阅读说明：本技术 一种硝苯地平渗透泵组合物的制备设备及其制备工艺 (Preparation equipment and preparation process of nifedipine osmotic pump composition ) 是由 卞建钢 潘秀芝 李成文 马浩 王延杰 张华魏 邵黎明 于 2021-08-11 设计创作，主要内容包括：本发明涉及硝苯地平渗透泵缓释技术领域,具体的说是一种硝苯地平渗透泵组合物的制备设备及其制备工艺,包括装置主体,所述装置主体的顶侧安装有液压杆,所述液压杆的底侧设有配槽结构,所述配槽结构的底侧设有顶起结构,所述液压杆的两侧设有下料结构,所述下料结构的内侧安装有封闭结构,所述装置主体的内部安装有清洁结构,通过配槽结构可以实现双层压片,同时保证压制界面的平整,通过顶起结构可以方便使用者对完成压制的片剂进行取出,通过下料结构可以方便同时对两种粉剂进行添加,通过封闭结构可以方便对余料进行回收,所述装置主体的内部安装有清洁结构,通过清洁结构可以快速对装置表面残留的粉剂进行清理。(The invention relates to the technical field of nifedipine osmotic pump sustained release, in particular to a preparation device and a preparation process of a nifedipine osmotic pump composition, which comprises a device main body, wherein a hydraulic rod is arranged on the top side of the device main body, a matched groove structure is arranged on the bottom side of the hydraulic rod, a jacking structure is arranged on the bottom side of the matched groove structure, blanking structures are arranged on two sides of the hydraulic rod, a closed structure is arranged on the inner side of the blanking structure, a cleaning structure is arranged in the device main body, double-layer tabletting can be realized through the matched groove structure, the smoothness of a pressing interface is ensured at the same time, a user can conveniently take out tablets after pressing through the jacking structure, two kinds of powder can be conveniently and simultaneously added through the blanking structure, the excess materials can be conveniently recycled through the closed structure, and the cleaning structure is arranged in the device main body, can clear up the remaining powder in device surface fast through clean structure.)

1. The utility model provides a preparation equipment of nifedipine permeate pump composition, its characterized in that, includes device main part (1), hydraulic stem (2) are installed to the top side of device main part (1), the bottom side of hydraulic stem (2) is equipped with joins in marriage groove structure (3), the bottom side of joining in marriage groove structure (3) is equipped with jack-up structure (6), the both sides of hydraulic stem (2) are equipped with blanking structure (4), enclosed construction (7) are installed to the inboard of blanking structure (4), the internally mounted of device main part (1) has clean structure (5).

2. The preparation equipment of the nifedipine permeate pump composition according to claim 1, characterized in that: the groove matching structure (3) comprises a first fan plate (31) and a second fan plate (32), the first fan plate (31) and the second fan plate (32) are stacked, the first fan plate (31) and the second fan plate (32) are rotatably connected with the device main body (1), the first fan plate (31) and the second fan plate (32) are respectively provided with a pressure sheet groove (34), the end parts of the first fan plate (31) and the second fan plate (32) are respectively rotatably connected with a connecting rod (35), the other ends of the two connecting rods (35) are rotatably connected with a pulling block (36), a second spring (39a) is fixedly connected between the pulling block (36) and the inner side of the device main body (1), the side surface of the pulling block (36) is rotatably connected with a pulley (37), and the side surface of the pulling block (36) is abutted with a push-pull rod (33) through the pulley (37), the end part of the push-pull rod (33) is rotatably connected with the device main body (1).

3. The preparation equipment of the nifedipine permeate pump composition according to claim 2, characterized in that: sliding connection has splashproof sleeve (38) on hydraulic stem (2), fixedly connected with first spring (39) between splashproof sleeve (38) and hydraulic stem (2), just the internal diameter of splashproof sleeve (38) is greater than the diameter in pressure piece groove (34), the area of first sector (31) is less than second sector (32).

4. The preparation equipment of the nifedipine permeate pump composition according to claim 2, characterized in that: the jacking structure (6) comprises a drawing slide rod (61), the inner side of the device body (1) is connected with the drawing slide rod (61) in a sliding manner, the end part of the drawing slide rod (61) is fixedly connected with a fourth spring (62) with the inner side of the device body (1), the side surface of the drawing slide rod (61) is abutted against the push-pull rod (33), the other end of the drawing slide rod (61) is fixedly connected with a first rack (63), the side surface of the first rack (63) is meshed with a reversing gear (64), the side surface of the reversing gear (64) is meshed with a second rack (65), the first rack (63) and the second rack (65) are vertically arranged, the top end of the second rack (65) is vertically and fixedly connected with a jacking rod (67), the jacking rod (67) is connected with the device body (1) in a sliding manner, and a fifth spring (66) is fixedly connected between the second rack (65) and the device body (1), the number of the jacking rods (67) is four, and the four jacking rods (67) are distributed on the top side of the second rack (65) in a diamond shape.

5. The preparation equipment of the nifedipine permeate pump composition according to claim 2, characterized in that: blanking structure (4) include mounting groove (41), the bilateral symmetry of hydraulic stem (2) is equipped with two mounting grooves (41), fixed connection between the side of mounting groove (41) and device main part (1), the inboard sliding connection of mounting groove (41) has material bottle (42), the outside of material bottle (42) is through protruding circle (44) and mounting groove (41) looks block, the bottom fixedly connected with passage (45) of mounting groove (41), two the bottom of passage (45) is inconsistent with the surface of first fan board (31) and second fan board (32) respectively.

6. The preparation equipment of the nifedipine permeate pump composition according to claim 5, characterized in that: the bottom side of the second fan plate (32) is provided with a contact plate (43), the contact plate (43) is in sliding connection with the second fan plate (32), the side face of the contact plate (43) is in sliding connection with the device body (1), the bottom side of the contact plate (43) is abutted against a positioning block (46), and a third spring (47) is fixedly connected between the positioning block (46) and the device body (1).

7. The preparation equipment of the nifedipine permeate pump composition according to claim 5, characterized in that: the sealing structure (7) comprises a sealing cover (71), the bottom end of the material bottle (42) is connected with the sealing cover (71) in a sliding mode, a tooth groove (72) is formed in the bottom side of the sealing cover (71), a pulling plate (73) is abutted to the bottom side of the sealing cover (71), the pulling plate (73) is meshed with the sealing cover (71) through the tooth groove (72), the sealing cover (71) and the pulling plate (73) are both obliquely arranged, the pulling plate (73) is connected with the mounting groove (41) in a sliding mode, and a sixth spring (74) is fixedly connected between the pulling plate (73) and the mounting groove (41).

8. The apparatus for preparing nifedipine permeate pump composition according to claim 7, characterized in that: the side sliding connection of mounting groove (41) has control piece (76), fixedly connected with seventh spring (77) between control piece (76) and mounting groove (41), fixedly connected with clamping column (78) on control piece (76), the tip of clamping column (78) is contradicted in arm-tie (73), draw-in groove (75) have been seted up to the bottom side of arm-tie (73).

9. The preparation equipment of the nifedipine permeate pump composition according to claim 1, characterized in that: the cleaning structure (5) comprises a rocker (51), the side face of the device main body (1) is rotatably connected with the rocker (51), an air cavity (53) is formed in the device main body (1), a fan plate (54) is fixedly connected to the rocker (51), an air guide block (55) is arranged on the side face of the device main body (1), two ends of the air guide block (55) are respectively and fixedly connected with a rotating shaft (56), the air guide block (55) is rotatably connected with the device main body (1) through the rotating shaft (56), a worm wheel (57) is fixedly connected to the rotating shaft (56), an adjusting worm (52) is meshed with the side face of the worm wheel (57), and the adjusting worm (52) is rotatably connected with the device main body (1).

10. The process for preparing apparatus for nifedipine permeate pump composition according to any one of claims 1 to 9, characterized in that: the method comprises the following steps:

s1: firstly, when the nifedipine osmotic pump composition is prepared, the drug powder and the propellant powder need to be subjected to double-layer pressing, the prepared drug powder and the propellant powder are added through a blanking structure (4) respectively, and a closed structure (7) is arranged in the blanking structure (4), so that the blanking amount of the powder can be conveniently adjusted, and meanwhile, the residual materials are conveniently recovered;

s2: after the feeding of the powder is completed through the blanking structure (4), a user can realize the quantitative extraction and layered stacking process of the two powders through the groove matching structure (3), simultaneously the extracted powders can be simultaneously positioned in the same hole groove, and then the two powders are pressed by matching the hydraulic rod (2), so that the double-layer tabletting of the two powders is realized, the components on two sides in the tablet are uniformly layered and are not doped, and the medicament components are ensured to have good slow release effect;

s3: after completing the cycle of tabletting operation through the blanking structure (4), a user needs to eject the tablets in the pore grooves through the jacking structure (6) so as to conveniently take out and collect the tablets, and after completing the processing of the tablets, a semipermeable membrane needs to be coated outside the tablets through a subsequent process, and micro-pore opening is carried out on the coated semipermeable membrane, so that the preparation of the nifedipine osmotic pump composition is completed;

s4: finally, after the tablet pressing process is completed, a user can clean the powder remained on the surface of the device through the cleaning structure (5), so that the maintenance of the device is facilitated.

Technical Field

The invention relates to the technical field of nifedipine osmotic pump sustained release, in particular to a preparation device and a preparation process of a nifedipine osmotic pump composition.

Background

Nifedipine, also known as 1, 4-dihydro-2, 6-dimethyl-4- (2-nitrophenyl) -3, 5-pyridinedicarboxylic acid dimethyl ester, is a dihydropyridine calcium antagonist used for the prevention and treatment of coronary heart disease angina, especially angina pectoris caused by variant angina pectoris and coronary artery spasm. Has no adverse effect on respiratory function, is suitable for angina pectoris patients with respiratory tract obstruction diseases, and has better curative effect than beta receptor antagonist. It is also suitable for various types of hypertension, and has good curative effect on intractable and severe hypertension. Because of reducing afterload, the medicine also has good curative effect on intractable congestive heart failure, and is suitable for long-term administration. In order to enable the drug effect of nifedipine to be continuously exerted, a process of an osmotic pump tablet is needed to play a sustained release effect on the drug, so that the drug taking frequency of a patient is reduced.

Carry out nifedipine osmotic pump tablet at present and add man-hour, need carry out double-deck suppression to the tablet core, traditional single punching press piece equipment only can carry out the suppression of individual layer tablet, is difficult to guarantee the clear and definite layering between two kinds of powders when adopting the manual interpolation that carries out two kinds of powders simultaneously, probably leads to the slow-release effect of tablet relatively poor, accomplishes the processing back simultaneously, and the powder of remaining on the device is difficult to the clearance.

Disclosure of Invention

Aiming at the problems in the prior art, the invention provides a preparation device and a preparation process of a nifedipine osmotic pump composition.

The technical scheme adopted by the invention for solving the technical problems is as follows: the utility model provides a preparation equipment of nifedipine permeate pump composition, includes the device main part, the hydraulic stem is installed on the top side of device main part, the bottom side of hydraulic stem is equipped with and joins in marriage the groove structure, the bottom side of joining in marriage the groove structure is equipped with the jack-up structure, the both sides of hydraulic stem are equipped with blanking structure, enclosed construction is installed to blanking structure's inboard, the internally mounted of device main part has clean structure.

Specifically, the groove matching structure comprises a first fan plate and a second fan plate, the first fan plate and the second fan plate are stacked, the first fan plate and the second fan plate are rotatably connected with the device main body, the first fan plate and the second fan plate are respectively provided with a pressure sheet groove, the end parts of the first fan plate and the second fan plate are rotatably connected with a connecting rod, the other ends of the two connecting rods are rotatably connected with a traction block, a second spring is fixedly connected between the traction block and the inner side of the device main body, the side surface of the traction block is rotatably connected with a pulley, the side surface of the traction block is abutted against a push-pull rod through the pulley, the end part of the push-pull rod is rotatably connected with the device main body, a splash-proof sleeve is slidably connected on the hydraulic rod, a first spring is fixedly connected between the splash-proof sleeve and the hydraulic rod, and the inner diameter of the splash-proof sleeve is larger than the diameter of the pressure sheet groove, the area of the first fan plate is smaller than that of the second fan plate.

Specifically, the jacking structure comprises a traction slide bar, the inner side of the device body is connected with the traction slide bar in a sliding mode, the end portion of the traction slide bar is fixedly connected with a fourth spring on the inner side of the device body, the side face of the traction slide bar is abutted to the push-pull rod, the other end of the traction slide bar is fixedly connected with a first rack, the side face of the first rack is meshed with a reversing gear, the side face of the reversing gear is meshed with a second rack, the first rack and the second rack are vertically arranged, the top end of the second rack is fixedly connected with a jacking rod in a vertical mode, the jacking rod is connected with the device body in a sliding mode, a fifth spring is fixedly connected between the second rack and the device body, the number of the jacking rods is four, and the four jacking rods are distributed on the top side of the second rack in a diamond shape.

Concretely, blanking structure includes the mounting groove, the bilateral symmetry of hydraulic stem is equipped with two mounting grooves, fixed connection between the side of mounting groove and the device main part, the inboard sliding connection of mounting groove has the storage bottle, protruding circle and mounting groove looks block are passed through in the outside of storage bottle, the bottom fixedly connected with passage of mounting groove, two the bottom of passage is inconsistent with the surface of first fan board and second fan board respectively, the bottom side of second fan board is equipped with the touch panel, touch panel and second fan board sliding connection, the side and the device main part sliding connection of touch panel, the bottom side of touch panel is contradicted and is had the locating piece, fixedly connected with third spring between locating piece and the device main part.

Specifically, the enclosed construction includes sealed lid, the bottom sliding connection of storage bottle has sealed lid, the tooth's socket has been seted up to the bottom side of sealed lid, the bottom side of sealed lid is contradicted there is the arm-tie, just the arm-tie passes through tooth's socket and sealed lid and meshes mutually, sealed lid and arm-tie all are the slope setting, sliding connection between arm-tie and the mounting groove, just fixedly connected with sixth spring between arm-tie and the mounting groove, the side sliding connection of mounting groove has the control block, fixedly connected with seventh spring between control block and the mounting groove, fixedly connected with clamping column on the control block, the tip of clamping column is contradicted in the arm-tie, the draw-in groove has been seted up to the bottom side of arm-tie.

Specifically, the cleaning structure comprises a rocker, the side face of the device main body is connected with the rocker in a rotating mode, an air cavity is formed in the device main body, a fan plate is fixedly connected to the rocker, an air guide block is arranged on the side face of the device main body, rotating shafts are fixedly connected to two ends of the air guide block respectively, the air guide block is connected with the device main body in a rotating mode through the rotating shafts, a worm wheel is fixedly connected to the rotating shafts, an adjusting worm is meshed with the side face of the worm wheel, and the adjusting worm is connected with the device main body in a rotating mode.

Specifically, the preparation process of the preparation equipment of the nifedipine permeate pump composition comprises the following steps:

s1: firstly, when the nifedipine osmotic pump composition is prepared, the drug powder and the propellant powder need to be subjected to double-layer pressing, the prepared drug powder and the propellant powder are added through a blanking structure respectively, a closed structure is arranged in the blanking structure, the blanking amount of the powder can be conveniently adjusted, and meanwhile, the surplus materials are conveniently recovered.

S2: accomplish the interpolation back of powder through blanking structure, the user can realize carrying out the process that the ration was drawed and the layering stacks to two kinds of powders through joining in marriage the groove structure, makes the powder of drawing simultaneously to be located same hole inslot, then cooperates the hydraulic stem to suppress, realizes the double-deck preforming to two kinds of powders to guarantee that the composition layering of both sides is even not taken place to dope in the tablet, guarantees that the medicament composition has good slowly-releasing effect.

S3: after accomplishing the circulation of a preforming operation through blanking structure, the user need come ejecting to the tablet in the hole groove through the jack-up structure, conveniently collects taking out of tablet, and the tablet is accomplished the processing back, need wrap the pellicle outside the preforming through subsequent technology to carry out the micro-opening to the pellicle of cladding, accomplish the preparation to nifedipine permeate pump composition promptly.

S4: finally, after the tablet pressing process is completed, a user can clean the powder remained on the surface of the device through the cleaning structure, and the maintenance of the device is facilitated.

The invention has the beneficial effects that:

(1) according to the preparation equipment and the preparation process of the nifedipine osmotic pump composition, the bottom side of the hydraulic rod is provided with the matched groove structure, the bottom side of the matched groove structure is provided with the jacking structure, double-layer tabletting can be realized through the matched groove structure, the smoothness of a pressing interface is ensured, and a user can conveniently take out tablets after pressing through the jacking structure, namely: firstly, a first fan plate and a second fan plate are arranged on the side surface of a device main body, the first fan plate is arranged on the top side of the second fan plate, the area of the first fan plate is smaller than that of the second fan plate, the first fan plate and the second fan plate can rotate around the same point on the device main body, the first fan plate and the second fan plate are provided with pressing sheet grooves, the pressing sheet grooves on the two fan plates can be aligned or staggered through rotating the first fan plate and the second fan plate, meanwhile, the pressing sheet grooves on the first fan plate are always positioned on the second fan plate in the rotating range due to the fact that the area of the first fan plate is smaller than that of the second fan plate, the end parts of the two fan plates are connected with connecting rods, the other ends of the two connecting rods are provided with pulling blocks, when the pulling blocks slide in the device main body, the first fan plate and the second fan plate can be driven to reversely rotate, so that the overlapping and the staggering of the two pressing sheet grooves are controlled, and under the static state, through the push of the second spring, the two tablet grooves are in an overlapped state, and meanwhile, in order to drive the fan plates, a user can drive the traction block by pulling the push-pull rod positioned on the side face of the device body to enable the overlapped tablet grooves to be staggered, on the other hand, when the device is in a static state, the top side of the tablet grooves is provided with a hydraulic rod, powder in the tablet grooves can be extruded through the hydraulic rod, the outer side of the hydraulic rod is provided with a splash-proof sleeve which can prevent the powder from splashing out when the hydraulic rod is used for pressing, after the hydraulic rod completes a punching process, in order to take out tablets in a groove hole formed by overlapping the tablet grooves on the first fan plate and the second fan plate conveniently, at the moment, the user can push the push-pull rod to the other side, at the moment, the push-pull rod drives the traction slide rod on the other side, the first rack at the other end of the traction slide rod can continuously drive the second rack to vertically move upwards through the reversing gear, four jacking rods distributed in a diamond shape are arranged on the second rack, and the jacking rods can extend out and push out the pressing sheet in the slot hole, so that a user can extract the pressing sheet conveniently.

(2) According to the preparation equipment and the preparation process of the nifedipine permeate pump composition, the two sides of the hydraulic rod are provided with the blanking structures, the inner sides of the blanking structures are provided with the closed structures, two kinds of powder can be conveniently added at the same time through the blanking structures, and excess materials can be conveniently recycled through the closed structures, namely: when the tablet pressing is formally carried out, a user firstly needs to add two kinds of raw material powder into two material bottles on two sides respectively, after the addition is finished, the powder can flow downwards and is remained to the surface of a first fan plate or a second fan plate along a material guide pipe on the bottom side, meanwhile, because the lengths of the two material guide pipes on the two sides are different, the bottom ends of the material guide pipes on the two sides can be respectively and tightly abutted against the surfaces of the first fan plate and the second fan plate, the powder seepage is avoided, in the feeding stage, the user pulls a push-pull rod, the first fan plate and the second fan plate start to rotate, when the two material guide pipes rotate to the maximum angle, the two tablet pressing grooves are respectively aligned with the material guide pipes on the same side, so that the powder continuously flows, the tablet pressing grooves corresponding to be filled under the gravity are filled, then the push-pull rod is released by the user, the first fan plate and the second fan plate rotate, the powder filling device simultaneously carries the filled powder to rotate until the two tabletting grooves are overlapped again, the addition of double-layer medicament is completed at the moment, the connection surface of the two powders has good flatness due to the horizontal movement of the first fan plate and the second fan plate, meanwhile, the punching and tabletting operation can be started through a hydraulic rod along with the overlapping of the two tabletting grooves, on the other hand, the bottom side of the second fan plate is provided with a touch plate capable of freely sliding, the touch plate repeatedly contacts with the powder in the rotating process of the second fan plate, the cleaning is convenient, after the tabletting production is completed, if more residual materials still exist in the material bottle, in order to conveniently recover the residual materials, the end part of the material bottle is provided with an obliquely arranged sealing cover, the bottom side of the sealing cover is meshed with a pull plate through a tooth socket, after the material bottle is placed in the mounting groove, a user can pull the pull plate to slide the sealing cover, thereby open the storage bottle, make the powder begin to flow, and opening and shutting of arm-tie can also fix a position through control block and block post, keep the state that sealed lid opened, and when needing to retrieve the clout, the user can relieve the positioned state to the arm-tie through the control block, sealed lid reseals under the promotion of sixth spring this moment, can directly take out the storage bottle this moment, sealed lid is the slant setting, make the powder be difficult to appear revealing, can make things convenient for the flow of powder simultaneously under the state of opening.

(3) According to the preparation equipment and the preparation process of the nifedipine permeate pump composition, the cleaning structure is arranged in the device main body, and powder remained on the surface of the device can be quickly cleaned through the cleaning structure, namely: after the pressure plate link, more cuttings may be remained in the position of device suppression, in order to get rid of the cuttings fast, the user can wave the rocker that is located the side of device body, make the inboard sector of device body begin to rotate, and produce the cuttings of air current to corresponding direction by the exit position of air guide block and blow away, the user can also rotate the regulation worm simultaneously, the transmission through the worm wheel drives the air guide block and takes place to rotate around the pivot, and then the direction of change air current, reach more comprehensive clean effect, the convenience is to the routine maintenance of device.

Drawings

The invention is further illustrated with reference to the following figures and examples.

FIG. 1 is a schematic structural diagram of the overall structure of a preferred embodiment of the apparatus for preparing nifedipine permeate pump compositions provided by the present invention;

FIG. 2 is a schematic view of a connection structure of the groove arrangement and the cleaning arrangement shown in FIG. 1;

FIG. 3 is an enlarged view of the structure A shown in FIG. 2;

FIG. 4 is a schematic view of the connection of the device body and the mating groove structure shown in FIG. 1;

FIG. 5 is a schematic view showing a coupling structure of the apparatus body and the cleaning structure shown in FIG. 1;

FIG. 6 is a schematic view showing a connection structure of the groove fitting structure and the jack-up structure shown in FIG. 2

FIG. 7 is an enlarged view of the structure B shown in FIG. 6

FIG. 8 is an enlarged view of the structure C shown in FIG. 6;

fig. 9 is a flow chart of a preparation process of the nifedipine permeate pump composition provided by the invention.

In the figure: 1. the device comprises a device body, 2, a hydraulic rod, 3, a groove matching structure, 31, a first fan plate, 32, a second fan plate, 33, a push-pull rod, 34, a pressing sheet groove, 35, a connecting rod, 36, a pulling block, 37, a pulley, 38, a splash-proof sleeve, 39, a first spring, 39a, a second spring, 4, a blanking structure, 41, a mounting groove, 42, a material bottle, 43, an abutting plate, 44, a convex ring, 45, a material guide pipe, 46, a positioning block, 47, a third spring, 5, a cleaning structure, 51, a rocker, 52, an adjusting worm, 53, an air cavity, 54, a fan plate, 55, an air guide block, 56, a rotating shaft, 57, a worm gear, 6, a jacking structure, 61, a pulling slide rod, 62, a fourth spring, 63, a first rack, 64, a reversing gear, 65, a second rack, 66, a fifth spring, 67, a jacking rod, 7, a sealing structure, 71, a sealing cover, 72, a tooth grooves, 73, a pulling plates, 74, a groove 73, a pulling plates, 74, a groove, Sixth spring, 75, card slot, 76, control block, 77, seventh spring, 78, joint post.

Detailed Description

In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.

As shown in fig. 1 to 9, the apparatus for preparing a nifedipine permeate pump composition comprises an apparatus main body 1, a hydraulic rod 2 is installed on the top side of the apparatus main body 1, a distribution groove structure 3 is arranged on the bottom side of the hydraulic rod 2, a jacking structure 6 is arranged on the bottom side of the distribution groove structure 3, blanking structures 4 are arranged on two sides of the hydraulic rod 2, a sealing structure 7 is installed on the inner side of the blanking structures 4, and a cleaning structure 5 is installed inside the apparatus main body 1.

Specifically, the groove matching structure 3 includes a first sector plate 31 and a second sector plate 32, the first sector plate 31 and the second sector plate 32 are stacked, the first sector plate 31 and the second sector plate 32 are rotatably connected with the device main body 1, the first sector plate 31 and the second sector plate 32 are both provided with a tablet pressing groove 34, the end portions of the first sector plate 31 and the second sector plate 32 are both rotatably connected with a connecting rod 35, the other ends of the two connecting rods 35 are rotatably connected with a pulling block 36, a second spring 39a is fixedly connected between the pulling block 36 and the inner side of the device main body 1, the side surface of the pulling block 36 is rotatably connected with a pulley 37, the side surface of the pulling block 36 is abutted with a push rod 33 through the pulley 37, the end portion of the push rod 33 is rotatably connected with the device main body 1, the hydraulic rod 2 is slidably connected with a splash-proof sleeve 38, a first spring 39 is fixedly connected between the splash-proof sleeve 38 and the hydraulic rod 2, the inner diameter of the splash-proof sleeve 38 is larger than the diameter of the pressing sheet groove 34, and the area of the first fan plate 31 is smaller than that of the second fan plate 32; namely: firstly, the first fan board 31 and the second fan board 32 are arranged on the side surface of the device main body 1, the first fan board 31 is arranged on the top side of the second fan board 32 and has an area smaller than that of the second fan board 32, both the first fan board 31 and the second fan board 32 can rotate around the same point on the device main body 1, the first fan board 31 and the second fan board 32 are provided with the pressing sheet groove 34, the pressing sheet grooves 34 on the two fan boards can be aligned or dislocated by rotating the first fan board 31 and the second fan board 32, meanwhile, the pressing sheet groove 34 on the first fan board 31 is always positioned on the second fan board 32 in the rotating range due to the fact that the area of the first fan board 31 is smaller than that of the second fan board 32, the end portions of the two fan boards are connected with the connecting rods 35, and the other ends of the two connecting rods 35 are provided with the pulling block 36, when the pulling block 36 slides in the device body 1, the first fan plate 31 and the second fan plate 32 are driven to rotate reversely, so as to control the overlapping and dislocation of the two pressing sheet grooves 34, and in a static state, the two pressing sheet grooves 34 are in an overlapping state by the pushing of the second spring 39a, and meanwhile, in order to drive the fan plates, a user can drive the pulling block 36 by pulling the push-pull rod 33 located on the side surface of the device body 1, so as to make the overlapped pressing sheet grooves 34 rotate and stagger, on the other hand, when the device is in a static state as a whole, the hydraulic rod 2 is arranged on the top side of the pressing sheet groove 34, the powder in the pressing sheet groove 34 can be squeezed by the hydraulic rod 2, and the anti-splash sleeve 38 is arranged outside the hydraulic rod 2, the powder can be prevented from splashing when the hydraulic rod 2 is pressed.

In particular, the jacking structure 6 comprises a pulling slide rod 61, the pulling slide rod 61 is connected with the inner side of the device body 1 in a sliding way, a fourth spring 62 is fixedly connected to the end of the pulling slide 61 and the inner side of the apparatus body 1, the side surface of the traction sliding rod 61 is abutted against the push-pull rod 33, the other end of the traction sliding rod 61 is fixedly connected with a first rack 63, a reversing gear 64 is meshed with the side surface of the first rack 63, a second rack 65 is meshed with the side surface of the reversing gear 64, the first rack 63 and the second rack 65 are arranged perpendicularly to each other, and the top end of the second rack 65 is vertically and fixedly connected with a jacking rod 67, the jacking rod 67 is in sliding connection with the device main body 1, a fifth spring 66 is fixedly connected between the second rack 65 and the device main body 1, four jacking rods 67 are arranged, and the four jacking rods 67 are distributed on the top side of the second rack 65 in a rhombic shape; namely: after the hydraulic rod 2 completes a stamping process, in order to facilitate taking out a tablet in a slot formed by overlapping tablet slots 34 on the first sector plate 31 and the second sector plate 32, at this time, a user can push the push-pull rod 33 to the other side, at this time, the push-pull rod 33 drives the pull slide rod 61 on the other side back, the first rack 63 at the other end of the pull slide rod 61 can continue to drive the second rack 65 to move vertically and upwards through the reversing gear 64, the second rack 65 is provided with four jacking rods 67 distributed in a diamond shape, at this time, the jacking rods 67 will extend out and jack out the tablet in the slot, and the user can take out the tablet conveniently.

Specifically, the blanking structure 4 includes an installation groove 41, two installation grooves 41 are symmetrically arranged on two sides of the hydraulic rod 2, a side surface of each installation groove 41 is fixedly connected with the device main body 1, a material bottle 42 is slidably connected to an inner side of each installation groove 41, an outer side of each material bottle 42 is clamped with the installation groove 41 through a convex ring 44, a material guide pipe 45 is fixedly connected to a bottom end of each installation groove 41, bottom ends of the two material guide pipes 45 respectively abut against the surfaces of the first fan plate 31 and the second fan plate 32, a contact plate 43 is arranged on a bottom side of the second fan plate 32, the contact plate 43 is slidably connected with the second fan plate 32, a side surface of the contact plate 43 is slidably connected with the device main body 1, a positioning block 46 is arranged on a bottom side of the contact plate 43, and a third spring 47 is fixedly connected between the positioning block 46 and the device main body 1; namely: during the formal tabletting process, a user first needs to add two kinds of raw powder into the two material bottles 42 on two sides, after the addition is completed, the powder flows downward, and the powder is retained on the surfaces of the first fan plate 31 or the second fan plate 32 along the material guiding pipes 45 on the bottom side, meanwhile, because the lengths of the two material guiding pipes 45 on the two sides are not consistent, the bottom ends of the material guiding pipes 45 on the two sides can be tightly abutted against the surfaces of the first fan plate 31 and the second fan plate 32 respectively, so as to avoid the seepage of the powder, during the loading stage, the user pulls the push-pull rod 33, at this moment, the first fan plate 31 and the second fan plate 32 start to rotate, and after the two fan plates rotate to the maximum angle, at this moment, the two tablet pressing grooves 34 are respectively aligned with the material guiding pipes 45 on the same side, so that the powder continues to flow and the corresponding tablet pressing grooves 34 are filled up under the gravity, then, the user releases the push-pull rod 33, at this time, the first fan plate 31 and the second fan plate 32 rotate and simultaneously carry the loaded powder to rotate, until after the two tablet pressing grooves 34 are overlapped again, the addition of the double-layer powder is completed at this time, due to the horizontal movement of the first fan plate 31 and the second fan plate 32, the connection surface of the two powders has good flatness, and simultaneously, with the overlapping of the two tablet pressing grooves 34, the stamping and tablet pressing operation can also be started through the hydraulic rod 2, on the other hand, the bottom side of the second fan plate 32 is provided with the contact plate 43 which can slide freely, and the contact plate 43 repeatedly contacts with the powder in the rotation process of the second fan plate 32, so that the cleaning is convenient.

Specifically, the closed structure 7 includes a sealing cover 71, the bottom end of the material bottle 42 is slidably connected with the sealing cover 71, a tooth groove 72 is formed in the bottom side of the sealing cover 71, a pulling plate 73 is abutted against the bottom side of the sealing cover 71, the pulling plate 73 is engaged with the sealing cover 71 through the tooth groove 72, the sealing cover 71 and the pulling plate 73 are both arranged in an inclined manner, the pulling plate 73 is slidably connected with the mounting groove 41, a sixth spring 74 is fixedly connected between the pulling plate 73 and the mounting groove 41, a control block 76 is slidably connected to the side surface of the mounting groove 41, a seventh spring 77 is fixedly connected between the control block 76 and the mounting groove 41, an engaging column 78 is fixedly connected to the control block 76, the end of the engaging column 78 is abutted against the pulling plate 73, and a engaging groove 75 is formed in the bottom side of the pulling plate 73; namely: after the production of the tablet is completed, if there is still more residue in the material bottle 42, in order to facilitate the recovery of the residue, the end of the material bottle 42 is provided with the sealing cover 71 which is obliquely arranged, and the bottom side of the sealing cover 71 is engaged with the pulling plate 73 through the tooth socket 72, after the material bottle 42 is placed in the mounting groove 41, a user can pull the pulling plate 73 to slide the sealing cover 71, thereby opening the material bottle 42, so that the powder starts to flow, and the opening and closing of the pulling plate 73 can also be positioned through the control block 76 and the engaging column 78, so as to maintain the state that the sealing cover 71 is opened, and when the residue needs to be recovered, the user can release the positioning state of the pulling plate 73 through the control block 76, and at this time, the sealing cover 71 reseals under the pushing of the sixth spring 74, at this time, the material bottle 42 can be directly taken out, and the sealing cover 71 is obliquely arranged, so that the powder is difficult to leak, and the powder can conveniently flow under the opening state.

Specifically, the cleaning structure 5 comprises a rocker 51, the side surface of the device main body 1 is rotatably connected with the rocker 51, an air cavity 53 is formed in the device main body 1, a fan plate 54 is fixedly connected to the rocker 51, an air guide block 55 is arranged on the side surface of the device main body 1, two ends of the air guide block 55 are respectively and fixedly connected with a rotating shaft 56, the air guide block 55 is rotatably connected with the device main body 1 through the rotating shaft 56, a worm wheel 57 is fixedly connected to the rotating shaft 56, an adjusting worm 52 is meshed with the side surface of the worm wheel 57, and the adjusting worm 52 is rotatably connected with the device main body 1; namely: after the end of the segment pressing ring, more powder possibly remains at the pressing position of the device, in order to quickly remove the powder, a user can rock the rocker 51 positioned on the side surface of the device body 1, so that the fan plate 54 on the inner side of the device body 1 starts to rotate, air flow is generated at the outlet position of the air guide block 55 to blow away the powder in the corresponding direction, meanwhile, the user can rotate the adjusting worm 52, the air guide block 55 is driven to rotate around the rotating shaft 56 through the transmission effect of the worm wheel 57, the direction of the air flow is changed, a more comprehensive cleaning effect is achieved, and the daily maintenance of the device is facilitated.

Specifically, referring to fig. 9, fig. 9 is a flow chart of a preparation process of a preparation apparatus of a nifedipine permeate pump composition provided by the present invention, and the preparation process of the preparation apparatus of the nifedipine permeate pump composition is characterized in that: the method comprises the following steps:

s1: firstly, when the nifedipine osmotic pump composition is prepared, the drug powder and the propellant powder need to be subjected to double-layer pressing, the prepared drug powder and the propellant powder are added through the blanking structure 4 respectively, the sealing structure 7 is arranged in the blanking structure 4, the blanking amount of the powder can be conveniently adjusted, and meanwhile, the surplus materials are conveniently recycled.

S2: accomplish the interpolation back of powder through blanking structure 4, the user can realize carrying out the ration to two kinds of powders through joining in marriage groove structure 3 and draw and the process that the layering stacks, makes the powder of drawing simultaneously to be located same hole inslot, then cooperates hydraulic stem 2 to suppress, realizes the double-deck preforming to two kinds of powders to guarantee that the composition layering of both sides is even not taken place to dope in the tablet, guarantees that the medicament composition has good slowly-releasing effect.

S3: after accomplishing the circulation of a preforming operation through blanking structure 4, the user need come ejecting to the tablet in the hole groove through jack-up structure 6, conveniently to the collection of taking out of tablet, and the tablet is accomplished the processing back, need wrap the pellicle outside the preforming through subsequent technology to carry out the micro-opening to the pellicle of cladding, accomplish the preparation to nifedipine osmotic pump composition promptly.

S4: finally, after the tablet pressing process is completed, the user can clean the powder remained on the surface of the device through the cleaning structure 5, so that the maintenance of the device is facilitated.

When the invention is used, firstly, a first fan plate 31 and a second fan plate 32 are arranged on the side surface of a device main body 1, the first fan plate 31 is arranged on the top side of the second fan plate 32, the area of the first fan plate 31 is smaller than that of the second fan plate 32, the first fan plate 31 and the second fan plate 32 can rotate around the same point on the device main body 1, the first fan plate 31 and the second fan plate 32 are provided with a pressure sheet groove 34, the pressure sheet grooves 34 on the first fan plate 31 can be aligned or staggered by rotating the first fan plate 31 and the second fan plate 32, meanwhile, the pressure sheet groove 34 on the first fan plate 31 is always positioned on the second fan plate 32 in the rotating range due to the fact that the area of the first fan plate 31 is smaller than that of the second fan plate 32, the end parts of the two fan plates are connected with a connecting rod 35, the other ends of the two connecting rods 35 are provided with a pulling block 36, when the pulling block 36 slides in the device main body 1, the first fan plate 31 and the second fan plate 32 can be driven to reversely rotate, thereby controlling the overlapping and dislocation of the two tablet grooves 34, and in the static state, the two tablet grooves 34 are in the overlapping state by the push of the second spring 39a, and in order to drive the fan plate, the user can drive the pulling block 36 by pulling the push-pull rod 33 located at the side of the device main body 1, so as to make the overlapped tablet grooves 34 rotate and stagger, on the other hand, when the device is in the static state as a whole, the top side of the tablet groove 34 is provided with the hydraulic rod 2, the powder in the tablet groove 34 can be pressed by the hydraulic rod 2, and the outer side of the hydraulic rod 2 is provided with the splash-proof sleeve 38, so as to prevent the powder from splashing out when the hydraulic rod 2 is used for pressing, after the hydraulic rod 2 completes a punching process, in order to conveniently take out the tablet in the groove hole formed by overlapping the tablet grooves 34 on the first fan plate 31 and the second fan plate 32, at this time, the user can push the push-pull rod 33 to the other side, at this time, the push-pull rod 33 drives the pulling slide rod 61 on the other side, the first rack 63 at the other end of the pulling slide rod 61 can continue to drive the second rack 65 to move vertically and upwardly through the reversing gear 64, the second rack 65 is provided with four jacking rods 67 distributed in a diamond shape, at this time, the jacking rods 67 will extend out and push out the pressing sheet located in the slot hole, so that the user can conveniently extract the pressing sheet, when formally performing pressing sheet processing, the user firstly needs to add two kinds of raw material powders into the two material bottles 42 on both sides, after the addition is completed, the powders will flow downwardly and remain on the surface of the first sector plate 31 or the second sector plate 32 along the material guide tubes 45 on the bottom side, and simultaneously, because the lengths of the two material guide tubes 45 on both sides are inconsistent, the bottom ends of the material guide tubes 45 on both sides can respectively tightly abut against the surfaces of the first sector plate 31 and the second sector plate 32, the powder seepage is avoided, in the feeding stage, a user pulls the push-pull rod 33, the first fan plate 31 and the second fan plate 32 start to rotate, after the first fan plate 31 and the second fan plate 32 rotate at the maximum angle, the two tablet grooves 34 are respectively aligned with the material guide pipes 45 on the same side, so that the powder continues to flow and the corresponding tablet grooves 34 are filled under the gravity, then the user releases the push-pull rod 33, the first fan plate 31 and the second fan plate 32 rotate and simultaneously carry the filled powder to rotate, until the two tablet grooves 34 are overlapped again, the double-layer addition of the medicament is completed, due to the horizontal movement of the first fan plate 31 and the second fan plate 32, the connecting surface of the two powders has good flatness, and meanwhile, along with the overlapping of the two tablet grooves 34, the punching and tablet pressing operation can also start to be carried out through the hydraulic rod 2, on the other hand, the bottom side of the second fan plate 32 is provided with a freely sliding abutting plate 43, the abutting plate 43 repeatedly contacts with the powder during the rotation of the second fan plate 32, so that the cleaning is convenient, after the tablet production is completed, if more excess materials still exist in the material bottle 42, in order to facilitate the recovery of the excess materials, the end part of the material bottle 42 is provided with a sealing cover 71 which is obliquely arranged, the bottom side of the sealing cover 71 is meshed with a pulling plate 73 through a tooth socket 72, after the material bottle 42 is placed in the mounting groove 41, a user can pull the pulling plate 73 to slide the sealing cover 71, so that the material bottle 42 is opened, so that the powder starts to flow, the opening and closing of the pulling plate 73 can be positioned through a control block 76 and a clamping column 78, the opening state of the sealing cover 71 is kept, and when the excess materials need to be recovered, the positioning state of the pulling plate 73 can be released through the control block 76 by the user, at this time, the sealing cover 71 is resealed under the push of the sixth spring 74, and at this time, the material bottle 42 can be directly taken out, the sealing cover 71 is obliquely arranged, so that the powder is difficult to leak, and the flow of the powder can be facilitated under the opening state, after the end of the segment pressing ring, there may be more powder left at the pressing position of the device, and in order to remove the powder rapidly, the user may shake the rocking bar 51 located at the side of the device body 1, so that the fan plate 54 inside the device body 1 starts to rotate, and the airflow generated by the outlet position of the air guide block 55 blows off the powder scraps in the corresponding direction, meanwhile, the user can rotate the adjusting worm 52, drive the air guide block 55 to rotate around the rotating shaft 56 through the transmission action of the worm wheel 57, and then change the direction of air current, reach more comprehensive clean effect, the convenient routine maintenance to the device.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.