阅读说明：本技术 一种枇杷花颗粒及其制备工艺 (A kind of loquat flower particle and its preparation process ) 是由 陈冰 林新华 朱爱明 刘小英 彭建平 黄康平 蔡倩倩 许达芬 邓钰 于 2019-06-03 设计创作，主要内容包括：本发明公开了一种枇杷花颗粒及其制备工艺,特别涉及于中药制剂技术领域。该方法通过对枇杷花中水体物的提取、精制、制备、制粒、整粒及包装得到成品。通过本发明制备枇杷花颗粒剂,不仅工艺简单,且质量可控,为枇杷花颗粒剂的研发和推广提供了良好的依据,并有助于枇杷花资源更好地去被开发及利用,能够在一定程度上提高社会和经济效益,具有广阔的应用前景。(The invention discloses a kind of loquat flower particle and its preparation processes, in particular to technical field of traditional Chinese medicine preparation.This method is by the extraction, purification, preparation, granulation of water body object, whole grain in loquat flower and being packaged to be finished product.Loquat flower granule is prepared through the invention, not only simple process, and it is quality controllable, good foundation is provided for the research and development and popularization of loquat flower granule, and facilitates loquat flower resource and preferably go to be developed and utilized, social and economic benefit can be improved to a certain extent, had broad application prospects.)

1. a kind of loquat flower particle, which is characterized in that it includes loquat flower water extract dry cream fine powder, auxiliary material, the loquat flower water The ratio of extract dry cream fine powder and the auxiliary material be 1:1 ~ 4, the auxiliary material be pharmaceutically acceptable auxiliary material it is one such or Two kinds.

2. a kind of loquat flower particle according to claim 1, which is characterized in that it includes that loquat flower water extract dry cream is thin The ratio of powder, mannitol, the loquat flower water extract dry cream fine powder and the mannitol is 1:4.

3. a kind of preparation process of loquat flower particle according to claim 1, which comprises the following steps:

(1) extraction of loquat flower water extract

Broken wall crushing is spare after loquat flower is placed in oven drying；Use water as Extraction solvent, the ratio of loquat flower powder and water It is placed in 40 ~ 95 DEG C of water-baths for 0.5 ~ 1.5:10 ~ 30(g:ml), 1.5 ~ 4h of soak at room temperature, flow back 1.5 ~ 3h；Reflux finishes Afterwards, 25 ~ 40min of ultrasound at 30 ~ 90 DEG C；

(2) purification of loquat flower water extract

After ultrasound, extracting solution is centrifuged 3 ~ 7min in the centrifuge that revolving speed is 4500 ~ 6000r/min；Supernatant is taken to subtract Press filtration, filtrate are condensed into liquid extract through Rotary Evaporators, and liquid extract is continued to flash to thick medicinal extract；

(3) preparation of loquat flower water extract dry cream fine powder

By thick medicinal extract after -90 ~ -75 DEG C of freezings, it is placed in vacuum freeze drier and is lyophilized into dry loose block；Scrape Pi Rake flower water takes object block, is ground into fine powder, weighs quality, save backup in 4 DEG C of hermetically dryings；The loquat flower water body obtained The content of general flavone is 4%-5% in object dry cream fine powder, the content of total triterpene saponin(e is 11%-12%, the content of total polyphenols is 1%- 2%, the content of total starches is 3%-4%；

(4) granulation of loquat flower particle

Loquat flower water extract dry cream fine powder is weighed in container, appropriate 20 ~ 95% ethanol wet is added, is added in 55 DEG C of water-baths Thermal softening；The extract and auxiliary materials and mixing of softening are added 20 ~ 95% ethyl alcohol as wetting agent, bind the humidity to softwood to hold It is agglomerating, subject to the dissipating of touching after cross sieve and prepare particle, and in time that wet granular is dry, loquat flower particle is made in whole grain.

4. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that in above-mentioned steps (1) Ultrasonic power is 200 ~ 400W, and frequency is 20 ~ 70KHz.

5. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that in above-mentioned steps (1) The temperature of oven drying is 60 ~ 90 DEG C, and the time is 15 ~ 40h.

6. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that rotation in above-mentioned steps (2) The revolving speed for turning evaporimeter is 50~80r/min, and temperature is 40 ~ 75 DEG C.

7. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that in above-mentioned steps (3) The drying temperature of vacuum freeze drier is -75 ~ -30 DEG C, and pressure is 5 ~ 25.0pa.

8. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that second in above-mentioned steps (4) The concentration of alcohol is 75%.

9. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that done in above-mentioned steps (4) Dry temperature is 30 ~ 90 DEG C.

10. a kind of preparation process of loquat flower particle according to claim 3, which is characterized in that sieve in above-mentioned steps (4) The mesh number of net is 16 mesh.

Technical field

The invention belongs to technical field of traditional Chinese medicine preparation, specifically a kind of loquat flower particle and its preparation process.

Background technique

For loquat as Small Subtropical evergreen fruit trees, the resource in China is very abundant.Loquat originates in China The southeast is mainly distributed on each area on the south the Changjiang river, and wherein the ground such as Sichuan, Anhui, Jiangsu, Zhejiang, Fujian are major production areas, And Fujian Province, headed by the loquat resource of Putian, Loquat-Shaped Cake yield occupies list before the world.The nutrition of loquat and medical value are high, Each position such as its root, stem, leaf, flower, fruit, seed is recorded in the multi-sections ancient books and records such as Compendium of Material Medica to be used as medicine.Wherein, loquat It spends warm-natured, has the effect of into lung and dispelling cold, preventing phlegm from forming and stopping coughing, stomach function regulating sending down abnormally ascending, can be used for treating the diseases such as cold, phlegm blood, intermittent headache.It is existing For medical research discovery loquat flower contain flavonoids, triterpene saponin, Polyphenols, polysaccharide, amino acid, alkaloid etc. chemistry at Point, have the function of cough-relieving, antibacterial, protect liver, anti-inflammatory, hypoglycemic, antiallergy, anti-oxidant and protection stomach lining etc..Loguat leaf is normal Medicinal part, and it is very few about the utilization of loquat flower and research.Loquat flower is in full bloom in autumn and winter, and the florescence is 2 ~3 months, the yield of loquat flower was very high, and the flower number of flower spike is generally between 70~110, and more is more than 260 reachable, in order to reduce Nutrient consumption is to improve setting ratio, and orchard workers often carry out flower thinning fruit retention, and every plant of loquat probably dredges 60%~80% flower, per acre There are about the loquat flowers of 100kg to be wasted in large quantities, therefore the research and utilization to loquat flower are of far-reaching significance.In recent years, with air The decline of quality, people are also increasingly increasing the demand of moistening lung product, and loquat flower has effects that moistening lung, meet just Instantly the demand of people, and then have developed the products such as loquat flower tea, loquat nectar, loquat flower water.Loquat flower is main at present For tea making, related preparations are phoenix feathers and unicorn horns, and granule both saves decoction and absorb fast spy on the basis of decoction Point, and there is advantage small in size, convenient for taking and saving, preparation process is simple compared with tablet and injection in addition, and all the advantages make The development of granule is especially rapid.

The present invention is intended to provide a kind of loquat flower particle and its preparation process, it is desirable to for commercially producing for loquat flower particle It provides according to and refers to, while increasing the reasonable utilization of loquat flower, it is made to turn waste into wealth, expand social and economic benefit.

Summary of the invention

The purpose of the present invention is to provide a kind of loquat flower particle and its preparation processes.

To achieve the above object, the present invention adopts the following technical scheme that:

A kind of loquat flower particle comprising loquat flower water extract dry cream fine powder, auxiliary material, the loquat flower water extract dry cream are thin The ratio of powder and the auxiliary material is 1:1~4, and the auxiliary material is that pharmaceutically acceptable auxiliary material is one such or two kinds.

Preferably comprising loquat flower water extract dry cream fine powder, mannitol, the loquat flower water extract dry cream fine powder and institute The ratio for stating mannitol is 1:4.

A kind of preparation process of loquat flower particle, comprising the following steps:

(1) extraction of loquat flower water extract

Broken wall crushing is spare after loquat flower is placed in oven drying；Use water as Extraction solvent, loquat flower powder and water Ratio is 0.5~1.5:10~30 (g:ml), and 1.5~4h of soak at room temperature is placed in 40~95 DEG C of water-baths, reflux 1.5~ 3h；After reflux, 25~40min of ultrasound at 30~90 DEG C；

(2) purification of loquat flower water extract

After ultrasound, extracting solution is centrifuged 3~7min in the centrifuge that revolving speed is 4500~6000r/min；It takes Clear liquid is filtered under diminished pressure, and filtrate is condensed into liquid extract through Rotary Evaporators, and liquid extract is continued to flash to thick medicinal extract；

(3) preparation of loquat flower water extract dry cream fine powder

By thick medicinal extract after -90~-75 DEG C of freezings, it is placed in vacuum freeze drier and is lyophilized into dry loose block； It scrapes loquat flower water and takes object block, be ground into fine powder, weigh quality, saved backup in 4 DEG C of hermetically dryings；The loquat obtained The content of general flavone is 4%-5% in flower water body object dry cream fine powder, the content of total triterpene saponin(e is 11%-12%, total polyphenols Content is 1%-2%, the content of total starches is 3%-4%.

(4) granulation of loquat flower particle

Loquat flower water extract dry cream fine powder is weighed in container, appropriate 20~95% ethanol wet is added, in 55 DEG C of water-baths It is heated and softened in pot；The extract and auxiliary materials and mixing of softening are added 20~95% ethyl alcohol as wetting agent, bind doing to softwood Humidity is agglomerating with what is held, and touching is that rear sieve of crossing prepares particle subject to dissipating, and in time by wet granular drying, loquat flower is made in whole grain Particle.

Preferably, the ultrasonic power in above-mentioned steps (1) is 200~400W, and frequency is 20~70KHz.

Preferably, the temperature of the oven drying in above-mentioned steps (1) is 60~90 DEG C, and the time is 15~40h.

Preferably, the revolving speed of Rotary Evaporators is 50~80r/min in above-mentioned steps (2), and temperature is 40~75 DEG C.

Preferably, the drying temperature of the vacuum freeze drier in above-mentioned steps (3) be -75~-30 DEG C, pressure be 5~ 25.0pa。

Preferably, the concentration of ethyl alcohol is 75% in above-mentioned steps (4).

Preferably, drying temperature is 30~90 DEG C in above-mentioned steps (4).

Preferably, the mesh number of sieve is 16 mesh in above-mentioned steps (4).

The present invention has the advantages that prepare loquat flower granule through the invention, not only simple process, and it is quality controllable, Provide good foundation for the research and development and popularization of loquat flower granule, and facilitate loquat flower resource preferably go to be developed and It utilizes, social and economic benefit can be improved to a certain extent, had broad application prospects.

Detailed description of the invention

Fig. 1 is rutin standard curve figure；

Fig. 2 is ursolic acid canonical plotting；

Fig. 3 is gallic acid canonical plotting；

Fig. 4 is D- (+)-glucose standard curve figure；

Specific embodiment

In order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below will In conjunction with technical scheme in the embodiment of the invention is clearly and completely described in the embodiment of the present invention.