阅读说明：本技术 一种治疗慢性咽炎的药物组合物及其制备方法和用途 (Pharmaceutical composition for treating chronic pharyngitis and preparation method and application thereof ) 是由 夏隆江 何宇新 李建惠 李昌龙 李时凤 刘蓓 于 2019-09-04 设计创作，主要内容包括：本发明提供了一种治疗慢性咽炎的药物组合物及其制备方法和用途。该药物组合物是由如下重量配比的原料药制备而成的制剂：罗汉果10～20份,乌梅10～20份,桔梗8～15份,甘草5～12份,蒲公英5～12份,胖大海5～10份,菊花5～10份,栀子5～10份,余甘子2～7份,青果2～7份。本发明药物组合物全部由药食同源的药物组成,提高了药物的安全性,增加了适用范围和人群。本发明药物组合物能够有效治疗慢性咽炎,对慢性咽炎所致的咽部不适感,如异物感、痒感、灼热感、干燥感和/或刺激感,以及咽部微痛、咽部咳嗽、伴随恶心感、咽部粘膜增厚,有黏稠或黏浓性分泌物等症状有明显的消除或缓解作用。同时,本发明药物组合物药味配伍精当,缺一不可,改变用药配比会影响治疗效果。(The invention provides a pharmaceutical composition for treating chronic pharyngitis and a preparation method and application thereof. The pharmaceutical composition is a preparation prepared from the following raw materials in parts by weight: 10-20 parts of momordica grosvenori, 10-20 parts of dark plum, 8-15 parts of platycodon grandiflorum, 5-12 parts of liquorice, 5-12 parts of dandelion, 5-10 parts of scaphium scaphigerum, 5-10 parts of chrysanthemum, 5-10 parts of gardenia, 2-7 parts of phyllanthus emblica and 2-7 parts of Chinese olive. The pharmaceutical composition of the invention is completely composed of medicines with homology of medicine and food, improves the safety of the medicines, and increases the application range and crowds. The pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious effects of eliminating or relieving pharyngeal discomfort, such as foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation, as well as symptoms of pharyngeal slight pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or thick secretion and the like caused by the chronic pharyngitis. Meanwhile, the medicine composition of the invention has precise and appropriate compatibility of medicines and can not achieve the effect of treatment by changing the medicine proportion.)

1. A pharmaceutical composition for treating chronic pharyngitis, which is characterized in that: the preparation is prepared from the following raw material medicines in parts by weight: 10-20 parts of momordica grosvenori, 10-20 parts of dark plum, 8-15 parts of platycodon grandiflorum, 5-12 parts of liquorice, 5-12 parts of dandelion, 5-10 parts of scaphium scaphigerum, 5-10 parts of chrysanthemum, 5-10 parts of gardenia, 2-7 parts of phyllanthus emblica and 2-7 parts of Chinese olive.

2. The pharmaceutical composition of claim 1, wherein: the preparation is prepared from the following raw material medicines in parts by weight: 15 parts of momordica grosvenori, 15 parts of dark plum, 12 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of dandelion, 8 parts of scaphium scaphigerum, 8 parts of chrysanthemum, 8 parts of gardenia, 6 parts of emblic leafflower fruit and 6 parts of Chinese olive.

3. The pharmaceutical composition according to claim 1 or 2, characterized in that: the preparation is prepared by taking medicinal powder of raw material medicines, water or organic solvent extract of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.

4. the pharmaceutical composition of claim 3, wherein: the preparation is an oral preparation.

5. The pharmaceutical composition of claim 4, wherein: the oral preparation is decoction, oral liquid, granule, capsule, tablet, powder, and bagged steeping drug.

6. A method of preparing a pharmaceutical composition according to any one of claims 1 to 5, wherein: it comprises the following steps:

(1) Weighing the raw material medicines in the weight ratio;

(2) the raw materials are directly pulverized, or the raw materials are decocted with water or extracted by an organic solvent, the extract is concentrated, and pharmaceutically acceptable auxiliary materials are added to prepare the preparation.

7. The method of claim 6, wherein: it comprises the following steps:

(1) Weighing the raw material medicines in the weight ratio;

(2) Drying the raw materials at 60-100 deg.C, pulverizing, sieving with 10-60 mesh sieve, mixing the medicinal powders, and packaging to obtain bagged steeping preparation.

8. Use of the pharmaceutical composition of any one of claims 1-5 in the preparation of a medicament for treating chronic pharyngitis.

9. Use according to claim 8, characterized in that: the chronic pharyngitis is chronic simple pharyngitis and/or chronic hypertrophic pharyngitis.

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating chronic pharyngitis, and a preparation method and application thereof.

Background

The chronic pharyngitis is diffuse pharyngeal lesion caused by chronic infection, and is characterized by mainly chronic congestion of a pharyngeal mucosa layer, more lymphocyte infiltration around blood vessels, hyperplasia of connective tissues and lymphatic tissues under the mucosa, granular swelling of the pharyngeal posterior wall, hypertrophy of mucous glands and hypersecretion of serious patients. The main symptoms are pharyngeal discomfort, such as foreign body sensation, dry throat, pharynx itch, sore throat, cough, nausea and even vomiting. The etiology includes: the local factors are: acute pharyngitis attacks repeatedly and can be converted into chronic pharyngitis. Diseases of adjacent organs, such as chronic tonsillitis, odontitis, dental caries, chronic rhinitis, chronic sinusitis and other inflammatory secretion flow into pharynx, or chronic rhinopathy causes difficulty in nasal ventilation and mouth breathing, and chronic irritation of pharynx such as excessive smoking and drinking, dust, harmful gas and spicy food can cause the disease; whole body factors: such as anemia, dyspepsia, chronic inflammation of lower respiratory tract, cardiovascular diseases, endocrine function disorder, vitamin deficiency and hypoimmunity.

The chronic pharyngitis has a certain treatment effect when being taken with antibiotics, but the disease is easy to relapse, the disease course is long, and if the chronic pharyngitis is taken with antibiotics for a long time, various complications such as bacterial resistance, imbalance of normal flora in vivo and the like can be caused. The development of the traditional Chinese medicine preparation for treating the chronic pharyngitis is a reasonable choice. The traditional Chinese medicine considers that the pathogenesis of chronic pharyngitis is mainly caused by lung-kidney yin deficiency, body fluid deficiency, flaring-up of deficient fire and throat fumigation, and the treatment mainly aims at nourishing yin and lowering fire, but the clinical symptoms show that the curative effect of a plurality of patients is poor. At present, the pharmaceutical composition for treating chronic pharyngitis is not available.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for treating chronic pharyngitis and a preparation method and application thereof.

The invention provides a pharmaceutical composition for treating chronic pharyngitis, which is a preparation prepared from the following raw material medicines in parts by weight: 10-20 parts of momordica grosvenori, 10-20 parts of dark plum, 8-15 parts of platycodon grandiflorum, 5-12 parts of liquorice, 5-12 parts of dandelion, 5-10 parts of scaphium scaphigerum, 5-10 parts of chrysanthemum, 5-10 parts of gardenia, 2-7 parts of phyllanthus emblica and 2-7 parts of Chinese olive.

Further, the pharmaceutical composition is a preparation prepared from the following raw material medicines in parts by weight: 15 parts of momordica grosvenori, 15 parts of dark plum, 12 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of dandelion, 8 parts of scaphium scaphigerum, 8 parts of chrysanthemum, 8 parts of gardenia, 6 parts of emblic leafflower fruit and 6 parts of Chinese olive.

Furthermore, the pharmaceutical composition is a preparation prepared by taking the medicinal powder of the raw material medicines, the water or organic solvent extract of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials according to the weight ratio.

Further, the formulation is an oral formulation.

Further, the oral preparation is decoction, oral liquid, granules, capsules, tablets, powder and bagged steeping agents.

The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps:

(1) weighing the raw material medicines in the weight ratio;

(2) The raw materials are directly pulverized, or the raw materials are decocted with water or extracted by an organic solvent, the extract is concentrated, and pharmaceutically acceptable auxiliary materials are added to prepare the preparation.

Further, the preparation method comprises the following steps:

(1) Weighing the raw material medicines in the weight ratio;

(2) Drying the raw materials at 60-100 deg.C, pulverizing, sieving with 10-60 mesh sieve, mixing the medicinal powders, and packaging to obtain bagged steeping preparation.

The invention also provides application of the pharmaceutical composition in preparing a medicine for treating chronic pharyngitis.

further, the chronic pharyngitis is chronic simple pharyngitis and/or chronic hypertrophic pharyngitis.

The medicinal composition consists of ten medicaments of momordica grosvenori, dark plum fruit, platycodon grandiflorum, liquorice, dandelion, boat-fruited sterculia seed, chrysanthemum, gardenia, emblic leafflower fruit and Chinese olive. The prescription takes emblic leafflower fruit and Chinese olive as monarch drugs for clearing throat and relieving sore throat. The assistant drugs are prepared from dark plum, momordica grosvenori, boat-fruited sterculia seed and platycodon grandiflorum acid which are used for sweetening yin, moistening throat and reducing phlegm, and the assistant drugs are used for rapidly improving discomfort such as dry and itching throat, expectoration and the like. The dandelion, the chrysanthemum and the gardenia are used as adjuvants for clearing away heat and toxic materials, removing dampness, eliminating damp-heat toxin and eliminating inflammation, so that the effects of monarch and minister medicines are more obvious, and the repeated attack of pharyngitis can be prevented. The guiding drug is liquorice, and has the effects of harmonizing the effect of the other drugs and detoxifying and relieving sore throat.

The pharmaceutical composition of the invention is completely composed of medicines with homology of medicine and food, improves the safety of the medicines, and increases the application range and crowds. Clinical test results show that the pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious effects of eliminating or relieving symptoms of pharyngeal discomfort caused by the chronic pharyngitis, such as foreign body sensation, itching sensation, burning sensation, dryness and/or irritation, pharyngeal slight pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or thick secretion and the like. Meanwhile, the medicine composition of the invention has precise and appropriate compatibility of medicines and can not achieve the effect of treatment by changing the medicine proportion.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Detailed Description

the raw materials and equipment used in the embodiment of the present invention are known products and obtained by purchasing commercially available products.