repairing nutrient components, sundry bacteria can be bred, the environment can be greatly influenced, and the foot membrane is not convenient to degrade and is not environment-friendly.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: the existing skin repair liquid has more and more complex components, further increases the cost, has poor effect, and can promote the breeding of mixed bacteria after being applied to a foot mask body to cause the problem of environmental pollution; provides a preparation method of the environment-friendly degradable foot repairing membrane for solving the problems.

The invention is realized by the following technical scheme:

a preparation method of an environment-friendly degradable foot repairing membrane comprises the following steps:

(1) adopting polylactic acid fiber to prepare a foot membrane, wherein the thickness of the foot membrane is 0.2-0.5 um;

(2) dissolving sodium hyaluronate, sodium polyglutamate, heterozygotic alginate oligosaccharide and natural deep sea salt in water to prepare a repairing solution;

(3) coating the repairing liquid on one side of the foot membrane contacting with the skin, and drying at normal temperature;

(4) repeating the step (3) for 2-5 times to obtain a finished product;

the repair liquid comprises 3-5 parts of hyaluronic acid or hyaluronate, 0.01-5 parts of polyglutamic acid or polyglutamate, 0.5-5 parts of alginate oligosaccharide, 2-2.5 parts of sea salt and 10-15 parts of water.

Hyaluronic Acid (HA) in the invention is a high molecular acidic mucopolysaccharide, widely distributed in animal and human connective tissue extracellular matrix, and plays an important role as a matrix in human skin. Recently, foreign researches show that extracellular matrix macromolecular hyaluronic acid is activated into bioactive hyaluronic acid by hyaluronidase, and the bioactive hyaluronic acid is combined with extracellular CD44 and TLR4 receptors, so that defensin 2 secretion of skin mucosa can be promoted, and inflammation can be inhibited. The literature indicates that bioactive hyaluronic acid and defensin 2 are antagonists of endotoxin, and may regulate wound inflammation and scar healing.

Polyglutamic acid (gamma-PGA) is a polymer material synthesized by fermentation of microbial bacillus, also called natto gum and polyglutamic acid. The gamma-PGA is formed by connecting D-glutamic acid and L-glutamic acid monomers through alpha-amino and gamma-carboxyl by amido bond, and the relative molecular weight is (1-10) × 10⁵With approximately 0 relative to water molecules. The strong hydrophilic ability of the contact angle leads the water-absorbing and moisture-preserving capability to be super strong 5000 times, and the degradation product is pollution-free glutamic acid. The large molecular side chain of gamma-PGA has a large amount of ionizable-NH₂And functional groups such as-COOH and the like are easy to modify, can be identified by ligands on the cell surface, are favorable for cell adhesion, and can fix molecules with biological activity such as protein, polypeptide, amino acid and the like on the surface of the material through the groups, thereby further improving the cell affinity of the material.

The alginate oligosaccharide is also called sodium alginate oligosaccharide, is an oligomer formed by degrading sodium alginate, and consists of mannuronic acid, guluronic acid (Q) or a hybrid section of mannuronic acid and guluronic acid (Q). The existing preparation method of the sodium alginate oligosaccharide mainly comprises a physical degradation method, an acid degradation method, an oxidative degradation method, an enzymolysis method and the like. The brown algae oligosaccharide has low molecular weight, strong water solubility and high stability, has a plurality of biological activities such as tumor resistance, oxidation resistance, bacteriostasis, cell growth induction and the like, and has wide development prospects in the fields of medicine development, functional food development, green agriculture and the like.

The natural deep sea salt is the essence of sea, is prepared by refining sea water which is more than 5000 meters from the coast line and less than 200 meters from the sea surface, is sweet, is not dead and salty, has no heavy metal pollution, and does not contain any additive and anticaking agent, wherein various mineral substances and trace elements necessary for human bodies are contained in the natural deep sea salt in a balanced manner. This is a salt that human ancestors rely on for survival. The natural sea salt has pH of 7, and belongs to neutral salt. Besides sodium chloride, natural sea salt also completely retains various natural mineral substances such as potassium, calcium, magnesium, iron and the like required by human bodies and stored in seawater, and provides necessary mineral elements for restoring the barrier function of skin. Meanwhile, the composition also has the effects of sterilization, antivirus (the effects of Ag and Zn), antiallergic (the effect of Mn) and anti-inflammatory (the effect of Cu). Foreign relevant documents report that dead sea salt with high magnesium content can effectively assist in repairing skin barrier function.

The components are non-animal-derived raw materials, and have high biological safety and biocompatibility. According to the invention, a layer of moisturizing biopolymer membrane can be formed on the skin with damaged barrier function through the membrane forming property of hyaluronic acid and polyglutamic acid, so that the moisturizing biopolymer membrane has protection and nursing effects on damaged skin, and can effectively reduce nursing cost.

By the optimized design of the proportion, the protective and nursing effects can be effectively achieved, and the effects of better assisting barrier function recovery and the like can be achieved, such as: antibacterial, antiinflammatory, and scar preventing effects.

In addition, the foot membrane body is composed of polylactic acid fibers, and the foot membrane body is combined with the repair liquid, so that the generation of mixed bacteria can be inhibited, the environment-friendly effect is achieved, the degradation efficiency is high, and the effect is very obvious.

Further, the alginate oligosaccharide is selected from polymannuronic acid oligosaccharide, polyguluronic acid oligosaccharide or hybrid alginate oligosaccharide.

Further, the sea salt is natural deep sea salt, dead sea salt or bamboo salt prepared from natural sea salt.

Further, the hyaluronate is selected from hyaluronic acid, sodium hyaluronate, zinc hyaluronate or hyaluronic acid oligosaccharide.

Further, the polyglutamic acid or polyglutamate is polyglutamic acid, sodium polyglutamate or manganese polyglutamate.

Compared with the prior art, the invention has the following advantages and beneficial effects:

1. the raw materials of the invention are non-animal-derived raw materials, and have higher biological safety and biocompatibility;

2. the hyaluronic acid and the polyglutamic acid have film forming properties, a layer of moisturizing biopolymer film can be formed on the skin with damaged barrier function, the protective and nursing effects on the damaged skin are achieved, and the nursing cost can be effectively reduced; the two have the effect of mutual promotion, so that the overall effect is greatly improved;

3. the invention has the effects of antibiosis, antiphlogosis, avoiding scar possibility and the like;

4. the foot membrane body is composed of polylactic acid fibers, and the foot membrane body is combined with the repair liquid, so that the generation of mixed bacteria can be inhibited, the environment-friendly effect is achieved, the degradation efficiency is high, and the effect is very obvious.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.