阅读说明：本技术 可调控取栓装置 (Adjustable bolt taking device ) 是由 穆磊 程文杰 许永松 王孟静 范文吉 武永昭 于 2021-08-24 设计创作，主要内容包括：本公开涉及一种可调控取栓装置,包括：可调节手柄,具有中空结构；可调节手柄包括调节旋钮；调节细丝,近端与调节旋钮相连接,可在调节旋钮的调节下实现转动和/或轴向移动；输送导管,近端插接在可调节手柄的中空结构中,套设在调节细丝之外；取栓支架,近端与调节细丝的远端相连接,在调节细丝的拉动下实现膨胀或收缩；通过调节旋钮及调节细丝还可以调节多组成单元取栓支架的单元的打开顺序；导向部件,与取栓支架的远端相连接。在使用时,通过旋转或推拉调节旋钮实现取栓支架在病变部位的膨胀打开,从而实现对血栓的捕获并随装置取出。(The present disclosure relates to an adjustable bolt taking device, including: an adjustable handle having a hollow structure; the adjustable handle comprises an adjusting knob; the adjusting filament, the near end of which is connected with the adjusting knob, can realize rotation and/or axial movement under the adjustment of the adjusting knob; the near end of the conveying conduit is inserted into the hollow structure of the adjustable handle and sleeved outside the adjusting filament; the thrombus taking support, the near end of which is connected with the far end of the adjusting filament, realizes expansion or contraction under the pulling of the adjusting filament; the opening sequence of the units of the multi-component embolectomy support can be adjusted through the adjusting knob and the adjusting filaments; and the guide part is connected with the far end of the embolectomy bracket. When the thrombus taking device is used, the thrombus taking support is expanded and opened at a lesion part by rotating or pushing and pulling the adjusting knob, so that thrombus is captured and taken out along with the thrombus taking device.)

1. An adjustable embolectomy device, the device comprising:

an adjustable handle having a hollow structure, the adjustable handle including an adjustment knob;

an adjusting filament, a proximal end of the adjusting filament being connected with the adjusting knob, the adjusting filament being configured to be rotated and/or axially moved by adjustment of the adjusting knob;

the proximal end of the conveying catheter is inserted into the hollow structure of the adjustable handle, and the conveying catheter is sleeved outside the adjusting filament;

a thrombectomy stent, wherein the proximal end of the thrombectomy stent is connected with the distal end of the adjusting filament, and the thrombectomy stent is configured to expand or contract under the pulling of the adjusting filament.

2. The adjustable deadbolt assembly of claim 1, wherein the adjustment mode of the adjustment knob comprises at least one of:

a rotating mode and a push-pull mode.

3. The adjustable embolectomy device of claim 1, further comprising:

the guide part is connected with the far end of the bolt taking support and comprises a developing spring, and a ball head is arranged on the developing spring.

4. The controllable embolectomy device of claim 1, wherein the embolectomy support comprises one basket or a plurality of baskets connected in series.

5. The controllable embolectomy device of claim 4, wherein at least a portion of the proximal and/or distal ends of the basket are provided with a visible marking.

6. The controllable embolectomy device of claim 4, wherein the basket is provided with macro-mesh capture zones or thrombus capture pockets.

7. The adjustable embolectomy device of claim 4, wherein the basket is a wire-woven structure or a laser-engraved structure.

8. The adjustable embolectomy device of claim 7, wherein the wire diameter of the wire braid structure is in the range of 0.03-0.12 mm.

9. The adjustable bolt taking device as claimed in claim 7, wherein the width of the support rib of the laser engraving structure is in the range of 0.04-0.12 mm, and the thickness of the support rib is in the range of 0.03-0.10 mm.

10. The adjustable bolt taking device as claimed in claim 3, wherein the wire diameter range of the developing spring is 0.02-0.06 mm;

the length range of the developing spring is 5-15 mm;

the diameter range of the developing spring is 0.2-0.5 mm.

11. The adjustable and controllable embolectomy device of claim 1, wherein the overall length of the embolectomy support is adjusted within a range of 10-60 mm;

the adjusting range of the diameter of the thrombus taking support is 1.0-6.0 mm.

12. The controllable embolectomy device of claim 4, wherein the basket at the distal end of the embolectomy stent is in a disc-like configuration in an open state, and the outer diameter of the disc-like configuration is adaptive to the inner diameter of the blood vessel.

13. The controllable embolectomy device of claim 4, wherein the spatial configuration of the embolectomy device in the open state of the basket of the embolectomy device is any one or more of ellipsoidal, spindle-shaped, rugby-ball-shaped, bulb-shaped, gourd-shaped, pear-shaped, and dumbbell-shaped.

Technical Field

The disclosure relates to the field of medical equipment, in particular to an adjustable thrombus removal device.

Background

Acute ischemic stroke is nerve tissue injury caused by ischemic necrosis of local brain tissue due to sudden blockage of cerebral blood flow, and is a main disease causing death and disability of the middle-aged and elderly people. With the increasing population and living standard of the elderly, the incidence of cerebrovascular diseases is increasing. Recanalization of blood vessels is the key to the treatment of acute ischemic stroke, and the current conventional methods for treating acute ischemic stroke include two major categories: intravascular thrombolysis and mechanical embolectomy.

The intravascular thrombolysis is formed by injecting the thrombolysis agent near a lesion in a blood vessel with a duct, so that high thrombolysis concentration is formed in the local part of the lesion instantly, the thrombolysis speed is accelerated, and the opportunity of recanalization of the blood vessel is increased. Firstly, the venous thrombolysis is required to be carried out within 3 hours of the onset of disease, the arterial thrombolysis time window is within 6 hours, and few patients can receive the thrombolysis treatment; secondly, thrombolytic therapy is only suitable for small-volume thrombi, and the effect on large-volume small thrombi is not ideal; thrombolysis requires extremely large doses of thrombolytic drugs to dissolve, but this is prone to cause various complications and risks. In order to solve the problem of intravascular thrombolysis, mechanical thrombus removal is adopted for patients who are not suitable for drug thrombolysis.

The existing common laser engraving integral thrombus taking support has the defects of poor remote lesion capability, thrombus escape, easiness in damaging blood vessels by pulling and bending, high complications and the like, and suffers from the following problems.

Disclosure of Invention

In order to overcome the deficiencies of the prior art, the present disclosure provides an adjustable bolt removal device to at least partially solve the above technical problems.

In order to achieve the above object, the present disclosure provides an adjustable embolectomy device, comprising:

an adjustable handle having a hollow structure, the adjustable handle including an adjustment knob;

an adjusting filament, a proximal end of the adjusting filament being connected with the adjusting knob, the adjusting filament being configured to be rotated and/or axially moved by adjustment of the adjusting knob;

the proximal end of the conveying catheter is inserted into the hollow structure of the adjustable handle, and the conveying catheter is sleeved outside the adjusting filament;

a thrombectomy stent, wherein the proximal end of the thrombectomy stent is connected with the distal end of the adjusting filament, and the thrombectomy stent is configured to expand or contract under the pulling of the adjusting filament.

In some aspects, the adjustment mode of the adjustment knob includes at least one of:

a rotating mode and a push-pull mode.

In some aspects, further comprising:

the guide component is connected with the far end of the embolectomy bracket; the guide component comprises a developing spring, and a ball head is arranged on the developing spring.

In some aspects, the embolectomy support comprises one basket or a plurality of baskets connected in series.

In some aspects, at least a portion of the proximal and/or distal ends of the basket are provided with a visualization marker.

In some aspects, the basket is provided with macro-mesh capture zones or thrombus capture pockets.

In some aspects, the basket is a wire weave structure or a laser engraved structure.

In some aspects, the wire diameter of the wire braid structure ranges from 0.03 mm to 0.12 mm.

In some schemes, the width range of the support rib of the laser engraving structure is 0.04-0.12 mm, and the thickness range is 0.03-0.10 mm.

In some schemes, the wire diameter range of the developing spring is 0.02-0.06 mm;

the length range of the developing spring is 5-15 mm;

the diameter range of the developing spring is 0.2-0.5 mm.

In some schemes, the adjustment range of the overall length of the embolectomy support is 10-60 mm;

the adjusting range of the diameter of the thrombus taking support is 1.0-6.0 mm.

In some aspects, the basket at the distal end of the embolectomy stent is in a disc-shaped structure in an open state, and the outer diameter of the disc-shaped structure is adaptive to the inner diameter of the blood vessel.

In some embodiments, the spatial configuration of the basket of the embolectomy holder in the open state is any one or more of an ellipsoid, a spindle, a rugby, a bulb, a gourd, a pear, and a dumbbell.

The embodiment of the disclosure provides an adjustable thrombus removal device, wherein the near end of the device is an adjustable handle, the far end of the adjustable handle is connected with a conveying catheter, an adjusting filament is arranged in the conveying catheter, the near end of the adjusting filament is connected with an adjusting knob arranged on the adjustable handle, and the far end of the adjusting filament is connected with a thrombus removal support. The adjusting thread is pulled through the operation modes of rotation or horizontal pushing and the like of the adjusting knob, so that the thrombus taking support is expanded and opened under the action of the adjusting thread, the thrombus is captured, the far end of the thrombus taking support can be tightly attached to the inner wall of the blood vessel, and the thrombus is prevented from escaping. Meanwhile, the guide component at the far end of the bolt taking bracket adopts a developable spring with a ball head, so that the far end of the bolt taking bracket has stronger passing capacity.

Drawings

Fig. 1 is a schematic structural diagram of an adjustable thrombus removal device according to a first embodiment of the disclosure;

FIG. 2 is an enlarged schematic view of a distal structure of an adjustable embolectomy device according to a first embodiment of the present disclosure;

FIG. 3 is a schematic view illustrating an operation of the adjustable bolt-removing device according to an embodiment of the disclosure;

fig. 4 is a second schematic view illustrating operation of the controllable embolectomy device according to the first embodiment of the present disclosure;

FIG. 5a is a schematic view illustrating an initial state of a thrombectomy stent provided in an embodiment of the present disclosure;

FIG. 5b is a schematic view of a thrombectomy stent provided in accordance with an embodiment of the present disclosure in a semi-open state at a lesion site;

FIG. 5c is a schematic view of a thrombectomy stent provided in accordance with an embodiment of the present disclosure in a fully opened state at a lesion site;

FIG. 6a is a schematic view illustrating an open state of a thrombus removal stent of an adjustable thrombus removal device at a lesion site according to a second embodiment of the disclosure;

fig. 6b is a schematic structural diagram of a basket of an adjustable bolt-removing device according to a second embodiment of the disclosure;

FIG. 7 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a lesion site according to a third embodiment of the disclosure;

FIG. 8 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased part according to a fourth embodiment of the disclosure;

FIG. 9 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased part according to a fifth embodiment of the disclosure;

FIG. 10 is a schematic view illustrating an opened state of an embolectomy stent of an adjustable and controllable embolectomy device at a diseased site according to a sixth embodiment of the present disclosure;

FIG. 11 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased site according to a seventh embodiment of the disclosure;

FIG. 12 is a schematic view illustrating an opened state of an embolectomy stent of an adjustable and controllable embolectomy device at a diseased part according to an eighth embodiment of the present disclosure;

FIG. 13 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a lesion site according to a ninth embodiment of the disclosure;

FIG. 14 is a schematic view illustrating an open state of an embolectomy stent of an adjustable and controllable embolectomy device at a diseased site according to a tenth embodiment of the present disclosure;

FIG. 15 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased site according to an eleventh embodiment of the disclosure;

FIG. 16 is a schematic view illustrating an opened state of an embolectomy stent of an adjustable and controllable embolectomy device at a diseased site according to a twelfth embodiment of the disclosure;

FIG. 17 is a schematic view illustrating an opened state of an embolectomy stent of an adjustable and controllable embolectomy device in a diseased region according to a thirteenth embodiment of the present disclosure;

FIG. 18 is a schematic view of an open state of an embolectomy stent of an adjustable and controllable embolectomy device provided by a fourteenth embodiment of the disclosure at a diseased site;

FIG. 19 is a schematic view of an open position of a thrombectomy support of the controllable thrombectomy device according to fifteenth embodiment of the present disclosure.

Detailed Description

The technical solution of the present disclosure is further described in detail by the accompanying drawings and examples.

The embodiment of the disclosure provides an adjustable thrombus taking device, which pulls an adjusting filament in a conveying catheter by rotating and/or pushing and pulling an adjusting knob of an adjustable handle, so that a thrombus taking support is expanded and opened under the pulling of the adjusting filament, thrombus is captured, meanwhile, the far end of the thrombus taking support in an opening state can be tightly attached to the inner wall of a blood vessel, the thrombus is prevented from escaping, and a guide part at the far end of the thrombus taking support adopts a developing spring with a ball head, so that the far end of the thrombus taking support has stronger passing capacity.

As discussed in this disclosure, the terms "distal" or "proximal" are used hereinafter in relation to a description of a position or orientation relative to a hand-held end of a treating physician or medical interventionalist. "distal" or "distal side" is a location that is distal to the direction of the hand-held end of the physician or interventionalist. "proximal" or "proximally" is a location in the direction of the hand-held end of a physician or interventionalist. The terms "occlusion", "thrombus" or "occlusion" are used interchangeably.

The present disclosure is described in detail below with reference to specific embodiments, but it should be understood that the following embodiments are not intended to limit the present disclosure, and those skilled in the art can conceive of other similar schemes based on the concept of the present disclosure by combining and arranging specific features in the embodiments.

Fig. 1 is a schematic structural diagram of an adjustable bolt-removing device according to an embodiment of the disclosure; fig. 2 is an enlarged schematic view of a distal structure of an adjustable embolectomy device according to a first embodiment of the present disclosure. As shown in fig. 1 and 2, the adjustable embolectomy device comprises: an adjustable handle 1, an adjusting knob 2, a conveying catheter 3, a thrombus taking support 4, a guide part 5 and an adjusting filament 6. Wherein the guide member 5 includes a developing spring 51 and a ball head 52.

The near-end of the adjustable bolt taking device is adjustable handle 1, adjustable handle 1 is used for the handheld operation of doctor, and adjustable handle 1 has a hollow structure, and adjustable handle 1 includes adjust knob 2.

The proximal end of the adjusting filament 6 is connected with the adjusting knob 2, and the adjusting filament 6 can realize the rotation and/or the axial movement of the adjusting filament 6 under the adjustment of the adjusting knob 2, namely, the tightening and the loosening of the adjusting filament 6 are realized by operating the adjusting knob 2. The operation mode of the adjusting knob 2 can be set to a rotating mode and a push-pull mode.

The proximal end of the conveying conduit 4 is inserted into the hollow structure of the adjustable handle 1, and the conveying conduit 4 is sleeved outside the adjusting filament 6.

The proximal end of the thrombus taking support 4 is connected with the distal end of the adjusting filament 6, the thrombus taking support 4 is a thrombus taking device with an adjustable shape, the adjusting filament 6 can be pulled by operating the adjusting knob 2, so that the thrombus taking support 4 can adjust the diameter from small to large under the stretching action of the adjusting filament 6, and the length is shortened to a certain extent in the axial direction.

The distal end of the thrombectomy support 4 is further connected with a guide part 5, wherein the guide part 5 comprises a developing spring 51, and a bulb 52 is arranged on the developing spring 51. The developing spring 51 is of a soft spring structure, and the ball head 52 is of a ball cap structure, so that the passing capacity of the distal end of the thrombus taking device in the blood vessel can be obviously improved.

FIG. 3 is a schematic view illustrating an operation of the adjustable bolt-removing device according to an embodiment of the disclosure; as shown in fig. 3, the thrombus removal stent 4 reaches a thrombus 8 at a lesion site in a blood vessel 7 by the delivery catheter 3 and the adjustment filaments 6.

Fig. 4 is a second schematic view illustrating operation of the controllable embolectomy device according to the first embodiment of the present disclosure; as shown in fig. 4, the thrombectomy stent 4 achieves capture of a thrombus 8 within the blood vessel 7 in a fully open state.

FIGS. 5a to 5c are schematic views showing the change of the working state of the thrombectomy stent of the controllable thrombectomy device according to the first embodiment of the present disclosure, wherein FIG. 5a is a schematic view showing the initial state of the thrombectomy stent 4 just before reaching the lesion site, and the thrombectomy stent 4 is not yet radially controlled; at the moment, the thrombus removal support 4 is regulated and controlled by operating the adjusting knob 2, the thrombus removal support 4 slowly becomes a middle tensioning state shown in fig. 5b, and the thrombus removal support 4 is in a semi-expansion state at the moment; further, the thrombus taking support 4 is tensioned and regulated through the adjusting knob 2, so that the thrombus taking support 4 is further radially expanded, clings to the inner wall of the blood vessel 7, and the thrombus 8 is captured through the depressed area in the middle of the thrombus taking support 4.

FIG. 6a is a schematic view illustrating an open state of a thrombus removal stent of an adjustable thrombus removal device at a lesion site according to a second embodiment of the disclosure; fig. 6b is a schematic structural diagram of a basket of an adjustable bolt-removing device according to a second embodiment of the disclosure; as shown in FIGS. 6a and 6b, the embolectomy support 4 may be comprised of one or more baskets 41 connected in series, each end of the basket 41 may be provided with a developable indicia 42. When the bolt taking support is opened by adopting a multi-series structure, different unit support structures can be opened in different space states at the same time. The basket 41 may be provided with a large mesh capture area or a thrombus capture depression; the basket 41 may be a wire-woven structure or a laser-engraved structure. If a metal wire weaving structure is adopted, the wire diameter range of the metal wire is 0.03-0.12 mm; if the laser engraving structure is adopted, the width range of the support rib of the laser engraving structure is 0.04-0.12 mm, and the thickness range of the support rib of the laser engraving structure is 0.03-0.10 mm, so that the laser engraving structure has unique mechanical characteristics, and the passing performance and the safety of the laser engraving structure in blood vessels are improved. The spatial form of the basket 41 in the open state can be ellipsoidal, spindle-shaped, rugby-shaped, bulb-shaped, gourd-shaped, pear-shaped or dumbbell-shaped and other different structures, and the bolt taking support 4 can be formed by randomly combining a plurality of baskets 41 in different forms. The thrombus taking support 4 consisting of the net baskets 41 with different shapes is provided with a large mesh capture area or a thrombus capture concave area, so that thrombus can be captured more effectively; the mesh area of the depressed area of the existing self-expanding stent is 9.5mm²On the other hand, the adjustable control provided by the embodiment of the disclosureThe mesh area of the large mesh capture area or the thrombus capture concave area of the thrombus capture support of the thrombus removal device can be 5-19.5 mm²Adjusting; preferably 10-18 mm²To adjust for the same.

The metal wire knitted net basket 41 can be knitted by single-strand wires or by 2-5 strands of wires after being wound; the metal wire can be made of nickel-titanium alloy, platinum core nickel-titanium composite wire, platinum wire and other materials with good development performance, and has the function of shape memory; the basket 41 may be formed by composite knitting using metal wires of the above-mentioned materials, or may be formed by knitting a single material of the above-mentioned materials.

The adjusting range of the length of the thrombus taking support 4 is 10-60 mm, and the adjusting range of the diameter of the thrombus taking support is 1.0-6.0 mm.

The developing spring 51 at the far end of the bolt taking device has the wire diameter range of 0.02-0.06 mm, the length range of 5-15 mm and the diameter range of 0.2-0.5 mm.

FIG. 7 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a lesion site according to a third embodiment of the disclosure; as shown in fig. 7, the thrombus removal stent 4 is completely opened at the position of the thrombus 8 at the lesion site in the blood vessel 7, the thrombus removal stent 4 is composed of 2 baskets 41 with the same size, the metal wires of the baskets 41 are wound by a plurality of strands of filaments, and the single basket is in an ellipsoid shape.

FIG. 8 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased part according to a fourth embodiment of the disclosure; as shown in fig. 8, the thrombus removal stent 4 is completely opened at the position of the thrombus 8 at the lesion site in the blood vessel 7, the thrombus removal stent 4 is composed of 2 baskets 41 with the same size, the metal wires of the baskets 41 are wound by a plurality of strands of thin wires, and a single basket is in a gourd shape.

FIG. 9 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased part according to a fifth embodiment of the disclosure; as shown in fig. 9, the thrombus removal stent 4 is completely opened at the thrombus 8 of the lesion site in the blood vessel 7, the thrombus removal stent 4 is composed of 4 net baskets 41 with different sizes, the two net baskets 41 in the middle are one large and one small, the mesh openings of the net baskets 41 are large, which is beneficial to effectively capturing massive thrombus, the mesh openings of the net baskets 41 at the two ends are densely woven after the net baskets 41 at the two ends are opened, and the net basket 41 at the farthest end can effectively prevent the escape of a distal embolus in the thrombus removal process.

FIG. 10 is a schematic view illustrating an opened state of an embolectomy stent of an adjustable and controllable embolectomy device at a diseased site according to a sixth embodiment of the present disclosure; as shown in figure 10, the thrombus removal stent 4 is completely opened at the lesion part thrombus 8 in the blood vessel 7, the thrombus removal stent 4 is composed of 2 ellipsoidal baskets and a basket with a disc-shaped structure, the basket with the disc-shaped structure is positioned at the farthest end of the thrombus removal stent 4, the outer diameter of the disc-shaped structure is the same as the inner diameter of the blood vessel 7, the disc-shaped structure can be tightly attached to the inner wall of the blood vessel 7 after being opened, and the escape of a distal embolus can be effectively prevented in the thrombus removal process. The outer diameter of the disc-like structure is usually the same as or slightly larger than the inner diameter of the vessel, and in the open state the outer diameter of the disc-like structure is adaptive to the inner diameter of the vessel.

FIG. 11 is a schematic view illustrating an opened state of a thrombus removal stent of an adjustable thrombus removal device at a diseased site according to a seventh embodiment of the disclosure; as shown in fig. 11, the thrombus removal stent 4 is completely opened at the thrombus 8 at the lesion site in the blood vessel 7, the thrombus removal stent 4 is composed of 7 baskets 41 with different sizes, and two thrombus capture concave areas are formed at the middle section of the thrombus removal stent 4, which is beneficial to capturing the thrombus 8.

Fig. 12-17 show various structures of the embolectomy stent 4, which can be made of a metal wire woven structure or a laser engraved structure.

FIG. 18 is a schematic view of an open state of an embolectomy stent of an adjustable and controllable embolectomy device provided by a fourteenth embodiment of the disclosure at a diseased site; as shown in figure 18, the thrombus removal support 4 is completely opened at the position of a thrombus 8 at a lesion part in a blood vessel 7, the thrombus removal support 4 is a novel support, a supporting rib structure is adopted inside, the expansion of the periphery is realized through the supporting rib structure inside, the structure is similar to the movement principle of an umbrella, and the expansion of the thrombus removal support 4 is realized by controlling the adjusting filaments 6 to pull the supporting ribs in the middle to move backwards.

FIG. 19 is a schematic illustration of an open position of a thrombectomy support of the controllable thrombectomy device according to a fifteenth embodiment of the present disclosure; as shown in fig. 19, in the fully opened state, the thrombus extraction stent 4 is composed of 3 ellipsoidal baskets, the 3 baskets are of an integrally woven structure, no cylindrical connection point exists between the two baskets, and a functional concave area beneficial to thrombus capture is formed between the two adjacent baskets.

The specific working process of the adjustable bolt taking device provided by the embodiment of the disclosure is carried out as follows:

the adjusting knob 2 on the adjustable handle 1 is operated by rotating or pushing and pulling to pull the adjusting filament 6, the adjusting filament 6 is used for tensioning the thrombus taking support 4, the thrombus 8 at the lesion part in the blood vessel 7 of the thrombus taking support 4 is expanded and opened, the thrombus 8 is captured, the thrombus taking support 4 and the captured thrombus are withdrawn into the middle catheter together after the thrombus is captured, and then the whole thrombus is withdrawn together outside the body, so that the operation of taking out the thrombus in the blood vessel is realized.

The above-mentioned embodiments, objects, technical solutions and advantages of the present disclosure are described in further detail, it should be understood that the above-mentioned embodiments are merely illustrative of the present disclosure and are not intended to limit the scope of the present disclosure, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present disclosure should be included in the scope of the present disclosure.