阅读说明：本技术 化妆品和/或皮肤病学组合物及其在化妆品领域和在皮肤病的辅助治疗中的用途 (Cosmetics and/or dermatological compositions and its in cosmetic field and the purposes in dermopathic adjuvant treatment ) 是由 马西莫·塔尔奇西奥·泰尔诺 于 2018-04-20 设计创作，主要内容包括：本发明涉及包括维生素E乙酸酯、D-泛醇三乙酸酯和Olus油的化妆品和/或皮肤病学组合物,及其在化妆品和皮肤病学领域中的用途。(The present invention relates to the cosmetics and/or dermatological compositions that include vitamin e acetate, D-pantothenyl aleohol triacetate and Olus oil, and its purposes in cosmetics and dermatological field.)

1. cosmetics and/or dermatological compositions, comprising:

A) vitamin e acetate by weight in the 5-80% of composition (w/w) range；

B) the D-pantothenyl aleohol triacetate in 1-10% (w/w) range；

C) vegetable oil in 5-30% (w/w) range (Olus oil).

2. composition according to claim 1, comprising:

A) vitamin e acetate in 5-40% (w/w) range；

B) the D-pantothenyl aleohol triacetate in 2-7% (w/w) range；

C) vegetable oil in 15-30% (w/w) range (Olus oil).

3. composition according to claim 1 or 2, further includes:

D) the double more acyl group adipate esters -1 of-two glycerol or the more acyl group adipic acids of double-two glycerol in 10-30% (w/w) range Or mixtures thereof ester -2.

4. composition according to any one of the preceding claims, further includes:

E) amount is less than or equal to the zinc oxide of 20% (w/w).

5. composition according to any one of the preceding claims, further includes:

F) at least one compound selected from the group being made up of: jojoba oil, butyl octanol salicylate, carbonic acid diethyl Own ester, apricot kernel oil, the ethyl ester of sher butter, oleyl alcohol eruciate,

Wherein, at least one compound exists in the range of 5-30% (w/w).

6. composition according to any one of the preceding claims, further includes:

G) at least one of following compounds: triethoxy octyl silane, stearyl alcohol glycyrrhetin acid esters, ruscogenin, New ruscogenin, laureth -9, phytic acid, is mentioned with the Hamamelis bark that hamameli tannin measures acetyl group tetrapeptide The ethyl ester of object, vitaminF is taken,

In the range of 0-3% (w/w).

7. composition according to any one of the preceding claims, comprising:

A) vitamin e acetate, in the range of 5-15% (w/w)；

B) D-pantothenyl aleohol triacetate, in the range of 1.5-4% (w/w)；

C) vegetable oil (Olus oil), in the range of 20-30% (w/w)；

D) or mixtures thereof the more acyl group adipate esters -1 of double-two glycerol or the more acyl group adipate esters -2 of double-two glycerol, in 10- In the range of 20% (w/w)；

E) zinc oxide, in the range of 4-20% (w/w).

8. composition according to claim 1 to 6, comprising:

A) vitamin e acetate, in the range of 30-40% (w/w)；

B) D-pantothenyl aleohol triacetate, in the range of 3-7% (w/w)；

C) vegetable oil (Olus oil), in the range of 20-30% (w/w).

D) or mixtures thereof the more acyl group adipate esters -1 of double-two glycerol or the more acyl group adipate esters -2 of double-two glycerol, in 20- In the range of 30% (w/w).

9. composition according to any one of the preceding claims, wherein the composition is anhydrous.

10. composition according to any one of the preceding claims, wherein the composition does not include the hydrocarbon of mineral sources.

11. according to purposes of one or more compositions in cosmetics in preceding claims.

12. one or more compositions in -10 are for treating and/or preventing dermatological diseases according to claim 1 Purposes.

13. one or more compositions in -10 according to claim 1 are used for purposes according to claim 12, In, the dermatological diseases are selected from the group being made up of: hemorrhoid, crack, bedsore, dermatitis, the disease of crissum and anal intestine region Suffer from, such as itch, shouting pain, stimulation and pain, the hyperemia of hemorrhoid vascular plexus, the prolapsus of anal intestine pipe mucous membrane liner.

14. composition according to claim 7, the purposes of the dermatitis for treating anogenital region domain.

15. composition according to claim 8, for treating the purposes of hemorrhoid.

Technical field

Use the present invention relates to cosmetics and/or dermatological compositions and its in cosmetic field and as drug On the way.

Background technique

Skin is one of most important organ of human body: it provides protection against environmental injury, is responsible for our appearance And tactile.However, it can become dry and may become coarse and tight, or even cracks and itch when skin dehydration, because This its ability correctly to play a role is damaged.

Skin water shortage can show in various ways, such as drying, peeling, small incised wound, rubescent, inflammation, continue it is tight and It itches, these can further show as different forms according to impacted seriousness and area.When skin starts to lose When removing moisture, it will become tight and coarse.If not treating drying, and if skin further dries out, its meeting Become it is very tight, in the form of sheets and cracking.

Dry skin is by extrinsic factor (such as environment and extreme weather conditions, seasonal variations, ultraviolet light) and endogenous Caused by factor (such as flowing of inherent cause, hormone, age, diet) the two.One people may be simultaneously by several factors It influences, and with increasing with the origin cause of formation, the severity of dry skin be will increase.

Understand cause dry skin factor to prevent and treat this problem be certain to it is helpful.The process to dry out In the first step be to lose surface lipids, these surface lipids form natural barrier on the skin to prevent water point evaporation.When When this lipid barrier is destroyed, water will evaporate, and important substance in combination is easy to be removed in scrubbing process. Due to lacking these natural moisturizing factor, thus skin cannot keep enough waters and become drying.If such case is held Continue down, then the hydration network in deep skin will be damaged, and moisture can subtract to the flowing on the surface or upper layer of skin It is few, cause skin to become very dry.

Summary of the invention

In the first embodiment, the present invention relates to cosmetics and/or dermatological compositions comprising:

(a) vitamin e acetate by weight in the 5-80% of composition (w/w) range；

(b) the D-pantothenyl aleohol triacetate in 1-10% (w/w) range；

(c) vegetable oil in 5-30% (w/w) range (Olus oil).

Compositions listed above a), b) and c) generally by weight with 100% (w/w's) less than or equal to composition Percentage is present in cosmetics and/or dermatological compositions.

In another embodiment, the present invention relates to compositions of the invention to be used for dermatology relevant to chapped skin The treatment and prevention of disease.

In yet another embodiment, the purposes the present invention relates to composition of the invention in cosmetic field.

Detailed description of the invention

Fig. 1: different serious for treating by the composition (Comp 1B) of test according to the preferred embodiment of the present invention The histogram of the hemorrhoid of degree result obtained: I grades (Figure 1A), II grades (Figure 1B) and III level (Fig. 1 C).

Specific embodiment

The present invention relates to compositions comprising:

A) dimension by weight within the scope of the 5-80% of composition, preferably by weight in 5-40% (w/w) range Raw element E acetic acid esters；

B) D-pantothenyl aleohol by weight in the 1-10% of composition (w/w) range, preferably in 2-7% (w/w) range Triacetate；

C) plant by weight in the 5-30% of composition (w/w) range, preferably in 15-35% (w/w) range Oil (Olus oil).

Mixture that vegetable oil Olus oil is made of the triglycerides of the fatty acid C16-C18 of complete plant source (such as Palm oil and palm kernal oils, coconut oil and rapeseed oil), be free of any additive.It is faint yellow tasteless oil, is resisted with high Oxidation stability, good dispersion level and occlusive.It is generally found in trade nameIt is sold under Pura.

Compositions listed above a), b) and c) generally by weight with 100% (w/w's) less than or equal to composition Amount is present in cosmetics and/or dermatological compositions of the invention, preferably in the range of 25-90% (w/w), more preferably In the range of 35-80% (w/w), even more preferably in the range of 40-70% (w/w).

Preferably, compositions listed above a), b) and c) 35% (w/ generally by weight to be approximately equal to composition W), it is approximately equal to 40% (w/w), 65% (w/w) is approximately equal to, is approximately equal to 85% (w/w), is approximately equal to 100% (w/w's) Amount is present in cosmetics and/or dermatological compositions.

Preferably, composition of the invention further include cosmetically and/or excipient acceptable in dermatology, until Reach 100% by weight.

Preferably, composition of the invention is anhydrous.In cosmetic field, term " anhydrous " refers to that water activity is lower than 0.6% composition (according to UNI EN ISO 29621)；Preferably, composition of the invention is free of preservative.

Preferably, composition according to the present invention further include:

D) by weight in the 5-35% of composition (w/w) range, preferably in 10-30% (w/w) range double-two The mixture of the more acyl group adipate esters -1 of glycerol or the more acyl group adipate esters -2 of double-two glycerol or both；These are all plant sources Substance, it is tasteless and apparently without lanolin Huang such as Olus oil, show and the ability of combination water that lanolin is similar, In There is good adhesion strength on skin and there are excellent toxicology profiles.

Preferably, composition according to the present invention further include:

E) it is less than or equal to 20% (w/w) of composition, the preferably oxidation in 4-20% (w/w) range by weight Zinc.The compound shows excellent protective nature；Therefore, the group according to the preferred embodiment of the present invention including zinc oxide Object is closed in the preparation for treating rubescent skin, in the dermatitis (such as diaper dermatitis) of genital region, and in bedsore It is all highly useful in preventing.

Preferably, composition according to the present invention further include:

F) at least one compound selected from the group being made up of: jojoba oil, butyl octanol salicylate, carbonic acid two Ethylhexyl, apricot kernel oil, the ethyl ester of sher butter, oleyl alcohol eruciate；Wherein, at least one compound to exist by weight In 5-30% (w/w) range of composition, preferably exist in 5-15% (w/w) range.

Preferably, composition according to the present invention further include:

G) one of following compound or a variety of: triethoxy octyl silane (triethoxy-caprylyl- Silane), stearyl alcohol glycyrrhetin acid esters, ruscogenin, new ruscogenin, acetyl group tetrapeptide, laureth -9, Phytic acid measures Hamamelis (Hamamelis) bark extract of (for potency), the ethyl ester of vitaminF with hamameli tannin；Respectively From by weight between the 0-3% of composition (w/w).

Preferably, composition of the invention includes:

A) vitamin e acetate of about 75% (w/w)；

B) the D-pantothenyl aleohol triacetate of about 5% (w/w)；

C) vegetable oil (Olus oil) of about 20% (w/w).

Preferably, composition of the invention includes:

A) vitamin e acetate of about 35% (w/w)；

B) the D-pantothenyl aleohol triacetate of about 5% (w/w)；

C) vegetable oil (Olus oil) of about 25% (w/w).

Preferably, composition of the invention includes:

A) vitamin e acetate of about 10% (w/w)；

B) the D-pantothenyl aleohol triacetate of about 2.5% (w/w)；

C) vegetable oil (Olus oil) of about 25% (w/w).

It is shown in particularly preferred composition (Comp) according to the present invention Tables 1 and 2 below:

Table 1

Table 2

It is highly preferred that the amount of the oil of Olus by weight is the amount of 29% (w/w) and zinc in the composition Comp 1A of table 2 For 20% (w/w).

Techniques known in the art preparation can be used in composition of the invention, such as mixes.

For example, cosmetic composition can be prepared as follows: in a reservoir, solid component is mixed under slow stirring to 80 DEG C, until obtaining liquid and limpid group.Powder (if there is in preparation) is added under strong stirring, maintains the temperature at 80 ℃；In another container, remaining liquid component is preheated to 70 DEG C, and is then added in preparation under moderate agitation；So Quality is cooled to 30 DEG C under slow stirring afterwards.

In another embodiment, the purposes the present invention relates to composition of the invention in cosmetics.

In yet another embodiment, the present invention relates to compositions of the invention treats skin for prevention and/or (auxiliary) Disease learns disease.

Preferably, the dermatological diseases are selected from the group that is made up of: hemorrhoid, crack, bedsore, dermatitis, crissum and The illness (such as itch, shouting pain, stimulation and pain) in anal intestine region, the hyperemia of hemorrhoid vascular plexus, the prolapsus of anal intestine pipe mucous membrane liner.

Therefore, the present invention relates to the methods of (auxiliary) treatment dermatological diseases, by by composition application of the invention In showing or risky display skin is uncomfortable or one or more bodies of dermatological diseases (such as those of outlined above) Body region.

Composition according to the present invention can be carried out one or more times a day with topical application (even in internal situation), Amount will change according to the clinical condition of patient to be treated.

Composition of the invention unexpectedly overcomes composition that is well known in the prior art and hereinbefore mentioning The shortcomings that, i.e. sense organ and cosmetic properties is those of poor；Therefore, it may be advantageously used with the wider region of body.

In addition, composition of the invention has the composition with the prior art in terms of preventing and treating dermatological diseases It is comparable or than its more superior effect.