阅读说明：本技术 一种红豆杉含有紫杉醇改性再生纤维素纤维的制备方法 (Preparation method of taxol-containing modified regenerated cellulose fiber ) 是由 郑建国 郑杰 于 2021-08-11 设计创作，主要内容包括：本发明提供一种红豆杉含有紫杉醇改性再生纤维素纤维的制备方法,涉及纤维素制备技领域。该红豆杉含有紫杉醇改性再生纤维素纤维的制备方法,包括以下步骤：将提取完紫杉醇的红豆杉废料进行集中收集,将收集完成的红豆杉废料进行破碎处理得到红豆杉颗粒,将破碎完成的红豆杉颗粒在2％浓度的氢氧化钠溶液以及100摄氏度条件下煮沸100分钟后,待溶液温度降至75摄氏度左右时,加入浓度为5％的双氧水,继续加热0.5小时,保持温度在75摄氏度左右,之后过滤,用蒸馏水充分洗涤滤渣至中性,干燥后即得到红豆杉纤维素样品。通过将提取紫杉醇的红豆杉废料进行改性处理,制备成含有紫杉醇的纺织纤维,达到废物利用,更加绿色环保的目的。(The invention provides a preparation method of taxol-containing modified regenerated cellulose fibers of taxus chinensis, and relates to the technical field of cellulose preparation. The preparation method of the taxol-containing modified regenerated cellulose fiber comprises the following steps: the method comprises the steps of collecting taxus waste after paclitaxel extraction in a centralized manner, crushing the collected taxus waste to obtain taxus particles, boiling the crushed taxus particles in a sodium hydroxide solution with the concentration of 2% at 100 ℃ for 100 minutes, adding hydrogen peroxide with the concentration of 5% when the temperature of the solution is reduced to about 75 ℃, continuing heating for 0.5 hour, keeping the temperature at about 75 ℃, filtering, fully washing filter residues with distilled water to be neutral, and drying to obtain a taxus cellulose sample. The taxol-containing textile fiber is prepared by modifying the taxus waste from which the taxol is extracted, so that the purposes of waste utilization and more environmental protection are achieved.)

1. A preparation method of taxol-containing modified regenerated cellulose fibers is characterized by comprising the following steps: the method comprises the following steps:

s1, carrying out centralized collection on the taxus waste after paclitaxel extraction;

s2, crushing the collected taxus waste to obtain taxus particles;

s3, boiling the crushed Chinese yew particles in a sodium hydroxide solution with the concentration of 2% for 100 minutes at 100 ℃, adding hydrogen peroxide with the concentration of 5% when the temperature of the solution is reduced to about 75 ℃, continuously heating for 0.5 hour, keeping the temperature at about 75 ℃, filtering, fully washing filter residues with distilled water to be neutral, and drying to obtain a Chinese yew cellulose sample;

s4, preparing a high-concentration single or compound inorganic salt solution;

s5, adding a certain amount of a taxus chinensis cellulose sample into the inorganic salt solution prepared in the step S4, adding a proper amount of paclitaxel solution, and stirring and dissolving at a certain temperature to obtain a uniform taxus chinensis cellulose solution containing paclitaxel;

s6, cooling the taxol-containing Taxus chinensis cellulose solution prepared in S5 to obtain high-strength and high-toughness taxol-containing Taxus chinensis cellulose gel;

s7, treating the taxol-containing taxus chinensis cellulose gel obtained in the step S6 by using a specific spinning process, cooling and solidifying in a coagulating bath, washing to remove salt, and drying to obtain taxol-containing regenerated taxus chinensis cellulose fibers.

2. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: in the step S4, the inorganic salt is a metal salt, the metal cations are Li +, Mg2+, Al3+, Ca2+, Ti4+, Mn2+, Fe3+, Co2+, Cu2+, Zn2+ and the anions are Cl-.

3. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: the concentration of the inorganic salt solution in the step S4 is inorganic salt: the water was in a molar ratio of 1: 5.

4. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: the adding amount of the taxus chinensis cellulose sample in the step S5 is 10% of the mass of the inorganic salt solution.

5. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: in the step S5, the stirring temperature is 20-150 ℃.

6. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: and S7, the treatment method of the taxol-containing Taxus chinensis cellulose gel is wet spinning to obtain taxol-containing regenerated Taxus chinensis cellulose fibers.

7. The method for preparing taxol-containing modified regenerated cellulose fibers according to claim 1, which is characterized in that: the coagulating bath in the step S7 is one of an organic solvent, a mixed solution of an organic solvent and water, and a dilute acid solution.

Technical Field

The invention relates to the technical field of cellulose preparation, in particular to a preparation method of taxol-containing modified regenerated cellulose fibers.

Background

The taxol is a natural secondary metabolite separated and purified from the bark of a gymnosperm yew, and has good anti-tumor effect through clinical verification, and particularly has special effects on ovarian cancer, uterine cancer, breast cancer and the like with high incidence rate of cancer. Paclitaxel is the most popular anticancer drug in the international market in recent years, and is considered to be one of the most effective anticancer drugs in human for the next 20 years.

The regenerated cellulose fiber is prepared by using natural cellulose as a raw material, and only changing the physical structure of the natural cellulose without changing the chemical structure of the natural cellulose, so that the regenerated cellulose fiber with better performance is prepared.

The existing taxus chinensis can generate a large amount of taxus chinensis waste materials in the process of extracting the taxol, and the taxus chinensis waste materials also contain trace taxol, so that the taxol extraction method has great economic benefit if waste can be utilized.

The existing regenerated cellulose fiber is used more and more frequently in daily life, but has no anticancer physical therapy effect, and a preparation method of taxol-containing modified regenerated cellulose fiber is provided for solving the problems.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides a preparation method of taxol-containing modified regenerated cellulose fibers of taxus chinensis, which solves the problems that the existing taxus chinensis waste is difficult to treat and the existing textile fibers do not have anticancer physical therapy effect.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme: a method for preparing taxol-containing modified regenerated cellulose fibers comprises the following steps:

s1, carrying out centralized collection on the taxus waste after paclitaxel extraction;

s2, crushing the collected taxus waste to obtain taxus particles;

s3, boiling the crushed Chinese yew particles in a sodium hydroxide solution with the concentration of 2% for 100 minutes at 100 ℃, adding hydrogen peroxide with the concentration of 5% when the temperature of the solution is reduced to about 75 ℃, continuously heating for 0.5 hour, keeping the temperature at about 75 ℃, filtering, fully washing filter residues with distilled water to be neutral, and drying to obtain a Chinese yew cellulose sample;

s4, preparing a high-concentration single or compound inorganic salt solution;

s5, adding a certain amount of a taxus chinensis cellulose sample into the inorganic salt solution prepared in the step S4, adding a proper amount of paclitaxel solution, and stirring and dissolving at a certain temperature to obtain a uniform taxus chinensis cellulose solution containing paclitaxel;

s6, cooling the taxol-containing Taxus chinensis cellulose solution prepared in S5 to obtain high-strength and high-toughness taxol-containing Taxus chinensis cellulose gel;

s7, treating the taxol-containing taxus chinensis cellulose gel obtained in the step S6 by using a specific spinning process, cooling and solidifying in a coagulating bath, washing to remove salt, and drying to obtain taxol-containing regenerated taxus chinensis cellulose fibers.

Preferably, the inorganic salt in the step S4 is a metal salt, the metal cations are Li +, Mg2+, Al3+, Ca2+, Ti4+, Mn2+, Fe3+, Co2+, Cu2+, Zn2+, and the anion is Cl-.

Preferably, the concentration of the inorganic salt solution in the step S4 is inorganic salt: the water was in a molar ratio of 1: 5.

Preferably, the amount of the cellulose sample of the yew added in the step S5 is 10% of the mass of the inorganic salt solution.

Preferably, the stirring temperature in the step S5 is 20 to 150 ℃.

Preferably, the processing method of the taxol-containing yew cellulose gel in the step S7 is wet spinning, so as to obtain taxol-containing regenerated yew cellulose fibers.

Preferably, the coagulation bath in step S7 is one of an organic solvent, a mixed solution of an organic solvent and water, and a dilute acid solution.

(III) advantageous effects

The invention provides a preparation method of taxol-containing modified regenerated cellulose fibers.

The method has the following beneficial effects:

1. according to the preparation method of the taxol-containing modified regenerated cellulose fiber, provided by the invention, taxol waste materials from taxol extraction are modified to prepare taxol-containing textile fibers, so that the purposes of waste utilization and more environmental protection are achieved.

2. The paclitaxel-containing regenerated cellulose fiber prepared by the preparation method of paclitaxel-containing modified regenerated cellulose fiber provided by the invention can be prepared into textiles for use, and has certain physiotherapy and anticancer effects.

3. According to the preparation method of the taxol-containing modified regenerated cellulose fiber, provided by the invention, raw materials and chemical reagents used in the process are low in price and easy to obtain, and chemical pollution is avoided in the production process, so that the preparation method is more green and environment-friendly, has lower cost and has higher economic benefit.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example (b):

the embodiment of the invention provides a preparation method of taxol-containing modified regenerated cellulose fibers, which comprises the following steps:

s1, carrying out centralized collection on the taxus waste after paclitaxel extraction;

s2, crushing the collected taxus waste to obtain taxus particles;

s3, boiling the crushed Chinese yew particles in a sodium hydroxide solution with the concentration of 2% for 100 minutes at 100 ℃, adding hydrogen peroxide with the concentration of 5% when the temperature of the solution is reduced to about 75 ℃, continuously heating for 0.5 hour, keeping the temperature at about 75 ℃, filtering, fully washing filter residues with distilled water to be neutral, and drying to obtain a Chinese yew cellulose sample;

s4, preparing a high-concentration single or compound inorganic salt solution;

s5, adding a certain amount of a taxus chinensis cellulose sample into the inorganic salt solution prepared in the step S4, adding a proper amount of paclitaxel solution, and stirring and dissolving at a certain temperature to obtain a uniform taxus chinensis cellulose solution containing paclitaxel;

s6, cooling the taxol-containing Taxus chinensis cellulose solution prepared in S5 to obtain high-strength and high-toughness taxol-containing Taxus chinensis cellulose gel;

s7, treating the taxol-containing taxus chinensis cellulose gel obtained in the step S6 by using a specific spinning process, cooling and solidifying in a coagulating bath, washing to remove salt, and drying to obtain taxol-containing regenerated taxus chinensis cellulose fibers.

The inorganic salt in the step S4 is a metal salt, the metal cations are Li +, Mg2+, Al3+, Ca2+, Ti4+, Mn2+, Fe3+, Co2+, Cu2+, Zn2+ respectively, and the anion is Cl —, and the concentration of the inorganic salt solution in the step S4 is inorganic salt: the molar ratio of water is 1:5, the adding amount of the taxus chinensis cellulose sample in the step S5 is 10% of the mass of the inorganic salt solution, the stirring temperature in the step S5 is 20-150 ℃, the treatment method of the taxus chinensis cellulose gel containing paclitaxel in the step S7 is wet spinning to obtain the taxus chinensis cellulose fiber containing paclitaxel, and the coagulation bath in the step S7 is one of organic solvent, mixed liquid of organic solvent and water and dilute acid solution.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.