阅读说明：本技术 产生液体烟草提取物的改进方法 (Improved method for producing liquid tobacco extract ) 是由 M·比亚斯奥利 M·法里纳 F·夫劳恩多弗 J·库克 S·兰纳斯佩泽 S·劳恩斯坦因 B 于 2020-06-05 设计创作，主要内容包括：提供了一种产生液体烟草提取物的方法,其包括步骤：制备烟草起始材料；在125摄氏度与160摄氏度之间的提取温度下加热所述烟草起始材料达90分钟至270分钟之间；收集加热步骤期间从烟草起始材料释放的挥发性化合物；以及形成包含所收集的挥发性化合物的液体烟草提取物。(A method of producing a liquid tobacco extract is provided, comprising the steps of: preparing a tobacco starting material; heating the tobacco starting material at an extraction temperature of between 125 ℃ and 160 ℃ for between 90 minutes and 270 minutes; collecting volatile compounds released from the tobacco starting material during the heating step; and forming a liquid tobacco extract comprising the collected volatile compounds.)

1. A method of producing a liquid tobacco extract, the method comprising the steps of:

preparing a tobacco starting material;

heating the tobacco starting material at an extraction temperature of between 125 ℃ and 160 ℃ for between 90 minutes and 270 minutes;

collecting volatile compounds released from the tobacco starting material during the heating step; and

forming a liquid tobacco extract comprising the collected volatile compounds.

2. The method of claim 1, wherein the tobacco starting material is heated at an extraction temperature of between 125 degrees Celsius and 140 degrees Celsius.

3. The method of claim 1 or 2, wherein the tobacco starting material is heated at the extraction temperature for at least 120 minutes.

4. The method according to any preceding claim, wherein the extraction temperature is selected to provide a liquid tobacco extract having a nicotine content of at least 0.2 wt% on a dry weight basis.

5. The method of any preceding claim, wherein the extraction temperature is selected to provide a weight ratio of (β -ionone + β -damascenone) to (phenol) of at least about 0.25.

6. The method of any preceding claim, wherein the extraction temperature is selected to provide (dimethylhydroxyfuranone + (2, 3-diethyl-5-methylpyrazine) × 100)) at least about 5 x 10 (nicotine) pairs^-4In a weight ratio of (a).

7. A method according to any preceding claim, wherein the tobacco starting material is heated in a flow of inert gas.

8. A method according to any preceding claim, wherein the tobacco starting material is impregnated with an aerosol-forming agent prior to the heating step.

9. The method of any preceding claim, wherein the volatile compounds are collected by condensation.

10. The method according to any one of claims 1 to 8, wherein the volatile compounds are collected by absorption into a liquid carrier, preferably an aerosol former.

11. The method of claim 10, wherein the aerosol former comprises glycerin, propylene glycol, or a combination thereof.

12. The method of any preceding claim, further comprising the step of drying or concentrating the collected volatile compounds.

13. The method of any preceding claim, wherein the step of preparing the tobacco starting material comprises grinding the tobacco material to form a tobacco powder.

14. A method according to any preceding claim, wherein in the step of preparing the tobacco starting material, the tobacco is not subjected to any treatment suitable for altering the pH of the tobacco.

15. A liquid tobacco extract produced by the method of any preceding claim.

Nicotine compositions according to examples 2a and 2b of the invention contain acceptably low levels of undesired compounds such as phenol, 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone, (R, S) -N-nitrosoanatabine, (R, S) -N-nitrosoanabasine, N-nitrosonornicotine and 2-furancarbinol.

Example 3

This example provides three nicotine compositions according to the invention, each being a liquid tobacco extract obtained directly from an extraction process at a temperature of 130 degrees celsius for 3 hours.

Example 3a

Example 3a relates to a liquid tobacco extract derived from a flavourant smoky light tobacco material. The contents of the liquid tobacco extract of example 3a were as follows:

■ Nicotine: 0.4% w/w

■ propylene glycol: 84% by weight/weight

■ acetic acid: 1.0% w/w

■ water: 12.5% w/w

■ balance (including flavoring): 2.1% w/w

Example 3b

Example 3b relates to a liquid tobacco extract derived from fire tube flue-cured light-colored tobacco material. The contents of the liquid tobacco extract of example 3b were as follows:

■ Nicotine: 1.2% w/w

■ propylene glycol: 84% by weight/weight

■ acetic acid: 1.0% w/w

■ water: 12.5% w/w

■ balance (including flavoring): 1.3% w/w

Example 3c

Example 3c relates to a liquid tobacco extract derived from burley tobacco material. The contents of the liquid tobacco extract of example 3c were as follows:

■ Nicotine: 2.6% w/w

■ propylene glycol: 84% by weight/weight

■ acetic acid: 0.5% by weight/weight

■ water: 12.5% w/w

■ balance (including flavoring): 0.4% w/w

The nicotine composition of example 3 provides optimized levels of desirable flavor compounds such as beta-damascenone and beta-ionone for undesirable compounds such as phenol, 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone, (R, S) -N-nitrosoanatabine, (R, S) -N-nitrosoanabasine, N-nitrosonornicotine and 2-furancarbinol. The nicotine composition also provides a level of nicotine with desirable flavor compounds such as dimethylhydroxyfuranone and 2, 3-diethyl-5-methylpyrazine.

Example 4

The liquid tobacco extract of example 1 was concentrated during the dehydration process to reduce the moisture level of the liquid tobacco extract to about 15%.

Glycerin is added to the resulting concentrated liquid tobacco extract to form a nicotine composition such that the nicotine composition contains 20% by weight glycerin and 80% by weight liquid tobacco extract based on the weight of the nicotine composition.

Example 5

Example 4 relates to a nicotine composition according to the invention in the form of a gel. The gel nicotine composition was formed from the liquid tobacco extract of example 1. The contents of the gel nicotine composition were as follows:

■ liquid tobacco extract of example 1: 99.0% w/w

■ agar: 1.0% w/w

Example 6

Three tobacco starting materials were prepared from fire-tube flue-cured light-colored tobacco material (6A), burley tobacco material (6B) and flavoured tobacco material (6C), respectively.

Each of the three tobacco materials was cut to form tobacco pieces having dimensions of 2.5 mm by 2.5 mm, and the tobacco pieces were loaded into the extraction chamber without compression.

Each of the tobacco starting materials was heated within the extraction chamber to a temperature of 130 degrees celsius for a period of 120 minutes. During heating, a nitrogen flow was passed through the extraction chamber at a flow rate of 2 liters/min.

Volatile compounds released from each tobacco starting material during the heating step were collected by absorption into the liquid solvent formed from propylene glycol at 0 degrees celsius.

The liquid tobacco extract is obtained directly from such an extraction process. Each liquid extract obtained from each of the three tobacco starting materials was then concentrated at 55 degrees celsius under vacuum (50 mbar) until a moisture content of 12% ± 2% was reached.

TABLE 2 values for selected weight ratios of desirable tobacco compounds to undesirable tobacco compounds within liquid tobacco extracts

In all three liquid extracts 6A, 6B and 6C according to the invention, the weight ratio of (β -ionone + β -damascenone) to (phenol) is consistent and significantly higher than 2.0. Furthermore, in all three liquid extracts 6A, 6B and 6C according to the invention, the weight ratio of (dimethylhydroxyfuranone + (2, 3-diethyl-5-methylpyrazine) × 100)) to (nicotine) is consistent and significantly higher than 1 × 10^-3. In addition, in all three liquid extracts 6A, 6B and 6C according to the invention, the weight ratio of (β -ionone + β -damascenone) to (4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone + (R, S) -N-nitrosoanatabine + (R, S) -N-nitrosoanabasine + N-nitrosonornicotine + ((2-furancarbinol)/600)) is consistently and significantly higher than 3.