阅读说明：本技术 凝胶管制备装置及其制得的用于青光眼引流的微米级凝胶管 (Gel tube preparation facilities and its micron order gel tube obtained for Glaucoma Drainage ) 是由 谭睿哲 李锐聪 邹鹏 梁丽金 陈琦 于 2019-10-08 设计创作，主要内容包括：本发明提供了一种凝胶管制备装置及其制得的用于青光眼引流的微米级凝胶管,涉及医学新材料技术领域,该凝胶管制备装置包括凝胶腔体、金属丝和拉丝装置；所述凝胶腔体主要由内外包覆设置的凝胶内腔和保温外腔组成；同时,凝胶腔体设置有金属丝进口和金属丝出口,所述金属丝通过拉丝装置由金属丝进口进入凝胶腔体,并在凝胶内腔中粘附凝胶后从金属丝出口的中心穿出,得到外层包覆有凝胶的金属丝,经固化成型后抽出金属丝,制备得到凝胶管；此外,所述金属丝出口的内径与金属丝直径的比例为4～2:1。通过上述制备装置制得的用于青光眼引流的微米级凝胶管相对于现有的溶液吸附凝固法制备得到的软管具有表面平整、粗细均匀的优势。(The present invention provides a kind of gel tube preparation facilities and its micron order gel tubes obtained for Glaucoma Drainage, are related to medicine new material technology field, which includes gel cavity, wire and wire-drawing frame；The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；Simultaneously, gel cavity is provided with wire import and wire outlet, the wire enters gel cavity by wire import by wire-drawing frame, and it is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtain the wire that external sheath has gel, wire is extracted out after cured molding, and gel tube is prepared；In addition, the internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.There is for the micron order gel tube of Glaucoma Drainage relative to the hose that existing solution absorption freezing method is prepared the advantage of surfacing, even thickness as made from above-mentioned preparation facilities.)

1. a kind of gel tube preparation facilities, which is characterized in that the preparation facilities includes gel cavity, wire and wire drawing dress It sets；

The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；

The gel cavity be provided with wire import and wire outlet, the wire by wire-drawing frame by wire into Mouth enters gel cavity, and is pierced by after adhesive gel from the center that wire exports in gel inner cavity, and obtaining external sheath has The wire of gel extracts wire out after cured molding, gel tube is prepared；

The internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.

2. gel tube preparation facilities according to claim 1, which is characterized in that be injected with macromolecule in the gel inner cavity The gel solution of hydrogel material；Heat preservation liquid is injected in the heat preservation exocoel.

3. gel tube preparation facilities according to claim 1 or 2, which is characterized in that the heat preservation exocoel is provided with heat preservation Liquid entrance and the outlet of heat preservation liquid, for keeping the temperature the flowing of liquid.

4. gel tube preparation facilities according to claim 1, which is characterized in that the wire outlet is provided with cold But device, the external sheath being pierced by from wire outlet have the wire of gel to protrude into cooler, are adhered to wire outer layer Gel cooled and solidified.

5. gel tube preparation facilities according to claim 4, which is characterized in that the wire-drawing frame include into idler wheel and Guide roller；

Wherein, it is described enter an idler wheel for controlling the direction that wire enters gel cavity；The guide roller is for controlling gold Belong to the direction that silk is pierced by from cooler；

Preferably, the wire-drawing frame further includes wind-up roll shaft, the outer layer packet for pulling wire and pulling out to guide roller The wire for being covered with curing gel is wound.

6. a kind of gel tube, which is characterized in that the gel tube is mainly by the described in any item gel control of Claims 1 to 5 Standby device is made.

7. gel tube according to claim 6, which is characterized in that the gel tube is mainly by macromolecule hydrogel material system ；

Preferably, the gel tube is mainly made by biocompatible hydrogel material；

It is highly preferred that the gel tube is mainly made by gelatin.

8. a kind of preparation method of gel tube according to claim 6 or 7, which is characterized in that the method includes following Step:

Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to macromolecule water-setting in gel inner cavity The gel solution of glue material is then pierced by from the center that wire exports, wire surface is made to be stained with gel solution, then will Surface adhesion has the wire of gel solution to be solidified, and finally extracts wire out, obtains gel tube.

9. a kind of micron order gel tube for Glaucoma Drainage, which is characterized in that the gel tube mainly by claim 1~ 5 described in any item gel tube preparation facilities are made；

The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；

Preferably, the internal diameter that wire exports in the preparation facilities is 400 μm, and the diameter of wire is 100 μm.

10. a kind of preparation method of the micron order gel tube according to claim 9 for Glaucoma Drainage, feature exist In the described method comprises the following steps:

Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to gelatin solution in gel inner cavity, It is then pierced by from the center that wire exports, so that wire surface is stained with gelatin solution, then have gelatin molten surface adhesion The wire of liquid is successively solidified, is crosslinked, is dried；It finally extracts wire out, obtains solidifying for the micron order of Glaucoma Drainage Sebific duct；

Preferably, the method specifically includes the following steps:

(a), gelatin solution is added in gel inner cavity, and the injection heat preservation liquid in heat preservation exocoel；

(c), there is the wire of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally extraction gold Belong to silk, obtains the micron order gel tube for Glaucoma Drainage；

Preferably, the concentration of the gelatin is 0.25~0.70g/ml；

Preferably, the water that the heat preservation liquid is 45~70 DEG C；

Preferably, the crosslinking agent of the crosslinking is polyalcohols solution；

It is highly preferred that the crosslinking agent of the crosslinking is the glutaraldehyde solution of volume mass score 0.5~1%；

Preferably, the time of the crosslinking be 2~for 24 hours；

It is highly preferred that the time of the crosslinking is for 24 hours；

Preferably, the time of the drying is 12~48h；

It is highly preferred that the time of the drying is for 24 hours.

Technical field

The present invention relates to medical new material technology fields, more particularly, to a kind of gel tube preparation facilities and its use obtained In the micron order gel tube of Glaucoma Drainage.

Background technique

Glaucoma is one of three big diseases causing blindnesses of the mankind, and total crowd's disease incidence is 1%, and 45 years old is 2% later.Green light Eye can cause the unusual high pressure in eyes, so as to cause optic nerve injury.With the growth of patient age, intraocular pressure will be increased persistently Lasting damage is caused to optic nerve.Current primary treatments concentrate on reducing intraocular pressure, keep intraocular pressure in normal range Within, guarantee that patient is able to maintain certain eyesight.

Traditional treatment method includes being led to using drug to reduce intraocular pressure.However, drug therapy can cause much not Good reaction can not accurately control intraocular pressure.Moreover, patient is often listless in drug treatment, patient is influenced Normal life.In addition to drug therapy, Glaucoma Drainage valve gear is implanted by surgical operation, the drainage valve gear is by by anterior chamber In aqueous humor discharge, thus reach reduce intraocular pressure curative effect.However present Glaucoma Drainage valve gear volume is larger, wound compared with Weight, it is postoperative to be easy to cause infection, leave cicatricial tissue, it is serious or even need second operation.In addition to draining valve gear, metal draws Stream nail is also method more commonly used recently, however metal drainage nail quality is harder, and foreign body sensation is strong, and patient's use feeling is poor.

In recent years, also occur some exporting to aqueous humor in trabecular network using micron order hose as Glaucoma Drainage pipe To reduce the therapeutic scheme of intraocular pressure, however existing micron order hose is prepared using the method for solution absorption solidification, Such as disclose one in CN107811752A and tubular form is added in chitosan solution, it is adsorbed followed by chitosan solidifying Solid method prepare the scheme of micron order hose, but hose made from this kind of scheme there is a problem of one it is obvious be exactly soft Pipe surface out-of-flatness, thickness are also uneven, while this kind of scheme preparation process is complicated, time and effort consuming, and economy is also poor.

Therefore, it researchs and develops that a kind of preparation process is simple, process is easily-controllable, while there is surfacing, even thickness is excellent The micron order gel tube and its preparation facilities for Glaucoma Drainage of point, are prepared hose to alleviate existing cladding freezing method Preparation process is complicated, surface irregularity, and thickness also non-uniform problem becomes very necessary and urgent.

In view of this, the present invention is specifically proposed.

Summary of the invention

The first object of the present invention is to provide a kind of gel tube preparation facilities, gel made from the gel tube preparation facilities Pipe has the advantage of surfacing, even thickness relative to the hose that existing solution absorption freezing method is prepared.

The second object of the present invention is to provide a kind of gel tube, and the gel tube is mainly by above-mentioned gel tube preparation facilities It is made.

The third object of the present invention is to provide a kind of preparation method of gel tube, and the preparation method is relative to existing molten Liquid, which adsorbs freezing method, has preparation process simple, the easily-controllable advantage of process.

The fourth object of the present invention is to provide a kind of micron order gel tube for Glaucoma Drainage, this is used for glaucoma The micron order gel tube of drainage has the advantage of surfacing, internal-and external diameter even thickness, while also having more is suitable for glaucoma Aqueous humor drainage internal-and external diameter.

The fifth object of the present invention is to provide a kind of preparation method of micron order gel tube for Glaucoma Drainage.

A kind of gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity, wire and wire drawing Device；

The gel inner cavity and heat preservation exocoel that the gel cavity is mainly arranged by interior outer cladding form；

The gel cavity is provided with wire import and wire outlet, and the wire is by wire-drawing frame by metal Silk import enters gel cavity, and is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtains outer layer packet It is covered with the wire of gel, wire is extracted out after cured molding, gel tube is prepared；

The internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.

Further, gel solution is injected in the gel inner cavity；Heat preservation liquid is injected in the heat preservation exocoel.

Further, the heat preservation exocoel is provided with heat preservation liquid entrance and the outlet of heat preservation liquid, for keeping the temperature the flowing of liquid.

Further, the wire outlet is provided with cooler, and the external sheath being pierced by from wire outlet has The wire of gel protrudes into cooler, and the gel adhered to wire outer layer cools and solidifies.

Further, the wire-drawing frame includes into idler wheel and guide roller；

Wherein, it is described enter an idler wheel for controlling the direction that wire enters gel cavity；The guide roller is for controlling The direction that wire processed is pierced by from cooler；

Preferably, the wire-drawing frame further includes wind-up roll shaft, for pulling wire and pulling out to guide roller outer The wire that layer is coated with curing gel is wound.

A kind of gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.

Further, the gel tube is mainly made by macromolecule hydrogel material；

Preferably, the gel tube is mainly made by biocompatible hydrogel material；

It is highly preferred that the gel tube is mainly made by gelatin.

A kind of preparation method of above-mentioned gel tube provided by the invention, the described method comprises the following steps:

Wire is entered into gel cavity by wire import by wire-drawing frame, and adheres to macromolecule in gel inner cavity The gel solution of hydrogel material is then pierced by from the center that wire exports, so that wire surface is stained with gel solution, so There is the wire of gel solution to solidify surface adhesion afterwards, finally extract wire out, obtains gel tube.

A kind of micron order gel tube for Glaucoma Drainage provided by the invention, the gel tube is mainly by above-mentioned gel Pipe preparation facilities is made；

Wherein, the internal diameter that wire exports in the preparation facilities is 300~1000 μm, the diameter of wire is 100~ 500μm；

The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；

Preferably, the internal diameter that wire exports in the preparation facilities is 400 μm, and the diameter of wire is 100 μm.

The preparation method of the above-mentioned micron order gel tube for Glaucoma Drainage of one kind provided by the invention, the method packet Include following steps:

Wire is entered into gel cavity by wire import by wire-drawing frame, and adherency gelatin is molten in gel inner cavity Liquid is then pierced by from the center that wire exports, so that wire surface is stained with gelatin solution, surface adhesion is then had gelatin The wire of solution is successively solidified, is crosslinked, is dried；It finally extracts wire out, obtains the micron order for Glaucoma Drainage Gel tube；

Preferably, the method specifically includes the following steps:

(a), gelatin solution is added in gel inner cavity, and the injection heat preservation liquid in heat preservation exocoel；

(b), wire is entered into gel cavity by wire import by wire-drawing frame, and adhered in gel inner cavity bright Sol solution is then pierced by from the center that wire exports, obtains the wire that surface adhesion has gelatin solution；

(c), there is the wire of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally take out Wire out obtains the micron order gel tube for Glaucoma Drainage；

Preferably, the concentration of the gelatin is 0.25~0.70g/ml；

Preferably, the water that the heat preservation liquid is 45~70 DEG C；

Preferably, the crosslinking agent of the crosslinking is polynary aldehydes solution；

It is highly preferred that the crosslinking agent of the crosslinking is the glutaraldehyde solution of volume mass score 0.5~1%；

Preferably, the time of the crosslinking be 2~for 24 hours；

It is highly preferred that the time of the crosslinking is for 24 hours；

Preferably, the time of the drying is 12~48h；

It is highly preferred that the time of the drying is for 24 hours.

Compared with prior art, the invention has the benefit that

Gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity, wire and wire-drawing frame；Institute It states the gel inner cavity that gel cavity is mainly arranged by interior outer cladding to form with heat preservation exocoel, wherein gel inner cavity is solidifying for storing Glue, heat preservation exocoel for keeping the temperature, to avoid during preparing gel tube gel be cured；Meanwhile gel cavity is arranged There are wire import and wire outlet, the wire enters gel cavity by wire import by wire-drawing frame, and It is pierced by after adhesive gel from the center that wire exports in gel inner cavity, obtains the wire that external sheath has gel, it is cured It extracts wire after molding out, gel tube is prepared；In addition, the internal diameter of the wire outlet and the ratio of wire diameter are 4~2:1.The special ratios of the internal diameter and wire diameter that are exported by above-mentioned wire are arranged, and can to go out from wire The periphery gel that wire is pierced by mouthful is scraped attached visibly homogeneous, while the periphery of gel is also more smooth.Therefore, by above-mentioned system Gel tube made from standby device has surfacing, thickness equal relative to the hose that existing solution absorption freezing method is prepared Even advantage.

Gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.The gel tube is opposite Have the advantages that surfacing, internal-and external diameter even thickness in the hose that existing solution absorption freezing method is prepared.

The preparation method of gel tube provided by the invention, this method by wire by wire-drawing frame by wire import into Enter gel cavity, and adhere to the gel solution of macromolecule hydrogel material in gel inner cavity, then from wire outlet The heart is pierced by, and wire surface is made to be stained with gel solution, then has the wire of gel solution to solidify surface adhesion, most After extract wire out, obtain gel tube.The preparation method of above-mentioned gel tube has system relative to existing solution absorption freezing method Standby simple process, the easily-controllable advantage of process are fully compatible for heavy industrialization and quickly produce.

Provided by the present invention for the micron order gel tube of Glaucoma Drainage, which is mainly prepared by above-mentioned gel tube Device is made；Wherein, the internal diameter that wire exports in above-mentioned preparation facilities is 300~1000 μm, and the diameter of wire is 100 ~500 μm；The micron order gel tube for Glaucoma Drainage is mainly made by gelatin.This is used for the micron of Glaucoma Drainage Grade gel tube is prepared by above-mentioned apparatus and material, the advantage with surfacing, internal-and external diameter even thickness, while also being had There is the internal-and external diameter of the aqueous humor drainage of more suitable glaucoma.

Provided by the present invention for the preparation method of the micron order gel tube of Glaucoma Drainage, this method passes through wire Wire-drawing frame enters gel cavity by wire import, and gelatin solution is adhered in gel inner cavity, then exports from wire Center be pierced by, so that wire surface is stained with gelatin solution, then by surface adhesion have the wire of gel solution successively into Row solidification, crosslinking, drying；It finally extracts wire out, obtains the micron order gel tube for Glaucoma Drainage；Above-mentioned preparation method Relative to the existing method for preparing Glaucoma Drainage using solution absorption freezing method, have preparation process simple, process is easily-controllable Advantage.

Detailed description of the invention

It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor It puts, is also possible to obtain other drawings based on these drawings.

Fig. 1 is the gel tube preparation facilities structural schematic diagram that the embodiment of the present invention 1 provides.

Icon: 1- gel cavity；2- wire；11- wire import；The outlet of 12- wire；13- gel inner cavity；14- Keep the temperature exocoel；141- keeps the temperature liquid entrance；142- keeps the temperature liquid outlet；4- cooler；3- wire-drawing frame；31- enters an idler wheel；32- draws Guide roll wheel；33- wind-up roll shaft.

Specific embodiment

Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.

According to an aspect of the present invention, a kind of gel tube preparation facilities, the preparation facilities include gel cavity 1, gold Belong to silk 2 and wire-drawing frame 3；

The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form；

The gel cavity 1 is provided with wire import 11 and wire outlet 12, and the wire 2 is filled by wire drawing Set 3 by wire import 11 enter gel cavity 1, and in gel inner cavity 13 after adhesive gel from wire outlet 12 center It is pierced by, obtains the wire 2 that external sheath has gel, extract wire 2 after cured molding out, gel tube is prepared；

The ratio of 2 diameter of internal diameter and wire of the wire outlet 12 is 4~2:1.

Gel tube preparation facilities provided by the invention, the preparation facilities include gel cavity 1, wire 2 and wire-drawing frame 3；The gel inner cavity 13 and heat preservation exocoel 14 that the gel cavity 1 is mainly arranged by interior outer cladding form, wherein gel inner cavity 13 For storing gel, heat preservation exocoel 14 for keeping the temperature, to avoid during preparing gel tube gel be cured；Meanwhile Gel cavity 1 be provided with wire import 11 and wire outlet 12, the wire 2 by wire-drawing frame 3 by wire into Mouth 11 enters gel cavity 1, and is pierced by after adhesive gel from the center of wire outlet 12 in gel inner cavity 13, obtains outer Layer is coated with the wire 2 of gel, extracts wire 2 after cured molding out, gel tube is prepared；In addition, the wire The ratio of 2 diameter of internal diameter and wire of outlet 12 is 4~2:1.Pass through the internal diameter and wire 2 of above-mentioned wire outlet 12 The special ratios of diameter are arranged, and the periphery gel for being pierced by wire 2 from wire outlet 12 can be made to scrape very attached It is even, while the periphery of gel is also more smooth.Therefore, the gel tube as made from above-mentioned preparation facilities is inhaled relative to existing solution The hose that attached freezing method is prepared has the advantage of surfacing, even thickness.

In the preferred embodiment of the present invention, macromolecule hydrogel material is injected in the gel inner cavity 13 Gel solution；Heat preservation liquid is injected in the heat preservation exocoel 14.

As a preferred embodiment, the gel for being injected with macromolecule hydrogel material in above-mentioned gel inner cavity 13 is molten Liquid, the gel solution is further to prepare gel tube；It is injected with heat preservation liquid in above-mentioned heat preservation exocoel 14, the guarantor for gel Temperature, to avoid during preparing gel tube gel be cured.

In the preferred embodiment of the present invention, the heat preservation exocoel 14 is provided with heat preservation liquid entrance 141 and heat preservation Liquid outlet 142, for keeping the temperature the flowing of liquid.

As a preferred embodiment, above-mentioned heat preservation exocoel 14 is provided with heat preservation liquid entrance 141 and the outlet of heat preservation liquid 142, for keeping the temperature the flowing of liquid, the temperature to realize heat preservation liquid is constant, and gel during preparing gel tube is avoided to cool down Solidification.

In the preferred embodiment of the present invention, the wire outlet 12 is provided with and communicated with cooler 4, from metal The external sheath that silk outlet 12 is pierced by has the wire 2 of gel to protrude into cooler 4, the gel adhered to 2 outer layer of wire It is cooled and solidified.

As a preferred embodiment, the cooler 4 can be cooling pipe.

In the preferred embodiment of the present invention, the wire-drawing frame 3 includes into idler wheel 31 and guide roller 32；

Wherein, it is described enter an idler wheel 31 be used for control wire 2 enter gel cavity 1 direction；The guide roller 32 The direction being pierced by from cooler 4 for controlling wire 2；

Preferably, it is described enter an idler wheel 31 and guide roller 32 be in same horizontal line so that wire 2 is in gel chamber Horizontality is in body 1.

In the preferred embodiment of the present invention, the wire-drawing frame 3 further includes wind-up roll shaft 33, for pulling gold Belong to silk 2 and the external sheath pulled out to guide roller 32 has the wire 2 of curing gel to wind.

According to an aspect of the present invention, a kind of gel tube, the gel tube is mainly by above-mentioned gel tube preparation facilities system .

Gel tube provided by the invention, the gel tube are mainly made by above-mentioned gel tube preparation facilities.The gel tube is opposite Have the advantages that surfacing, internal-and external diameter even thickness in the hose that existing solution absorption freezing method is prepared.

In the preferred embodiment of the present invention, the gel tube is mainly made by macromolecule hydrogel material；

As a preferred embodiment, the gel tube is mainly made by gelatin, pigskin source gelatin, gelatin are selected Glue intensity be 170-195g Bloom.It is dissolved in the hot water that the optimal solution temperature of gelatin is 45 DEG C~60 DEG C in this method. After being dissolved in hot water, gelled after cooling.Dry state gel tube is obtained after drying, in water can water absorption and swelling, volume increase, can rise To the effect of self-retaining, gelatin hydrogel has preferable flexibility.

According to an aspect of the present invention, a kind of preparation method of above-mentioned gel tube, the described method comprises the following steps:

Wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and is glued in gel inner cavity 13 Attached gel solution is then pierced by from the center of wire outlet 12, so that 2 surface adhesion of wire is had gel solution, then by table The wire 2 that face is stained with gel solution is solidified, and is finally extracted wire 2 out, is obtained gel tube.

The preparation method of gel tube provided by the invention, this method by wire 2 by wire-drawing frame 3 by wire into Mouth 11 enters gel cavity 1, and the gel solution of macromolecule hydrogel material is adhered in gel inner cavity 13, then from wire The center of outlet 12 is pierced by, and so that 2 surface adhesion of wire is had gel solution, then surface adhesion is had to the wire of gel solution 2 are solidified, and are finally extracted wire 2 out, are obtained gel tube.The preparation method of above-mentioned gel tube is adsorbed relative to existing solution Freezing method has preparation process simple, and the easily-controllable advantage of process is fully compatible for heavy industrialization and quickly produces.

According to an aspect of the present invention, a kind of micron order gel tube for Glaucoma Drainage, the gel tube are main It is made by above-mentioned gel tube preparation facilities；

Wherein, the internal diameter of wire outlet 12 is 300~1000 μm in the preparation facilities, and the diameter of wire 2 is 100~500 μm；

The micron order gel tube for Glaucoma Drainage is mainly made by gelatin；

Provided by the present invention for the micron order gel tube of Glaucoma Drainage, which is mainly prepared by above-mentioned gel tube Device is made；Wherein, the internal diameter of wire outlet 12 is 300~1000 μm in above-mentioned preparation facilities, and the diameter of wire 2 is 100~500 μm；The micron order gel tube for Glaucoma Drainage is mainly made by gelatin.This is for Glaucoma Drainage Micron order gel tube is prepared by above-mentioned apparatus and material, the advantage with surfacing, internal-and external diameter even thickness, simultaneously Also there is the internal-and external diameter of the aqueous humor drainage of more suitable glaucoma.

In the preferred embodiment of the present invention, the internal diameter of wire outlet 12 is 400 μm in the preparation facilities, When the diameter of wire 2 is 100 μm, the micron order gel tube drainage effect obtained for Glaucoma Drainage is optimal.

According to an aspect of the present invention, a kind of preparation method of the above-mentioned micron order gel tube for Glaucoma Drainage, It the described method comprises the following steps:

Wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and is glued in gel inner cavity 13 Attached gelatin solution is then pierced by from the center of wire outlet 12, so that 2 surface adhesion of wire is had gelatin solution, then by table The wire 2 that face is stained with gel solution is successively solidified, is crosslinked, is dried；It finally extracts wire 2 out, obtains for green light The micron order gel tube of eye drainage；

Provided by the present invention for the preparation method of the micron order gel tube of Glaucoma Drainage, this method leads to wire 2 It crosses wire-drawing frame 3 and gel cavity 1 is entered by wire import 11, and adhere to gelatin solution in gel inner cavity 13, then from gold The center for belonging to silk outlet 12 is pierced by, and so that 2 surface adhesion of wire is had gelatin solution, then surface adhesion is had to the gold of gel solution Belong to silk 2 successively to be solidified, be crosslinked, dried；It finally extracts wire 2 out, obtains the micron order gel tube for Glaucoma Drainage； Above-mentioned preparation method has preparation process letter relative to the existing method for preparing Glaucoma Drainage using solution absorption freezing method It is single, the easily-controllable advantage of process.

In the preferred embodiment of the present invention, the method specifically includes the following steps:

(a), gelatin solution is added in gel inner cavity 13, and the injection heat preservation liquid in heat preservation exocoel 14；

(b), wire 2 is entered into gel cavity 1 by wire import 11 by wire-drawing frame 3, and in gel inner cavity 13 Middle adherency gelatin solution is then pierced by from the center of wire outlet 12, obtains the wire 2 that surface adhesion has gelatin solution；

(c), there is the wire 2 of gelatin solution successively to be solidified step (b) surface adhesion, be crosslinked, dry；Finally take out Wire 2 out obtain the micron order gel tube for Glaucoma Drainage；

In above-mentioned preferred embodiment, the concentration that the gelatin is is 0.25~0.70g/ml；

In above-mentioned preferred embodiment, the water for keeping the temperature liquid and being 45~70 DEG C；

In above-mentioned preferred embodiment, the crosslinking agent of the crosslinking is the glutaraldehyde of volume mass score 0.5~1% Solution；

In above-mentioned preferred embodiment, time of the crosslinking is 2~for 24 hours；

Preferably, the time of the crosslinking is for 24 hours.

In above-mentioned preferred embodiment, the time of the drying is 12~48h.

Preferably, the time of the drying is for 24 hours.

Technical solution of the present invention is described further below in conjunction with embodiment and attached drawing.