阅读说明：本技术 一种促进骨骼生长的儿童配方奶粉及其制备方法 (Children formula milk powder for promoting bone growth and preparation method thereof ) 是由 唐焱 于 2021-08-16 设计创作，主要内容包括：本发明公开了一种促进骨骼的儿童配方奶粉及其制备方法。该配方奶粉含有全脂奶粉、脱盐乳清粉、脱脂奶粉、低聚异麦芽糖、乳矿物盐、复合维生素、复合矿物质、二十二碳六烯酸、乳清蛋白粉、乳铁蛋白、水解蛋黄粉、N-乙酰神经氨酸、牛初乳、山药粉、鸡内金粉、骨胶原蛋白肽、初乳碱性蛋白,有效促进钙的吸收,有利于骨骼快速成长。(The invention discloses a children formula milk powder for promoting bones and a preparation method thereof. The formula milk powder contains whole milk powder, desalted whey powder, skimmed milk powder, isomaltooligosaccharide, milk mineral salt, compound vitamins, compound minerals, docosahexaenoic acid, whey protein powder, lactoferrin, hydrolyzed yolk powder, N-acetylneuraminic acid, bovine colostrum, yam powder, chicken's gizzard-skin powder, bone collagen peptide and colostrum basic protein, effectively promotes the absorption of calcium, and is beneficial to the rapid growth of bones.)

1. The children formula milk powder for promoting bone growth is characterized by comprising the following components in parts by weight: 20-40 parts of whole milk powder, 20-40 parts of desalted whey powder, 15-25 parts of skimmed milk powder, 2-10 parts of isomaltooligosaccharide, 0.5-5 parts of milk mineral salt, 0.1-0.5 part of compound vitamin, 0.1-1 part of compound mineral, 0.05-0.3 part of docosahexaenoic acid, 0.1-1 part of whey protein powder, 0.05-0.5 part of lactoferrin, 0.005-0.03 part of hydrolyzed yolk powder, 0.005-0.03 part of N-acetylneuraminic acid, 0.1-0.5 part of cow colostrum powder, 0.01-0.1 part of yam powder, 0.01-0.1 part of chicken colostrum powder, 0.05-0.5 part of collagen peptide and 0.05-0.5 part of basic protein.

2. The formula of claim 1, wherein the formula comprises the following components in parts by weight: 30 parts of whole milk powder, 30 parts of desalted whey powder, 20 parts of skimmed milk powder, 5 parts of isomaltooligosaccharide, 2 parts of milk mineral salt, 0.3 part of vitamin complex, 0.5 part of compound mineral substance, 0.1 part of docosahexaenoic acid, 0.4 part of whey protein powder, 0.2 part of lactoferrin, 0.01 part of hydrolyzed yolk powder, 0.01 part of N-acetylneuraminic acid, 0.25 part of bovine colostrum, 0.05 part of yam powder, 0.05 part of chicken's gizzard-membrane powder, 0.2 part of bone collagen peptide and 0.15 part of colostrum basic protein.

3. The formula according to any one of claims 1-2, wherein said multivitamins comprise sodium L-ascorbate, dl-alpha-tocopheryl acetate, vitamin a acetate, vitamin D3, calcium D-pantothenate, thiamine hydrochloride, pyridoxine hydrochloride, folic acid and cyanocobalamin.

4. Formula according to claim 3, characterized in that said multivitamins comprise the following raw materials in grams per 1 g: 150mg of L-sodium ascorbate 100-₃0.01-0.05mg, 5-25mg of D-calcium pantothenate, 0.5-3mg of thiamine hydrochloride, 0.5-2mg of pyridoxine hydrochloride, 0.1-1mg of folic acid and 0.002-0.01mg of cyanocobalamine.

5. The formula of claim 4, wherein each 1g of said multivitamins comprises the following grams of raw materials: 126mg of L-sodium ascorbate, 10mg of dl-alpha-tocopherol acetate, 1.6mg of vitamin A acetate and D vitamin₃0.023mg, 12mg of D-calcium pantothenate, 1.8mg of thiamine hydrochloride, 1.1mg of pyridoxine hydrochloride, 0.5mg of folic acid, and 0.007mg of cyanocobalamine.

6. Formula according to any one of claims 1 to 5, wherein said complex mineral comprises magnesium oxide, ferric pyrophosphate and zinc oxide.

7. The formula of claim 6, wherein each 1g of said composite mineral comprises the following grams of raw materials: 100 mg of magnesium oxide; 80-300mg of ferric pyrophosphate; 10-30mg of zinc oxide.

8. The formula of claim 7, wherein each 1g of said composite mineral comprises the following grams of raw materials: 240mg of magnesium oxide; 146mg of ferric pyrophosphate; 17mg of zinc oxide.

9. The preparation method of the children formula milk powder for promoting bone growth is characterized by comprising the following steps:

mixing the formula amount of the whole milk powder, the desalted whey powder, the skimmed milk powder, the isomaltooligosaccharide, the milk mineral salt, the vitamin complex, the compound mineral substance, the docosahexaenoic acid, the whey protein powder, the lactoferrin, the hydrolyzed yolk powder, the N-acetylneuraminic acid, the bovine colostrum, the yam powder, the chicken's gizzard-membrane powder, the ossein peptide and the colostrum basic protein according to any one of the claims 1 to 8, carrying out vacuum blending, wherein the vacuum degree, the temperature and the time of the mixing are respectively-0.6 Mpa, 65 ℃ and 1.5 hours, homogenizing, cooling, temporarily storing, spraying high-purity steam, concentrating, carrying out spray drying, carrying out powder receiving, storing, carrying out semi-finished product inspection, packaging, carrying out finished product inspection, and warehousing, thus obtaining the milk powder.

Technical Field

The invention relates to the field of production of formula milk powder, and further relates to children formula milk powder for promoting bone growth and a preparation method thereof.

Background

With the progress of society and the increasing of human beings, the height word is more and more important in the mind of people, and up to now, the height word not only is a standard for measuring the health of children but also is a mark of an image of an adult (particularly a young person), and the height word is related to the problems of life, upgradeability, aesthetic quality, employment, marriage of male and female lovers and the like of people. Meanwhile, the method is also an important standard reflecting the quality and constitution of the country and the ethnic groups for the country and the ethnic groups. Genetic and acquired influences are two factors that determine height. Acquired factors include nutrition, work and rest, exercise, mood, diseases, etc., of which diet is the most important component.

A study published in the journal of clinical Nutrition of the United states of America shows that children who eat dairy daily are taller than children who do not. Other published studies have found that insulin-like growth factor 1(IGF-1) and milk proteins (i.e., casein and whey) contained in milk products contribute to height. Moreover, increasing the intake of milk products, especially milk, can promote the increase of bone density of adults and prevent osteoporosis. The milk product has the advantages of high growth for children: (1) the milk product has high calcium content, can help the development of bones, enables the bones to become denser and reduces the risk of fracture; (2) the nutrients required for stimulating growth potential and body height exist in animal food, the milk product has obvious effect, and the ratio of the contained oil amino acid to the increased amino acid is complete; (3) the peak value of bone density is improved, and the peak value of bone density is improved as much as possible before the skeleton of the child is mature, so that the child can resist osteoporosis brought by age; (4) in addition to calcium, dairy products are rich in phosphorus, magnesium, proteins and vitamin D, all of which contribute to bone growth and promote mineral absorption.

99% of calcium in human body is stored in bone, and when the intake of calcium is insufficient, the calcium in bone is released into blood to maintain the concentration of calcium in blood, resulting in lower and lower bone density. The existing formula milk powder on the market has the efficacy of calcium supplement, but the defects of low calcium content and low calcium supplement efficiency generally exist, and the defects are not beneficial to the healthy growth of bones.

Disclosure of Invention

In order to overcome the defects and shortcomings in the prior art, the invention aims at providing the children formula milk powder for promoting the growth of bones; the milk powder can promote bone growth by improving calcium supplementing efficiency.

The invention also aims to provide a preparation method of the children formula milk powder.

The purpose of the invention is realized by the following technical scheme:

the children formula milk powder for promoting bone growth comprises the following components in parts by weight: 20-40 parts of whole milk powder, 20-40 parts of desalted whey powder, 15-25 parts of skimmed milk powder, 2-10 parts of isomaltooligosaccharide, 0.5-5 parts of milk mineral salt, 0.1-0.5 part of compound vitamin, 0.1-1 part of compound mineral, 0.05-0.3 part of docosahexaenoic acid, 0.1-1 part of whey protein powder, 0.05-0.5 part of lactoferrin, 0.005-0.03 part of hydrolyzed yolk powder, 0.005-0.03 part of N-acetylneuraminic acid, 0.1-0.5 part of cow colostrum powder, 0.01-0.1 part of yam powder, 0.01-0.1 part of chicken colostrum powder, 0.05-0.5 part of collagen peptide and 0.05-0.5 part of basic protein.

Preferably, the formula milk powder consists of the following components in parts by weight: 30 parts of whole milk powder, 30 parts of desalted whey powder, 20 parts of skimmed milk powder, 5 parts of isomaltooligosaccharide, 2 parts of milk mineral salt, 0.3 part of vitamin complex, 0.5 part of compound mineral substance, 0.1 part of docosahexaenoic acid, 0.4 part of whey protein powder, 0.2 part of lactoferrin, 0.01 part of hydrolyzed yolk powder, 0.01 part of N-acetylneuraminic acid, 0.25 part of bovine colostrum, 0.05 part of yam powder, 0.05 part of chicken's gizzard-membrane powder, 0.2 part of bone collagen peptide and 0.15 part of colostrum basic protein.

Preferably, the multivitamins comprise sodium L-ascorbate, dl-alpha-tocopherol acetate, vitamin A acetate, vitamin D3, calcium D-pantothenate, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, and cyanocobalamine.

Preferably, the compound vitamin contains the following raw materials in gram per 1 g: 150mg of L-sodium ascorbate 100-₃0.01-0.05mg, 5-25mg of D-calcium pantothenate, 0.5-3mg of thiamine hydrochloride, 0.5-2mg of pyridoxine hydrochloride, 0.1-1mg of folic acid and 0.002-0.01mg of cyanocobalamine.

Preferably, the compound vitamin contains the following raw materials in gram per 1 g: 126mg of L-sodium ascorbate, 10mg of dl-alpha-tocopherol acetate, 1.6mg of vitamin A acetate and D vitamin₃0.023mg, 12mg of D-calcium pantothenate, 1.8mg of thiamine hydrochloride, 1.1mg of pyridoxine hydrochloride, 0.5mg of folic acid, and 0.007mg of cyanocobalamine.

Preferably, the composite mineral comprises magnesium oxide, ferric pyrophosphate and zinc oxide.

Preferably, the composite mineral substance comprises the following raw materials in grams per 1 g: 100 mg of magnesium oxide; 80-300mg of ferric pyrophosphate; 10-30mg of zinc oxide.

Preferably, the composite mineral substance comprises the following raw materials in grams per 1 g: 240mg of magnesium oxide; 146mg of ferric pyrophosphate; 17mg of zinc oxide.

The invention also discloses a preparation method of the children formula milk powder, which specifically comprises the following steps:

mixing the formula amount of whole milk powder, desalted whey powder, skimmed milk powder, isomaltooligosaccharide, milk mineral salt, compound vitamin, compound mineral substance, docosahexaenoic acid, whey protein powder, lactoferrin, hydrolyzed yolk powder, N-acetylneuraminic acid, bovine colostrum, yam powder, chicken's gizzard-skin powder, ossein peptide and colostrum basic protein, carrying out vacuum blending, wherein the mixing vacuum degree, temperature and time are-0.6 Mpa, 65 ℃ and 1.5 hours respectively, homogenizing, cooling for temporary storage, carrying out high-purity steam injection, concentrating and spray drying, then carrying out powder receiving, powder storage, semi-finished product inspection, packaging, finished product inspection and warehousing, thus obtaining the product.

Compared with the prior art, the invention has the following beneficial effects:

the main function of vitamin D is to promote the absorption of calcium and phosphorus by small intestinal mucosal cells. Calcium-binding protein is required for intestinal calcium ion absorption, and 1, 25-dihydroxy vitamin D3 can induce the protein synthesis and promote Ca²⁺The formula milk powder can promote the regeneration of calcium salt and the generation of new bone, promote the absorption of phosphorus and the reabsorption of renal tubule cells on calcium and phosphorus, improve the content of vitamin D, greatly improve the concentration of blood calcium and blood phosphorus, and is beneficial to the generation and calcification of new bone.

Colostrum basic protein (CBP for short) is derived from bovine Colostrum, is an alkaline protein existing in whey, maintains dynamic benign balance among skeletal cells, not only supplements calcium, and enables the skeletal to actively absorb calcium, thereby achieving the purpose of enhancing bone density. It has the advantages of increasing the number of osteoblasts (osteoblasts) in the bone; stimulating osteoblasts (osteblasts) to produce collagen; is helpful for absorbing calcium and preventing calcium loss; inhibit osteoclast (osteoclasts) activity; regulating bone metabolism.

Collagen is a structural protein of extracellular matrix, a main component in animal connective tissue, and is also a functional protein with the largest content and the widest distribution in mammals, and has close relation with the formation, maturation and intercellular information transmission of tissues, joint lubrication, wound healing, calcification, blood coagulation, aging and the like. The collagen peptide has not only a lot of physiological activities of collagen but also properties that collagen does not have. Compared with collagen, the collagen peptide is a small molecular peptide, has lower molecular weight and better digestion and absorption, can be directly absorbed by intestinal tracts and enters blood to reach various parts of the body such as skin, liver, kidney and the like. A large number of domestic and foreign studies prove that the bone collagen peptide can promote the health of bone and joints (promote bone cell generation, accelerate bone development, improve bone firmness, relieve joint pain, improve the loss of proteoglycan in joint cartilage and the like).

The addition of the nutritional components can greatly promote calcium absorption and increase of bone density, thereby accelerating bone growth and further promoting the height development of children.

Detailed Description

The present invention will be further described with reference to the following examples.

Example 1

The embodiment provides a children formula milk powder for promoting bone growth, 30 parts of whole milk powder, 30 parts of desalted whey powder, 20 parts of skimmed milk powder, 5 parts of isomaltooligosaccharide, 2 parts of milk mineral salt, 0.3 part of vitamin complex, 0.5 part of compound mineral substance, 0.1 part of docosahexaenoic acid, 0.4 part of whey protein powder, 0.2 part of lactoferrin, 0.01 part of hydrolyzed yolk powder, 0.01 part of N-acetylneuraminic acid, 0.25 part of bovine colostrum, 0.05 part of yam powder, 0.05 part of chicken's gizzard-membrane powder, 0.2 part of collagen peptide and 0.15 part of colostrum basic protein; each 1g of the compound vitamin comprises the following raw materials in gram: 126mg of L-sodium ascorbate, 10mg of dl-alpha-tocopherol acetate, 1.6mg of vitamin A acetate and D vitamin₃0.023mg, 12mg of D-calcium pantothenate, 1.8mg of thiamine hydrochloride, 1.1mg of pyridoxine hydrochloride, 0.5mg of folic acid, 0.007mg of cyanocobalamine; each 1g of the composite mineral comprises the following raw materials in gram: 240mg of magnesium oxide; 146mg of ferric pyrophosphate; 17mg of zinc oxide.

Example 2

The embodiment provides a preparation method of children formula milk powder for promoting bone growth, which specifically comprises the following steps:

mixing the whole milk powder, the desalted whey powder, the skim milk powder, the isomaltooligosaccharide, the milk mineral salt, the vitamin complex, the mineral complex, the docosahexaenoic acid, the whey protein powder, the lactoferrin, the hydrolyzed yolk powder, the N-acetylneuraminic acid, the bovine colostrum, the yam powder, the chicken gizzard-membrane powder, the ossein peptide and the colostrum basic protein according to the formula amount in the example 1, carrying out vacuum blending, wherein the vacuum degree, the temperature and the time of the mixing are respectively-0.6 Mpa, 65 ℃ and 1.5 hours, carrying out homogenization, cooling temporary storage, high-purity steam injection, concentration and spray drying, then carrying out powder connection, powder storage, semi-finished product inspection, packaging, finished product inspection and warehousing, thus obtaining the product.

Example 3

Bone growth promoting efficacy test

1.1 test substance and method of eating test

The test group eats the formula milk powder of example 1 one cup in the morning and at night every day for 3 months; the control group 1 consumed the formula of the three components of vitamin D, collagen peptide and colostrum basic protein of example 1, one cup in the morning and at night every day for 3 months; control 2 was a natural growth group.

1.2 subjects and groups

240 children, half of both male and female, in 7-8 years old from a primary school in the city district were selected as observation targets. The living environment, family income, living standard and the like of the subject are basically similar, and no chronic disease exists after physical examination. The test subjects were randomly and evenly divided into a test diet group, a control group 1 and a control group 2, wherein each group comprises 40 men and women (the test diet group is separated from 2 men and 1 women and 77 effective persons, the control group 1 is separated from 1 men and 1 women and 78 effective persons and the control group 2 is 80 effective persons during the test period).

1.3 skeletal growth in children

And (3) physical measurement: weight, height; ultrasonic bone density measurement: the measuring instrument selects a Hongyang BMD-1000C ultrasonic bone analyzer, and takes the inner side part in front of the middle section of the tibia of the left calf as a measuring part.

Calculating the bone density value according to the following formula: bone density values are 3480.06 × (age-1.05) × (weight +0.61) × height.

Comparison of ultrasound bone density values before and after three experiments is shown in table 1. The increase in bone density values was significantly higher in the test group than in the two control groups (P < 0.05).

TABLE 1 variation of ultrasound bone Density values (m/s)

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.