阅读说明：本技术 一种基于静电纺丝技术制备纳米复合纤维膜的方法 (Method for preparing nano composite fiber membrane based on electrostatic spinning technology ) 是由 王滢 刘跃洲 吕丽华 钱永芳 李西月 刘妍靖 于 2021-09-01 设计创作，主要内容包括：本发明属于静电纺丝技术领域,具体涉及一种基于静电纺丝技术制备纳米复合纤维膜的方法。所述制备方法包括以下步骤：(1)将聚己内酯和聚乙烯吡咯烷酮溶于三氟乙醇中,磁力搅拌混匀,得到纺丝液；(2)将步骤(1)得到的纺丝液在静电纺丝机中进行静电纺丝,干燥,得到纳米复合纤维膜材料。本发明将聚己内酯、聚乙烯吡咯烷酮两种物质共混从而进行静电纺丝,得到直径小、比表面积大的纳米复合纤维膜,该结构与细胞外基质中的胶原蛋白结构相似,可应用在组织工程材料领域,而且该纳米复合纤维膜可作为一种良好的基材来负载纳米功能材料,从而制备功能纤维膜材料。(The invention belongs to the technical field of electrostatic spinning, and particularly relates to a method for preparing a nano composite fiber membrane based on an electrostatic spinning technology. The preparation method comprises the following steps: (1) dissolving polycaprolactone and polyvinylpyrrolidone in trifluoroethanol, and uniformly mixing the polycaprolactone and the polyvinylpyrrolidone by magnetic stirring to obtain a spinning solution; (2) and (2) performing electrostatic spinning on the spinning solution obtained in the step (1) in an electrostatic spinning machine, and drying to obtain the nano composite fiber membrane material. The invention blends two substances of polycaprolactone and polyvinylpyrrolidone for electrostatic spinning to obtain the nano composite fibrous membrane with small diameter and large specific surface area, the structure is similar to the structure of collagen in extracellular matrix and can be applied to the field of tissue engineering materials, and the nano composite fibrous membrane can be used as a good base material to load nano functional materials, thereby preparing the functional fibrous membrane material.)

1. A method for preparing a nano composite fiber membrane based on an electrostatic spinning technology is characterized by comprising the following steps:

(1) dissolving polycaprolactone and polyvinylpyrrolidone in trifluoroethanol, and uniformly mixing the polycaprolactone and the polyvinylpyrrolidone by magnetic stirring to obtain a spinning solution;

(2) and (2) adding the spinning solution obtained in the step (1) into an injector for electrostatic spinning, and drying to obtain the nano composite fiber membrane material.

2. The production method according to claim 1, wherein the mass fraction of the total solute in the spinning solution obtained in the step (1) is 10 to 15 wt%.

3. The preparation method according to claim 1, wherein the mass ratio of polycaprolactone to polyvinylpyrrolidone is 1: (1-1.5).

4. The production method according to claim 1, wherein the mass fraction of the total solute in the spinning solution is 12 wt%, and the mass ratio of polycaprolactone to polyvinylpyrrolidone is 1: 1.

5. the preparation method according to claim 1, wherein the electrospinning method in the step (2) is specifically: placing the spinning solution obtained in the step (1) into an injector, selecting a spinning nozzle with the inner diameter of 0.33 +/-0.01 mm, setting the voltage to be 18-22kV, the flow rate of the spinning solution to be 0.9-1.1mL/h and the receiving distance to be 17-19cm, carrying out electrostatic spinning process in an electrostatic spinning machine, and finally directly obtaining the nano composite fiber membrane on a receiving plate.

6. The production method according to claim 1, wherein the drying temperature in the step (2) is 90 to 110 ℃.

7. A nanocomposite fiber membrane obtained by the production method according to any one of claims 1 to 6.

Technical Field

The invention belongs to the technical field of electrostatic spinning, and particularly relates to a method for preparing a nano composite fiber membrane based on an electrostatic spinning technology.

Background

In recent years, biodegradable polymers have received increasing attention in the biomedical field. Some polymers have excellent biodegradability and biocompatibility, and are applied to sustained-release carriers of long-acting drugs, tissue engineering scaffolds and the like in the biomedical field, which has important practical significance in the fields of health, environmental protection, economy and the like. Liuqing and the like use polycaprolactone and polyvinylpyrrolidone as solutes and dichloromethane as solvents to prepare the nano-composite fiber membrane material. However, methylene dichloride used as a spinning solution solvent is extremely toxic and carcinogenic, and the condition of phase separation is easy to occur in the spinning process, so that the prepared fiber membrane is poor in usability. Therefore, the invention improves on the solvent, and adopts trifluoroethanol as the spinning solution solvent to improve the condition.

Disclosure of Invention

The invention aims to provide a method for preparing a nano composite fiber membrane based on an electrostatic spinning technology, wherein a spinning solvent is trifluoroethanol, and fluorine atoms have strong electronegativity, so that the acidity of the trifluoroethanol is enhanced, hydrogen bonds are easily formed, the chemical property of a spinning solution is stable, the spinning solution is not easy to phase separate, and continuous and uniform fibers can be obtained in the spinning process.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the invention provides a method for preparing a nano composite fiber membrane based on an electrostatic spinning technology, which comprises the following steps:

(1) dissolving polycaprolactone and polyvinylpyrrolidone in trifluoroethanol, and uniformly mixing the polycaprolactone and the polyvinylpyrrolidone by magnetic stirring to obtain a spinning solution;

(2) and (2) adding the spinning solution obtained in the step (1) into an injector for electrostatic spinning, and drying to obtain the nano composite fiber membrane material.

In the above technical scheme, further, the mass fraction of the total solute in the spinning solution obtained in the step (1) is 10-15 wt%.

In the above technical scheme, further, the mass ratio of polycaprolactone to polyvinylpyrrolidone is 1: (1-1.5).

In the above technical scheme, further, the mass fraction of the total solute in the spinning solution is 12 wt%, and the mass ratio of polycaprolactone to polyvinylpyrrolidone is 1: 1.

in the above technical solution, further, the electrostatic spinning method in the step (2) specifically includes: placing the spinning solution obtained in the step (1) into an injector, selecting a spinning nozzle with the inner diameter of 0.33 +/-0.01 mm, setting the voltage to be 18-22kV, the flow rate of the spinning solution to be 0.9-1.1mL/h and the receiving distance to be 17-19cm, carrying out electrostatic spinning process in an electrostatic spinning machine, and finally directly obtaining the nano composite fiber membrane on a receiving plate.

In the above technical solution, further, the drying temperature in the step (2) is 90-110 ℃.

The invention also provides a nano composite fiber membrane prepared by the preparation method.

The invention has the beneficial effects that:

the spinning solution solvent of the invention selects trifluoroethanol, and fluorine atoms have strong electronegativity, so that the acidity of the trifluoroethanol is enhanced, hydrogen bonds are easy to form, the spinning solution has stable chemical properties, the condition of phase separation is not easy to occur, and continuous and uniform fibers can be obtained in the spinning process.

The invention blends two substances of polycaprolactone and polyvinylpyrrolidone for electrostatic spinning to obtain the nano composite fibrous membrane with small diameter and large specific surface area, the structure of the nano composite fibrous membrane is similar to that of collagen in extracellular matrix, and the nano composite fibrous membrane can be used as a good base material to load nano functional materials, thereby further preparing the functional fibrous membrane material.

Drawings

FIG. 1 is an SEM image of a nano composite fiber membrane prepared in example 1;

FIG. 2 is an SEM image of the nano composite fiber membrane prepared in example 2.

Detailed Description

The following examples are presented to enable one of ordinary skill in the art to more fully understand the present invention and are not intended to limit the invention in any way.

Example 1

The spinning solution comprises the following solutes in percentage by mass: polyvinylpyrrolidone ═ 1: 1, a method for preparing a nanocomposite fiber membrane, the method comprising the steps of:

the mass ratio of (1): 1, weighing polycaprolactone and polyvinylpyrrolidone, dissolving the polycaprolactone and the polyvinylpyrrolidone in a trifluoroethanol solvent according to the mass fraction of 12 wt%, and fully and uniformly stirring the polycaprolactone and the polyvinylpyrrolidone by using a magnetic stirrer;

placing the composite spinning solution prepared in the step I into an injector, selecting a spinning nozzle with the inner diameter of 0.33 +/-0.01 mm, setting the voltage to be 20kV, the flow rate of the spinning solution to be 1mL/h and the receiving distance to be 18cm, carrying out an electrostatic spinning process in an electrostatic spinning machine, and finally directly obtaining the nano composite fiber membrane on a receiving plate;

③ taking the fiber membrane off the receiving plate by tweezers, drying at 100 ℃ and obtaining the SEM picture of the fiber membrane shown in figure 1.

Example 2

The spinning solution comprises the following solutes in percentage by mass: polyvinylpyrrolidone ═ 1: 1.5 a method of making a nanocomposite fiber membrane, the method comprising the steps of:

the mass ratio of (1): 1.5 weighing polycaprolactone and polyvinylpyrrolidone, dissolving the polycaprolactone and the polyvinylpyrrolidone in a trifluoroethanol solvent according to the mass fraction of 12 wt%, and fully and uniformly stirring the polycaprolactone and the polyvinylpyrrolidone by using a magnetic stirrer;

placing the composite spinning solution prepared in the step I into an injector, selecting a spinning nozzle with the inner diameter of 0.33 +/-0.01 mm, setting the voltage to be 20kV, the flow rate of the spinning solution to be 1mL/h and the receiving distance to be 18cm, carrying out an electrostatic spinning process in an electrostatic spinning machine, and finally directly obtaining the nano composite fiber membrane on a receiving plate;

③ the fiber membrane was removed from the receiving plate with tweezers and dried at 100 ℃ to obtain the fiber membrane, the SEM photograph of which is shown in FIG. 2.

As can be seen from fig. 1 and 2, when trifluoroethanol was used as the solvent, continuous and uniform nanofibers could be obtained by the electrospinning technique, and phase separation did not occur. The prepared nano composite fiber membrane can be used as a good base material to load nano functional materials, so that the functional fiber membrane material is prepared.

The above examples are merely preferred embodiments of the present invention, and are not intended to limit the embodiments. The protection scope of the present invention shall be subject to the scope defined by the claims. Other variations and modifications may be made on the basis of the above description. Obvious variations or modifications of this invention are within the scope of the invention.