阅读说明：本技术 治疗畜禽动物腹泻的药物组合物、其制备方法和用途 (Pharmaceutical composition for treating livestock and poultry diarrhea, preparation method and application thereof ) 是由 周阳 张志峰 于 2021-09-24 设计创作，主要内容包括：本申请涉及药物领域,具体而言,涉及一种治疗畜禽动物腹泻的药物组合物、其制备方法和用途。药物组合物的原料由按照以下重量份的组分组成：广藿香260-320份、茯苓260-320份、木香260-320份、紫苏叶260-320份及黄连180-220份。本申请提供的药物组合物能明显改善畜禽动物的肠道功能、使其活力增强、免疫力增强,毛皮发亮,增重快。(The application relates to the field of medicines, in particular to a pharmaceutical composition for treating livestock and poultry diarrhea, a preparation method and application thereof. The raw materials of the pharmaceutical composition comprise the following components in parts by weight: 320 portions of patchouli 260-320 portions, 320 portions of tuckahoe 260-320 portions, 320 portions of costus root 260-320 portions, 320 portions of perilla leaf 260-220 portions and 220 portions of coptis chinensis 180-220 portions. The pharmaceutical composition provided by the application can obviously improve the intestinal function of livestock and poultry, so that the vitality and the immunity of the livestock and poultry are enhanced, the fur is shiny, and the weight is increased quickly.)

1. The pharmaceutical composition for treating diarrhea of livestock and poultry is characterized by comprising the following raw materials in parts by weight:

320 portions of patchouli 260-320 portions, 320 portions of tuckahoe 260-320 portions, 320 portions of costus root 260-320 portions, 320 portions of perilla leaf 260-220 portions and 220 portions of coptis chinensis 180-220 portions.

2. The pharmaceutical composition for treating diarrhea of livestock and poultry according to claim 1, wherein the raw materials of the pharmaceutical composition comprise the following components in parts by weight:

300 parts of patchouli, 300 parts of tuckahoe, 300 parts of costus root, 300 parts of perilla leaf and 200 parts of coptis root.

3. The pharmaceutical composition for treating diarrhea in livestock and poultry according to claim 1 or 2, wherein the pharmaceutical composition is a decoction.

4. The pharmaceutical composition for treating diarrhea in livestock and poultry according to claim 1 or 2, wherein the particle size of the raw material is 20-100 mesh.

5. The pharmaceutical composition for treating diarrhea of livestock and poultry according to claim 1 or 2, wherein the pharmaceutical composition for treating diarrhea of livestock and poultry further comprises pharmaceutically acceptable excipients.

6. The method for preparing a pharmaceutical composition for treating diarrhea in livestock and poultry according to any one of claims 1 to 5, comprising:

crushing the raw materials, carrying out water extraction for 3-5 times, removing filter residues after water extraction, and taking filtrate.

7. The method for preparing a pharmaceutical composition for treating diarrhea of livestock and poultry according to claim 6, further comprising adding a preservative to the filtrate, wherein the content of the preservative is 0.01-0.02% of the volume of the filtrate.

8. The method for preparing a pharmaceutical composition for the treatment of diarrhea in livestock and poultry according to claim 6, wherein the volume of water is 3-5 times of the volume of the raw materials in the step of performing water extraction 3-5 times.

9. The method for preparing a pharmaceutical composition for treating diarrhea in livestock and poultry according to claim 6, wherein said step of pulverizing said raw materials comprises pulverizing to 20-100 mesh.

10. Use of the pharmaceutical composition for treating diarrhea in livestock and poultry according to any one of claims 1 to 5 in the preparation of a medicament for treating diarrhea in livestock and poultry of 12-20 days old.

Technical Field

The application relates to the field of medicines, in particular to a pharmaceutical composition for treating livestock and poultry diarrhea, a preparation method and application thereof.

Background

Because a stable micro-ecosystem is not established in the intestinal tract of the young livestock and poultry, the young livestock and poultry has low self-resistance, is sensitive to external stimulation and is easily affected by the invasion of various pathogenic microorganisms and various stress factors.

For example, infectious diarrhea is common in nursing piglets, while diarrhea caused by non-infectious factors such as daily ration antigen allergy, weaning, sudden feed change, cold, environmental stress, and the like, is mainly seen in nursing piglets. The two factors are closely related, and both affect each other and cause each other, and are often multiple infections or cross-mixed infections.

Mainly caused by digestive insufficiency, daily ration antigen allergy, lack of nutritional factors, stress factors and the like of livestock and poultry.

Disclosure of Invention

The application aims to provide a pharmaceutical composition for treating diarrhea of livestock and poultry, a preparation method and application thereof. Which aims to solve the problem of diarrhea of livestock and poultry animals.

The invention provides a pharmaceutical composition for treating livestock and poultry diarrhea, which comprises the following raw materials in parts by weight:

320 portions of patchouli 260-320 portions, 320 portions of tuckahoe 260-320 portions, 320 portions of costus root 260-320 portions, 320 portions of perilla leaf 260-220 portions and 220 portions of coptis chinensis 180-220 portions.

In some embodiments of the present invention, the raw materials of the pharmaceutical composition comprise the following components in parts by weight:

300 parts of patchouli, 300 parts of tuckahoe, 300 parts of costus root, 300 parts of perilla leaf and 200 parts of coptis root.

In some embodiments of the invention, the pharmaceutical composition is a decoction.

In some embodiments of the invention, the feedstock has a particle size of 20 to 100 mesh.

The invention also provides a preparation method of the pharmaceutical composition for treating livestock and poultry diarrhea, which comprises the following steps:

crushing the raw materials, carrying out water extraction for 3-5 times, removing filter residues after water extraction, and taking filtrate.

In some embodiments of the present invention, the method further comprises adding a preservative to the filtrate, wherein the preservative is present in an amount of 0.01 to 0.02% by volume of the filtrate.

In some embodiments of the invention, the volume of water is 3-5 times the volume of the feedstock in 3-5 water extraction steps.

In some embodiments of the present invention, in the step of crushing the raw materials, the raw materials are crushed to 20-100 mesh.

The invention also provides an application of the pharmaceutical composition for treating livestock and poultry diarrhea in preparation of a drug for treating livestock and poultry diarrhea of 12-20 days old.

The invention provides a pharmaceutical composition for treating livestock and poultry diarrhea, a preparation method and application thereof

The method has the following beneficial effects:

in the application, the pharmaceutical composition only comprising 320 parts of pogostemon cablin 260-amoxicillin, 320 parts of poria cocos 260-amoxicillin, 320 parts of costus root 260-amoxicillin, 320 parts of perilla leaf 260-amoxicillin and 220 parts of coptis chinensis 180-amoxicillin can replace the efficacy of colistin sulfate + amoxicillin. Avoiding the need to select from a plurality of medicaments; the five medicines can effectively improve the problem of diarrhea of livestock and poultry.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

The pharmaceutical composition for treating diarrhea of livestock and poultry, the preparation method and the use thereof according to the embodiment of the present application are specifically described below.

The pharmaceutical composition for treating livestock and poultry diarrhea comprises the following raw materials in parts by weight:

320 portions of patchouli 260-320 portions, 320 portions of tuckahoe 260-320 portions, 320 portions of costus root 260-320 portions, 320 portions of perilla leaf 260-220 portions and 220 portions of coptis chinensis 180-220 portions.

Herba Agastaches can be used for treating damp obstruction of middle energizer, abdominal distention and emesis, summer-heat and dampness exterior syndrome, early stage of damp-warm syndrome, fever and listlessness, chest distress and discomfort, cold-dampness retention of summer-heat, abdominal pain, vomiting and diarrhea, nasosinusitis headache.

Illustratively, the weight parts of the patchouli in the raw materials of the pharmaceutical composition may be 260 parts, 262 parts, 267 parts, 273 parts, 279 parts, 281 parts, 295 parts, 305 parts, 316 parts, 320 parts.

Poria cocos is used for edema, oliguria, phlegm-fluid retention, dizziness and palpitation, spleen deficiency, poor appetite, loose stool, diarrhea, uneasiness, palpitation and insomnia.

Illustratively, the weight parts of the poria cocos in the raw materials of the pharmaceutical composition may be 260 parts, 264 parts, 274 parts, 278 parts, 283 parts, 289 parts, 297 parts, 307 parts, 311 parts, 319 parts, 320 parts.

Mu Xiang is indicated for distending pain in chest and hypochondrium and stomach and abdomen, diarrhea and dysentery with tenesmus, indigestion and poor appetite. Roasted mu Xiang can relieve diarrhea and abdominal pain.

Illustratively, the parts by weight of costus root in the raw materials of the pharmaceutical composition can be 260 parts, 263 parts, 267 parts, 271 parts, 278 parts, 287 parts, 297 parts, 307 parts, 311 parts, 312 parts, 314 parts and 320 parts.

The perilla leaf, the part used as the medicine is mainly stem leaves and fruit, the leaf is a sweating, cough-relieving, aromatic stomach-invigorating diuretic, has the functions of easing pain, calming and detoxifying, and has high effect on treating cold, and patients with abdominal pain and vomiting due to fish and crab poisoning; the stem has the function of calming the air and preventing miscarriage; zi can relieve cough, dispel phlegm, relieve asthma and disperse mental depression.

Illustratively, the weight parts of the perilla leaves in the raw materials of the pharmaceutical composition can be 260 parts, 261 parts, 265 parts, 271 parts, 278 parts, 289 parts, 298 parts, 306 parts, 309 parts, 318 parts and 320 parts.

Coptis chinensis, dampness and heat, fullness and distention, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart-fire, vexation and insomnia, palpitation and restlessness, blood heat, hematemesis and epistaxis, conjunctival congestion, toothache, thirst, carbuncle and swelling and sore treatment; it is used externally to treat eczema, eczema and purulent ear canal.

Illustratively, the weight parts of the coptis chinensis in the raw materials of the pharmaceutical composition can be 180 parts, 181 parts, 186 parts, 189 parts, 197 parts, 199 parts, 203 parts, 205 parts, 209 parts, 211 parts, 213 parts, 216 parts and 220 parts.

In some embodiments of the present application, the raw materials of the pharmaceutical composition are composed of the following components in parts by weight: 300 parts of patchouli, 300 parts of tuckahoe, 300 parts of costus root, 300 parts of perilla leaf and 200 parts of coptis root.

In some embodiments of the present application, the pharmaceutical composition for treating diarrhea in a livestock animal further comprises a pharmaceutically acceptable excipient. Such as sweeteners, excipients, and the like.

In some embodiments of the present application, the feedstock has a particle size of 20 to 100 mesh.

The existing methods for treating piglet diarrhea are numerous, and medicines are also numerous. For example: coptis chinensis, phellodendron, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, purple perilla, wrinkled gianthyssop herb, costustoot, fried kudzu root, scorched hawthorn fruit, medicated leaven, plantain herb, pomegranate rind, Chinese pulsatilla root, purple perilla, rhizoma atractylodis, poria cocos, cassia twig, costustoot, ginger, scutellaria baicalensis, pinellia ternate, liquorice, poplar flower, purslane, colistin sulfate + amoxicillin, enrofloxacin, apramycin, amoxicillin, colistin sulfate, even florfenicol, sulfanilamide and the like.

In the application, the pharmaceutical composition only comprising 320 parts of pogostemon cablin 260-amoxicillin, 320 parts of poria cocos 260-amoxicillin, 320 parts of costus root 260-amoxicillin, 320 parts of perilla leaf 260-amoxicillin and 220 parts of coptis chinensis 180-amoxicillin can replace the efficacy of colistin sulfate + amoxicillin. Avoiding the need to select from a plurality of medicaments; the five medicines can effectively improve the problem of diarrhea of livestock and poultry.

The invention also provides a preparation method of the pharmaceutical composition for treating livestock and poultry diarrhea, which comprises the following steps:

crushing the raw materials, carrying out water extraction for 3-5 times, removing filter residues after water extraction, and taking filtrate.

For example, the raw materials are crushed to 20-100 meshes; then adding water for water extraction, and extracting with water for 3-5 times.

In some embodiments of the present application, the volume of water is 3-5 times the volume of the feedstock; for example, the volume of water is 4 times the volume of the powder, and then heated to 75-90 ℃ to boil for 1-4 hours; repeatedly extracting for 3-5 times, removing residue, and collecting filtrate.

In some embodiments of the invention, the method further comprises adding a preservative to the filtrate, wherein the preservative is contained in an amount of 0.01-0.02% by volume of the filtrate; for example, 0.01% preservative is added.

It should be noted that in other embodiments of the present application, the raw material may be processed by other methods, such as alcohol extraction.

The invention also provides an application of the pharmaceutical composition for treating livestock and poultry diarrhea in preparation of a drug for treating livestock and poultry diarrhea of 12-20 days old.

After research, the inventor finds that the pharmaceutical composition for treating livestock and poultry diarrhea provided by the application is particularly suitable for livestock and poultry with the age of 12-20 days.

For example, the pharmaceutical composition for treating diarrhea of livestock and poultry animals, provided by the application, is particularly suitable for piglets of 12-20 days old.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1

Embodiment 1 provides a traditional Chinese medicine extract for treating livestock and poultry diarrhea, which comprises the following raw materials: 300g of patchouli, 300g of tuckahoe, 300g of costus root, 300g of perilla leaf and 200g of coptis root.

The preparation method comprises the following steps: pulverizing all the medicinal materials into coarse powder, extracting with appropriate amount of water for 3 times, each for 2 hr, mixing extractive solutions to 1400ml, and adding 0.01% antiseptic.

Experimental example 1

1) Experimental methods

60 piglets in the diarrhea stage are selected, the ages of the piglets are 12-20 days old, and the piglets are randomly and averagely divided into three groups, namely a treatment group in example 1, a colistin sulfate (1mg/ml) + amoxicillin (1mg/ml) treatment group and a blank control group, and are respectively administrated by a filling method according to the dosage in the table 1. And ensure that the animals in each group are fed normally, and three groups are added with liquid supplementing salt in drinking water.

TABLE 1 dosage form for animals

2) Index of experimental determination

Observing the diet, mental condition, weight increment, diarrhea, etc. of the three groups of animals; in addition, the diarrhea rate and diarrhea index of each group were statistically analyzed, and the results are shown in tables 3 and 4.

Diarrhea score criteria are shown in table 2:

TABLE 2 statistical table of diarrhea scores of each group

Scoring	Index (I)
		0	Excrement drying (Normal)
1	Soft stool to form
		2	The feces is sticky (moderate diarrhea)
3	The excrement is sprayed like a water sample (severe diarrhea)

The calculation formula of the diarrhea rate and the diarrhea index is as follows:

diarrhea rate ═ (number of diarrhea heads/number of animals in the group) × 100%;

diarrhea index ═ (sum of stool scores/number of animals in the group) x 100%.

3) Results

TABLE 3 statistical conditions of diarrhea rate in each group

TABLE 4 statistical conditions of diarrhea index for each group

Note: in tables 3-4, the same column of abc indicates significant differences between groups if labeled with different lower case letters (p <0.05) and insignificant differences between groups if labeled with the same lower case letters (p > 0.05).

4) Analysis of

As can be seen from table 3, compared with the diarrhea rate of the treatment group of example 1, the treatment group of colistin sulfate + amoxicillin and the blank control group, the treatment group of example 1 and the treatment group of colistin sulfate + amoxicillin did not significantly differ (P >0.05) and the treatment group of colistin sulfate + amoxicillin and the blank control group did significantly differ (P <0.05) when the drug 1d was administered; when 2d is taken, the difference between groups is obvious (P < 0.05); when 3d was administered, the difference was significant for each group (P < 0.05).

As can be seen from table 4, the diarrhea index condition of the treatment group of example 1, the colistin sulfate + amoxicillin treatment group and the blank control group are significantly different (P <0.05) among the groups when the drug is applied for 1 d; the treatment group of example 1 was not significantly different from the colistin sulfate + amoxicillin treatment group when 2d was administered (P > 0.05); the difference between groups was significant when 3d was administered (P < 0.05).

From the experimental statistics results, in the experimental process of resisting piglet diarrhea, the treatment effect of the invention in the embodiment 1 is better than that of the method of colistin sulfate and amoxicillin.

In conclusion, after the piglet feed is taken in the embodiment 1 of the invention, the intestinal function of the piglet is obviously improved; the vitality and the immunity of the human body are enhanced, and gastrointestinal diseases do not occur; the piglet has good state, bright fur and quick weight increment.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.